JP2007506721A5 - - Google Patents
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- Publication number
- JP2007506721A5 JP2007506721A5 JP2006527490A JP2006527490A JP2007506721A5 JP 2007506721 A5 JP2007506721 A5 JP 2007506721A5 JP 2006527490 A JP2006527490 A JP 2006527490A JP 2006527490 A JP2006527490 A JP 2006527490A JP 2007506721 A5 JP2007506721 A5 JP 2007506721A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- heterocyclyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 41
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- -1 C 6-10 aryl-C (═O) — Chemical group 0.000 claims 5
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- VYFSBLLILXRPKD-UHFFFAOYSA-N n-(1,2-diphenylbenzimidazol-5-yl)propane-1-sulfonamide Chemical compound N=1C2=CC(NS(=O)(=O)CCC)=CC=C2N(C=2C=CC=CC=2)C=1C1=CC=CC=C1 VYFSBLLILXRPKD-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302573-1 | 2003-09-26 | ||
| SE0302573A SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| PCT/GB2004/004124 WO2005030732A1 (en) | 2003-09-26 | 2004-09-24 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506721A JP2007506721A (ja) | 2007-03-22 |
| JP2007506721A5 true JP2007506721A5 (https=) | 2007-11-08 |
| JP4896721B2 JP4896721B2 (ja) | 2012-03-14 |
Family
ID=29246982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527490A Expired - Lifetime JP4896721B2 (ja) | 2003-09-26 | 2004-09-24 | ベンゾイミダゾール誘導体、それを含む組成物、その製造方法およびその使用 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US8633235B2 (https=) |
| EP (1) | EP1670769B1 (https=) |
| JP (1) | JP4896721B2 (https=) |
| KR (1) | KR101170184B1 (https=) |
| CN (2) | CN1886379A (https=) |
| AR (1) | AR045819A1 (https=) |
| AT (1) | ATE430135T1 (https=) |
| AU (1) | AU2004276062B2 (https=) |
| BR (1) | BRPI0414780B8 (https=) |
| CA (1) | CA2539738C (https=) |
| CO (1) | CO5680443A2 (https=) |
| CY (1) | CY1110332T1 (https=) |
| DE (1) | DE602004020907D1 (https=) |
| DK (1) | DK1670769T3 (https=) |
| ES (1) | ES2324669T3 (https=) |
| HR (1) | HRP20090388T1 (https=) |
| IL (1) | IL174215A0 (https=) |
| IS (1) | IS8422A (https=) |
| MX (1) | MXPA06003197A (https=) |
| MY (1) | MY140630A (https=) |
| NO (1) | NO20061839L (https=) |
| NZ (1) | NZ545736A (https=) |
| PL (1) | PL1670769T3 (https=) |
| PT (1) | PT1670769E (https=) |
| RU (1) | RU2346938C2 (https=) |
| SA (1) | SA04250310B1 (https=) |
| SE (1) | SE0302573D0 (https=) |
| SI (1) | SI1670769T1 (https=) |
| TW (1) | TW200521117A (https=) |
| UA (1) | UA86776C2 (https=) |
| UY (1) | UY28536A1 (https=) |
| WO (1) | WO2005030732A1 (https=) |
| ZA (3) | ZA200602446B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1558252B1 (en) | 2002-08-02 | 2007-10-10 | Merck & Co., Inc. | Substituted furo [2,3-b]pyridine derivatives |
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| EP1797077B1 (en) | 2004-09-24 | 2012-02-15 | AstraZeneca AB | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i |
| CN101052639B (zh) * | 2004-09-24 | 2010-10-27 | 阿斯利康(瑞典)有限公司 | 苯并咪唑衍生物、含有它们的组合物、其制备方法和其用途 |
| AU2005287427B2 (en) * | 2004-09-24 | 2009-03-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof I |
| CA2582507A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparation thereof and uses thereof iii |
| ES2318556T3 (es) | 2004-11-02 | 2009-05-01 | Pfizer, Inc. | Derivados de sulfonil bencimidazol. |
| EP1912930A4 (en) * | 2005-07-29 | 2010-04-14 | Astrazeneca Ab | PROCESS FOR PREPARING GEMINAL ((DIFLUORCYCLOALKYL) METHYL) AMINE |
| TW200745049A (en) | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
| TW200808769A (en) | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| US20080139846A1 (en) * | 2006-09-01 | 2008-06-12 | Astrazeneca Ab | New Process 298 |
| US8236841B2 (en) * | 2006-09-13 | 2012-08-07 | Kyowa Hakko Kirin Co., Ltd. | Fused heterocycle derivative |
| US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
| RU2414899C1 (ru) * | 2009-12-29 | 2011-03-27 | Аверин Константин Михайлович | Средства для лечения рассеянного склероза |
| RU2454234C1 (ru) * | 2011-03-16 | 2012-06-27 | Константин Михайлович Аверин | Соли 1,3-диэтилбензимидазолия - иммуностимулирующие средства и фармацевтические композиции на их основе |
| WO2013188490A1 (en) * | 2012-06-13 | 2013-12-19 | Cytec Technology Corp. | Stabilizer compositions containing substituted chroman compounds and methods of use |
| HUE032306T2 (en) | 2012-06-26 | 2017-09-28 | Bayer Pharma AG | N- [4- (quinolin-4-yloxy) cyclohexyl (methyl)] (hetero) arylcarboxamides as androgen receptor antagonists, their production and use as pharmaceutical products |
| EP3762379A1 (en) | 2018-03-07 | 2021-01-13 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
| WO2020234103A1 (en) | 2019-05-21 | 2020-11-26 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| CN112010789A (zh) * | 2019-05-31 | 2020-12-01 | 中国科学院上海药物研究所 | 乙烯基磺酰胺或乙烯基酰胺类化合物及其制备方法和用途 |
| GB202019335D0 (en) * | 2020-12-08 | 2021-01-20 | Artelo Biosciences Ltd | Pharmaceutical compositions |
| KR102771568B1 (ko) * | 2022-03-04 | 2025-02-24 | 삼진제약주식회사 | 신규한 헤테로 고리 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1604908A (en) | 1965-06-24 | 1971-05-15 | Substd benzimidazoles - with anthelmintic,fungicidal activity and some with antiviral and antibacterial activity | |
| FR5354M (https=) | 1965-09-10 | 1967-09-11 | ||
| US5387600A (en) | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
| DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| DE4237557A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
| DE4237597A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
| WO1997024334A1 (en) | 1995-12-28 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| US6348032B1 (en) | 1998-11-23 | 2002-02-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with benzimidazole derivatives |
| US6534535B1 (en) | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| CZ2002959A3 (cs) | 1999-09-17 | 2002-07-17 | Millennium Pharmaceuticals, Inc. | Inhibitory faktoru Xa |
| US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| US7115645B2 (en) | 2000-01-14 | 2006-10-03 | Schering Aktiengesellschaft | 1,2 diarylbenzimidazoles and their pharmaceutical use |
| EE05515B1 (et) * | 2000-01-14 | 2012-02-15 | Schering@Aktiengesellschaft | 1 2 diarlbensimidasoolid mikrogliia aktivatsiooniga seotud haiguste raviks |
| US7329679B2 (en) * | 2000-01-27 | 2008-02-12 | Schering Aktiengesellschaft | 1,2 Diarylbenzimidazoles and their pharmaceutical use |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| WO2002046168A1 (en) | 2000-12-07 | 2002-06-13 | Astrazeneca Ab | Therapeutic benzimidazole compounds |
| SE0101387D0 (sv) * | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | Novel compounds |
| WO2002100833A1 (en) | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Rho KINASE INHIBITORS |
| TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
| SE0301699D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0301701D0 (sv) | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| WO2005007625A2 (en) | 2003-07-14 | 2005-01-27 | The University Of Tennessee Research Foundation | Heterocyclic amides with anti-tuberculosis activity |
| WO2005021547A2 (en) | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Heterocyclic cannabinoid cb2 receptor antagonists |
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302570D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302571D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302572D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| US20060035884A1 (en) | 2004-05-20 | 2006-02-16 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| WO2006009876A2 (en) | 2004-06-17 | 2006-01-26 | Cengent Therapeutics, Inc. | Trisubstituted nitrogen modulators of tyrosine phosphatases |
| CA2573426C (en) | 2004-07-30 | 2015-11-17 | Exelixis, Inc. | Pyrrole derivatives as pharmaceutical agents |
| US20060052421A1 (en) | 2004-09-09 | 2006-03-09 | Eastman Kodak Company | Conjugation agent |
| JP2008514589A (ja) | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | 化合物、それらを含有する組成物、それらの製造及びそれらの使用ｉｉｉｉ |
| CA2582507A1 (en) | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparation thereof and uses thereof iii |
| AU2005287427B2 (en) | 2004-09-24 | 2009-03-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof I |
| JP2008514591A (ja) | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | ベンゾイミダゾール誘導体及びカンナビノイド受容体リガンドとしてのその使用 |
| EP1794150A1 (en) | 2004-09-24 | 2007-06-13 | AstraZeneca AB | Benzimidazole derivatives and their use as cannabinoid receptor ligands I |
| EP1797077B1 (en) * | 2004-09-24 | 2012-02-15 | AstraZeneca AB | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i |
| JP2008514590A (ja) | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | ベンゾイミダゾール誘導体、それを含む組成物、その製造方法及びその使用 |
| WO2006033633A1 (en) | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparations thereof and uses thereof ii |
| ES2318556T3 (es) | 2004-11-02 | 2009-05-01 | Pfizer, Inc. | Derivados de sulfonil bencimidazol. |
| WO2006078941A2 (en) | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Novel sirtuin activating compounds and methods of use thereof |
| TW200745049A (en) | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
| TW200808769A (en) | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| TW200808772A (en) | 2006-06-13 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
-
2003
- 2003-09-26 SE SE0302573A patent/SE0302573D0/xx unknown
-
2004
- 2004-09-24 UY UY28536A patent/UY28536A1/es unknown
- 2004-09-24 HR HR20090388T patent/HRP20090388T1/xx unknown
- 2004-09-24 SI SI200431166T patent/SI1670769T1/sl unknown
- 2004-09-24 ES ES04768667T patent/ES2324669T3/es not_active Expired - Lifetime
- 2004-09-24 MY MYPI20043910A patent/MY140630A/en unknown
- 2004-09-24 MX MXPA06003197A patent/MXPA06003197A/es active IP Right Grant
- 2004-09-24 BR BRPI0414780A patent/BRPI0414780B8/pt not_active IP Right Cessation
- 2004-09-24 UA UAA200602693A patent/UA86776C2/ru unknown
- 2004-09-24 JP JP2006527490A patent/JP4896721B2/ja not_active Expired - Lifetime
- 2004-09-24 PT PT04768667T patent/PT1670769E/pt unknown
- 2004-09-24 KR KR1020067005825A patent/KR101170184B1/ko not_active Expired - Lifetime
- 2004-09-24 EP EP04768667A patent/EP1670769B1/en not_active Expired - Lifetime
- 2004-09-24 NZ NZ545736A patent/NZ545736A/en unknown
- 2004-09-24 AU AU2004276062A patent/AU2004276062B2/en not_active Expired
- 2004-09-24 TW TW093129150A patent/TW200521117A/zh unknown
- 2004-09-24 CN CNA2004800350086A patent/CN1886379A/zh active Pending
- 2004-09-24 DE DE602004020907T patent/DE602004020907D1/de not_active Expired - Lifetime
- 2004-09-24 RU RU2006113371/04A patent/RU2346938C2/ru active
- 2004-09-24 CN CN2010105277900A patent/CN102010373A/zh active Pending
- 2004-09-24 AT AT04768667T patent/ATE430135T1/de active
- 2004-09-24 PL PL04768667T patent/PL1670769T3/pl unknown
- 2004-09-24 DK DK04768667T patent/DK1670769T3/da active
- 2004-09-24 WO PCT/GB2004/004124 patent/WO2005030732A1/en not_active Ceased
- 2004-09-24 CA CA2539738A patent/CA2539738C/en not_active Expired - Lifetime
- 2004-09-24 AR ARP040103467A patent/AR045819A1/es not_active Application Discontinuation
- 2004-09-24 US US10/573,054 patent/US8633235B2/en active Active
- 2004-09-26 SA SA04250310A patent/SA04250310B1/ar unknown
-
2006
- 2006-03-09 IL IL174215A patent/IL174215A0/en unknown
- 2006-03-22 CO CO06028452A patent/CO5680443A2/es not_active Application Discontinuation
- 2006-03-24 ZA ZA200602446A patent/ZA200602446B/en unknown
- 2006-04-21 IS IS8422A patent/IS8422A/is unknown
- 2006-04-26 NO NO20061839A patent/NO20061839L/no not_active Application Discontinuation
-
2007
- 2007-03-13 ZA ZA200702131A patent/ZA200702131B/xx unknown
- 2007-03-16 ZA ZA200702226A patent/ZA200702226B/xx unknown
-
2009
- 2009-07-08 CY CY20091100725T patent/CY1110332T1/el unknown
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