JP2007509141A5 - - Google Patents

Info

Publication number

JP2007509141A5

JP2007509141A5 JP2006536485A JP2006536485A JP2007509141A5 JP 2007509141 A5 JP2007509141 A5 JP 2007509141A5 JP 2006536485 A JP2006536485 A JP 2006536485A JP 2006536485 A JP2006536485 A JP 2006536485A JP 2007509141 A5 JP2007509141 A5 JP 2007509141A5

Authority

JP

Japan

Prior art keywords

diazaspiro

isobutoxybenzyl

undecane

decane

benzyl

Prior art date

2004-10-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000217 alkyl group Chemical group 0.000 claims description 47
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 33
• -1 1,3-butadienyl Chemical group 0.000 claims description 30
• 229910052736 halogen Inorganic materials 0.000 claims description 28
• 125000005842 heteroatom Chemical group 0.000 claims description 28
• 150000002367 halogens Chemical class 0.000 claims description 23
• 125000003545 alkoxy group Chemical group 0.000 claims description 21
• 150000001875 compounds Chemical class 0.000 claims description 17
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 13
• 229910052757 nitrogen Inorganic materials 0.000 claims description 12
• 125000003118 aryl group Chemical group 0.000 claims description 11
• 229920006395 saturated elastomer Polymers 0.000 claims description 11
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 10
• 150000003839 salts Chemical class 0.000 claims description 10
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 9
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 9
• 239000012453 solvate Substances 0.000 claims description 9
• 125000001072 heteroaryl group Chemical group 0.000 claims description 8
• 238000000034 method Methods 0.000 claims description 8
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 8
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
• 125000001624 naphthyl group Chemical group 0.000 claims description 6
• SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 5
• 125000004076 pyridyl group Chemical group 0.000 claims description 5
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
• 125000004001 thioalkyl group Chemical group 0.000 claims description 4
• 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims description 3
• 150000001204 N-oxides Chemical class 0.000 claims description 3
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 3
• 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
• 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 3
• DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims description 2
• 238000006243 chemical reaction Methods 0.000 claims description 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
• 229910052799 carbon Inorganic materials 0.000 claims 7
• 229910052739 hydrogen Inorganic materials 0.000 claims 7
• 239000004305 biphenyl Substances 0.000 claims 6
• 235000010290 biphenyl Nutrition 0.000 claims 6
• 125000006267 biphenyl group Chemical group 0.000 claims 6
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 6
• 125000005336 allyloxy group Chemical group 0.000 claims 5
• 125000004181 carboxyalkyl group Chemical group 0.000 claims 5
• 229910052717 sulfur Inorganic materials 0.000 claims 5
• 102000009410 Chemokine receptor Human genes 0.000 claims 4
• 108050000299 Chemokine receptor Proteins 0.000 claims 4
• MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims 4
• 125000005843 halogen group Chemical group 0.000 claims 4
• SLBGWOAUEBXQFH-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 SLBGWOAUEBXQFH-UHFFFAOYSA-N 0.000 claims 3
• 102000019034 Chemokines Human genes 0.000 claims 3
• 108010012236 Chemokines Proteins 0.000 claims 3
• 125000004442 acylamino group Chemical group 0.000 claims 3
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• SRFAASSOCWCLLU-UHFFFAOYSA-N (4-chlorophenyl)-[7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(C2)C(=O)C=2C=CC(Cl)=CC=2)CC1 SRFAASSOCWCLLU-UHFFFAOYSA-N 0.000 claims 2
• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
• 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 2
• PCJRZWWIGKDMRN-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-[7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(C2)C(=O)CC=2C=CC(Cl)=CC=2)CC1 PCJRZWWIGKDMRN-UHFFFAOYSA-N 0.000 claims 2
• FSCSFWQSLHTMDZ-UHFFFAOYSA-N [2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-quinolin-2-ylmethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2N=C3C=CC=CC3=CC=2)CC1 FSCSFWQSLHTMDZ-UHFFFAOYSA-N 0.000 claims 2
• RUHVEBVCOKMWND-UHFFFAOYSA-N [8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-quinolin-2-ylmethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2N=C3C=CC=CC3=CC=2)CC1 RUHVEBVCOKMWND-UHFFFAOYSA-N 0.000 claims 2
• 239000002671 adjuvant Substances 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 150000001408 amides Chemical class 0.000 claims 2
• 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• ZLYJNVAOVLQKJT-UHFFFAOYSA-N furan-3-yl-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C2=COC=C2)CC1 ZLYJNVAOVLQKJT-UHFFFAOYSA-N 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• FEYNZXSXPMKCHU-UHFFFAOYSA-N (1,5-dimethylpyrazol-3-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C2=NN(C)C(C)=C2)CC1 FEYNZXSXPMKCHU-UHFFFAOYSA-N 0.000 claims 1
• NVIGTGNKOKHYPO-UHFFFAOYSA-N (1,5-dimethylpyrazol-3-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C2=NN(C)C(C)=C2)CC1 NVIGTGNKOKHYPO-UHFFFAOYSA-N 0.000 claims 1
• FWUHCPIFZVDGBU-UHFFFAOYSA-N (2,3-dichlorophenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C(=C(Cl)C=CC=2)Cl)CC1 FWUHCPIFZVDGBU-UHFFFAOYSA-N 0.000 claims 1
• ZJDWCFMINLRMLP-UHFFFAOYSA-N (2,3-dichlorophenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C(=C(Cl)C=CC=2)Cl)CC1 ZJDWCFMINLRMLP-UHFFFAOYSA-N 0.000 claims 1
• LMUTUMAOGUGMDR-UHFFFAOYSA-N (2,3-dichlorophenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C(=C(Cl)C=CC=2)Cl)CC1 LMUTUMAOGUGMDR-UHFFFAOYSA-N 0.000 claims 1
• LUMLNDNLHBCAGK-UHFFFAOYSA-N (2,3-dichlorophenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound ClC1=CC=CC(C(=O)N2CCC3(CCN(CC=4C(=CC=CC=4)OCC=4C=CC=CC=4)CC3)CC2)=C1Cl LUMLNDNLHBCAGK-UHFFFAOYSA-N 0.000 claims 1
• JJYUMTIICAOMEF-UHFFFAOYSA-N (2,3-dimethoxyphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound COC1=CC=CC(C(=O)N2CCC3(CN(CC=4C(=CC=CC=4)OCC(C)C)CC3)CC2)=C1OC JJYUMTIICAOMEF-UHFFFAOYSA-N 0.000 claims 1
• XZYMCSLKGZULDY-UHFFFAOYSA-N (2,3-dimethoxyphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound COC1=CC=CC(C(=O)N2CC3(CC2)CCN(CC=2C(=CC=CC=2)OCC(C)C)CC3)=C1OC XZYMCSLKGZULDY-UHFFFAOYSA-N 0.000 claims 1
• IRQOZPNXVYCZAU-UHFFFAOYSA-N (2,3-dimethoxyphenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C(=C(OC)C=CC=2)OC)CC1 IRQOZPNXVYCZAU-UHFFFAOYSA-N 0.000 claims 1
• DWKRCMMVHOFIOF-UHFFFAOYSA-N (2,3-dimethoxyphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound COC1=CC=CC(C(=O)N2CCC3(CCN(CC=4C(=CC=CC=4)OCC=4C=CC=CC=4)CC3)CC2)=C1OC DWKRCMMVHOFIOF-UHFFFAOYSA-N 0.000 claims 1
• YFJMZEJHUJRAMQ-UHFFFAOYSA-N (2,3-dimethylphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C(=C(C)C=CC=2)C)CC1 YFJMZEJHUJRAMQ-UHFFFAOYSA-N 0.000 claims 1
• ULWZOFBDDNRNBZ-UHFFFAOYSA-N (2,3-dimethylphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C(=C(C)C=CC=2)C)CC1 ULWZOFBDDNRNBZ-UHFFFAOYSA-N 0.000 claims 1
• AIKVZLFNCOSIIX-UHFFFAOYSA-N (2,3-dimethylphenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C(=C(C)C=CC=2)C)CC1 AIKVZLFNCOSIIX-UHFFFAOYSA-N 0.000 claims 1
• ICZVRRHOIKSTLE-UHFFFAOYSA-N (2,3-dimethylphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC1=CC=CC(C(=O)N2CCC3(CCN(CC=4C(=CC=CC=4)OCC=4C=CC=CC=4)CC3)CC2)=C1C ICZVRRHOIKSTLE-UHFFFAOYSA-N 0.000 claims 1
• GOBYZHBNEMKPIF-UHFFFAOYSA-N (2,4-dichlorophenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C(=CC(Cl)=CC=2)Cl)CC1 GOBYZHBNEMKPIF-UHFFFAOYSA-N 0.000 claims 1
• AUCCKLHEZNDFJX-UHFFFAOYSA-N (2,4-dichlorophenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C(=CC(Cl)=CC=2)Cl)CC1 AUCCKLHEZNDFJX-UHFFFAOYSA-N 0.000 claims 1
• NWKSJBVGOFOXIP-UHFFFAOYSA-N (2,4-dichlorophenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C(=CC(Cl)=CC=2)Cl)CC1 NWKSJBVGOFOXIP-UHFFFAOYSA-N 0.000 claims 1
• IMHCWLHGAZVIGJ-UHFFFAOYSA-N (2,4-dimethoxyphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound COC1=CC(OC)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 IMHCWLHGAZVIGJ-UHFFFAOYSA-N 0.000 claims 1
• NKDLCCSVBMTELE-UHFFFAOYSA-N (2,5-dimethylfuran-3-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C2=C(OC(C)=C2)C)CC1 NKDLCCSVBMTELE-UHFFFAOYSA-N 0.000 claims 1
• TYKCTWBGKRRXQV-UHFFFAOYSA-N (2,5-dimethylfuran-3-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C2=C(OC(C)=C2)C)CC1 TYKCTWBGKRRXQV-UHFFFAOYSA-N 0.000 claims 1
• DKSPGOFJZBRHLG-UHFFFAOYSA-N (2,6-dimethoxypyridin-3-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound COC1=NC(OC)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 DKSPGOFJZBRHLG-UHFFFAOYSA-N 0.000 claims 1
• QYAYJHPMIZOIMT-UHFFFAOYSA-N (2-chlorophenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C(=CC=CC=2)Cl)CC1 QYAYJHPMIZOIMT-UHFFFAOYSA-N 0.000 claims 1
• OGJLIYAVSUZRCZ-UHFFFAOYSA-N (2-chlorophenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C(=CC=CC=2)Cl)CC1 OGJLIYAVSUZRCZ-UHFFFAOYSA-N 0.000 claims 1
• GHKMNYSRDJZKFG-UHFFFAOYSA-N (2-chlorophenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C(=CC=CC=2)Cl)CC1 GHKMNYSRDJZKFG-UHFFFAOYSA-N 0.000 claims 1
• AJIGGZVVGGVWIM-UHFFFAOYSA-N (2-chlorophenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound ClC1=CC=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 AJIGGZVVGGVWIM-UHFFFAOYSA-N 0.000 claims 1
• MOBRKDSATUUXTE-UHFFFAOYSA-N (2-chloropyridin-4-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=C(Cl)N=CC=2)CC1 MOBRKDSATUUXTE-UHFFFAOYSA-N 0.000 claims 1
• YQULQZNEONLQEG-UHFFFAOYSA-N (2-chloropyridin-4-yl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C(Cl)N=CC=2)CC1 YQULQZNEONLQEG-UHFFFAOYSA-N 0.000 claims 1
• YYSQNJAVXFHMPU-UHFFFAOYSA-N (2-chloropyridin-4-yl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=NC(Cl)=CC(C(=O)N2CCC3(CCN(CC=4C(=CC=CC=4)OCC=4C=CC=CC=4)CC3)CC2)=C1 YYSQNJAVXFHMPU-UHFFFAOYSA-N 0.000 claims 1
• MLYDJZJBHDLWMW-UHFFFAOYSA-N (2-chloropyridin-4-yl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C(Cl)N=CC=2)CC1 MLYDJZJBHDLWMW-UHFFFAOYSA-N 0.000 claims 1
• SERLVJVFIJVSGD-UHFFFAOYSA-N (2-methoxy-4-methylsulfanylphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound COC1=CC(SC)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 SERLVJVFIJVSGD-UHFFFAOYSA-N 0.000 claims 1
• WXUPTIWBKBVYCU-UHFFFAOYSA-N (2-methoxy-4-methylsulfanylphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound COC1=CC(SC)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 WXUPTIWBKBVYCU-UHFFFAOYSA-N 0.000 claims 1
• SGTMFHCZHRULED-UHFFFAOYSA-N (2-methylfuran-3-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C2=C(OC=C2)C)CC1 SGTMFHCZHRULED-UHFFFAOYSA-N 0.000 claims 1
• JUCQERWMFQKZPS-UHFFFAOYSA-N (2-methylfuran-3-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C2=C(OC=C2)C)CC1 JUCQERWMFQKZPS-UHFFFAOYSA-N 0.000 claims 1
• PWEWRQUBVYNLTA-NXZHAISVSA-N (2e,4e)-6-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-6-oxohexa-2,4-dienoic acid Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)\C=C\C=C\C(O)=O)CC1 PWEWRQUBVYNLTA-NXZHAISVSA-N 0.000 claims 1
• XOJDEDSEANJOQW-UHFFFAOYSA-N (3,4-dichlorophenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 XOJDEDSEANJOQW-UHFFFAOYSA-N 0.000 claims 1
• ZEDKSSKFJFYEIA-UHFFFAOYSA-N (3,4-dichlorophenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 ZEDKSSKFJFYEIA-UHFFFAOYSA-N 0.000 claims 1
• NOPMNMXYSRUEPI-UHFFFAOYSA-N (3,4-dichlorophenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 NOPMNMXYSRUEPI-UHFFFAOYSA-N 0.000 claims 1
• QHOJSQLZWLVRCC-UHFFFAOYSA-N (3,4-dimethoxyphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 QHOJSQLZWLVRCC-UHFFFAOYSA-N 0.000 claims 1
• ULCNMQIXCYNMTB-UHFFFAOYSA-N (3,4-dimethoxyphenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C(OC)C(OC)=CC=2)CC1 ULCNMQIXCYNMTB-UHFFFAOYSA-N 0.000 claims 1
• NVKPQYKRYJWRDM-UHFFFAOYSA-N (3,4-dimethoxyphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 NVKPQYKRYJWRDM-UHFFFAOYSA-N 0.000 claims 1
• DUVMOJMZPDRZBJ-UHFFFAOYSA-N (3,5-dimethyl-1,2-oxazol-4-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C2=C(ON=C2C)C)CC1 DUVMOJMZPDRZBJ-UHFFFAOYSA-N 0.000 claims 1
• XXYZZPSVYWOUGJ-UHFFFAOYSA-N (3-chloro-2-methylphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C(=C(Cl)C=CC=2)C)CC1 XXYZZPSVYWOUGJ-UHFFFAOYSA-N 0.000 claims 1
• RXXNCSZDWXJPLE-UHFFFAOYSA-N (3-chloro-2-methylphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C(=C(Cl)C=CC=2)C)CC1 RXXNCSZDWXJPLE-UHFFFAOYSA-N 0.000 claims 1
• NROPPFZLOPROLD-UHFFFAOYSA-N (3-chloro-2-methylphenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C(=C(Cl)C=CC=2)C)CC1 NROPPFZLOPROLD-UHFFFAOYSA-N 0.000 claims 1
• FUPWSFTXMACQPZ-UHFFFAOYSA-N (3-chloro-4-methylphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C(Cl)C(C)=CC=2)CC1 FUPWSFTXMACQPZ-UHFFFAOYSA-N 0.000 claims 1
• LDYPHFYWCDFYPY-UHFFFAOYSA-N (3-methoxyphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound COC1=CC=CC(C(=O)N2CCC3(CN(CC=4C(=CC=CC=4)OCC(C)C)CC3)CC2)=C1 LDYPHFYWCDFYPY-UHFFFAOYSA-N 0.000 claims 1
• DIZIVLOEUVZGSR-UHFFFAOYSA-N (3-methoxyphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound COC1=CC=CC(C(=O)N2CC3(CC2)CCN(CC=2C(=CC=CC=2)OCC(C)C)CC3)=C1 DIZIVLOEUVZGSR-UHFFFAOYSA-N 0.000 claims 1
• VABPZOFSXMOXJL-UHFFFAOYSA-N (3-methoxyphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound COC1=CC=CC(C(=O)N2CCC3(CCN(CC=4C(=CC=CC=4)OCC=4C=CC=CC=4)CC3)CC2)=C1 VABPZOFSXMOXJL-UHFFFAOYSA-N 0.000 claims 1
• PEBBRDJQEZYMRG-UHFFFAOYSA-N (3-methyl-1,2-oxazol-4-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C(=NOC=2)C)CC1 PEBBRDJQEZYMRG-UHFFFAOYSA-N 0.000 claims 1
• ADSJTSMGJXOKTJ-UHFFFAOYSA-N (3-methyl-1,2-oxazol-4-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C(=NOC=2)C)CC1 ADSJTSMGJXOKTJ-UHFFFAOYSA-N 0.000 claims 1
• JJNOYAKTWWFYGN-UHFFFAOYSA-N (4-butoxyphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=CC(OCCCC)=CC=C1C(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 JJNOYAKTWWFYGN-UHFFFAOYSA-N 0.000 claims 1
• UTMDUXBSAVRSKY-UHFFFAOYSA-N (4-butoxyphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC(OCCCC)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 UTMDUXBSAVRSKY-UHFFFAOYSA-N 0.000 claims 1
• UKZYVIKILLUGGA-UHFFFAOYSA-N (4-butoxyphenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(OCCCC)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC)CC2)CC1 UKZYVIKILLUGGA-UHFFFAOYSA-N 0.000 claims 1
• IIPVVNQWHMXUMN-UHFFFAOYSA-N (4-chloro-2-methoxyphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound COC1=CC(Cl)=CC=C1C(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 IIPVVNQWHMXUMN-UHFFFAOYSA-N 0.000 claims 1
• XBJGIJMTCBXNLV-UHFFFAOYSA-N (4-chloro-2-methoxyphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound COC1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 XBJGIJMTCBXNLV-UHFFFAOYSA-N 0.000 claims 1
• KMHGNIWQUCYDNY-UHFFFAOYSA-N (4-chloro-2-methoxyphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound COC1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 KMHGNIWQUCYDNY-UHFFFAOYSA-N 0.000 claims 1
• JNOFKHJLCGOFGT-UHFFFAOYSA-N (4-chloro-2-methylsulfonylphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C(=CC(Cl)=CC=2)S(C)(=O)=O)CC1 JNOFKHJLCGOFGT-UHFFFAOYSA-N 0.000 claims 1
• AVUMUXWXQPUYAM-UHFFFAOYSA-N (4-chlorophenyl)-[2-[(2-pyridin-3-yloxyphenyl)methyl]-2,7-diazaspiro[3.5]nonan-7-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OC=3C=NC=CC=3)C2)CC1 AVUMUXWXQPUYAM-UHFFFAOYSA-N 0.000 claims 1
• TURMTVPAOLGSRH-UHFFFAOYSA-N (4-chlorophenyl)-[2-[(3-phenylmethoxyphenyl)methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CN(CC=3C=C(OCC=4C=CC=CC=4)C=CC=3)CC2)CC1 TURMTVPAOLGSRH-UHFFFAOYSA-N 0.000 claims 1
• ZQMVLFDSUBEGGP-UHFFFAOYSA-N (4-chlorophenyl)-[2-[(4-fluoro-3-phenoxyphenyl)methyl]-2,7-diazaspiro[3.5]nonan-7-yl]methanone Chemical compound C1=C(OC=2C=CC=CC=2)C(F)=CC=C1CN(C1)CC1(CC1)CCN1C(=O)C1=CC=C(Cl)C=C1 ZQMVLFDSUBEGGP-UHFFFAOYSA-N 0.000 claims 1
• UNMDZIJMDYSRCU-UHFFFAOYSA-N (4-chlorophenyl)-[2-[(4-fluoro-3-phenoxyphenyl)methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=C(OC=2C=CC=CC=2)C(F)=CC=C1CN(C1)CCC1(CC1)CCN1C(=O)C1=CC=C(Cl)C=C1 UNMDZIJMDYSRCU-UHFFFAOYSA-N 0.000 claims 1
• CCMJSRVNURGYSJ-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-7-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)C1 CCMJSRVNURGYSJ-UHFFFAOYSA-N 0.000 claims 1
• VXJGKXQMRRZLRX-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[4.5]decan-7-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CN(CCC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 VXJGKXQMRRZLRX-UHFFFAOYSA-N 0.000 claims 1
• PTNZALIUPQZMPZ-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 PTNZALIUPQZMPZ-UHFFFAOYSA-N 0.000 claims 1
• RGFVJJRPKXUZTD-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-(4-fluorophenoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-7-yl]methanone Chemical compound C1=CC(F)=CC=C1OC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)C1 RGFVJJRPKXUZTD-UHFFFAOYSA-N 0.000 claims 1
• NHLOFBXNWFJYEP-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-(4-fluorophenoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=CC(F)=CC=C1OC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 NHLOFBXNWFJYEP-UHFFFAOYSA-N 0.000 claims 1
• YJQVVNCZAHVDGO-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound S1C(Cl)=NC=C1COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 YJQVVNCZAHVDGO-UHFFFAOYSA-N 0.000 claims 1
• FUNNUOZFKZTROI-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-[3-(trifluoromethyl)phenoxy]phenyl]methyl]-2,7-diazaspiro[3.5]nonan-7-yl]methanone Chemical compound FC(F)(F)C1=CC=CC(OC=2C(=CC=CC=2)CN2CC3(C2)CCN(CC3)C(=O)C=2C=CC(Cl)=CC=2)=C1 FUNNUOZFKZTROI-UHFFFAOYSA-N 0.000 claims 1
• NEFZAIUAWAXRBZ-UHFFFAOYSA-N (4-chlorophenyl)-[2-[[2-[3-(trifluoromethyl)phenoxy]phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound FC(F)(F)C1=CC=CC(OC=2C(=CC=CC=2)CN2CC3(CC2)CCN(CC3)C(=O)C=2C=CC(Cl)=CC=2)=C1 NEFZAIUAWAXRBZ-UHFFFAOYSA-N 0.000 claims 1
• NDUXWJLMAYYXCC-UHFFFAOYSA-N (4-chlorophenyl)-[7-[(2-phenoxyphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OC=3C=CC=CC=3)CC2)C1 NDUXWJLMAYYXCC-UHFFFAOYSA-N 0.000 claims 1
• NKBDZFGRQCCUPH-UHFFFAOYSA-N (4-chlorophenyl)-[7-[(2-phenoxyphenyl)methyl]-2,7-diazaspiro[4.4]nonan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CN(CC=3C(=CC=CC=3)OC=3C=CC=CC=3)CC2)CC1 NKBDZFGRQCCUPH-UHFFFAOYSA-N 0.000 claims 1
• QRSYEGIFRAHIDH-UHFFFAOYSA-N (4-chlorophenyl)-[7-[(2-phenylmethoxyphenyl)methyl]-2,7-diazaspiro[4.4]nonan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 QRSYEGIFRAHIDH-UHFFFAOYSA-N 0.000 claims 1
• HLPLMCHPJNJQDR-UHFFFAOYSA-N (4-chlorophenyl)-[7-[(2-pyridin-3-yloxyphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OC=3C=NC=CC=3)CC2)C1 HLPLMCHPJNJQDR-UHFFFAOYSA-N 0.000 claims 1
• PSTNRKQEFUMVQG-UHFFFAOYSA-N (4-chlorophenyl)-[7-[(3-phenoxyphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C=C(OC=4C=CC=CC=4)C=CC=3)CC2)C1 PSTNRKQEFUMVQG-UHFFFAOYSA-N 0.000 claims 1
• KTYRHTVPTQJJNB-UHFFFAOYSA-N (4-chlorophenyl)-[7-[(3-phenylmethoxyphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C=C(OCC=4C=CC=CC=4)C=CC=3)CC2)C1 KTYRHTVPTQJJNB-UHFFFAOYSA-N 0.000 claims 1
• WRRRZUDCUHPTIR-UHFFFAOYSA-N (4-chlorophenyl)-[7-[(4-fluoro-3-phenoxyphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound C1=C(OC=2C=CC=CC=2)C(F)=CC=C1CN(CC1)CCC1(C1)CN1C(=O)C1=CC=C(Cl)C=C1 WRRRZUDCUHPTIR-UHFFFAOYSA-N 0.000 claims 1
• NZLNNNDBXLCGEP-UHFFFAOYSA-N (4-chlorophenyl)-[7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[4.4]nonan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 NZLNNNDBXLCGEP-UHFFFAOYSA-N 0.000 claims 1
• MEJZFZDOIBQQQU-UHFFFAOYSA-N (4-chlorophenyl)-[7-[[2-(4-fluorophenoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound C1=CC(F)=CC=C1OC1=CC=CC=C1CN1CCC2(CN(C2)C(=O)C=2C=CC(Cl)=CC=2)CC1 MEJZFZDOIBQQQU-UHFFFAOYSA-N 0.000 claims 1
• QOQWJTAGQCMGNB-UHFFFAOYSA-N (4-chlorophenyl)-[7-[[2-[3-(trifluoromethyl)phenoxy]phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone Chemical compound FC(F)(F)C1=CC=CC(OC=2C(=CC=CC=2)CN2CCC3(CN(C3)C(=O)C=3C=CC(Cl)=CC=3)CC2)=C1 QOQWJTAGQCMGNB-UHFFFAOYSA-N 0.000 claims 1
• HHKKTCPLAKLKEK-UHFFFAOYSA-N (4-chlorophenyl)-[7-[[3-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[4.4]nonan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC(CN2CC3(CN(CC3)C(=O)C=3C=CC(Cl)=CC=3)CC2)=C1 HHKKTCPLAKLKEK-UHFFFAOYSA-N 0.000 claims 1
• JOAKHURLCLAFIC-UHFFFAOYSA-N (4-chlorophenyl)-[8-[(3-phenylmethoxyphenyl)methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C=C(OCC=4C=CC=CC=4)C=CC=3)CC2)CC1 JOAKHURLCLAFIC-UHFFFAOYSA-N 0.000 claims 1
• HMDPQBCDYXZCLM-UHFFFAOYSA-N (4-chlorophenyl)-[8-[(4-fluoro-3-phenoxyphenyl)methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=C(OC=2C=CC=CC=2)C(F)=CC=C1CN(CC1)CCC1(C1)CCN1C(=O)C1=CC=C(Cl)C=C1 HMDPQBCDYXZCLM-UHFFFAOYSA-N 0.000 claims 1
• JYLSDPVKHOMAHG-UHFFFAOYSA-N (4-chlorophenyl)-[8-[(4-phenoxyphenyl)methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C=CC(OC=4C=CC=CC=4)=CC=3)CC2)CC1 JYLSDPVKHOMAHG-UHFFFAOYSA-N 0.000 claims 1
• UWPITOWSOQEZOQ-UHFFFAOYSA-N (4-chlorophenyl)-[8-[[2-(2,4-dichlorophenoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OC=3C(=CC(Cl)=CC=3)Cl)CC2)CC1 UWPITOWSOQEZOQ-UHFFFAOYSA-N 0.000 claims 1
• MRTLULZPKOHBRQ-UHFFFAOYSA-N (4-chlorophenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 MRTLULZPKOHBRQ-UHFFFAOYSA-N 0.000 claims 1
• QAYYCPSHKPIIHS-UHFFFAOYSA-N (4-chlorophenyl)-[8-[[2-(4-fluorophenoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC(F)=CC=C1OC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 QAYYCPSHKPIIHS-UHFFFAOYSA-N 0.000 claims 1
• JXULUBBOFJCXQM-UHFFFAOYSA-N (4-chlorophenyl)-[8-[[2-[3-(trifluoromethyl)phenoxy]phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound FC(F)(F)C1=CC=CC(OC=2C(=CC=CC=2)CN2CCC3(CN(CC3)C(=O)C=3C=CC(Cl)=CC=3)CC2)=C1 JXULUBBOFJCXQM-UHFFFAOYSA-N 0.000 claims 1
• HREVIXVHGALCMA-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 HREVIXVHGALCMA-UHFFFAOYSA-N 0.000 claims 1
• RFYUVDOAAJUIDW-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 RFYUVDOAAJUIDW-UHFFFAOYSA-N 0.000 claims 1
• HYLZAKLWGBKDBY-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(3,5-diethoxypyridin-4-yl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CN=CC(OCC)=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 HYLZAKLWGBKDBY-UHFFFAOYSA-N 0.000 claims 1
• YHKSOBZFXYKFOV-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(3-phenoxythiophen-2-yl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC3=C(C=CS3)OC=3C=CC=CC=3)CC2)CC1 YHKSOBZFXYKFOV-UHFFFAOYSA-N 0.000 claims 1
• GXCMLZQVQLFJSZ-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(3-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C=C(OCC=4C=CC=CC=4)C=CC=3)CC2)CC1 GXCMLZQVQLFJSZ-UHFFFAOYSA-N 0.000 claims 1
• OFQXWKBMSPQCSI-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(3-pyridin-2-yloxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C=C(OC=4N=CC=CC=4)C=CC=3)CC2)CC1 OFQXWKBMSPQCSI-UHFFFAOYSA-N 0.000 claims 1
• ARBACXISHQJXDO-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(4-fluoro-3-phenoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=C(OC=2C=CC=CC=2)C(F)=CC=C1CN(CC1)CCC1(CC1)CCN1C(=O)C1=CC=C(Cl)C=C1 ARBACXISHQJXDO-UHFFFAOYSA-N 0.000 claims 1
• MBOIDHAANMPQOU-UHFFFAOYSA-N (4-chlorophenyl)-[9-[(4-phenoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C=CC(OC=4C=CC=CC=4)=CC=3)CC2)CC1 MBOIDHAANMPQOU-UHFFFAOYSA-N 0.000 claims 1
• KPEBIXRQMFUTMJ-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(2,4-dichlorophenoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OC=3C(=CC(Cl)=CC=3)Cl)CC2)CC1 KPEBIXRQMFUTMJ-UHFFFAOYSA-N 0.000 claims 1
• FVIRTVGXWNRAMY-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(2-methoxyphenoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound COC1=CC=CC=C1OC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 FVIRTVGXWNRAMY-UHFFFAOYSA-N 0.000 claims 1
• PNORIZSLKMOCIM-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-2,9-diazaspiro[5.5]undecan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CCC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 PNORIZSLKMOCIM-UHFFFAOYSA-N 0.000 claims 1
• ACKKHACPPWZKLG-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(2-methylpropoxy)pyridin-3-yl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=NC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 ACKKHACPPWZKLG-UHFFFAOYSA-N 0.000 claims 1
• HIHPFYOVMYUYBG-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(3-methylbutoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 HIHPFYOVMYUYBG-UHFFFAOYSA-N 0.000 claims 1
• NBHZOOSVENOVAH-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(4-fluorophenoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(F)=CC=C1OC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 NBHZOOSVENOVAH-UHFFFAOYSA-N 0.000 claims 1
• CRTIODLVLHSSER-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(4-methylphenoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(C)=CC=C1OC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(Cl)=CC=2)CC1 CRTIODLVLHSSER-UHFFFAOYSA-N 0.000 claims 1
• AGKGJRFCHDJDTK-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-(pyridin-2-ylmethoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3N=CC=CC=3)CC2)CC1 AGKGJRFCHDJDTK-UHFFFAOYSA-N 0.000 claims 1
• DFLGBSAJRYIZGO-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-[(2,6-dichlorophenyl)methoxy]phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C(=CC=CC=3Cl)Cl)CC2)CC1 DFLGBSAJRYIZGO-UHFFFAOYSA-N 0.000 claims 1
• YIFAUCXTPJHPQT-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[2-[3-(trifluoromethyl)phenoxy]phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound FC(F)(F)C1=CC=CC(OC=2C(=CC=CC=2)CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=CC(Cl)=CC=2)=C1 YIFAUCXTPJHPQT-UHFFFAOYSA-N 0.000 claims 1
• QPJDUGWRGZOPGZ-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[3-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=CC(Cl)=CC=2)=C1 QPJDUGWRGZOPGZ-UHFFFAOYSA-N 0.000 claims 1
• KHCYJVDMWZFKCD-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[3-(pyridin-2-ylmethoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C=C(OCC=4N=CC=CC=4)C=CC=3)CC2)CC1 KHCYJVDMWZFKCD-UHFFFAOYSA-N 0.000 claims 1
• UDUUVKFILMVWAO-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[3-(pyridin-3-ylmethoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C=C(OCC=4C=NC=CC=4)C=CC=3)CC2)CC1 UDUUVKFILMVWAO-UHFFFAOYSA-N 0.000 claims 1
• RBGWZWATTGWGOT-UHFFFAOYSA-N (4-chlorophenyl)-[9-[[6-(2-methylpropoxy)pyridin-2-yl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC(CN2CCC3(CC2)CCN(CC3)C(=O)C=2C=CC(Cl)=CC=2)=N1 RBGWZWATTGWGOT-UHFFFAOYSA-N 0.000 claims 1
• KYASNWSODINYGC-UHFFFAOYSA-N (4-ethylphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=CC(CC)=CC=C1C(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 KYASNWSODINYGC-UHFFFAOYSA-N 0.000 claims 1
• HONSGVYPOPVNBD-UHFFFAOYSA-N (4-ethylphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC(CC)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 HONSGVYPOPVNBD-UHFFFAOYSA-N 0.000 claims 1
• SFHLTXGPSLHREN-UHFFFAOYSA-N (4-ethylphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(CC)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 SFHLTXGPSLHREN-UHFFFAOYSA-N 0.000 claims 1
• UUCHOWRUVQRXIP-UHFFFAOYSA-N (4-fluorophenyl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(F)=CC=2)CC1 UUCHOWRUVQRXIP-UHFFFAOYSA-N 0.000 claims 1
• STQOLMSFWBRIHJ-UHFFFAOYSA-N (4-imidazol-1-ylphenyl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(=CC=2)N2C=NC=C2)CC1 STQOLMSFWBRIHJ-UHFFFAOYSA-N 0.000 claims 1
• WGNKKYRMPQMKAA-UHFFFAOYSA-N (4-methoxyphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 WGNKKYRMPQMKAA-UHFFFAOYSA-N 0.000 claims 1
• LCCRCFPPCYBQBH-UHFFFAOYSA-N (4-methoxyphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 LCCRCFPPCYBQBH-UHFFFAOYSA-N 0.000 claims 1
• GPKJBVRVVPHIHD-UHFFFAOYSA-N (4-methoxyphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 GPKJBVRVVPHIHD-UHFFFAOYSA-N 0.000 claims 1
• QGZGFVBEWICKEP-UHFFFAOYSA-N (4-methoxythiophen-3-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound COC1=CSC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 QGZGFVBEWICKEP-UHFFFAOYSA-N 0.000 claims 1
• PVKLBTQKMSQKDF-UHFFFAOYSA-N (4-methylphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(C)=CC=2)CC1 PVKLBTQKMSQKDF-UHFFFAOYSA-N 0.000 claims 1
• GIOZKTQYTLMYLM-UHFFFAOYSA-N (4-methylphenyl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=CC(C)=CC=2)CC1 GIOZKTQYTLMYLM-UHFFFAOYSA-N 0.000 claims 1
• MSNHQFBLJWBGBG-UHFFFAOYSA-N (4-methylphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(C)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 MSNHQFBLJWBGBG-UHFFFAOYSA-N 0.000 claims 1
• LZPSFUFYZVBXOQ-UHFFFAOYSA-N (4-morpholin-4-ylphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C=1C=C(N2CCOCC2)C=CC=1C(=O)N(CC1)CCC1(CC1)CCN1CC1=CC=CC=C1OCC1=CC=CC=C1 LZPSFUFYZVBXOQ-UHFFFAOYSA-N 0.000 claims 1
• RGILUVYXGBIFIW-UHFFFAOYSA-N (4-phenoxyphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)N(CC1)CCC1(CC1)CCN1CC1=CC=CC=C1OCC1=CC=CC=C1 RGILUVYXGBIFIW-UHFFFAOYSA-N 0.000 claims 1
• JFGAPLCEYYKQNS-UHFFFAOYSA-N (4-tert-butylphenyl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(=CC=2)C(C)(C)C)CC1 JFGAPLCEYYKQNS-UHFFFAOYSA-N 0.000 claims 1
• ASQOWVVTNOKVRU-UHFFFAOYSA-N (4-tert-butylphenyl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(=CC=2)C(C)(C)C)CC1 ASQOWVVTNOKVRU-UHFFFAOYSA-N 0.000 claims 1
• LWCMCHJZIRLPJY-UHFFFAOYSA-N (4-tert-butylphenyl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 LWCMCHJZIRLPJY-UHFFFAOYSA-N 0.000 claims 1
• VAHNEBNBTSKPQH-UHFFFAOYSA-N (5-chlorothiophen-2-yl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2SC(Cl)=CC=2)CC1 VAHNEBNBTSKPQH-UHFFFAOYSA-N 0.000 claims 1
• MDORBGCVWZXQJN-UHFFFAOYSA-N (5-methyl-1,2-oxazol-4-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C2=C(ON=C2)C)CC1 MDORBGCVWZXQJN-UHFFFAOYSA-N 0.000 claims 1
• LUPBKYHHQJHCCC-UHFFFAOYSA-N (5-methyl-1,2-oxazol-4-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C2=C(ON=C2)C)CC1 LUPBKYHHQJHCCC-UHFFFAOYSA-N 0.000 claims 1
• OKWMBUHTJRUIHO-UHFFFAOYSA-N (6-chloropyridin-2-yl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2N=C(Cl)C=CC=2)CC1 OKWMBUHTJRUIHO-UHFFFAOYSA-N 0.000 claims 1
• AJQONPANPQIPGY-UHFFFAOYSA-N (6-chloropyridin-3-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=NC(Cl)=CC=2)CC1 AJQONPANPQIPGY-UHFFFAOYSA-N 0.000 claims 1
• WSMPDJVQPNLFER-UHFFFAOYSA-N (6-chloropyridin-3-yl)-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=NC(Cl)=CC=2)CC1 WSMPDJVQPNLFER-UHFFFAOYSA-N 0.000 claims 1
• JULCORUJWWZYBP-UHFFFAOYSA-N (6-chloropyridin-3-yl)-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound C1=NC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 JULCORUJWWZYBP-UHFFFAOYSA-N 0.000 claims 1
• DQMITIATTVSMGJ-UHFFFAOYSA-N (6-chloropyridin-3-yl)-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]methanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=NC(Cl)=CC=2)CC1 DQMITIATTVSMGJ-UHFFFAOYSA-N 0.000 claims 1
• ATBIGSKBZUKMDC-UHFFFAOYSA-N (6-methoxynaphthalen-2-yl)-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]methanone Chemical compound C1=CC2=CC(OC)=CC=C2C=C1C(=O)N(CC1)CCC1(C1)CCN1CC1=CC=CC=C1OCC(C)C ATBIGSKBZUKMDC-UHFFFAOYSA-N 0.000 claims 1
• IOIHVFIOTCXTOD-UHFFFAOYSA-N (6-methoxynaphthalen-2-yl)-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]methanone Chemical compound C1=CC2=CC(OC)=CC=C2C=C1C(=O)N(C1)CCC1(CC1)CCN1CC1=CC=CC=C1OCC(C)C IOIHVFIOTCXTOD-UHFFFAOYSA-N 0.000 claims 1
• LNXAIMAIZLKSMS-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[4.5]decan-7-yl]-2-pyridin-4-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CN(CCC2)C(=O)CC=2C=CN=CC=2)CC1 LNXAIMAIZLKSMS-UHFFFAOYSA-N 0.000 claims 1
• OAFRXRUDCRCOOW-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-(2-nitrophenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C(=CC=CC=2)[N+]([O-])=O)CC1 OAFRXRUDCRCOOW-UHFFFAOYSA-N 0.000 claims 1
• LHGGMEGEZHUUJH-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-(3-nitrophenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=C(C=CC=2)[N+]([O-])=O)CC1 LHGGMEGEZHUUJH-UHFFFAOYSA-N 0.000 claims 1
• OFNXUPTYIOXAPD-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-(4-methylsulfonylphenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=CC(=CC=2)S(C)(=O)=O)CC1 OFNXUPTYIOXAPD-UHFFFAOYSA-N 0.000 claims 1
• RULHVRMTPGYCCM-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-(4-nitrophenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=CC(=CC=2)[N+]([O-])=O)CC1 RULHVRMTPGYCCM-UHFFFAOYSA-N 0.000 claims 1
• OOHRQHHHLQQFJN-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-(4-propan-2-ylphenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=CC(=CC=2)C(C)C)CC1 OOHRQHHHLQQFJN-UHFFFAOYSA-N 0.000 claims 1
• CDMZIHQEQBQEEQ-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=CC(OC(F)(F)F)=CC=2)CC1 CDMZIHQEQBQEEQ-UHFFFAOYSA-N 0.000 claims 1
• WZMHONMKTCMPPF-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-pyridin-2-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2N=CC=CC=2)CC1 WZMHONMKTCMPPF-UHFFFAOYSA-N 0.000 claims 1
• CMQBXKFKKXOHLK-UHFFFAOYSA-N 1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]-2-pyridin-4-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=CN=CC=2)CC1 CMQBXKFKKXOHLK-UHFFFAOYSA-N 0.000 claims 1
• NSWLMAMWGBAVCO-UHFFFAOYSA-N 1-[4-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decane-8-carbonyl]phenyl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)C=2C=CC(=CC=2)C(C)=O)CC1 NSWLMAMWGBAVCO-UHFFFAOYSA-N 0.000 claims 1
• TWCHWOJIVRRGOO-UHFFFAOYSA-N 1-[4-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]phenyl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=CC(=CC=2)C(C)=O)CC1 TWCHWOJIVRRGOO-UHFFFAOYSA-N 0.000 claims 1
• CPXRORQTVVZAJR-UHFFFAOYSA-N 1-[4-[9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]phenyl]ethanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(=CC=2)C(C)=O)CC1 CPXRORQTVVZAJR-UHFFFAOYSA-N 0.000 claims 1
• PUZQPMKBPAGLMV-UHFFFAOYSA-N 1-[4-[9-[(2-phenylmethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]phenyl]ethanone Chemical compound C1=CC(C(=O)C)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OCC=3C=CC=CC=3)CC2)CC1 PUZQPMKBPAGLMV-UHFFFAOYSA-N 0.000 claims 1
• SDHAHASAGDBNTD-UHFFFAOYSA-N 1-[7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]-2-pyridin-2-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(C2)C(=O)CC=2N=CC=CC=2)CC1 SDHAHASAGDBNTD-UHFFFAOYSA-N 0.000 claims 1
• GKMGLAAJYHZGJI-UHFFFAOYSA-N 1-[7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]-2-pyridin-3-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(C2)C(=O)CC=2C=NC=CC=2)CC1 GKMGLAAJYHZGJI-UHFFFAOYSA-N 0.000 claims 1
• BMLKJKPDPGLJRJ-UHFFFAOYSA-N 1-[7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]-2-pyridin-4-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(C2)C(=O)CC=2C=CN=CC=2)CC1 BMLKJKPDPGLJRJ-UHFFFAOYSA-N 0.000 claims 1
• XRJCQTXFHDHUBN-UHFFFAOYSA-N 1-[7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[4.4]nonan-2-yl]-2-pyridin-4-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CN(CC2)C(=O)CC=2C=CN=CC=2)CC1 XRJCQTXFHDHUBN-UHFFFAOYSA-N 0.000 claims 1
• FGEDVFJJEKCEQH-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-(2-nitrophenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C(=CC=CC=2)[N+]([O-])=O)CC1 FGEDVFJJEKCEQH-UHFFFAOYSA-N 0.000 claims 1
• MJFYHRSWTMWASI-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-(3-nitrophenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=C(C=CC=2)[N+]([O-])=O)CC1 MJFYHRSWTMWASI-UHFFFAOYSA-N 0.000 claims 1
• JFZXCTDCJHXHRJ-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-(4-methylsulfonylphenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=CC(=CC=2)S(C)(=O)=O)CC1 JFZXCTDCJHXHRJ-UHFFFAOYSA-N 0.000 claims 1
• OASRJVAUMTXPRP-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-(4-nitrophenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=CC(=CC=2)[N+]([O-])=O)CC1 OASRJVAUMTXPRP-UHFFFAOYSA-N 0.000 claims 1
• LBENREQVFJFPDL-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-(4-propan-2-ylphenyl)ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=CC(=CC=2)C(C)C)CC1 LBENREQVFJFPDL-UHFFFAOYSA-N 0.000 claims 1
• VAENDSBYFHYBQF-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-[3-(trifluoromethyl)phenyl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=C(C=CC=2)C(F)(F)F)CC1 VAENDSBYFHYBQF-UHFFFAOYSA-N 0.000 claims 1
• CLTZYTPUGOPXFJ-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=CC(OC(F)(F)F)=CC=2)CC1 CLTZYTPUGOPXFJ-UHFFFAOYSA-N 0.000 claims 1
• SQLGFSQGYVLWDP-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-pyridin-2-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2N=CC=CC=2)CC1 SQLGFSQGYVLWDP-UHFFFAOYSA-N 0.000 claims 1
• XQRPKJKNVFFUOI-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-pyridin-3-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=NC=CC=2)CC1 XQRPKJKNVFFUOI-UHFFFAOYSA-N 0.000 claims 1
• KPURWJGHBAAIOE-UHFFFAOYSA-N 1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-pyridin-4-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=CN=CC=2)CC1 KPURWJGHBAAIOE-UHFFFAOYSA-N 0.000 claims 1
• IOBWQRZRMWMISJ-UHFFFAOYSA-N 1-[9-[[2-(2-methylpropoxy)phenyl]methyl]-2,9-diazaspiro[5.5]undecan-2-yl]-2-pyridin-4-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CCC2)C(=O)CC=2C=CN=CC=2)CC1 IOBWQRZRMWMISJ-UHFFFAOYSA-N 0.000 claims 1
• WICILWOXXADAAO-UHFFFAOYSA-N 1-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-2-pyridin-2-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)CC=2N=CC=CC=2)CC1 WICILWOXXADAAO-UHFFFAOYSA-N 0.000 claims 1
• ZMYSAKFIHBDLIB-UHFFFAOYSA-N 1-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-2-pyridin-3-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)CC=2C=NC=CC=2)CC1 ZMYSAKFIHBDLIB-UHFFFAOYSA-N 0.000 claims 1
• UHAGZAULFKJQKB-UHFFFAOYSA-N 1-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-2-pyridin-4-ylethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)CC=2C=CN=CC=2)CC1 UHAGZAULFKJQKB-UHFFFAOYSA-N 0.000 claims 1
• GLTSBRUWOZVDLL-UHFFFAOYSA-N 2,4-dimethyl-1,3-benzoxazole Chemical compound C1=CC=C2OC(C)=NC2=C1C GLTSBRUWOZVDLL-UHFFFAOYSA-N 0.000 claims 1
• ZOZZIVOEWLWIJP-UHFFFAOYSA-N 2,4-dimethyl-5-[[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]sulfonyl]-1,3-thiazole Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)S(=O)(=O)C2=C(N=C(C)S2)C)CC1 ZOZZIVOEWLWIJP-UHFFFAOYSA-N 0.000 claims 1
• ITBKTOAUTLJXHO-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=C3OCOC3=CC=2)CC1 ITBKTOAUTLJXHO-UHFFFAOYSA-N 0.000 claims 1
• VMDTUEYHPJLMLD-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=C3OCOC3=CC=2)CC1 VMDTUEYHPJLMLD-UHFFFAOYSA-N 0.000 claims 1
• PETFYVWPUATJBB-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C(=CC(Cl)=CC=2)Cl)CC1 PETFYVWPUATJBB-UHFFFAOYSA-N 0.000 claims 1
• XGHKIIHJJHZVRC-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C(=CC(Cl)=CC=2)Cl)CC1 XGHKIIHJJHZVRC-UHFFFAOYSA-N 0.000 claims 1
• KFQXGFSRPNPVON-UHFFFAOYSA-N 2-(2,4-difluorophenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C(=CC(F)=CC=2)F)CC1 KFQXGFSRPNPVON-UHFFFAOYSA-N 0.000 claims 1
• OREDVXIKZCFVJU-UHFFFAOYSA-N 2-(2,4-difluorophenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C(=CC(F)=CC=2)F)CC1 OREDVXIKZCFVJU-UHFFFAOYSA-N 0.000 claims 1
• KRQGARLTBJBRDM-UHFFFAOYSA-N 2-(2,5-difluorophenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C(=CC=C(F)C=2)F)CC1 KRQGARLTBJBRDM-UHFFFAOYSA-N 0.000 claims 1
• YMQSHLLSWNGNOH-UHFFFAOYSA-N 2-(2,5-difluorophenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C(=CC=C(F)C=2)F)CC1 YMQSHLLSWNGNOH-UHFFFAOYSA-N 0.000 claims 1
• CRHQCIKQHKUOCW-UHFFFAOYSA-N 2-(2-fluorophenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C(=CC=CC=2)F)CC1 CRHQCIKQHKUOCW-UHFFFAOYSA-N 0.000 claims 1
• DWXDWFCZKNFDDG-UHFFFAOYSA-N 2-(2-fluorophenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C(=CC=CC=2)F)CC1 DWXDWFCZKNFDDG-UHFFFAOYSA-N 0.000 claims 1
• DPHQOVDDEBDHJF-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound C1=C(OC)C(OC)=CC=C1CC(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 DPHQOVDDEBDHJF-UHFFFAOYSA-N 0.000 claims 1
• IXWOZBBVWGWCFU-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound C1=C(OC)C(OC)=CC=C1CC(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 IXWOZBBVWGWCFU-UHFFFAOYSA-N 0.000 claims 1
• HZKKSKHXDNULHC-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=C(F)C=C(F)C=2)CC1 HZKKSKHXDNULHC-UHFFFAOYSA-N 0.000 claims 1
• BDSVRQWGIQAICL-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=C(F)C=C(F)C=2)CC1 BDSVRQWGIQAICL-UHFFFAOYSA-N 0.000 claims 1
• LHCXJOCQCRKCPK-UHFFFAOYSA-N 2-(3,5-dimethylphenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=C(C)C=C(C)C=2)CC1 LHCXJOCQCRKCPK-UHFFFAOYSA-N 0.000 claims 1
• XRHRVHMRBGXMLU-UHFFFAOYSA-N 2-(3-methoxy-4-phenylmethoxyphenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound C=1C=C(OCC=2C=CC=CC=2)C(OC)=CC=1CC(=O)N(CC1)CCC1(C1)CCN1CC1=CC=CC=C1OCC(C)C XRHRVHMRBGXMLU-UHFFFAOYSA-N 0.000 claims 1
• FFTATLHVUBBLLF-UHFFFAOYSA-N 2-(3-methoxy-4-phenylmethoxyphenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound C=1C=C(OCC=2C=CC=CC=2)C(OC)=CC=1CC(=O)N(C1)CCC1(CC1)CCN1CC1=CC=CC=C1OCC(C)C FFTATLHVUBBLLF-UHFFFAOYSA-N 0.000 claims 1
• DAQNUHXQCXYDGV-UHFFFAOYSA-N 2-(4-butoxyphenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound C1=CC(OCCCC)=CC=C1CC(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 DAQNUHXQCXYDGV-UHFFFAOYSA-N 0.000 claims 1
• IQSKAZNZKZZHDG-UHFFFAOYSA-N 2-(4-butoxyphenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound C1=CC(OCCCC)=CC=C1CC(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OCC(C)C)CC2)CC1 IQSKAZNZKZZHDG-UHFFFAOYSA-N 0.000 claims 1
• XNJRICSGZRPHFW-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=CC(Cl)=CC=2)CC1 XNJRICSGZRPHFW-UHFFFAOYSA-N 0.000 claims 1
• LRNXENFTHQGJSA-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=CC(Cl)=CC=2)CC1 LRNXENFTHQGJSA-UHFFFAOYSA-N 0.000 claims 1
• SNFRPAMCIZMHRY-UHFFFAOYSA-N 2-(4-chlorophenyl)sulfonyl-7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[3.5]nonane Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(C2)S(=O)(=O)C=2C=CC(Cl)=CC=2)CC1 SNFRPAMCIZMHRY-UHFFFAOYSA-N 0.000 claims 1
• LJWNEWZITWJJAY-UHFFFAOYSA-N 2-(4-chlorophenyl)sulfonyl-7-[[2-(2-methylpropoxy)phenyl]methyl]-2,7-diazaspiro[4.4]nonane Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CN(CC2)S(=O)(=O)C=2C=CC(Cl)=CC=2)CC1 LJWNEWZITWJJAY-UHFFFAOYSA-N 0.000 claims 1
• FNXINTNTCDFCGD-UHFFFAOYSA-N 2-(4-chlorophenyl)sulfonyl-9-[[2-(2-methylpropoxy)phenyl]methyl]-2,9-diazaspiro[5.5]undecane Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CCC2)S(=O)(=O)C=2C=CC(Cl)=CC=2)CC1 FNXINTNTCDFCGD-UHFFFAOYSA-N 0.000 claims 1
• HGABHTWIMLUZCL-UHFFFAOYSA-N 2-(4-methylphenyl)-1-[2-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-8-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CC2(CCN(CC2)C(=O)CC=2C=CC(C)=CC=2)CC1 HGABHTWIMLUZCL-UHFFFAOYSA-N 0.000 claims 1
• KXDXEYRKRLBRMI-UHFFFAOYSA-N 2-(4-methylphenyl)-1-[8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]ethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)CC=2C=CC(C)=CC=2)CC1 KXDXEYRKRLBRMI-UHFFFAOYSA-N 0.000 claims 1
• IFMZUBODLOGVQN-UHFFFAOYSA-N 2-(n-[2-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-2-oxoethyl]anilino)acetic acid Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)CN(CC(O)=O)C=2C=CC=CC=2)CC1 IFMZUBODLOGVQN-UHFFFAOYSA-N 0.000 claims 1
• PTIYMFCFHMNUGR-UHFFFAOYSA-N 2-[2-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-2-oxoethoxy]acetic acid Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)COCC(O)=O)CC1 PTIYMFCFHMNUGR-UHFFFAOYSA-N 0.000 claims 1
• BOYYATBELJIKOV-UHFFFAOYSA-N 2-[2-[9-[[2-(2-methylpropoxy)phenyl]methyl]-3,9-diazaspiro[5.5]undecane-3-carbonyl]phenyl]acetic acid Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C(=CC=CC=2)CC(O)=O)CC1 BOYYATBELJIKOV-UHFFFAOYSA-N 0.000 claims 1
• FNRZRWBBDDTDHP-UHFFFAOYSA-N 2-[2-[[2-(4-chlorobenzoyl)-2,7-diazaspiro[3.5]nonan-7-yl]methyl]phenoxy]benzonitrile Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OC=3C(=CC=CC=3)C#N)CC2)C1 FNRZRWBBDDTDHP-UHFFFAOYSA-N 0.000 claims 1
• MMTMJNRRGVDDMA-UHFFFAOYSA-N 2-[2-[[2-(4-chlorobenzoyl)-2,8-diazaspiro[4.5]decan-8-yl]methyl]phenoxy]benzonitrile Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CC2(CCN(CC=3C(=CC=CC=3)OC=3C(=CC=CC=3)C#N)CC2)CC1 MMTMJNRRGVDDMA-UHFFFAOYSA-N 0.000 claims 1
• RMCCIALHHXCZNR-UHFFFAOYSA-N 2-[2-[[3-(4-chlorobenzoyl)-3,9-diazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzonitrile Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CCN(CC=3C(=CC=CC=3)OC=3C(=CC=CC=3)C#N)CC2)CC1 RMCCIALHHXCZNR-UHFFFAOYSA-N 0.000 claims 1
• OOIXYFBGROQLDI-UHFFFAOYSA-N 2-[2-[[7-(4-chlorobenzoyl)-2,7-diazaspiro[3.5]nonan-2-yl]methyl]phenoxy]benzonitrile Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC2(CN(CC=3C(=CC=CC=3)OC=3C(=CC=CC=3)C#N)C2)CC1 OOIXYFBGROQLDI-UHFFFAOYSA-N 0.000 claims 1
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• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
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• 125000000242 4-chlorobenzoyl group Chemical group ClC1=CC=C(C(=O)*)C=C1 0.000 claims 1
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• XVVKUAXKWWUJKW-UHFFFAOYSA-N [8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-naphthalen-2-ylmethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=C3C=CC=CC3=CC=2)CC1 XVVKUAXKWWUJKW-UHFFFAOYSA-N 0.000 claims 1
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• NJPVYKLNBZJZHW-UHFFFAOYSA-N [8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-pyridin-4-ylmethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C=CN=CC=2)CC1 NJPVYKLNBZJZHW-UHFFFAOYSA-N 0.000 claims 1
• HJCQUWRBYLOYNF-UHFFFAOYSA-N [8-[[2-(2-methylpropoxy)phenyl]methyl]-2,8-diazaspiro[4.5]decan-2-yl]-quinolin-4-ylmethanone Chemical compound CC(C)COC1=CC=CC=C1CN1CCC2(CN(CC2)C(=O)C=2C3=CC=CC=C3N=CC=2)CC1 HJCQUWRBYLOYNF-UHFFFAOYSA-N 0.000 claims 1
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• QJPPSMLCVAWTNQ-UHFFFAOYSA-N [9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-(3-methylsulfonylphenyl)methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=C(C=CC=2)S(C)(=O)=O)CC1 QJPPSMLCVAWTNQ-UHFFFAOYSA-N 0.000 claims 1
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• XMKQINDAMJENEH-UHFFFAOYSA-N [9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-(4-fluorophenyl)methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(F)=CC=2)CC1 XMKQINDAMJENEH-UHFFFAOYSA-N 0.000 claims 1
• SDKRIOSUNQLALH-UHFFFAOYSA-N [9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-(4-methoxyphenyl)methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(OC)=CC=2)CC1 SDKRIOSUNQLALH-UHFFFAOYSA-N 0.000 claims 1
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• YPHGVMQGEHSTBB-UHFFFAOYSA-N [9-[(2-ethoxyphenyl)methyl]-3,9-diazaspiro[5.5]undecan-3-yl]-(4-phenoxyphenyl)methanone Chemical compound CCOC1=CC=CC=C1CN1CCC2(CCN(CC2)C(=O)C=2C=CC(OC=3C=CC=CC=3)=CC=2)CC1 YPHGVMQGEHSTBB-UHFFFAOYSA-N 0.000 claims 1
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• 125000004744 butyloxycarbonyl group Chemical group 0.000 claims 1
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