CN1898239A - 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 - Google Patents

新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 Download PDF

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Publication number
CN1898239A
CN1898239A CNA200480038668XA CN200480038668A CN1898239A CN 1898239 A CN1898239 A CN 1898239A CN A200480038668X A CNA200480038668X A CN A200480038668XA CN 200480038668 A CN200480038668 A CN 200480038668A CN 1898239 A CN1898239 A CN 1898239A
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diazaspiro
isobutoxybenzyl
undecane
decane
benzyl
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Chinese (zh)
Inventor
哈坎·布莱德
斯蒂芬·康诺利
黑兹尔·J·戴克
安妮亚·利西厄斯
斯蒂芬·普赖斯
艾戈尔·沙莫夫斯基
马科·范登霍伊维尔
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1898239A publication Critical patent/CN1898239A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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  • Endocrinology (AREA)
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  • Hematology (AREA)
  • Pain & Pain Management (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
CNA200480038668XA 2003-10-23 2004-10-21 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 Pending CN1898239A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE03028115 2003-10-23
SE0302811A SE0302811D0 (sv) 2003-10-23 2003-10-23 Novel compounds

Publications (1)

Publication Number Publication Date
CN1898239A true CN1898239A (zh) 2007-01-17

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CNA200480038668XA Pending CN1898239A (zh) 2003-10-23 2004-10-21 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途

Country Status (17)

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US (1) US20070249648A1 (enExample)
EP (1) EP1678178A1 (enExample)
JP (1) JP2007509141A (enExample)
KR (1) KR20060088557A (enExample)
CN (1) CN1898239A (enExample)
AR (1) AR046600A1 (enExample)
AU (1) AU2004284028B2 (enExample)
BR (1) BRPI0415613A (enExample)
CA (1) CA2542226A1 (enExample)
IL (1) IL174698A0 (enExample)
MX (1) MXPA06004300A (enExample)
NO (1) NO20062335L (enExample)
SE (1) SE0302811D0 (enExample)
TW (1) TW200528451A (enExample)
UY (1) UY28572A1 (enExample)
WO (1) WO2005040167A1 (enExample)
ZA (1) ZA200603174B (enExample)

Cited By (4)

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CN102939290A (zh) * 2010-03-19 2013-02-20 辉瑞大药厂 2,3-二氢-1h-茚-1-基-2,7-二氮杂螺[3.6]壬烷衍生物及其作为生长激素释放肽受体的拮抗剂或反向激动剂的用途
CN104271581A (zh) * 2011-12-22 2015-01-07 会聚制药有限公司 用作电压门控钠通道调制剂的2-(吡啶-2基)-1,7-二氮杂螺[4.4]壬-6-酮化合物
CN104364239A (zh) * 2012-06-13 2015-02-18 霍夫曼-拉罗奇有限公司 新型二氮杂螺环烷烃和氮杂螺环烷烃
CN113207291A (zh) * 2018-10-24 2021-08-03 亚瑞克西斯制药公司 2-(2-丙烯酰基-2,6-二氮杂螺[3.4]辛-6-基)-6-(1h-吲唑-4-基)苄腈衍生物及相关化合物作为用于抑制肿瘤转移的g12c突变kras蛋白的抑制剂

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SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) * 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
US7435830B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
WO2006107252A1 (en) * 2005-04-04 2006-10-12 Astrazeneca Ab Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases
EP1869045A1 (en) * 2005-04-04 2007-12-26 AstraZeneca AB Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases
JP2008534678A (ja) * 2005-04-04 2008-08-28 アストラゼネカ・アクチエボラーグ 新規ジアザスピロアルカン類およびｃｃｒ８介在疾患の処置のためのそれらの使用
GB0514018D0 (en) * 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
TW200800999A (en) * 2005-09-06 2008-01-01 Astrazeneca Ab Novel compounds
CA2669736C (en) 2005-11-03 2017-02-21 Chembridge Research Laboratories, Inc. Heterocyclic compounds as tyrosine kinase modulators
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
AU2007256597A1 (en) * 2006-06-09 2007-12-13 Icos Corporation Substituted phenyl acetic acids as DP-2 antagonists
CA2657639A1 (en) * 2006-07-19 2008-01-24 Astrazeneca Ab Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity
CN101541805A (zh) 2006-09-15 2009-09-23 先灵公司 用于治疗疼痛和脂代射紊乱的氮杂环丁烷和氮杂环丁酮衍生物
MX2009002920A (es) * 2006-09-15 2009-04-01 Schering Corp Tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos.
CA2663500A1 (en) 2006-09-15 2008-03-20 Schering Corporation Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism
WO2008099165A1 (en) * 2007-02-15 2008-08-21 Astrazeneca Ab Piperidine derivatives and their use for treatment of ccr8 mediated diseases
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
US20120083476A1 (en) * 2009-06-05 2012-04-05 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
WO2010151815A2 (en) * 2009-06-25 2010-12-29 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
EP2773351B1 (en) 2011-10-31 2017-08-23 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013184202A1 (en) * 2012-06-08 2013-12-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fbxo3 inhibitors
MX368615B (es) 2012-09-25 2019-10-09 Hoffmann La Roche Derivados bicíclicos como inhibidores de la autotaxina (atx) que son inhibidores de la producción de ácido lisofosfatídico (lpa) y el uso de los mismos.
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
WO2015048570A2 (en) * 2013-09-26 2015-04-02 Sanford-Burnham Medical Research Institute Ebi2 modulators
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
DK3074400T3 (en) 2013-11-26 2018-01-15 Hoffmann La Roche Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors
WO2015140130A1 (en) * 2014-03-17 2015-09-24 Remynd Nv Oxadiazole compounds
CA2937616A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
ES2898765T3 (es) 2015-04-10 2022-03-08 Araxes Pharma Llc Compuestos de quinazolina sustituidos y métodos de uso de los mismos
UA121775C2 (uk) 2015-07-31 2020-07-27 Пфайзер Інк. 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl
CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
WO2017050732A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
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