JP2022554391A5 - - Google Patents
Info
- Publication number
- JP2022554391A5 JP2022554391A5 JP2022526330A JP2022526330A JP2022554391A5 JP 2022554391 A5 JP2022554391 A5 JP 2022554391A5 JP 2022526330 A JP2022526330 A JP 2022526330A JP 2022526330 A JP2022526330 A JP 2022526330A JP 2022554391 A5 JP2022554391 A5 JP 2022554391A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- substituted
- independently selected
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025032508A JP7827911B2 (ja) | 2019-11-05 | 2025-03-03 | ＭｒｇｐｒＸ２アンタゴニストおよびその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962931174P | 2019-11-05 | 2019-11-05 | |
| US62/931,174 | 2019-11-05 | ||
| US201962931627P | 2019-11-06 | 2019-11-06 | |
| US62/931,627 | 2019-11-06 | ||
| US202063046476P | 2020-06-30 | 2020-06-30 | |
| US63/046,476 | 2020-06-30 | ||
| PCT/US2020/059226 WO2021092262A1 (en) | 2019-11-05 | 2020-11-05 | Mrgprx2 antagonists and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025032508A Division JP7827911B2 (ja) | 2019-11-05 | 2025-03-03 | ＭｒｇｐｒＸ２アンタゴニストおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022554391A JP2022554391A (ja) | 2022-12-28 |
| JP2022554391A5 true JP2022554391A5 (https=) | 2023-10-31 |
| JP7645256B2 JP7645256B2 (ja) | 2025-03-13 |
Family
ID=73654898
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022526330A Active JP7645256B2 (ja) | 2019-11-05 | 2020-11-05 | ＭｒｇｐｒＸ２アンタゴニストおよびその使用 |
| JP2025032508A Active JP7827911B2 (ja) | 2019-11-05 | 2025-03-03 | ＭｒｇｐｒＸ２アンタゴニストおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025032508A Active JP7827911B2 (ja) | 2019-11-05 | 2025-03-03 | ＭｒｇｐｒＸ２アンタゴニストおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230027929A1 (https=) |
| EP (1) | EP4054570A1 (https=) |
| JP (2) | JP7645256B2 (https=) |
| CN (2) | CN114901280B (https=) |
| AU (1) | AU2020378009A1 (https=) |
| CA (1) | CA3159628A1 (https=) |
| IL (1) | IL292692B1 (https=) |
| WO (1) | WO2021092262A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019533022A (ja) | 2016-10-24 | 2019-11-14 | ユマニティ セラピューティクス，インコーポレーテッド | 化合物及びその使用 |
| EP3566055B1 (en) | 2017-01-06 | 2025-03-12 | Janssen Pharmaceutica NV | Scd inhibitor for the treatment of neurological disorders |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2019183587A1 (en) | 2018-03-23 | 2019-09-26 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2020154571A1 (en) | 2019-01-24 | 2020-07-30 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2021092240A1 (en) | 2019-11-05 | 2021-05-14 | Dermira, Inc. | Mrgprx2 antagonists for the treatment of inflammatory disorders |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
| WO2022152852A1 (en) * | 2021-01-15 | 2022-07-21 | Glaxosmithkline Intellectual Property Development Limited | Antagonists of mrgx2 |
| CN115925622B (zh) * | 2023-02-10 | 2025-04-22 | 山西永津集团有限公司 | 一种3-氰基吡啶-2-基氨基甲酸叔丁酯的合成方法 |
| WO2025002360A1 (zh) * | 2023-06-30 | 2025-01-02 | 北京普祺医药科技股份有限公司 | 一种mrgprx2拮抗剂、药物组合物以及其用途 |
| IL326496A (en) * | 2023-08-17 | 2026-04-01 | Sanofi Sa | Pyridyl imidazoles – their preparation and therapeutic application |
| WO2025042736A1 (en) | 2023-08-18 | 2025-02-27 | Incyte Corporation | Bicyclic heterocycles as mrgprx2 antagonists |
| WO2025160430A1 (en) | 2024-01-25 | 2025-07-31 | Incyte Corporation | Bicyclic heterocycles as mrgprx2 antagonists |
| WO2025222040A1 (en) | 2024-04-19 | 2025-10-23 | Escient Pharmaceuticals, Inc. | Mrgprx2 modulators for use in treating mrgprx2 dependent conditions in subjects with low ige |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3493555A (en) * | 1966-03-23 | 1970-02-03 | Nepera Chem Co Inc | 3-phenylazo-2,6-pyridyl dicyclopropane-carboxamide |
| US4287207A (en) * | 1979-03-31 | 1981-09-01 | Taiho Pharmaceutical Company, Limited | Pharmaceutical composition containing 1,3,5-substituted biuret compound |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| JP2531989B2 (ja) * | 1988-09-14 | 1996-09-04 | 吉富製薬株式会社 | ピリジン化合物 |
| JPH05201981A (ja) * | 1991-08-06 | 1993-08-10 | Ichikawa Gosei Kagaku Kk | ２−アミノ−３−ニトロ−５−ハロゲノピリジン類の製造方法 |
| US5290943A (en) * | 1991-02-21 | 1994-03-01 | Ichikawa Gosei Chemical Co., Ltd. | Method of producing 2-acyl amino 5-halogenopyridine compounds |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| US20060004029A1 (en) * | 2002-08-30 | 2006-01-05 | Akihiko Tsuruoka | Nitrogen-containing aromatic derivatives |
| WO2004069160A2 (en) * | 2003-01-28 | 2004-08-19 | Smithkline Beecham Corporation | Chemical compounds |
| EP1696915A1 (en) * | 2003-12-19 | 2006-09-06 | Pfizer, Inc. | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-hsd-1) for the treatment of diabetes and obesity |
| CN1736989A (zh) * | 2004-08-20 | 2006-02-22 | 中国科学院大连化学物理研究所 | 一种杂环菊酯类化合物及其在除草杀菌方面的应用 |
| KR20080063865A (ko) * | 2005-11-28 | 2008-07-07 | 에프. 호프만-라 로슈 아게 | 다이아실글리세롤 아실전이효소(ｄｇａｔ)의 저해제 |
| AU2007230911A1 (en) * | 2006-03-23 | 2007-10-04 | Synta Pharmaceuticals Corp. | Benzimidazolyl-pyridine compounds for inflammation and immune-related uses |
| WO2008063625A2 (en) * | 2006-11-20 | 2008-05-29 | Adolor Corporation | Pyridine compounds and methods of their use |
| ATE510827T1 (de) * | 2007-10-12 | 2011-06-15 | Ingenium Pharmaceuticals Gmbh | Inhibitoren von proteinkinasen |
| WO2010094644A1 (en) * | 2009-02-17 | 2010-08-26 | Neurosearch A/S | Substituted pyridine derivatives and their medical use |
| WO2011074658A1 (ja) * | 2009-12-18 | 2011-06-23 | 田辺三菱製薬株式会社 | 新規抗血小板薬 |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| EP2545037A1 (en) * | 2010-03-10 | 2013-01-16 | Ingenium Pharmaceuticals GmbH | Inhibitors of protein kinases |
| JP6112486B2 (ja) * | 2010-04-27 | 2017-04-12 | カルシメディカ，インク． | 細胞内カルシウムを調節する化合物 |
| US20120316182A1 (en) * | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| FR2982261B1 (fr) * | 2011-11-04 | 2014-06-13 | Galderma Res & Dev | Nouveaux amides, et leur utilisation pharmaceutique ou cosmetique |
| TW201329067A (zh) * | 2011-12-08 | 2013-07-16 | Amgen Inc | 作為ｇｋａ活化劑之脲化合物 |
| WO2014125426A1 (en) * | 2013-02-15 | 2014-08-21 | Aurigene Discovery Technologies Limited | Trisubstituted heterocyclic derivatives as ror gamma modulators |
| US9758505B2 (en) * | 2014-02-12 | 2017-09-12 | Iteos Therapeutics | 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use |
| AR106679A1 (es) * | 2015-11-13 | 2018-02-07 | Basf Se | Oxadiazoles sustituidos para combatir hongos fitopatógenos |
| CN105924387A (zh) * | 2016-04-28 | 2016-09-07 | 西安交通大学 | 一种具有抗肿瘤活性的双芳基脲化合物及其制备方法和应用 |
| WO2018114783A1 (en) * | 2016-12-23 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Tetrazole containing compounds |
| EP3498694A1 (en) * | 2017-12-12 | 2019-06-19 | Medibiofarma, S.L. | New benzamide derivatives as ppar-gamma modulators |
-
2020
- 2020-11-05 CN CN202080091458.6A patent/CN114901280B/zh active Active
- 2020-11-05 IL IL292692A patent/IL292692B1/en unknown
- 2020-11-05 JP JP2022526330A patent/JP7645256B2/ja active Active
- 2020-11-05 AU AU2020378009A patent/AU2020378009A1/en active Pending
- 2020-11-05 WO PCT/US2020/059226 patent/WO2021092262A1/en not_active Ceased
- 2020-11-05 EP EP20817126.4A patent/EP4054570A1/en active Pending
- 2020-11-05 CA CA3159628A patent/CA3159628A1/en active Pending
- 2020-11-05 US US17/773,404 patent/US20230027929A1/en active Pending
- 2020-11-05 CN CN202510638326.5A patent/CN120698981A/zh active Pending
-
2025
- 2025-03-03 JP JP2025032508A patent/JP7827911B2/ja active Active
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