JP2020511410A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020511410A5 JP2020511410A5 JP2019531241A JP2019531241A JP2020511410A5 JP 2020511410 A5 JP2020511410 A5 JP 2020511410A5 JP 2019531241 A JP2019531241 A JP 2019531241A JP 2019531241 A JP2019531241 A JP 2019531241A JP 2020511410 A5 JP2020511410 A5 JP 2020511410A5
- Authority
- JP
- Japan
- Prior art keywords
- ethyl
- tetrahydropyran
- azepine
- pyrazolo
- spiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16203335 | 2016-12-12 | ||
| EP16203335.1 | 2016-12-12 | ||
| PCT/EP2017/082424 WO2018108910A1 (en) | 2016-12-12 | 2017-12-12 | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511410A JP2020511410A (ja) | 2020-04-16 |
| JP2020511410A5 true JP2020511410A5 (https=) | 2021-01-21 |
| JP7008073B2 JP7008073B2 (ja) | 2022-01-25 |
Family
ID=57542834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531241A Expired - Fee Related JP7008073B2 (ja) | 2016-12-12 | 2017-12-12 | 置換ピラゾロアゼピン－４－オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11065257B2 (https=) |
| EP (1) | EP3551632B1 (https=) |
| JP (1) | JP7008073B2 (https=) |
| CN (1) | CN110167944B (https=) |
| ES (1) | ES2981006T3 (https=) |
| RU (1) | RU2768746C2 (https=) |
| WO (1) | WO2018108910A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3642210T3 (da) | 2017-06-20 | 2024-12-09 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| PT3724196T (pt) | 2017-12-15 | 2023-01-13 | Union Therapeutics As | Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2803299B1 (fr) * | 2000-01-05 | 2004-09-17 | Warner Lambert Co | NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| WO2004098520A2 (en) | 2003-05-01 | 2004-11-18 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| TW200745106A (en) | 2005-10-03 | 2007-12-16 | Astrazeneca Ab | Chemical compounds |
| US7671069B2 (en) | 2006-03-30 | 2010-03-02 | Chemocentryx, Inc. | Tricyclic, heteroaromatic compounds modulating CXCR4 and/ or CXCR7 |
| ES2372320T3 (es) * | 2006-11-15 | 2012-01-18 | Vertex Pharmceuticals Incorporated | Compuestos útiles como inhibidores de proteínas quinasas. |
| CA2676933C (en) * | 2007-02-28 | 2015-09-29 | Leo Pharma A/S | Novel phosphodiesterase inhibitors |
| GB0704652D0 (en) | 2007-03-09 | 2007-04-18 | Syngenta Participations Ag | Novel herbicides |
| US8637501B2 (en) | 2009-07-01 | 2014-01-28 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof |
| WO2018108231A1 (en) | 2016-12-12 | 2018-06-21 | Leo Pharma A/S | Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors |
| JP6850886B2 (ja) | 2016-12-12 | 2021-03-31 | レオ ファーマ アクティーゼルスカブ | 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
-
2017
- 2017-12-12 EP EP17811328.8A patent/EP3551632B1/en active Active
- 2017-12-12 RU RU2019121694A patent/RU2768746C2/ru active
- 2017-12-12 ES ES17811328T patent/ES2981006T3/es active Active
- 2017-12-12 CN CN201780076412.5A patent/CN110167944B/zh not_active Expired - Fee Related
- 2017-12-12 JP JP2019531241A patent/JP7008073B2/ja not_active Expired - Fee Related
- 2017-12-12 US US16/468,444 patent/US11065257B2/en active Active
- 2017-12-12 WO PCT/EP2017/082424 patent/WO2018108910A1/en not_active Ceased
-
2021
- 2021-06-10 US US17/303,955 patent/US20220362259A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12528818B2 (en) | Compositions and methods for inhibition of RAS | |
| CN1902196B (zh) | 噻唑衍生物 | |
| JP7611278B2 (ja) | 金属酵素阻害剤化合物 | |
| AU2008322595B2 (en) | Method of treating arthritis | |
| EP2736904B1 (en) | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) | |
| CA2918284A1 (en) | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core | |
| CN116531380A (zh) | 用于治疗癌症的2-杂芳基-3-氧代-2,3-二氢哒嗪-4-甲酰胺 | |
| RU2015154987A (ru) | Гетероциклические производные | |
| JP6706023B2 (ja) | 線維症の小分子阻害剤 | |
| JP2020511410A5 (https=) | ||
| JP2016503785A5 (https=) | ||
| CN111108109A (zh) | 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途 | |
| JP2020536915A5 (https=) | ||
| JP2021501183A5 (https=) | ||
| JP2019532974A5 (https=) | ||
| RU2019121694A (ru) | Замещенные пиразолоазепин-4-оны и их применение в качестве ингибиторов фосфодиэстеразы | |
| CN110088108A (zh) | 取代的吡唑并氮杂*-4-酮类及其作为磷酸二酯酶抑制剂的用途 | |
| CN106188027A (zh) | 芳杂环类衍生物及其在药物中的应用 | |
| JP2024545552A (ja) | Ｒｉｐｋ１阻害剤として縮合したヘテロ環 | |
| KR101764458B1 (ko) | 치환 피리딘 화합물 | |
| CN109476637A (zh) | 杂环脯氨酰胺衍生物 | |
| KR20100021444A (ko) | 플루오로퀴놀론을 사용하여 염증을 조절하기 위한 조성물 및 방법 | |
| JPWO2021092264A5 (https=) | ||
| WO2007043426A1 (ja) | 皮膚炎治療剤 | |
| CN113563245A (zh) | 取代的吡咯烷类化合物及其在药物中的应用 |