KR101066501B1 - 치환된 피페라진 - Google Patents
치환된 피페라진 Download PDFInfo
- Publication number
- KR101066501B1 KR101066501B1 KR1020067012854A KR20067012854A KR101066501B1 KR 101066501 B1 KR101066501 B1 KR 101066501B1 KR 1020067012854 A KR1020067012854 A KR 1020067012854A KR 20067012854 A KR20067012854 A KR 20067012854A KR 101066501 B1 KR101066501 B1 KR 101066501B1
- Authority
- KR
- South Korea
- Prior art keywords
- nhr
- alkyl
- halogen
- mmol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *Cc1cc(Br)ccc1Cl Chemical compound *Cc1cc(Br)ccc1Cl 0.000 description 63
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- FASVGIACLKHOCJ-UHFFFAOYSA-N Cc([nH]nc1-c2nc(C)ccc2)c1Br Chemical compound Cc([nH]nc1-c2nc(C)ccc2)c1Br FASVGIACLKHOCJ-UHFFFAOYSA-N 0.000 description 2
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/732,897 US7842693B2 (en) | 2002-06-12 | 2003-12-09 | Substituted piperazines |
| US10/732,897 | 2003-12-09 | ||
| US10/979,882 US20050256130A1 (en) | 2002-06-12 | 2004-11-01 | Substituted piperazines |
| US10/979,882 | 2004-11-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20060108732A KR20060108732A (ko) | 2006-10-18 |
| KR101066501B1 true KR101066501B1 (ko) | 2011-09-21 |
Family
ID=34681747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067012854A Expired - Fee Related KR101066501B1 (ko) | 2003-12-09 | 2004-12-08 | 치환된 피페라진 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050256130A1 (https=) |
| EP (1) | EP1691810A4 (https=) |
| JP (1) | JP4988355B2 (https=) |
| KR (1) | KR101066501B1 (https=) |
| AU (1) | AU2004296879B2 (https=) |
| CA (1) | CA2548426A1 (https=) |
| WO (1) | WO2005056015A1 (https=) |
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| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7435830B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
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| US7777035B2 (en) * | 2005-06-22 | 2010-08-17 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| BRPI0612112A8 (pt) * | 2005-06-22 | 2017-12-26 | Chemocentryx Inc | composto, composição farmacêutica, e, método de tratar doenças ou condições mediadas por ccr1. |
| US7790726B2 (en) * | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
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| JP6163205B2 (ja) | 2012-06-20 | 2017-07-12 | ノバルティス アーゲー | 補体経路モジュレーターおよびその使用 |
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| AU2013355054B2 (en) | 2012-12-07 | 2017-08-24 | Chemocentryx, Inc. | Diazole lactams |
| US9637505B2 (en) | 2013-03-15 | 2017-05-02 | Dow Agrosciences Llc | 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides |
| EA030067B1 (ru) | 2013-07-22 | 2018-06-29 | Идорсиа Фармасьютиклз Лтд | Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона |
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| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| CN109310677A (zh) | 2016-04-07 | 2019-02-05 | 凯莫森特里克斯股份有限公司 | 通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷 |
| AU2017281907B2 (en) * | 2016-06-23 | 2021-10-21 | St. Jude Children's Research Hospital, Inc. | Small molecule modulators of pantothenate kinases |
| EP3731859B1 (en) | 2017-12-27 | 2025-08-20 | St. Jude Children's Research Hospital, Inc. | Pyridazine compounds for use to treat disorders associated with castor |
| KR102728619B1 (ko) | 2017-12-27 | 2024-11-08 | 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 | 판토테네이트 키나제의 소분자 조절제 |
| CN116640097B (zh) * | 2022-02-16 | 2025-10-24 | 浙江理工大学 | 一种脂肪胺参与的5-三氟甲基取代的1,2,4-三氮唑化合物的制备方法 |
| CN115754084B (zh) * | 2022-11-30 | 2024-07-12 | 天和药业有限公司 | 一种吗伐考昔的分析方法 |
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- 2004-12-08 JP JP2006544042A patent/JP4988355B2/ja not_active Expired - Lifetime
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11513364A (ja) * | 1995-09-11 | 1999-11-16 | 藤沢薬品工業株式会社 | ベンズイミダゾール誘導体類および骨疾患の予防および/または治療のためのその用途 |
| WO2002014314A2 (en) * | 2000-08-14 | 2002-02-21 | Ortho Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004296879B2 (en) | 2011-11-17 |
| EP1691810A1 (en) | 2006-08-23 |
| CA2548426A1 (en) | 2005-06-23 |
| EP1691810A4 (en) | 2009-07-01 |
| WO2005056015A1 (en) | 2005-06-23 |
| JP2007513969A (ja) | 2007-05-31 |
| AU2004296879A1 (en) | 2005-06-23 |
| US20050256130A1 (en) | 2005-11-17 |
| JP4988355B2 (ja) | 2012-08-01 |
| KR20060108732A (ko) | 2006-10-18 |
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