CN1898239A - 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 - Google Patents

新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 Download PDF

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Publication number
CN1898239A
CN1898239A CNA200480038668XA CN200480038668A CN1898239A CN 1898239 A CN1898239 A CN 1898239A CN A200480038668X A CNA200480038668X A CN A200480038668XA CN 200480038668 A CN200480038668 A CN 200480038668A CN 1898239 A CN1898239 A CN 1898239A
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diazaspiro
isobutoxybenzyl
undecane
decane
benzyl
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Chinese (zh)
Inventor
哈坎·布莱德
斯蒂芬·康诺利
黑兹尔·J·戴克
安妮亚·利西厄斯
斯蒂芬·普赖斯
艾戈尔·沙莫夫斯基
马科·范登霍伊维尔
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1898239A publication Critical patent/CN1898239A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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CNA200480038668XA 2003-10-23 2004-10-21 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 Pending CN1898239A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE03028115 2003-10-23
SE0302811A SE0302811D0 (sv) 2003-10-23 2003-10-23 Novel compounds

Publications (1)

Publication Number Publication Date
CN1898239A true CN1898239A (zh) 2007-01-17

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CNA200480038668XA Pending CN1898239A (zh) 2003-10-23 2004-10-21 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途

Country Status (17)

Country Link
US (1) US20070249648A1 (enExample)
EP (1) EP1678178A1 (enExample)
JP (1) JP2007509141A (enExample)
KR (1) KR20060088557A (enExample)
CN (1) CN1898239A (enExample)
AR (1) AR046600A1 (enExample)
AU (1) AU2004284028B2 (enExample)
BR (1) BRPI0415613A (enExample)
CA (1) CA2542226A1 (enExample)
IL (1) IL174698A0 (enExample)
MX (1) MXPA06004300A (enExample)
NO (1) NO20062335L (enExample)
SE (1) SE0302811D0 (enExample)
TW (1) TW200528451A (enExample)
UY (1) UY28572A1 (enExample)
WO (1) WO2005040167A1 (enExample)
ZA (1) ZA200603174B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
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CN102939290A (zh) * 2010-03-19 2013-02-20 辉瑞大药厂 2,3-二氢-1h-茚-1-基-2,7-二氮杂螺[3.6]壬烷衍生物及其作为生长激素释放肽受体的拮抗剂或反向激动剂的用途
CN104271581A (zh) * 2011-12-22 2015-01-07 会聚制药有限公司 用作电压门控钠通道调制剂的2-(吡啶-2基)-1,7-二氮杂螺[4.4]壬-6-酮化合物
CN104364239A (zh) * 2012-06-13 2015-02-18 霍夫曼-拉罗奇有限公司 新型二氮杂螺环烷烃和氮杂螺环烷烃
CN113207291A (zh) * 2018-10-24 2021-08-03 亚瑞克西斯制药公司 2-(2-丙烯酰基-2,6-二氮杂螺[3.4]辛-6-基)-6-(1h-吲唑-4-基)苄腈衍生物及相关化合物作为用于抑制肿瘤转移的g12c突变kras蛋白的抑制剂

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SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
JP4845873B2 (ja) * 2004-03-03 2011-12-28 ケモセントリックス インコーポレーティッド 二環式および架橋した窒素複素環
EP1869044A1 (en) * 2005-04-04 2007-12-26 AstraZeneca AB Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases
JP2008534679A (ja) * 2005-04-04 2008-08-28 アストラゼネカ・アクチエボラーグ 新規ジアザスピロアルカン類およびｃｃｒ８介在疾患の処置のためのそれらの使用
EP1869046A1 (en) * 2005-04-04 2007-12-26 AstraZeneca AB Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases
GB0514018D0 (en) * 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
TW200800999A (en) * 2005-09-06 2008-01-01 Astrazeneca Ab Novel compounds
US8629147B2 (en) 2005-11-03 2014-01-14 Chembridge Corporation Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
AU2007256597A1 (en) * 2006-06-09 2007-12-13 Icos Corporation Substituted phenyl acetic acids as DP-2 antagonists
KR20090030347A (ko) * 2006-07-19 2009-03-24 아스트라제네카 아베 신규 트리시클릭 스피로피페리딘 화합물, 이들의 합성 및 이들의 케모킨 수용체 활성의 조절제로서의 용도
CN101541795A (zh) * 2006-09-15 2009-09-23 先灵公司 用于治疗疼痛、糖尿病和脂类代谢紊乱的螺-稠合氮杂环丁烷衍生物
WO2008033460A2 (en) * 2006-09-15 2008-03-20 Schering Corporation Treating pain, diabetes, and lipid metabolism disorders
EP2061796A2 (en) 2006-09-15 2009-05-27 Schering Corporation Azetidine and azetidinone derivatives useful in treating pain and disorders of lipid metabolism
WO2008099165A1 (en) * 2007-02-15 2008-08-21 Astrazeneca Ab Piperidine derivatives and their use for treatment of ccr8 mediated diseases
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
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WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
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WO2010151815A2 (en) * 2009-06-25 2010-12-29 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
WO2013066718A2 (en) * 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AU2013272288B2 (en) * 2012-06-08 2018-01-18 The United States Government As Represented By The Department Of Veterans Affairs FBXO3 inhibitors
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US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
US10196369B2 (en) * 2013-09-26 2019-02-05 Sanford Burnham Prebys Medical Discovery Institute Spirocyclic EBI2 modulators
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
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EP3119774A1 (en) * 2014-03-17 2017-01-25 reMynd NV Oxadiazole compounds
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AU2015238537B2 (en) 2014-03-26 2019-08-01 F. Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
EA201792214A1 (ru) 2015-04-10 2018-01-31 Араксис Фарма Ллк Соединения замещенного хиназолина
PE20180694A1 (es) 2015-07-31 2018-04-23 Pfizer Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il-carbamato y derivados de 1,1,1-trifluoro-4-hidroxibutan-2-il-carbamato como inhibidores de magl
UA123362C2 (uk) 2015-09-04 2021-03-24 Ф. Хоффманн-Ля Рош Аг Феноксиметильні похідні
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