KR20060133994A - 디프테리아 독소의 생산 방법 - Google Patents

디프테리아 독소의 생산 방법 Download PDF

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Publication number
KR20060133994A
KR20060133994A KR1020067011556A KR20067011556A KR20060133994A KR 20060133994 A KR20060133994 A KR 20060133994A KR 1020067011556 A KR1020067011556 A KR 1020067011556A KR 20067011556 A KR20067011556 A KR 20067011556A KR 20060133994 A KR20060133994 A KR 20060133994A
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KR
South Korea
Prior art keywords
diphtheria
medium
analog
diphtheria toxin
amino acids
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020067011556A
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English (en)
Korean (ko)
Inventor
팀 리
쉐펑 위
Original Assignee
사노피 파스퇴르 리미티드
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Application filed by 사노피 파스퇴르 리미티드 filed Critical 사노피 파스퇴르 리미티드
Publication of KR20060133994A publication Critical patent/KR20060133994A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020067011556A 2003-12-12 2004-11-30 디프테리아 독소의 생산 방법 Withdrawn KR20060133994A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48178003P 2003-12-12 2003-12-12
US60/481,780 2003-12-12

Publications (1)

Publication Number Publication Date
KR20060133994A true KR20060133994A (ko) 2006-12-27

Family

ID=34676553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067011556A Withdrawn KR20060133994A (ko) 2003-12-12 2004-11-30 디프테리아 독소의 생산 방법

Country Status (12)

Country Link
US (1) US20110097359A1 (https=)
EP (1) EP1692269A4 (https=)
JP (1) JP2007513613A (https=)
KR (1) KR20060133994A (https=)
CN (1) CN1894399A (https=)
AU (1) AU2004297299A1 (https=)
BR (1) BRPI0417076A (https=)
CA (1) CA2546769A1 (https=)
IL (1) IL175873A0 (https=)
MX (1) MXPA06006630A (https=)
WO (1) WO2005056773A1 (https=)
ZA (1) ZA200604772B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042542A2 (en) * 2004-10-19 2006-04-27 Statens Serum Institut Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin
US7375188B2 (en) * 2005-07-29 2008-05-20 Mallinckrodt Baker, Inc. Vegetarian protein a preparation and methods thereof
RS51999B (sr) * 2008-08-28 2012-04-30 Novartis Ag Dobijanje skvalena iz hiperprodukcijskih kvasaca
CN101503725B (zh) * 2009-03-19 2012-06-06 浙江天元生物药业有限公司 一种用于提高白喉类毒素纯度的工艺
AU2010201410B2 (en) * 2010-03-30 2015-04-30 Pelican Technology Holdings, Inc. High level expression of recombinant CRM197
EP2553102B1 (en) 2010-03-30 2015-12-09 Pfenex Inc. High level expression of recombinant toxin proteins
DE102011118371B4 (de) 2011-11-11 2014-02-13 Novartis Ag Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung
DE102011122891B4 (de) 2011-11-11 2014-12-24 Novartis Ag Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen
EP2592137A1 (en) 2011-11-11 2013-05-15 Novartis AG Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
GB2495341B (en) * 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
AU2013203663B2 (en) * 2011-11-11 2015-05-28 Novartis Ag Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
CN102766647A (zh) * 2012-07-25 2012-11-07 天津康希诺生物技术有限公司 在白喉杆菌中稳定复制的表达载体及含该载体的白喉杆菌
US10905146B2 (en) * 2013-07-12 2021-02-02 The Coca-Cola Company Compositions for improving rebaudioside M solubility
CN104027797B (zh) * 2014-06-19 2015-08-26 山东亦度生物技术有限公司 一种白喉疫苗的制备方法
CN104263678A (zh) * 2014-09-02 2015-01-07 成都欧林生物科技股份有限公司 一种白喉杆菌培养基及应用其制备白喉类毒素的方法
GB2556883A (en) * 2016-11-22 2018-06-13 Liebman Miriam Apparatus for transportation and storage of footwear
WO2018193475A2 (en) 2017-04-22 2018-10-25 Biological E Limited An improved method for high level production of crm
CN110452838B (zh) * 2019-07-18 2020-12-29 艾美卫信生物药业（浙江）有限公司 一种crm197菌种培养基、配制方法及发酵培养方法
CN114806973B (zh) * 2022-06-08 2024-02-23 艾美坚持生物制药有限公司 一种提高crm197蛋白产量的生长因子及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE372376T1 (de) * 1997-05-28 2007-09-15 Novartis Vaccines & Diagnostic Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs
US6558926B1 (en) * 1999-07-16 2003-05-06 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products

Also Published As

Publication number Publication date
IL175873A0 (en) 2006-10-05
US20110097359A1 (en) 2011-04-28
JP2007513613A (ja) 2007-05-31
CN1894399A (zh) 2007-01-10
ZA200604772B (en) 2007-10-31
BRPI0417076A (pt) 2007-03-13
EP1692269A1 (en) 2006-08-23
EP1692269A4 (en) 2007-09-26
AU2004297299A1 (en) 2005-06-23
MXPA06006630A (es) 2007-04-16
WO2005056773A1 (en) 2005-06-23
CA2546769A1 (en) 2005-06-23

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PA0105 International application

Patent event date: 20060612

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid