CA2546769A1 - Production of diphtheria toxin - Google Patents

Production of diphtheria toxin Download PDF

Info

Publication number
CA2546769A1
CA2546769A1 CA002546769A CA2546769A CA2546769A1 CA 2546769 A1 CA2546769 A1 CA 2546769A1 CA 002546769 A CA002546769 A CA 002546769A CA 2546769 A CA2546769 A CA 2546769A CA 2546769 A1 CA2546769 A1 CA 2546769A1
Authority
CA
Canada
Prior art keywords
medium
analog
diphtheria toxin
animal
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002546769A
Other languages
English (en)
French (fr)
Inventor
Tim Lee
Xuefeng Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2546769A1 publication Critical patent/CA2546769A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002546769A 2003-12-12 2004-11-30 Production of diphtheria toxin Abandoned CA2546769A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48178003P 2003-12-12 2003-12-12
US60/481,780 2003-12-12
PCT/CA2004/002024 WO2005056773A1 (en) 2003-12-12 2004-11-30 Production of diphtheria toxin

Publications (1)

Publication Number Publication Date
CA2546769A1 true CA2546769A1 (en) 2005-06-23

Family

ID=34676553

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002546769A Abandoned CA2546769A1 (en) 2003-12-12 2004-11-30 Production of diphtheria toxin

Country Status (12)

Country Link
US (1) US20110097359A1 (https=)
EP (1) EP1692269A4 (https=)
JP (1) JP2007513613A (https=)
KR (1) KR20060133994A (https=)
CN (1) CN1894399A (https=)
AU (1) AU2004297299A1 (https=)
BR (1) BRPI0417076A (https=)
CA (1) CA2546769A1 (https=)
IL (1) IL175873A0 (https=)
MX (1) MXPA06006630A (https=)
WO (1) WO2005056773A1 (https=)
ZA (1) ZA200604772B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2556883A (en) * 2016-11-22 2018-06-13 Liebman Miriam Apparatus for transportation and storage of footwear

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042542A2 (en) * 2004-10-19 2006-04-27 Statens Serum Institut Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin
US7375188B2 (en) * 2005-07-29 2008-05-20 Mallinckrodt Baker, Inc. Vegetarian protein a preparation and methods thereof
RS51999B (sr) * 2008-08-28 2012-04-30 Novartis Ag Dobijanje skvalena iz hiperprodukcijskih kvasaca
CN101503725B (zh) * 2009-03-19 2012-06-06 浙江天元生物药业有限公司 一种用于提高白喉类毒素纯度的工艺
AU2010201410B2 (en) * 2010-03-30 2015-04-30 Pelican Technology Holdings, Inc. High level expression of recombinant CRM197
EP2553102B1 (en) 2010-03-30 2015-12-09 Pfenex Inc. High level expression of recombinant toxin proteins
DE102011118371B4 (de) 2011-11-11 2014-02-13 Novartis Ag Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung
DE102011122891B4 (de) 2011-11-11 2014-12-24 Novartis Ag Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen
EP2592137A1 (en) 2011-11-11 2013-05-15 Novartis AG Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
GB2495341B (en) * 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
AU2013203663B2 (en) * 2011-11-11 2015-05-28 Novartis Ag Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
CN102766647A (zh) * 2012-07-25 2012-11-07 天津康希诺生物技术有限公司 在白喉杆菌中稳定复制的表达载体及含该载体的白喉杆菌
US10905146B2 (en) * 2013-07-12 2021-02-02 The Coca-Cola Company Compositions for improving rebaudioside M solubility
CN104027797B (zh) * 2014-06-19 2015-08-26 山东亦度生物技术有限公司 一种白喉疫苗的制备方法
CN104263678A (zh) * 2014-09-02 2015-01-07 成都欧林生物科技股份有限公司 一种白喉杆菌培养基及应用其制备白喉类毒素的方法
WO2018193475A2 (en) 2017-04-22 2018-10-25 Biological E Limited An improved method for high level production of crm
CN110452838B (zh) * 2019-07-18 2020-12-29 艾美卫信生物药业（浙江）有限公司 一种crm197菌种培养基、配制方法及发酵培养方法
CN114806973B (zh) * 2022-06-08 2024-02-23 艾美坚持生物制药有限公司 一种提高crm197蛋白产量的生长因子及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE372376T1 (de) * 1997-05-28 2007-09-15 Novartis Vaccines & Diagnostic Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs
US6558926B1 (en) * 1999-07-16 2003-05-06 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2556883A (en) * 2016-11-22 2018-06-13 Liebman Miriam Apparatus for transportation and storage of footwear

Also Published As

Publication number Publication date
IL175873A0 (en) 2006-10-05
KR20060133994A (ko) 2006-12-27
US20110097359A1 (en) 2011-04-28
JP2007513613A (ja) 2007-05-31
CN1894399A (zh) 2007-01-10
ZA200604772B (en) 2007-10-31
BRPI0417076A (pt) 2007-03-13
EP1692269A1 (en) 2006-08-23
EP1692269A4 (en) 2007-09-26
AU2004297299A1 (en) 2005-06-23
MXPA06006630A (es) 2007-04-16
WO2005056773A1 (en) 2005-06-23

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Legal Events

Date Code Title Description
FZDE Discontinued