JP2024513881A5 - - Google Patents

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Publication number
JP2024513881A5
JP2024513881A5 JP2023561271A JP2023561271A JP2024513881A5 JP 2024513881 A5 JP2024513881 A5 JP 2024513881A5 JP 2023561271 A JP2023561271 A JP 2023561271A JP 2023561271 A JP2023561271 A JP 2023561271A JP 2024513881 A5 JP2024513881 A5 JP 2024513881A5
Authority
JP
Japan
Prior art keywords
unsubstituted
substituted
pharmaceutically acceptable
alkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023561271A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024513881A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/023573 external-priority patent/WO2022216762A1/en
Publication of JP2024513881A publication Critical patent/JP2024513881A/ja
Publication of JP2024513881A5 publication Critical patent/JP2024513881A5/ja
Pending legal-status Critical Current

Links

JP2023561271A 2021-04-08 2022-04-06 オキサゼピン化合物及びがんの治療におけるその使用 Pending JP2024513881A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/085959 2021-04-08
CN2021085959 2021-04-08
PCT/US2022/023573 WO2022216762A1 (en) 2021-04-08 2022-04-06 Oxazepine compounds and uses thereof in the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2024513881A JP2024513881A (ja) 2024-03-27
JP2024513881A5 true JP2024513881A5 (https=) 2025-04-02

Family

ID=81387302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023561271A Pending JP2024513881A (ja) 2021-04-08 2022-04-06 オキサゼピン化合物及びがんの治療におけるその使用

Country Status (12)

Country Link
US (1) US20240383915A1 (https=)
EP (1) EP4320132A1 (https=)
JP (1) JP2024513881A (https=)
KR (1) KR20230167386A (https=)
CN (1) CN117083279A (https=)
AR (1) AR125304A1 (https=)
AU (1) AU2022254674A1 (https=)
BR (1) BR112023020773A2 (https=)
CA (1) CA3215949A1 (https=)
MX (1) MX2023011873A (https=)
TW (1) TWI868441B (https=)
WO (1) WO2022216762A1 (https=)

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AU2023231139A1 (en) 2022-03-11 2024-09-05 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
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AU2023320914A1 (en) * 2022-08-11 2025-02-27 Beone Medicines I Gmbh Heterocyclic compounds, compositions thereof, and methods of treatment therewith
WO2024041573A1 (en) * 2022-08-25 2024-02-29 Zai Lab (Shanghai) Co., Ltd. Fused multi-heterocyclic compounds as kras g12d modulators and uses thereof
AU2023363515A1 (en) * 2022-10-18 2025-04-17 Idience Co., Ltd. Novel triheterocyclic compounds
JP2025535367A (ja) * 2022-10-19 2025-10-24 ジェネンテック, インコーポレイテッド 6-アザ部分を含むオキサゼピン化合物およびその使用
TW202430179A (zh) 2022-11-21 2024-08-01 美商樹線生物科學公司 螺環二氫哌喃并嘧啶KRas抑制劑
WO2024153180A1 (zh) * 2023-01-18 2024-07-25 上海艾力斯医药科技股份有限公司 杂环类化合物、其药物组合物及其用途
US12448399B2 (en) 2023-01-26 2025-10-21 Arvinas Operations, Inc. Cereblon-based KRAS degrading PROTACs and uses related thereto
WO2024197503A1 (en) * 2023-03-27 2024-10-03 Nikang Therapeutics , Inc. Tricyclic derivatives as kras inhibitors
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
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CN121100123A (zh) 2023-04-14 2025-12-09 锐新医药公司 Ras抑制剂的结晶形式
CN121464140A (zh) 2023-04-14 2026-02-03 锐新医药公司 Ras抑制剂的结晶形式、含有其的组合物及其使用方法
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ras相關疾病或病症之組合療法
CN121194980A (zh) * 2023-05-16 2025-12-23 和记黄埔医药(上海)有限公司 三环类化合物及其用途
CN121605110A (zh) * 2023-06-06 2026-03-03 金橘生物科技公司 取代杂环化合物及其用途
CN121263417A (zh) * 2023-06-30 2026-01-02 金橘生物科技公司 取代的稠合三环胺化合物及其作为ras抑制剂的用途
CN116903499B (zh) * 2023-07-11 2025-05-30 上海应用技术大学 无水氟磺酰基二氟乙酸铜盐及其制备方法与应用
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
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TW202528315A (zh) 2023-09-21 2025-07-16 美商樹線生物科學公司 螺環二氫哌喃并吡啶KRas抑制劑
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WO2025096738A1 (en) * 2023-11-01 2025-05-08 Incyte Corporation Kras inhibitors
WO2025111586A1 (en) 2023-11-22 2025-05-30 Genentech, Inc. Polymorphs of and synthetic process for an aza-tetracyclic oxazepine inhibitor of kras-g12d
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