JP2006528646A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006528646A5 JP2006528646A5 JP2006521305A JP2006521305A JP2006528646A5 JP 2006528646 A5 JP2006528646 A5 JP 2006528646A5 JP 2006521305 A JP2006521305 A JP 2006521305A JP 2006521305 A JP2006521305 A JP 2006521305A JP 2006528646 A5 JP2006528646 A5 JP 2006528646A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- group
- heteroaryl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003118 aryl group Chemical group 0.000 description 21
- 125000000217 alkyl group Chemical group 0.000 description 18
- 125000001072 heteroaryl group Chemical group 0.000 description 14
- 125000000623 heterocyclic group Chemical group 0.000 description 14
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 239000001257 hydrogen Substances 0.000 description 10
- -1 aryloxyalkynyl Chemical group 0.000 description 8
- 125000001188 haloalkyl group Chemical group 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 125000001424 substituent group Chemical group 0.000 description 7
- 125000003710 aryl alkyl group Chemical group 0.000 description 6
- 125000000753 cycloalkyl group Chemical group 0.000 description 6
- 125000001475 halogen functional group Chemical group 0.000 description 6
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 3
- 125000004181 carboxyalkyl group Chemical group 0.000 description 3
- 125000004438 haloalkoxy group Chemical group 0.000 description 3
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 description 2
- 125000005129 aryl carbonyl group Chemical group 0.000 description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 2
- 125000005243 carbonyl alkyl group Chemical group 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical group 0.000 description 2
- 125000001041 indolyl group Chemical group 0.000 description 2
- 125000004043 oxo group Chemical group O=* 0.000 description 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 1
- 125000005080 alkoxycarbonylalkenyl group Chemical group 0.000 description 1
- 125000005086 alkoxycarbonylalkynyl group Chemical group 0.000 description 1
- 125000004686 alkyl sulfanyl alkyl group Chemical group 0.000 description 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
- 125000005018 aryl alkenyl group Chemical group 0.000 description 1
- 125000005015 aryl alkynyl group Chemical group 0.000 description 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 description 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000005019 carboxyalkenyl group Chemical group 0.000 description 1
- 125000004966 cyanoalkyl group Chemical group 0.000 description 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 description 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 125000004967 formylalkyl group Chemical group 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000004447 heteroarylalkenyl group Chemical group 0.000 description 1
- 125000005312 heteroarylalkynyl group Chemical group 0.000 description 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 description 1
- 125000005020 hydroxyalkenyl group Chemical group 0.000 description 1
- 125000005016 hydroxyalkynyl group Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000004971 nitroalkyl group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/626,092 | 2003-07-24 | ||
| US10/626,092 US20050020619A1 (en) | 2003-07-24 | 2003-07-24 | Thienopyridine kinase inhibitors |
| US10/838,132 | 2004-05-03 | ||
| US10/838,132 US20050026944A1 (en) | 2003-07-24 | 2004-05-03 | Thienopyridine and furopyridine kinase inhibitors |
| PCT/US2004/024003 WO2005010009A1 (en) | 2003-07-24 | 2004-07-26 | Thienopyridine and furopyridine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006528646A JP2006528646A (ja) | 2006-12-21 |
| JP2006528646A5 true JP2006528646A5 (https=) | 2011-03-03 |
| JP4707192B2 JP4707192B2 (ja) | 2011-06-22 |
Family
ID=34108157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521305A Expired - Fee Related JP4707192B2 (ja) | 2003-07-24 | 2004-07-26 | チエノピリジンおよびフロピリジン系キナーゼ阻害薬 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20050026944A1 (https=) |
| EP (1) | EP1648905B1 (https=) |
| JP (1) | JP4707192B2 (https=) |
| KR (2) | KR101120936B1 (https=) |
| CN (1) | CN103087078A (https=) |
| AT (1) | ATE419253T1 (https=) |
| AU (2) | AU2004259765B2 (https=) |
| BR (1) | BRPI0412894A (https=) |
| CA (1) | CA2532982C (https=) |
| CY (1) | CY1111599T1 (https=) |
| DE (1) | DE602004018780D1 (https=) |
| DK (1) | DK1648905T3 (https=) |
| ES (1) | ES2319302T3 (https=) |
| IL (1) | IL173348A (https=) |
| MX (1) | MXPA06000919A (https=) |
| NZ (1) | NZ544712A (https=) |
| PL (1) | PL1648905T3 (https=) |
| PT (1) | PT1648905E (https=) |
| WO (1) | WO2005010009A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1620094A4 (en) * | 2003-05-06 | 2010-04-28 | Glaxosmithkline Llc | NEW CHEMICAL COMPOUNDS |
| US7899855B2 (en) * | 2003-09-08 | 2011-03-01 | Intel Corporation | Method, apparatus and instructions for parallel data conversions |
| GB0325836D0 (en) * | 2003-11-05 | 2003-12-10 | Celltech R&D Ltd | Biological products |
| TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
| US20050256154A1 (en) * | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
| US20060281768A1 (en) * | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
| US7566721B2 (en) * | 2005-08-08 | 2009-07-28 | Osi Pharmaceuticals, Inc. | Substituted thienol[2,3-d]pyrimidines as kinase inhibitors |
| JP2009504692A (ja) * | 2005-08-16 | 2009-02-05 | エフ．ホフマン−ラ ロシュ アーゲー | 新規４−アミノ−チエノ［３，２−ｃ］ピリジン−７−カルボン酸アミド |
| CA2621830C (en) * | 2005-09-15 | 2013-12-03 | F. Hoffmann-La Roche Ag | 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives |
| JP2009514899A (ja) * | 2005-11-04 | 2009-04-09 | スミスクライン ビーチャム コーポレーション | チエノピリジンＢ−Ｒａｆキナーゼ阻害剤 |
| CN101336244B (zh) * | 2005-12-08 | 2011-11-30 | 雅培制药有限公司 | 用作蛋白激酶抑制剂的9元杂二环化合物 |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| TW200801008A (en) * | 2005-12-29 | 2008-01-01 | Abbott Lab | Protein kinase inhibitors |
| US7659283B2 (en) * | 2006-02-14 | 2010-02-09 | Vertex Pharmaceuticals Incorporated | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases |
| US7932390B2 (en) * | 2006-06-29 | 2011-04-26 | Hoffman-La Roche Inc. | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives |
| US7994321B2 (en) | 2006-08-08 | 2011-08-09 | Hoffmann-La Roche Inc. | Substituted thieno[3,2-C]pyridine-7-carboxylic acid derivatives |
| WO2008018881A1 (en) * | 2006-08-10 | 2008-02-14 | Osi Pharmaceuticals, Inc. | 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors |
| MX2010001636A (es) * | 2007-08-14 | 2010-03-15 | Hoffmann La Roche | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
| AR070317A1 (es) * | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
| CA2723358A1 (en) * | 2008-05-05 | 2009-11-12 | Allison B. Reiss | Method for improving cardiovascular risk profile of cox inhibitors |
| AR074481A1 (es) * | 2008-12-05 | 2011-01-19 | Abbott Lab | Derivados de tienopiridina como inhibidores de quinasa |
| EP2491030B1 (en) | 2009-10-22 | 2015-07-15 | Fibrotech Therapeutics PTY LTD | Fused ring analogues of anti-fibrotic agents |
| TWI482770B (zh) * | 2010-06-09 | 2015-05-01 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| CA2802042A1 (en) * | 2010-06-09 | 2011-12-15 | Abbott Laboratories | Crystalline forms of kinase inhibitors |
| TWI492949B (zh) * | 2010-06-09 | 2015-07-21 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| AU2011271518A1 (en) | 2010-07-02 | 2012-12-13 | Alcon Research, Ltd. | Compounds for the treatment of posterior segment disorders and diseases |
| RU2013120966A (ru) | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
| US8436179B2 (en) | 2011-07-20 | 2013-05-07 | Abbvie Inc. | Kinase inhibitor with improved solubility profile |
| CN103396414B (zh) * | 2013-07-16 | 2015-06-03 | 浙江医药高等专科学校 | 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途 |
| CN104945411B (zh) * | 2014-03-27 | 2018-07-31 | 南京勇山生物科技有限公司 | 噻吩并[3,2-c]吡啶类化合物、其制备方法及应用 |
| WO2015157360A1 (en) | 2014-04-08 | 2015-10-15 | Abbvie Inc. | Processes to make protein kinase inhibitors |
| WO2016047678A1 (ja) * | 2014-09-25 | 2016-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| CA3052036A1 (en) | 2017-02-03 | 2018-08-09 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
| MX2023005747A (es) | 2020-11-18 | 2023-07-28 | Deciphera Pharmaceuticals Llc | Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos. |
| KR20240113496A (ko) | 2021-12-03 | 2024-07-22 | 데시페라 파마슈티칼스, 엘엘씨. | Gcn2 및 perk 키나아제 억제제로서의 헤테로고리 화합물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2221213T3 (es) * | 1997-10-20 | 2004-12-16 | F. Hoffmann-La Roche Ag | Inhibidores de kinasa biciclicos. |
| WO2000038683A1 (en) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| PL354241A1 (en) * | 1999-09-17 | 2003-12-29 | Abbott Gmbh & Co.Kgabbott Gmbh & Co.Kg | Kinase inhibitors as therapeutic agents |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| CN1186324C (zh) * | 2000-04-27 | 2005-01-26 | 山之内制药株式会社 | 稠合杂芳基衍生物 |
| EP1373240B1 (en) * | 2001-03-14 | 2005-06-15 | Eli Lilly And Company | Retinoid x receptor modulators |
| AU2002333524A1 (en) * | 2001-09-11 | 2003-03-24 | Glaxosmithkline K.K. | Furo-and thienopyrimidine derivatives as angiogenesis inhibitors |
| EP1620094A4 (en) * | 2003-05-06 | 2010-04-28 | Glaxosmithkline Llc | NEW CHEMICAL COMPOUNDS |
-
2004
- 2004-05-03 US US10/838,132 patent/US20050026944A1/en not_active Abandoned
- 2004-07-26 DK DK04779180T patent/DK1648905T3/da active
- 2004-07-26 AU AU2004259765A patent/AU2004259765B2/en not_active Ceased
- 2004-07-26 AT AT04779180T patent/ATE419253T1/de active
- 2004-07-26 MX MXPA06000919A patent/MXPA06000919A/es active IP Right Grant
- 2004-07-26 EP EP04779180A patent/EP1648905B1/en not_active Expired - Lifetime
- 2004-07-26 JP JP2006521305A patent/JP4707192B2/ja not_active Expired - Fee Related
- 2004-07-26 BR BRPI0412894-0A patent/BRPI0412894A/pt not_active IP Right Cessation
- 2004-07-26 KR KR1020067001692A patent/KR101120936B1/ko not_active Expired - Fee Related
- 2004-07-26 PL PL04779180T patent/PL1648905T3/pl unknown
- 2004-07-26 WO PCT/US2004/024003 patent/WO2005010009A1/en not_active Ceased
- 2004-07-26 NZ NZ544712A patent/NZ544712A/en not_active IP Right Cessation
- 2004-07-26 DE DE602004018780T patent/DE602004018780D1/de not_active Expired - Lifetime
- 2004-07-26 CN CN2012105340956A patent/CN103087078A/zh active Pending
- 2004-07-26 ES ES04779180T patent/ES2319302T3/es not_active Expired - Lifetime
- 2004-07-26 CA CA2532982A patent/CA2532982C/en not_active Expired - Fee Related
- 2004-07-26 PT PT04779180T patent/PT1648905E/pt unknown
- 2004-07-26 KR KR1020117023338A patent/KR20110123797A/ko not_active Withdrawn
-
2006
- 2006-01-24 IL IL173348A patent/IL173348A/en not_active IP Right Cessation
-
2009
- 2009-03-12 CY CY20091100278T patent/CY1111599T1/el unknown
- 2009-12-22 AU AU2009251083A patent/AU2009251083B2/en not_active Ceased