KR101120936B1 - 티에노피리딘 및 푸로피리딘 키나제 억제제 - Google Patents

티에노피리딘 및 푸로피리딘 키나제 억제제 Download PDF

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Publication number
KR101120936B1
KR101120936B1 KR1020067001692A KR20067001692A KR101120936B1 KR 101120936 B1 KR101120936 B1 KR 101120936B1 KR 1020067001692 A KR1020067001692 A KR 1020067001692A KR 20067001692 A KR20067001692 A KR 20067001692A KR 101120936 B1 KR101120936 B1 KR 101120936B1
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South Korea
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group
alkyl
aryl
amino
phenyl
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Expired - Fee Related
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KR1020067001692A
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Korean (ko)
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KR20060056344A (ko
Inventor
파트릭 벳슈만
앤드류 에프. 버챗
데이빗 제이. 캘더우드
마이클 엘. 커틴
스티븐 케이. 데이빗슨
히터 엠. 데이비스
로빈 알. 프레이
하워드 알. 헤이먼
개빈 씨. 허스트
피터 흐른씨아르
마이클 알. 마이클라이즈
멜라니 에이. 먹키
폴 라퍼티
캐롤 케이. 와다
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아보트 러보러터리즈
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Priority claimed from US10/626,092 external-priority patent/US20050020619A1/en
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Publication of KR20060056344A publication Critical patent/KR20060056344A/ko
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Publication of KR101120936B1 publication Critical patent/KR101120936B1/ko
Assigned to 애브비 바하마스 리미티드 reassignment 애브비 바하마스 리미티드 권리의 전부이전등록 Assignors: 아보트 러보러터리즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • A—HUMAN NECESSITIES
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
KR1020067001692A 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제 Expired - Fee Related KR101120936B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/626,092 2003-07-24
US10/626,092 US20050020619A1 (en) 2003-07-24 2003-07-24 Thienopyridine kinase inhibitors
US10/838,132 2004-05-03
US10/838,132 US20050026944A1 (en) 2003-07-24 2004-05-03 Thienopyridine and furopyridine kinase inhibitors
PCT/US2004/024003 WO2005010009A1 (en) 2003-07-24 2004-07-26 Thienopyridine and furopyridine kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117023338A Division KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Publications (2)

Publication Number Publication Date
KR20060056344A KR20060056344A (ko) 2006-05-24
KR101120936B1 true KR101120936B1 (ko) 2012-03-29

Family

ID=34108157

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Application Number Title Priority Date Filing Date
KR1020067001692A Expired - Fee Related KR101120936B1 (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제
KR1020117023338A Withdrawn KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Family Applications After (1)

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KR1020117023338A Withdrawn KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Country Status (19)

Country Link
US (1) US20050026944A1 (https=)
EP (1) EP1648905B1 (https=)
JP (1) JP4707192B2 (https=)
KR (2) KR101120936B1 (https=)
CN (1) CN103087078A (https=)
AT (1) ATE419253T1 (https=)
AU (2) AU2004259765B2 (https=)
BR (1) BRPI0412894A (https=)
CA (1) CA2532982C (https=)
CY (1) CY1111599T1 (https=)
DE (1) DE602004018780D1 (https=)
DK (1) DK1648905T3 (https=)
ES (1) ES2319302T3 (https=)
IL (1) IL173348A (https=)
MX (1) MXPA06000919A (https=)
NZ (1) NZ544712A (https=)
PL (1) PL1648905T3 (https=)
PT (1) PT1648905E (https=)
WO (1) WO2005010009A1 (https=)

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US20060281768A1 (en) * 2005-06-10 2006-12-14 Gaul Michael D Thienopyrimidine and thienopyridine kinase modulators
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JP2009504692A (ja) * 2005-08-16 2009-02-05 エフ．ホフマン−ラ ロシュ アーゲー 新規４−アミノ−チエノ［３，２−ｃ］ピリジン−７−カルボン酸アミド
CA2621830C (en) * 2005-09-15 2013-12-03 F. Hoffmann-La Roche Ag 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives
JP2009514899A (ja) * 2005-11-04 2009-04-09 スミスクライン ビーチャム コーポレーション チエノピリジンＢ−Ｒａｆキナーゼ阻害剤
CN101336244B (zh) * 2005-12-08 2011-11-30 雅培制药有限公司 用作蛋白激酶抑制剂的9元杂二环化合物
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US7659283B2 (en) * 2006-02-14 2010-02-09 Vertex Pharmaceuticals Incorporated Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases
US7932390B2 (en) * 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
US7994321B2 (en) 2006-08-08 2011-08-09 Hoffmann-La Roche Inc. Substituted thieno[3,2-C]pyridine-7-carboxylic acid derivatives
WO2008018881A1 (en) * 2006-08-10 2008-02-14 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors
MX2010001636A (es) * 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
CA2723358A1 (en) * 2008-05-05 2009-11-12 Allison B. Reiss Method for improving cardiovascular risk profile of cox inhibitors
AR074481A1 (es) * 2008-12-05 2011-01-19 Abbott Lab Derivados de tienopiridina como inhibidores de quinasa
EP2491030B1 (en) 2009-10-22 2015-07-15 Fibrotech Therapeutics PTY LTD Fused ring analogues of anti-fibrotic agents
TWI482770B (zh) * 2010-06-09 2015-05-01 Abbvie Bahamas Ltd 結晶型激酶抑制劑
CA2802042A1 (en) * 2010-06-09 2011-12-15 Abbott Laboratories Crystalline forms of kinase inhibitors
TWI492949B (zh) * 2010-06-09 2015-07-21 Abbvie Bahamas Ltd 結晶型激酶抑制劑
AU2011271518A1 (en) 2010-07-02 2012-12-13 Alcon Research, Ltd. Compounds for the treatment of posterior segment disorders and diseases
RU2013120966A (ru) 2010-10-08 2014-11-20 Эббви Инк. ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
CN103396414B (zh) * 2013-07-16 2015-06-03 浙江医药高等专科学校 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途
CN104945411B (zh) * 2014-03-27 2018-07-31 南京勇山生物科技有限公司 噻吩并[3,2-c]吡啶类化合物、其制备方法及应用
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MX2023005747A (es) 2020-11-18 2023-07-28 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos.
KR20240113496A (ko) 2021-12-03 2024-07-22 데시페라 파마슈티칼스, 엘엘씨. Gcn2 및 perk 키나아제 억제제로서의 헤테로고리 화합물

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NZ544712A (en) 2009-09-25
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AU2009251083B2 (en) 2012-02-16
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