JP2007513613A - ジフテリア毒素の産生 - Google Patents

ジフテリア毒素の産生 Download PDF

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Publication number
JP2007513613A
JP2007513613A JP2006543324A JP2006543324A JP2007513613A JP 2007513613 A JP2007513613 A JP 2007513613A JP 2006543324 A JP2006543324 A JP 2006543324A JP 2006543324 A JP2006543324 A JP 2006543324A JP 2007513613 A JP2007513613 A JP 2007513613A
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JP
Japan
Prior art keywords
medium
diphtheria
diphtheria toxin
toxin
analog
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Pending
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JP2006543324A
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English (en)
Japanese (ja)
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JP2007513613A5 (https=
Inventor
リー，ティム
ユー，シュエフェン
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Sanofi Pasteur Ltd
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Sanofi Pasteur Ltd
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Application filed by Sanofi Pasteur Ltd filed Critical Sanofi Pasteur Ltd
Publication of JP2007513613A publication Critical patent/JP2007513613A/ja
Publication of JP2007513613A5 publication Critical patent/JP2007513613A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006543324A 2003-12-12 2004-11-30 ジフテリア毒素の産生 Pending JP2007513613A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48178003P 2003-12-12 2003-12-12
PCT/CA2004/002024 WO2005056773A1 (en) 2003-12-12 2004-11-30 Production of diphtheria toxin

Publications (2)

Publication Number Publication Date
JP2007513613A true JP2007513613A (ja) 2007-05-31
JP2007513613A5 JP2007513613A5 (https=) 2008-01-24

Family

ID=34676553

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006543324A Pending JP2007513613A (ja) 2003-12-12 2004-11-30 ジフテリア毒素の産生

Country Status (12)

Country Link
US (1) US20110097359A1 (https=)
EP (1) EP1692269A4 (https=)
JP (1) JP2007513613A (https=)
KR (1) KR20060133994A (https=)
CN (1) CN1894399A (https=)
AU (1) AU2004297299A1 (https=)
BR (1) BRPI0417076A (https=)
CA (1) CA2546769A1 (https=)
IL (1) IL175873A0 (https=)
MX (1) MXPA06006630A (https=)
WO (1) WO2005056773A1 (https=)
ZA (1) ZA200604772B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500648A (ja) * 2008-08-28 2012-01-12 ノバルティス アーゲー 高度に生産する酵母からのスクアレンの生産
JP2014500269A (ja) * 2011-11-11 2014-01-09 ノバルティス アーゲー ヒトワクチンとしての使用に適するジフテリアトキソイドの生成のための動物由来成分を含まない発酵培地
KR20200010218A (ko) * 2017-04-22 2020-01-30 바이오로지칼 이 리미티드 Crm197의 높은 수준의 생산을 위한 개선된 방법

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042542A2 (en) * 2004-10-19 2006-04-27 Statens Serum Institut Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin
US7375188B2 (en) * 2005-07-29 2008-05-20 Mallinckrodt Baker, Inc. Vegetarian protein a preparation and methods thereof
CN101503725B (zh) * 2009-03-19 2012-06-06 浙江天元生物药业有限公司 一种用于提高白喉类毒素纯度的工艺
AU2010201410B2 (en) * 2010-03-30 2015-04-30 Pelican Technology Holdings, Inc. High level expression of recombinant CRM197
EP2553102B1 (en) 2010-03-30 2015-12-09 Pfenex Inc. High level expression of recombinant toxin proteins
DE102011118371B4 (de) 2011-11-11 2014-02-13 Novartis Ag Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung
DE102011122891B4 (de) 2011-11-11 2014-12-24 Novartis Ag Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen
EP2592137A1 (en) 2011-11-11 2013-05-15 Novartis AG Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
AU2013203663B2 (en) * 2011-11-11 2015-05-28 Novartis Ag Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
CN102766647A (zh) * 2012-07-25 2012-11-07 天津康希诺生物技术有限公司 在白喉杆菌中稳定复制的表达载体及含该载体的白喉杆菌
US10905146B2 (en) * 2013-07-12 2021-02-02 The Coca-Cola Company Compositions for improving rebaudioside M solubility
CN104027797B (zh) * 2014-06-19 2015-08-26 山东亦度生物技术有限公司 一种白喉疫苗的制备方法
CN104263678A (zh) * 2014-09-02 2015-01-07 成都欧林生物科技股份有限公司 一种白喉杆菌培养基及应用其制备白喉类毒素的方法
GB2556883A (en) * 2016-11-22 2018-06-13 Liebman Miriam Apparatus for transportation and storage of footwear
CN110452838B (zh) * 2019-07-18 2020-12-29 艾美卫信生物药业（浙江）有限公司 一种crm197菌种培养基、配制方法及发酵培养方法
CN114806973B (zh) * 2022-06-08 2024-02-23 艾美坚持生物制药有限公司 一种提高crm197蛋白产量的生长因子及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558926B1 (en) * 1999-07-16 2003-05-06 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500648A (ja) * 2008-08-28 2012-01-12 ノバルティス アーゲー 高度に生産する酵母からのスクアレンの生産
JP2014500269A (ja) * 2011-11-11 2014-01-09 ノバルティス アーゲー ヒトワクチンとしての使用に適するジフテリアトキソイドの生成のための動物由来成分を含まない発酵培地
KR20200010218A (ko) * 2017-04-22 2020-01-30 바이오로지칼 이 리미티드 Crm197의 높은 수준의 생산을 위한 개선된 방법
JP2020517274A (ja) * 2017-04-22 2020-06-18 バイオロジカル イー リミテッド Ｃｒｍ１９７の高レベル製造のための改良法
JP7161493B2 (ja) 2017-04-22 2022-10-26 バイオロジカル イー リミテッド Ｃｒｍ１９７の高レベル製造のための改良法
KR102637436B1 (ko) 2017-04-22 2024-02-15 바이오로지칼 이 리미티드 Crm197의 높은 수준의 생산을 위한 개선된 방법

Also Published As

Publication number Publication date
IL175873A0 (en) 2006-10-05
KR20060133994A (ko) 2006-12-27
US20110097359A1 (en) 2011-04-28
CN1894399A (zh) 2007-01-10
ZA200604772B (en) 2007-10-31
BRPI0417076A (pt) 2007-03-13
EP1692269A1 (en) 2006-08-23
EP1692269A4 (en) 2007-09-26
AU2004297299A1 (en) 2005-06-23
MXPA06006630A (es) 2007-04-16
WO2005056773A1 (en) 2005-06-23
CA2546769A1 (en) 2005-06-23

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