TW202126651A - 吡啶酮化合物及使用方法 - Google Patents

吡啶酮化合物及使用方法 Download PDF

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Publication number
TW202126651A
TW202126651A TW109133416A TW109133416A TW202126651A TW 202126651 A TW202126651 A TW 202126651A TW 109133416 A TW109133416 A TW 109133416A TW 109133416 A TW109133416 A TW 109133416A TW 202126651 A TW202126651 A TW 202126651A
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TW
Taiwan
Prior art keywords
membered
alkyl
group
fluorophenyl
alkylene
Prior art date
Application number
TW109133416A
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English (en)
Chinese (zh)
Inventor
林 班儂
米娜 布依
發明 蔣
傑克 馬恩
安德魯 勞布
賈斯汀 桑文特
班傑明 斯潘格勒
健雲 曹
王勇
維 許
Original Assignee
美商艾克塞里克斯公司
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Application filed by 美商艾克塞里克斯公司 filed Critical 美商艾克塞里克斯公司
Publication of TW202126651A publication Critical patent/TW202126651A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW109133416A 2019-09-26 2020-09-25 吡啶酮化合物及使用方法 TW202126651A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962906647P 2019-09-26 2019-09-26
US62/906,647 2019-09-26
US202063053530P 2020-07-17 2020-07-17
US63/053,530 2020-07-17

Publications (1)

Publication Number Publication Date
TW202126651A true TW202126651A (zh) 2021-07-16

Family

ID=72827019

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109133416A TW202126651A (zh) 2019-09-26 2020-09-25 吡啶酮化合物及使用方法

Country Status (8)

Country Link
US (1) US12371428B2 (https=)
EP (1) EP4034532A1 (https=)
JP (1) JP2022551422A (https=)
CN (1) CN114787144A (https=)
AU (1) AU2020351782A1 (https=)
CA (1) CA3155924A1 (https=)
TW (1) TW202126651A (https=)
WO (1) WO2021062245A1 (https=)

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WO2024217587A1 (zh) * 2023-04-21 2024-10-24 南京正大天晴制药有限公司 具有axl抑制活性的取代吡嗪化合物
WO2024259060A1 (en) * 2023-06-16 2024-12-19 Kinnate Biopharma Inc. Inhibitors of met kinase
CN117343046A (zh) * 2023-09-25 2024-01-05 辽宁大学 一种新型3-氧代-4-取代芳基-3,4-二氢吡嗪-2-甲酰胺类化合物及其应用
WO2025096463A1 (en) * 2023-10-30 2025-05-08 Vibliome Therapeutics, Llc Plk4 modulators
CN118878515B (zh) * 2024-06-19 2025-10-28 河北科技大学 一种取代苯胺嘧啶类化合物及其制备方法和用途

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JP2022551422A (ja) 2019-09-26 2022-12-09 エグゼリクシス， インコーポレイテッド ピリドン化合物およびタンパク質キナーゼの調節における使用の方法
JP2023514725A (ja) 2020-02-24 2023-04-07 エグゼリクシス， インコーポレイテッド 化合物および使用方法

Also Published As

Publication number Publication date
US12371428B2 (en) 2025-07-29
EP4034532A1 (en) 2022-08-03
CN114787144A (zh) 2022-07-22
US20220315579A1 (en) 2022-10-06
CA3155924A1 (en) 2021-04-01
WO2021062245A1 (en) 2021-04-01
AU2020351782A1 (en) 2022-04-21
JP2022551422A (ja) 2022-12-09

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