JP2022551422A5 - - Google Patents
Info
- Publication number
- JP2022551422A5 JP2022551422A5 JP2022518960A JP2022518960A JP2022551422A5 JP 2022551422 A5 JP2022551422 A5 JP 2022551422A5 JP 2022518960 A JP2022518960 A JP 2022518960A JP 2022518960 A JP2022518960 A JP 2022518960A JP 2022551422 A5 JP2022551422 A5 JP 2022551422A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- membered
- cycloalkyl
- condensed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962906647P | 2019-09-26 | 2019-09-26 | |
| US62/906,647 | 2019-09-26 | ||
| US202063053530P | 2020-07-17 | 2020-07-17 | |
| US63/053,530 | 2020-07-17 | ||
| PCT/US2020/052850 WO2021062245A1 (en) | 2019-09-26 | 2020-09-25 | Pyridone compounds and methods of use in the modulation of a protein kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022551422A JP2022551422A (ja) | 2022-12-09 |
| JP2022551422A5 true JP2022551422A5 (https=) | 2023-08-24 |
Family
ID=72827019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022518960A Ceased JP2022551422A (ja) | 2019-09-26 | 2020-09-25 | ピリドン化合物およびタンパク質キナーゼの調節における使用の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12371428B2 (https=) |
| EP (1) | EP4034532A1 (https=) |
| JP (1) | JP2022551422A (https=) |
| CN (1) | CN114787144A (https=) |
| AU (1) | AU2020351782A1 (https=) |
| CA (1) | CA3155924A1 (https=) |
| TW (1) | TW202126651A (https=) |
| WO (1) | WO2021062245A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022551422A (ja) | 2019-09-26 | 2022-12-09 | エグゼリクシス， インコーポレイテッド | ピリドン化合物およびタンパク質キナーゼの調節における使用の方法 |
| GB202004960D0 (en) * | 2020-04-03 | 2020-05-20 | Kinsenus Ltd | Inhibitor compounds |
| CA3211063A1 (en) | 2021-02-19 | 2022-08-25 | Exelixis, Inc. | Pyridone compounds and methods of use |
| IT202100022682A1 (it) * | 2021-09-01 | 2023-03-01 | Luigi Frati | Derivati pirimidinici e loro uso nel trattamento di tumori |
| WO2023114809A1 (en) | 2021-12-16 | 2023-06-22 | Kinnate Biopharma Inc. | Inhibitors of met kinase |
| CN114213404B (zh) * | 2021-12-27 | 2024-08-06 | 武汉九州钰民医药科技有限公司 | Vegfr抑制剂替沃扎尼的合成工艺 |
| CN117362275A (zh) * | 2022-06-29 | 2024-01-09 | 广州百霆医药科技有限公司 | 一种酪氨酸蛋白激酶抑制剂及其用途 |
| CN121038792A (zh) * | 2023-04-17 | 2025-11-28 | 赛琳治疗公司 | 用met激酶抑制剂治疗癌症 |
| WO2024217587A1 (zh) * | 2023-04-21 | 2024-10-24 | 南京正大天晴制药有限公司 | 具有axl抑制活性的取代吡嗪化合物 |
| WO2024259060A1 (en) * | 2023-06-16 | 2024-12-19 | Kinnate Biopharma Inc. | Inhibitors of met kinase |
| CN117343046A (zh) * | 2023-09-25 | 2024-01-05 | 辽宁大学 | 一种新型3-氧代-4-取代芳基-3,4-二氢吡嗪-2-甲酰胺类化合物及其应用 |
| WO2025096463A1 (en) * | 2023-10-30 | 2025-05-08 | Vibliome Therapeutics, Llc | Plk4 modulators |
| CN118878515B (zh) * | 2024-06-19 | 2025-10-28 | 河北科技大学 | 一种取代苯胺嘧啶类化合物及其制备方法和用途 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| WO1996003397A1 (en) | 1994-07-21 | 1996-02-08 | Akzo Nobel N.V. | Cyclic ketone peroxide formulations |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| EA001595B1 (ru) | 1996-04-12 | 2001-06-25 | Варнер-Ламберт Компани | Необратимые ингибиторы тирозинкиназ |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| WO2007033196A1 (en) * | 2005-09-14 | 2007-03-22 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| JP2009537632A (ja) * | 2006-05-19 | 2009-10-29 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 過剰増殖性障害および血管新生障害の処置に有用なピリドンカルボキサミド誘導体 |
| JP2009539878A (ja) | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| CN102816175B (zh) | 2011-06-09 | 2015-12-16 | 上海汇伦生命科技有限公司 | 一种杂环并吡啶酮类化合物,其中间体、制备方法和用途 |
| SG11201402004YA (en) * | 2011-11-14 | 2014-05-29 | Cephalon Inc | Uracil derivatives as axl and c-met kinase inhibitors |
| CN102643268B (zh) | 2011-12-30 | 2014-05-21 | 沈阳药科大学 | 喹啉类及噌啉类化合物及其应用 |
| WO2013180949A1 (en) | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
| CN104072480B (zh) | 2013-03-27 | 2016-12-28 | 沈阳药科大学 | 喹啉类化合物及其制备方法和应用 |
| TWI649308B (zh) * | 2013-07-24 | 2019-02-01 | 小野藥品工業股份有限公司 | 喹啉衍生物 |
| ES2749726T3 (es) | 2014-12-25 | 2020-03-23 | Ono Pharmaceutical Co | Derivado de quinolina |
| CN108530426A (zh) | 2017-03-02 | 2018-09-14 | 沈阳药科大学 | 含喹喔啉酮的4-苯氧基取代喹啉类化合物及其应用 |
| WO2019080723A1 (zh) | 2017-10-26 | 2019-05-02 | 北京越之康泰生物医药科技有限公司 | 多取代吡啶酮类衍生物、其制备方法及其医药用途 |
| CN109896997A (zh) | 2017-12-08 | 2019-06-18 | 中国药科大学 | N－酰基苯胺类c－Met激酶抑制剂的制备方法及其用途 |
| US20210177828A1 (en) | 2018-01-17 | 2021-06-17 | Nanjing Transthera Biosciences Co., Ltd. | Tam family kinase /and csf1r kinase inhibitor and use thereof |
| ES2985569T3 (es) | 2018-08-24 | 2024-11-06 | Transthera Sciences Nanjing Inc | Nuevo inhibidor de derivado de quinolina |
| CA3114987A1 (en) | 2018-08-27 | 2020-03-05 | Beijing Yuezhikangtai Biomedicines Co., Ltd. | Multi-substituted pyridone derivatives and medical use thereof |
| UY38349A (es) | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
| JP7542613B2 (ja) * | 2019-09-06 | 2024-08-30 | 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ | Ａｘｌとｃ－Ｍｅｔキナーゼ阻害活性を有する化合物およびその製造と使用 |
| JP2022551422A (ja) | 2019-09-26 | 2022-12-09 | エグゼリクシス， インコーポレイテッド | ピリドン化合物およびタンパク質キナーゼの調節における使用の方法 |
| JP2023514725A (ja) | 2020-02-24 | 2023-04-07 | エグゼリクシス， インコーポレイテッド | 化合物および使用方法 |
-
2020
- 2020-09-25 JP JP2022518960A patent/JP2022551422A/ja not_active Ceased
- 2020-09-25 AU AU2020351782A patent/AU2020351782A1/en not_active Abandoned
- 2020-09-25 TW TW109133416A patent/TW202126651A/zh unknown
- 2020-09-25 US US17/033,475 patent/US12371428B2/en active Active
- 2020-09-25 CN CN202080080953.7A patent/CN114787144A/zh active Pending
- 2020-09-25 CA CA3155924A patent/CA3155924A1/en active Pending
- 2020-09-25 EP EP20789784.4A patent/EP4034532A1/en active Pending
- 2020-09-25 WO PCT/US2020/052850 patent/WO2021062245A1/en not_active Ceased
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