JP2007508296A5 - - Google Patents
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- Publication number
- JP2007508296A5 JP2007508296A5 JP2006533359A JP2006533359A JP2007508296A5 JP 2007508296 A5 JP2007508296 A5 JP 2007508296A5 JP 2006533359 A JP2006533359 A JP 2006533359A JP 2006533359 A JP2006533359 A JP 2006533359A JP 2007508296 A5 JP2007508296 A5 JP 2007508296A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- tocopherol
- vitamin
- substance
- succinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 40
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 16
- 229930003427 Vitamin E Natural products 0.000 claims 15
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 15
- 239000000126 substance Substances 0.000 claims 15
- 229940046009 vitamin E Drugs 0.000 claims 15
- 235000019165 vitamin E Nutrition 0.000 claims 15
- 239000011709 vitamin E Substances 0.000 claims 15
- 150000003431 steroids Chemical class 0.000 claims 11
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 10
- 229960000984 tocofersolan Drugs 0.000 claims 10
- 239000004094 surface-active agent Substances 0.000 claims 9
- 239000002076 α-tocopherol Substances 0.000 claims 8
- 235000004835 α-tocopherol Nutrition 0.000 claims 8
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 claims 6
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 6
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 6
- 229940087168 alpha tocopherol Drugs 0.000 claims 6
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 claims 6
- 125000005456 glyceride group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229940042585 tocopherol acetate Drugs 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- 229960003387 progesterone Drugs 0.000 claims 5
- 239000000186 progesterone Substances 0.000 claims 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 5
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 4
- 229930003799 tocopherol Natural products 0.000 claims 4
- 239000011732 tocopherol Substances 0.000 claims 4
- 235000010384 tocopherol Nutrition 0.000 claims 4
- 229960001295 tocopherol Drugs 0.000 claims 4
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 3
- 229960002847 prasterone Drugs 0.000 claims 3
- 229960003604 testosterone Drugs 0.000 claims 3
- IELOKBJPULMYRW-IKTKBOKFSA-N 4-oxo-4-[[(2S)-2,5,7,8-tetramethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid Chemical compound CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(CC1)Oc(c(C)c2C)c1c(C)c2OC(CCC(O)=O)=O IELOKBJPULMYRW-IKTKBOKFSA-N 0.000 claims 2
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 claims 2
- 239000011627 DL-alpha-tocopherol Substances 0.000 claims 2
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims 2
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 claims 2
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000002640 tocopherol group Chemical group 0.000 claims 2
- 125000001020 α-tocopherol group Chemical group 0.000 claims 2
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 150000003900 succinic acid esters Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/444,935 | 2003-05-22 | ||
| US10/444,935 US20030236236A1 (en) | 1999-06-30 | 2003-05-22 | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| PCT/US2004/016286 WO2004105694A2 (en) | 2003-05-22 | 2004-05-24 | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177650A Division JP2011252015A (ja) | 2003-05-22 | 2011-08-15 | 疎水性薬物投与のための医薬組成物及び剤形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007508296A JP2007508296A (ja) | 2007-04-05 |
| JP2007508296A5 true JP2007508296A5 (OSRAM) | 2007-06-07 |
| JP4844972B2 JP4844972B2 (ja) | 2011-12-28 |
Family
ID=33489362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533359A Expired - Fee Related JP4844972B2 (ja) | 2003-05-22 | 2004-05-24 | 疎水性薬物投与のための医薬組成物及び剤形 |
| JP2011177650A Pending JP2011252015A (ja) | 2003-05-22 | 2011-08-15 | 疎水性薬物投与のための医薬組成物及び剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177650A Pending JP2011252015A (ja) | 2003-05-22 | 2011-08-15 | 疎水性薬物投与のための医薬組成物及び剤形 |
Country Status (7)
| Country | Link |
|---|---|
| US (9) | US20030236236A1 (OSRAM) |
| EP (2) | EP1624855A4 (OSRAM) |
| JP (2) | JP4844972B2 (OSRAM) |
| AU (1) | AU2004243013B2 (OSRAM) |
| CA (1) | CA2526616C (OSRAM) |
| NZ (1) | NZ543571A (OSRAM) |
| WO (1) | WO2004105694A2 (OSRAM) |
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-
2003
- 2003-05-22 US US10/444,935 patent/US20030236236A1/en not_active Abandoned
-
2004
- 2004-05-24 CA CA2526616A patent/CA2526616C/en not_active Expired - Fee Related
- 2004-05-24 JP JP2006533359A patent/JP4844972B2/ja not_active Expired - Fee Related
- 2004-05-24 WO PCT/US2004/016286 patent/WO2004105694A2/en not_active Ceased
- 2004-05-24 AU AU2004243013A patent/AU2004243013B2/en not_active Ceased
- 2004-05-24 NZ NZ543571A patent/NZ543571A/en not_active IP Right Cessation
- 2004-05-24 EP EP04753162A patent/EP1624855A4/en not_active Withdrawn
- 2004-05-24 EP EP10173114A patent/EP2246049A3/en not_active Withdrawn
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2009
- 2009-11-24 US US12/625,309 patent/US20100136105A1/en not_active Abandoned
- 2009-11-24 US US12/625,284 patent/US20100137271A1/en not_active Abandoned
-
2011
- 2011-08-15 JP JP2011177650A patent/JP2011252015A/ja active Pending
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2014
- 2014-11-07 US US14/535,536 patent/US20150064243A1/en not_active Abandoned
-
2015
- 2015-06-05 US US14/732,342 patent/US20160015649A1/en not_active Abandoned
- 2015-12-18 US US14/975,488 patent/US20160184435A1/en not_active Abandoned
-
2017
- 2017-07-26 US US15/660,932 patent/US20180125979A1/en not_active Abandoned
- 2017-09-25 US US15/714,541 patent/US20180264117A1/en not_active Abandoned
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2020
- 2020-03-13 US US16/818,950 patent/US20200282061A1/en not_active Abandoned
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