JP2007513613A5 - - Google Patents
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- Publication number
- JP2007513613A5 JP2007513613A5 JP2006543324A JP2006543324A JP2007513613A5 JP 2007513613 A5 JP2007513613 A5 JP 2007513613A5 JP 2006543324 A JP2006543324 A JP 2006543324A JP 2006543324 A JP2006543324 A JP 2006543324A JP 2007513613 A5 JP2007513613 A5 JP 2007513613A5
- Authority
- JP
- Japan
- Prior art keywords
- diphtheria
- medium
- analog
- diphtheria toxin
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 21
- 239000002609 medium Substances 0.000 claims 17
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 16
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 16
- 229940024606 amino acid Drugs 0.000 claims 13
- 150000001413 amino acids Chemical class 0.000 claims 13
- 206010013023 diphtheria Diseases 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 10
- 229940041514 candida albicans extract Drugs 0.000 claims 6
- 239000012138 yeast extract Substances 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 229960003983 diphtheria toxoid Drugs 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 230000003053 immunization Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 230000005526 G1 to G0 transition Effects 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48178003P | 2003-12-12 | 2003-12-12 | |
| PCT/CA2004/002024 WO2005056773A1 (en) | 2003-12-12 | 2004-11-30 | Production of diphtheria toxin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513613A JP2007513613A (ja) | 2007-05-31 |
| JP2007513613A5 true JP2007513613A5 (https=) | 2008-01-24 |
Family
ID=34676553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006543324A Pending JP2007513613A (ja) | 2003-12-12 | 2004-11-30 | ジフテリア毒素の産生 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110097359A1 (https=) |
| EP (1) | EP1692269A4 (https=) |
| JP (1) | JP2007513613A (https=) |
| KR (1) | KR20060133994A (https=) |
| CN (1) | CN1894399A (https=) |
| AU (1) | AU2004297299A1 (https=) |
| BR (1) | BRPI0417076A (https=) |
| CA (1) | CA2546769A1 (https=) |
| IL (1) | IL175873A0 (https=) |
| MX (1) | MXPA06006630A (https=) |
| WO (1) | WO2005056773A1 (https=) |
| ZA (1) | ZA200604772B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006042542A2 (en) * | 2004-10-19 | 2006-04-27 | Statens Serum Institut | Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin |
| US7375188B2 (en) * | 2005-07-29 | 2008-05-20 | Mallinckrodt Baker, Inc. | Vegetarian protein a preparation and methods thereof |
| RS51999B (sr) * | 2008-08-28 | 2012-04-30 | Novartis Ag | Dobijanje skvalena iz hiperprodukcijskih kvasaca |
| CN101503725B (zh) * | 2009-03-19 | 2012-06-06 | 浙江天元生物药业有限公司 | 一种用于提高白喉类毒素纯度的工艺 |
| AU2010201410B2 (en) * | 2010-03-30 | 2015-04-30 | Pelican Technology Holdings, Inc. | High level expression of recombinant CRM197 |
| EP2553102B1 (en) | 2010-03-30 | 2015-12-09 | Pfenex Inc. | High level expression of recombinant toxin proteins |
| DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
| DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
| EP2592137A1 (en) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
| GB2495341B (en) * | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| AU2013203663B2 (en) * | 2011-11-11 | 2015-05-28 | Novartis Ag | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
| CN102766647A (zh) * | 2012-07-25 | 2012-11-07 | 天津康希诺生物技术有限公司 | 在白喉杆菌中稳定复制的表达载体及含该载体的白喉杆菌 |
| US10905146B2 (en) * | 2013-07-12 | 2021-02-02 | The Coca-Cola Company | Compositions for improving rebaudioside M solubility |
| CN104027797B (zh) * | 2014-06-19 | 2015-08-26 | 山东亦度生物技术有限公司 | 一种白喉疫苗的制备方法 |
| CN104263678A (zh) * | 2014-09-02 | 2015-01-07 | 成都欧林生物科技股份有限公司 | 一种白喉杆菌培养基及应用其制备白喉类毒素的方法 |
| GB2556883A (en) * | 2016-11-22 | 2018-06-13 | Liebman Miriam | Apparatus for transportation and storage of footwear |
| WO2018193475A2 (en) | 2017-04-22 | 2018-10-25 | Biological E Limited | An improved method for high level production of crm |
| CN110452838B (zh) * | 2019-07-18 | 2020-12-29 | 艾美卫信生物药业（浙江）有限公司 | 一种crm197菌种培养基、配制方法及发酵培养方法 |
| CN114806973B (zh) * | 2022-06-08 | 2024-02-23 | 艾美坚持生物制药有限公司 | 一种提高crm197蛋白产量的生长因子及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE372376T1 (de) * | 1997-05-28 | 2007-09-15 | Novartis Vaccines & Diagnostic | Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs |
| US6558926B1 (en) * | 1999-07-16 | 2003-05-06 | Massachusetts Institute Of Technology | Method for production of tetanus toxin using media substantially free of animal products |
-
2004
- 2004-11-30 KR KR1020067011556A patent/KR20060133994A/ko not_active Withdrawn
- 2004-11-30 AU AU2004297299A patent/AU2004297299A1/en not_active Abandoned
- 2004-11-30 CN CNA2004800370696A patent/CN1894399A/zh active Pending
- 2004-11-30 EP EP04802201A patent/EP1692269A4/en not_active Withdrawn
- 2004-11-30 BR BRPI0417076-8A patent/BRPI0417076A/pt not_active IP Right Cessation
- 2004-11-30 WO PCT/CA2004/002024 patent/WO2005056773A1/en not_active Ceased
- 2004-11-30 JP JP2006543324A patent/JP2007513613A/ja active Pending
- 2004-11-30 CA CA002546769A patent/CA2546769A1/en not_active Abandoned
- 2004-11-30 US US10/582,576 patent/US20110097359A1/en not_active Abandoned
- 2004-11-30 MX MXPA06006630A patent/MXPA06006630A/es unknown
-
2006
- 2006-05-23 IL IL175873A patent/IL175873A0/en unknown
- 2006-06-09 ZA ZA200604772A patent/ZA200604772B/en unknown
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