CN1894399A - 白喉毒素的制备 - Google Patents

白喉毒素的制备 Download PDF

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Publication number
CN1894399A
CN1894399A CNA2004800370696A CN200480037069A CN1894399A CN 1894399 A CN1894399 A CN 1894399A CN A2004800370696 A CNA2004800370696 A CN A2004800370696A CN 200480037069 A CN200480037069 A CN 200480037069A CN 1894399 A CN1894399 A CN 1894399A
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CN
China
Prior art keywords
substratum
diphtheria toxin
analogue
amino acid
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800370696A
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English (en)
Chinese (zh)
Inventor
T·李
X·余
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Original Assignee
Aventis Pasteur Ltd
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Filing date
Publication date
Application filed by Aventis Pasteur Ltd filed Critical Aventis Pasteur Ltd
Publication of CN1894399A publication Critical patent/CN1894399A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2004800370696A 2003-12-12 2004-11-30 白喉毒素的制备 Pending CN1894399A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48178003P 2003-12-12 2003-12-12
US60/481,780 2003-12-12

Publications (1)

Publication Number Publication Date
CN1894399A true CN1894399A (zh) 2007-01-10

Family

ID=34676553

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800370696A Pending CN1894399A (zh) 2003-12-12 2004-11-30 白喉毒素的制备

Country Status (12)

Country Link
US (1) US20110097359A1 (https=)
EP (1) EP1692269A4 (https=)
JP (1) JP2007513613A (https=)
KR (1) KR20060133994A (https=)
CN (1) CN1894399A (https=)
AU (1) AU2004297299A1 (https=)
BR (1) BRPI0417076A (https=)
CA (1) CA2546769A1 (https=)
IL (1) IL175873A0 (https=)
MX (1) MXPA06006630A (https=)
WO (1) WO2005056773A1 (https=)
ZA (1) ZA200604772B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101503725B (zh) * 2009-03-19 2012-06-06 浙江天元生物药业有限公司 一种用于提高白喉类毒素纯度的工艺
CN102766647A (zh) * 2012-07-25 2012-11-07 天津康希诺生物技术有限公司 在白喉杆菌中稳定复制的表达载体及含该载体的白喉杆菌
CN104263678A (zh) * 2014-09-02 2015-01-07 成都欧林生物科技股份有限公司 一种白喉杆菌培养基及应用其制备白喉类毒素的方法
CN110452838A (zh) * 2019-07-18 2019-11-15 艾美卫信生物药业（浙江）有限公司 一种crm197菌种培养基、配制方法及发酵培养方法
CN110741013A (zh) * 2017-04-22 2020-01-31 生物E有限公司 用于高水平生产crm的改进方法
CN114806973A (zh) * 2022-06-08 2022-07-29 艾美卫信生物药业（浙江）有限公司 一种提高crm197蛋白产量的生长因子及其制备方法和应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042542A2 (en) * 2004-10-19 2006-04-27 Statens Serum Institut Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin
US7375188B2 (en) * 2005-07-29 2008-05-20 Mallinckrodt Baker, Inc. Vegetarian protein a preparation and methods thereof
RS51999B (sr) * 2008-08-28 2012-04-30 Novartis Ag Dobijanje skvalena iz hiperprodukcijskih kvasaca
AU2010201410B2 (en) * 2010-03-30 2015-04-30 Pelican Technology Holdings, Inc. High level expression of recombinant CRM197
EP2553102B1 (en) 2010-03-30 2015-12-09 Pfenex Inc. High level expression of recombinant toxin proteins
DE102011118371B4 (de) 2011-11-11 2014-02-13 Novartis Ag Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung
DE102011122891B4 (de) 2011-11-11 2014-12-24 Novartis Ag Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen
EP2592137A1 (en) 2011-11-11 2013-05-15 Novartis AG Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
GB2495341B (en) * 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
AU2013203663B2 (en) * 2011-11-11 2015-05-28 Novartis Ag Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
US10905146B2 (en) * 2013-07-12 2021-02-02 The Coca-Cola Company Compositions for improving rebaudioside M solubility
CN104027797B (zh) * 2014-06-19 2015-08-26 山东亦度生物技术有限公司 一种白喉疫苗的制备方法
GB2556883A (en) * 2016-11-22 2018-06-13 Liebman Miriam Apparatus for transportation and storage of footwear

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE372376T1 (de) * 1997-05-28 2007-09-15 Novartis Vaccines & Diagnostic Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs
US6558926B1 (en) * 1999-07-16 2003-05-06 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101503725B (zh) * 2009-03-19 2012-06-06 浙江天元生物药业有限公司 一种用于提高白喉类毒素纯度的工艺
CN102766647A (zh) * 2012-07-25 2012-11-07 天津康希诺生物技术有限公司 在白喉杆菌中稳定复制的表达载体及含该载体的白喉杆菌
CN104263678A (zh) * 2014-09-02 2015-01-07 成都欧林生物科技股份有限公司 一种白喉杆菌培养基及应用其制备白喉类毒素的方法
CN110741013A (zh) * 2017-04-22 2020-01-31 生物E有限公司 用于高水平生产crm的改进方法
CN110741013B (zh) * 2017-04-22 2023-08-08 生物E有限公司 用于高水平生产crm的改进方法
CN110452838A (zh) * 2019-07-18 2019-11-15 艾美卫信生物药业（浙江）有限公司 一种crm197菌种培养基、配制方法及发酵培养方法
CN110452838B (zh) * 2019-07-18 2020-12-29 艾美卫信生物药业（浙江）有限公司 一种crm197菌种培养基、配制方法及发酵培养方法
CN114806973A (zh) * 2022-06-08 2022-07-29 艾美卫信生物药业（浙江）有限公司 一种提高crm197蛋白产量的生长因子及其制备方法和应用
CN114806973B (zh) * 2022-06-08 2024-02-23 艾美坚持生物制药有限公司 一种提高crm197蛋白产量的生长因子及其制备方法和应用

Also Published As

Publication number Publication date
IL175873A0 (en) 2006-10-05
KR20060133994A (ko) 2006-12-27
US20110097359A1 (en) 2011-04-28
JP2007513613A (ja) 2007-05-31
ZA200604772B (en) 2007-10-31
BRPI0417076A (pt) 2007-03-13
EP1692269A1 (en) 2006-08-23
EP1692269A4 (en) 2007-09-26
AU2004297299A1 (en) 2005-06-23
MXPA06006630A (es) 2007-04-16
WO2005056773A1 (en) 2005-06-23
CA2546769A1 (en) 2005-06-23

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