JP2007513969A5 - - Google Patents
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- Publication number
- JP2007513969A5 JP2007513969A5 JP2006544042A JP2006544042A JP2007513969A5 JP 2007513969 A5 JP2007513969 A5 JP 2007513969A5 JP 2006544042 A JP2006544042 A JP 2006544042A JP 2006544042 A JP2006544042 A JP 2006544042A JP 2007513969 A5 JP2007513969 A5 JP 2007513969A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- aryl
- compound
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 239000000126 substance Substances 0.000 claims 13
- 125000000304 alkynyl group Chemical group 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 10
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000004450 alkenylene group Chemical group 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000004419 alkynylene group Chemical group 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- -1 2- (2,4-dinitro-imidazol-1-yl) -1- [4- (4-fluorophenyl) -piperazin-1-yl] -ethanone 2- (2,4-dinitro-imidazol-1-yl) -1- (4-phenyl-piperazin-1-yl) -ethanone Chemical compound 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- LMIJMOOVLDNTLB-UHFFFAOYSA-N 2-(3,5-dimethyl-4-nitropyrazol-1-yl)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone Chemical compound CC1=C([N+]([O-])=O)C(C)=NN1CC(=O)N1CCN(C=2C=CC(F)=CC=2)CC1 LMIJMOOVLDNTLB-UHFFFAOYSA-N 0.000 claims 1
- IEUFCZWQSBPTOF-UHFFFAOYSA-N 2-(4-nitroimidazol-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound C1=NC([N+](=O)[O-])=CN1CC(=O)N1CCN(C=2C=CC=CC=2)CC1 IEUFCZWQSBPTOF-UHFFFAOYSA-N 0.000 claims 1
- HTYBEXPZARGDNU-UHFFFAOYSA-N 2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone Chemical compound CC1=C(Cl)C(C(F)(F)F)=NN1CC(=O)N1CCN(C=2C=CC(F)=CC=2)CC1 HTYBEXPZARGDNU-UHFFFAOYSA-N 0.000 claims 1
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 claims 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000004316 oxathiadiazolyl group Chemical group O1SNN=C1* 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/732,897 US7842693B2 (en) | 2002-06-12 | 2003-12-09 | Substituted piperazines |
| US10/732,897 | 2003-12-09 | ||
| US10/979,882 US20050256130A1 (en) | 2002-06-12 | 2004-11-01 | Substituted piperazines |
| US10/979,882 | 2004-11-01 | ||
| PCT/US2004/041509 WO2005056015A1 (en) | 2003-12-09 | 2004-12-08 | Substituted piperazines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007513969A JP2007513969A (ja) | 2007-05-31 |
| JP2007513969A5 true JP2007513969A5 (https=) | 2008-02-07 |
| JP4988355B2 JP4988355B2 (ja) | 2012-08-01 |
Family
ID=34681747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544042A Expired - Lifetime JP4988355B2 (ja) | 2003-12-09 | 2004-12-08 | 置換ピペラジン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050256130A1 (https=) |
| EP (1) | EP1691810A4 (https=) |
| JP (1) | JP4988355B2 (https=) |
| KR (1) | KR101066501B1 (https=) |
| AU (1) | AU2004296879B2 (https=) |
| CA (1) | CA2548426A1 (https=) |
| WO (1) | WO2005056015A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1531822T3 (da) | 2002-06-12 | 2009-12-07 | Chemocentryx Inc | 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser |
| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7435830B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7777035B2 (en) * | 2005-06-22 | 2010-08-17 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| BRPI0612112A8 (pt) * | 2005-06-22 | 2017-12-26 | Chemocentryx Inc | composto, composição farmacêutica, e, método de tratar doenças ou condições mediadas por ccr1. |
| US7790726B2 (en) * | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
| JP2007106746A (ja) * | 2005-09-13 | 2007-04-26 | Tosoh Corp | 新規アリールホモピペラジン類、またはその塩と製造方法 |
| US7750012B2 (en) | 2005-12-21 | 2010-07-06 | Decode Genetics Ehf | Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation |
| US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| US7615556B2 (en) | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| US20090252779A1 (en) * | 2006-06-22 | 2009-10-08 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| JP4992320B2 (ja) * | 2006-07-18 | 2012-08-08 | 住友化学株式会社 | ハロゲノアリルフルフリルアルコール類の製造方法 |
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| DK2155712T3 (en) | 2007-05-22 | 2016-12-19 | Chemocentryx Inc | 3- (imidazolyl) pyrazolo [3,4-b] pyridines |
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| TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
| JP5654467B2 (ja) | 2008-09-11 | 2015-01-14 | ケモセントリックス，インコーポレイティド | ４−アミノ−３−（イミダゾリル）−ピラゾロ［３，４−ｄ］ピリミジン |
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| US8741892B2 (en) * | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
| US8642774B2 (en) * | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
| US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
| US8716277B2 (en) | 2011-12-14 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity |
| US8883789B2 (en) | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
| US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
| US8889677B2 (en) * | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
| WO2013108837A1 (ja) * | 2012-01-18 | 2013-07-25 | 興和株式会社 | Ｔｌｒ阻害作用を有するピラゾール誘導体 |
| PL2807153T3 (pl) * | 2012-01-25 | 2020-09-07 | Novartis Ag | Związki heterocykliczne i sposoby ich zastosowania |
| JP6163205B2 (ja) | 2012-06-20 | 2017-07-12 | ノバルティス アーゲー | 補体経路モジュレーターおよびその使用 |
| DK2888261T3 (en) * | 2012-08-27 | 2018-07-30 | Chemocentryx Inc | Antagonists of chemokine receptors |
| AU2013355054B2 (en) | 2012-12-07 | 2017-08-24 | Chemocentryx, Inc. | Diazole lactams |
| US9637505B2 (en) | 2013-03-15 | 2017-05-02 | Dow Agrosciences Llc | 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides |
| EA030067B1 (ru) | 2013-07-22 | 2018-06-29 | Идорсиа Фармасьютиклз Лтд | Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| JP6337218B2 (ja) | 2015-01-15 | 2018-06-06 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｃｘｃｒ３受容体調節剤としてのヒドロキシアルキル−ピペラジン誘導体 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| CN109310677A (zh) | 2016-04-07 | 2019-02-05 | 凯莫森特里克斯股份有限公司 | 通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷 |
| AU2017281907B2 (en) * | 2016-06-23 | 2021-10-21 | St. Jude Children's Research Hospital, Inc. | Small molecule modulators of pantothenate kinases |
| EP3731859B1 (en) | 2017-12-27 | 2025-08-20 | St. Jude Children's Research Hospital, Inc. | Pyridazine compounds for use to treat disorders associated with castor |
| KR102728619B1 (ko) | 2017-12-27 | 2024-11-08 | 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 | 판토테네이트 키나제의 소분자 조절제 |
| CN116640097B (zh) * | 2022-02-16 | 2025-10-24 | 浙江理工大学 | 一种脂肪胺参与的5-三氟甲基取代的1,2,4-三氮唑化合物的制备方法 |
| CN115754084B (zh) * | 2022-11-30 | 2024-07-12 | 天和药业有限公司 | 一种吗伐考昔的分析方法 |
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- 2004-12-08 EP EP04813774A patent/EP1691810A4/en not_active Withdrawn
- 2004-12-08 CA CA002548426A patent/CA2548426A1/en not_active Abandoned
- 2004-12-08 WO PCT/US2004/041509 patent/WO2005056015A1/en not_active Ceased
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