JP2007500187A5 - - Google Patents
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- Publication number
- JP2007500187A5 JP2007500187A5 JP2006521802A JP2006521802A JP2007500187A5 JP 2007500187 A5 JP2007500187 A5 JP 2007500187A5 JP 2006521802 A JP2006521802 A JP 2006521802A JP 2006521802 A JP2006521802 A JP 2006521802A JP 2007500187 A5 JP2007500187 A5 JP 2007500187A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- chloro
- compound
- alkyl
- quinolinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC1(*)C=C2N=C(*)*(*)=CC2=C(**=C)C=C1 Chemical compound CC1(*)C=C2N=C(*)*(*)=CC2=C(**=C)C=C1 0.000 description 4
- LCIMTQHLKRQXAS-UHFFFAOYSA-N CN(C=NN1)C1=O Chemical compound CN(C=NN1)C1=O LCIMTQHLKRQXAS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302139A SE0302139D0 (sv) | 2003-07-28 | 2003-07-28 | Novel compounds |
| PCT/SE2004/001144 WO2005009968A1 (en) | 2003-07-28 | 2004-07-21 | Quinoline derivates and their use in therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007500187A JP2007500187A (ja) | 2007-01-11 |
| JP2007500187A5 true JP2007500187A5 (https=) | 2007-07-26 |
Family
ID=27786663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521802A Withdrawn JP2007500187A (ja) | 2003-07-28 | 2004-07-21 | キノリン誘導体および治療におけるその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080058293A1 (https=) |
| EP (1) | EP1651610A1 (https=) |
| JP (1) | JP2007500187A (https=) |
| KR (1) | KR20060054370A (https=) |
| CN (1) | CN1829694A (https=) |
| AU (1) | AU2004259615A1 (https=) |
| BR (1) | BRPI0413094A (https=) |
| CA (1) | CA2532154A1 (https=) |
| CO (1) | CO5640110A2 (https=) |
| IL (1) | IL172826A0 (https=) |
| IS (1) | IS8329A (https=) |
| MX (1) | MXPA06000882A (https=) |
| RU (1) | RU2006102127A (https=) |
| SE (1) | SE0302139D0 (https=) |
| WO (1) | WO2005009968A1 (https=) |
| ZA (1) | ZA200600820B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| WO2006110516A1 (en) * | 2005-04-11 | 2006-10-19 | Abbott Laboratories | Acylhydrazide p2x7 antagonists and uses thereof |
| WO2007109172A2 (en) * | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| BRPI0709596A2 (pt) | 2006-03-16 | 2011-07-19 | Renovis Inc | compostos bicicloeteroarila como moduladores de p2x7 e seus usos |
| WO2008013494A1 (en) * | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | Quinoline derivatives as p2x7 receptor antagonist and their use in the treatment of rheumatoid arthritis, osteoarthritis, copd and ibd |
| BRPI0809106A2 (pt) * | 2007-03-22 | 2014-08-26 | Astrazeneca Ab | Derivados de quinolina para o tratamento de doenças inflamatórias |
| US8106073B2 (en) | 2007-11-30 | 2012-01-31 | Astrazeneca Ab | Quinoline derivatives 057 |
| CN102046240B (zh) | 2008-03-25 | 2014-06-25 | 阿费克蒂斯药品公司 | 新的p2x7r拮抗剂及其应用 |
| WO2010118921A1 (en) | 2009-04-14 | 2010-10-21 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| US9199939B2 (en) * | 2009-12-17 | 2015-12-01 | Merck Sharp & Dohme Corp. | Quinoline amide M1 receptor positive allosteric modulators |
| EP2569281A1 (en) | 2010-05-14 | 2013-03-20 | Affectis Pharmaceuticals AG | Novel methods for the preparation of p2x7r antagonists |
| WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| CN103687860B (zh) | 2011-07-22 | 2016-06-08 | 埃科特莱茵药品有限公司 | 作为p2x7受体拮抗剂的杂环酰胺衍生物 |
| EA024204B1 (ru) | 2012-01-20 | 2016-08-31 | Актелион Фармасьютиклз Лтд. | Производные гетероциклических амидов в качестве антагонистов p2xрецептора |
| AR093921A1 (es) | 2012-12-12 | 2015-06-24 | Actelion Pharmaceuticals Ltd | Derivados de indol carboxamida como antagonistas del receptor p2x7 |
| KR102232744B1 (ko) | 2012-12-18 | 2021-03-26 | 이도르시아 파마슈티컬스 리미티드 | Ｐ２ｘ７ 수용체 길항제로서의 인돌 카르복사미드 유도체 |
| ES2616883T3 (es) | 2013-01-22 | 2017-06-14 | Actelion Pharmaceuticals Ltd. | Derivados amida heterocíclicos como antagonistas del receptor P2X7 |
| KR102222220B1 (ko) | 2013-01-22 | 2021-03-03 | 이도르시아 파마슈티컬스 리미티드 | Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
| WO2015187905A1 (en) * | 2014-06-05 | 2015-12-10 | Merck Patent Gmbh | Novel quinoline derivatives and their use in neurodegenerative diseases |
| US11077100B2 (en) * | 2017-03-13 | 2021-08-03 | Raqualia Pharma Inc. | Tetrahydroquinoline derivatives as P2X7 receptor antagonists |
| CN111777638B (zh) * | 2020-05-22 | 2023-05-09 | 瀚海新拓(杭州)生物医药有限公司 | 喹啉类化合物、其制备方法、药物组合物和用途 |
| CN114989082B (zh) * | 2022-06-30 | 2024-06-21 | 华东理工大学 | 基于i价铜化物和三取代膦协同催化的羟氯喹的高效制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3471491A (en) * | 1967-08-28 | 1969-10-07 | Squibb & Sons Inc | Adamantyl-s-triazines |
| US3464998A (en) * | 1968-03-04 | 1969-09-02 | Searle & Co | Adamantyl esters and amides of pyridinecarboxylic acids |
| US4751292A (en) * | 1985-07-02 | 1988-06-14 | The Plant Cell Research Institute, Inc. | Adamantyl purines |
| DE69216873T2 (de) * | 1991-02-21 | 1997-08-21 | Sankyo Co | Benzolderivate zum Fördern der Produktion des Nervenwachstumsfaktors |
| DK0804419T3 (da) * | 1994-05-27 | 2003-11-24 | Glaxosmithkline Spa | Quinolinderivater som tachykinin NK 3-receptor-antagonister |
| AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
| EP0952832B1 (en) * | 1996-05-20 | 2008-08-27 | Darwin Discovery Limited | Quinoline carboxamides as tnf inhibitors and as pde-iv inhibitors |
| GB0013737D0 (en) * | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
| US8058441B2 (en) * | 2001-07-02 | 2011-11-15 | N.V. Organon | Tetrahydroquinoline derivatives |
| SE0103836D0 (sv) * | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
-
2003
- 2003-07-28 SE SE0302139A patent/SE0302139D0/xx unknown
-
2004
- 2004-07-21 US US10/566,320 patent/US20080058293A1/en not_active Abandoned
- 2004-07-21 KR KR1020067001966A patent/KR20060054370A/ko not_active Withdrawn
- 2004-07-21 WO PCT/SE2004/001144 patent/WO2005009968A1/en not_active Ceased
- 2004-07-21 AU AU2004259615A patent/AU2004259615A1/en not_active Abandoned
- 2004-07-21 MX MXPA06000882A patent/MXPA06000882A/es not_active Application Discontinuation
- 2004-07-21 RU RU2006102127/04A patent/RU2006102127A/ru not_active Application Discontinuation
- 2004-07-21 JP JP2006521802A patent/JP2007500187A/ja not_active Withdrawn
- 2004-07-21 CA CA002532154A patent/CA2532154A1/en not_active Abandoned
- 2004-07-21 BR BRPI0413094-4A patent/BRPI0413094A/pt not_active Application Discontinuation
- 2004-07-21 CN CNA2004800220985A patent/CN1829694A/zh active Pending
- 2004-07-21 EP EP04749180A patent/EP1651610A1/en not_active Withdrawn
-
2005
- 2005-12-26 IL IL172826A patent/IL172826A0/en unknown
-
2006
- 2006-01-25 CO CO06006724A patent/CO5640110A2/es not_active Application Discontinuation
- 2006-01-27 ZA ZA200600820A patent/ZA200600820B/en unknown
- 2006-02-24 IS IS8329A patent/IS8329A/is unknown
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