JP2022554392A5 - - Google Patents
Info
- Publication number
- JP2022554392A5 JP2022554392A5 JP2022526331A JP2022526331A JP2022554392A5 JP 2022554392 A5 JP2022554392 A5 JP 2022554392A5 JP 2022526331 A JP2022526331 A JP 2022526331A JP 2022526331 A JP2022526331 A JP 2022526331A JP 2022554392 A5 JP2022554392 A5 JP 2022554392A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- substituted
- compound
- alkyl
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962931186P | 2019-11-05 | 2019-11-05 | |
| US62/931,186 | 2019-11-05 | ||
| US201962931576P | 2019-11-06 | 2019-11-06 | |
| US62/931,576 | 2019-11-06 | ||
| US202063046481P | 2020-06-30 | 2020-06-30 | |
| US63/046,481 | 2020-06-30 | ||
| PCT/US2020/059228 WO2021092264A1 (en) | 2019-11-05 | 2020-11-05 | MrgprX2 ANTAGONISTS AND USES THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022554392A JP2022554392A (ja) | 2022-12-28 |
| JP2022554392A5 true JP2022554392A5 (https=) | 2023-10-31 |
| JP7787811B2 JP7787811B2 (ja) | 2025-12-19 |
Family
ID=73740488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022526331A Active JP7787811B2 (ja) | 2019-11-05 | 2020-11-05 | ＭｒｇｐｒＸ２アンタゴニストおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230002336A1 (https=) |
| EP (1) | EP4055011A1 (https=) |
| JP (1) | JP7787811B2 (https=) |
| CN (1) | CN114728919B (https=) |
| AU (1) | AU2020380926A1 (https=) |
| CA (1) | CA3159633A1 (https=) |
| IL (1) | IL292693A (https=) |
| WO (1) | WO2021092264A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115850094B (zh) * | 2022-09-07 | 2025-02-11 | 北华航天工业学院 | 一种利用1,2-环氧丁烷合成β-氨基醇的方法 |
| WO2025002360A1 (zh) * | 2023-06-30 | 2025-01-02 | 北京普祺医药科技股份有限公司 | 一种mrgprx2拮抗剂、药物组合物以及其用途 |
| WO2025042736A1 (en) | 2023-08-18 | 2025-02-27 | Incyte Corporation | Bicyclic heterocycles as mrgprx2 antagonists |
| WO2025160430A1 (en) | 2024-01-25 | 2025-07-31 | Incyte Corporation | Bicyclic heterocycles as mrgprx2 antagonists |
| KR20250121245A (ko) * | 2024-02-02 | 2025-08-12 | 삼진제약주식회사 | MRGPRX2 (Mas-related G-protein coupled receptor member X2) 길항제로서 신규 화합물 및 이를 포함하는 약학적 조성물 |
| WO2025222040A1 (en) | 2024-04-19 | 2025-10-23 | Escient Pharmaceuticals, Inc. | Mrgprx2 modulators for use in treating mrgprx2 dependent conditions in subjects with low ige |
| TW202547469A (zh) | 2024-04-19 | 2025-12-16 | 日商杏林製藥股份有限公司 | Mrgprx2拮抗劑、包含mrgprx2拮抗劑之醫藥組成物及治療mrgprx2媒介疾病或病症之方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4152442A (en) * | 1975-06-05 | 1979-05-01 | Lilly Industries Limited | Certain acylamino-oxa (or thia) diazoles in treatment of hypersensitivity conditions |
| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| DE3272640D1 (en) * | 1982-01-22 | 1986-09-18 | Basf Ag | Thiadiazole derivatives, process for their preparation, and their use in combatting unwanted plant growth |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| JP2006522744A (ja) * | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法 |
| GB0308511D0 (en) * | 2003-04-14 | 2003-05-21 | Astex Technology Ltd | Pharmaceutical compounds |
| EP1658072A4 (en) * | 2003-08-21 | 2009-03-25 | Pfizer Prod Inc | Compounds for the Treatment of Neurodegenerative Diseases |
| DE102004009933A1 (de) * | 2004-02-26 | 2005-09-15 | Merck Patent Gmbh | Verwendung von Thiadiazolharnstoffderivaten |
| EP2125799A1 (en) * | 2007-02-28 | 2009-12-02 | Smithkline Beecham Corporation | Thiadiazole derivatives, inhibitors of stearoyl-coa desaturase |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| MX2010013705A (es) * | 2008-06-13 | 2011-02-25 | Bayer Cropscience Ag | Nuevas amidas y tioamidas heteroaromaticas como plaguicidas. |
| WO2010073011A2 (en) * | 2008-12-23 | 2010-07-01 | Betagenon Ab | Compounds useful as medicaments |
| US8377639B2 (en) * | 2009-06-26 | 2013-02-19 | University Of Massachusetts | Compounds for modulating RNA binding proteins and uses therefor |
| PT2673285T (pt) * | 2010-12-09 | 2017-10-19 | Wockhardt Ltd | Resumo |
| CA2850551A1 (en) * | 2011-09-30 | 2013-04-04 | Endo Pharmaceuticals Inc. | Pyridine derivatives |
| ES2670517T3 (es) * | 2013-01-30 | 2018-05-30 | Sumitomo Chemical Company, Limited | Compuesto de amida, un agente de control de plagas de artrópodos y un método para controlar las plagas de artrópodos |
| EP3444251B1 (en) * | 2013-12-11 | 2023-06-07 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| US10253023B2 (en) * | 2014-10-06 | 2019-04-09 | Merck Patent Gmbh | Heteroaryl compounds as BTK inhibitors and uses thereof |
| CA3055194A1 (en) * | 2017-03-02 | 2018-09-07 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
-
2020
- 2020-11-05 EP EP20820596.3A patent/EP4055011A1/en active Pending
- 2020-11-05 CA CA3159633A patent/CA3159633A1/en active Pending
- 2020-11-05 CN CN202080082802.5A patent/CN114728919B/zh active Active
- 2020-11-05 US US17/773,414 patent/US20230002336A1/en active Pending
- 2020-11-05 AU AU2020380926A patent/AU2020380926A1/en active Pending
- 2020-11-05 JP JP2022526331A patent/JP7787811B2/ja active Active
- 2020-11-05 WO PCT/US2020/059228 patent/WO2021092264A1/en not_active Ceased
-
2022
- 2022-05-02 IL IL292693A patent/IL292693A/en unknown
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