KR101120936B1 - 티에노피리딘 및 푸로피리딘 키나제 억제제 - Google Patents

티에노피리딘 및 푸로피리딘 키나제 억제제 Download PDF

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Publication number
KR101120936B1
KR101120936B1 KR1020067001692A KR20067001692A KR101120936B1 KR 101120936 B1 KR101120936 B1 KR 101120936B1 KR 1020067001692 A KR1020067001692 A KR 1020067001692A KR 20067001692 A KR20067001692 A KR 20067001692A KR 101120936 B1 KR101120936 B1 KR 101120936B1
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South Korea
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group
alkyl
aryl
amino
phenyl
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KR1020067001692A
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Korean (ko)
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KR20060056344A (ko
Inventor
파트릭 벳슈만
앤드류 에프. 버챗
데이빗 제이. 캘더우드
마이클 엘. 커틴
스티븐 케이. 데이빗슨
히터 엠. 데이비스
로빈 알. 프레이
하워드 알. 헤이먼
개빈 씨. 허스트
피터 흐른씨아르
마이클 알. 마이클라이즈
멜라니 에이. 먹키
폴 라퍼티
캐롤 케이. 와다
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아보트 러보러터리즈
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Priority claimed from US10/626,092 external-priority patent/US20050020619A1/en
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Assigned to 애브비 바하마스 리미티드 reassignment 애브비 바하마스 리미티드 권리의 전부이전등록 Assignors: 아보트 러보러터리즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P7/06—Antianaemics
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Virology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
KR1020067001692A 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제 Expired - Fee Related KR101120936B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/626,092 US20050020619A1 (en) 2003-07-24 2003-07-24 Thienopyridine kinase inhibitors
US10/626,092 2003-07-24
US10/838,132 2004-05-03
US10/838,132 US20050026944A1 (en) 2003-07-24 2004-05-03 Thienopyridine and furopyridine kinase inhibitors
PCT/US2004/024003 WO2005010009A1 (en) 2003-07-24 2004-07-26 Thienopyridine and furopyridine kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117023338A Division KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Publications (2)

Publication Number Publication Date
KR20060056344A KR20060056344A (ko) 2006-05-24
KR101120936B1 true KR101120936B1 (ko) 2012-03-29

Family

ID=34108157

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Application Number Title Priority Date Filing Date
KR1020067001692A Expired - Fee Related KR101120936B1 (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제
KR1020117023338A Withdrawn KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Family Applications After (1)

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KR1020117023338A Withdrawn KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Country Status (19)

Country Link
US (1) US20050026944A1 (https=)
EP (1) EP1648905B1 (https=)
JP (1) JP4707192B2 (https=)
KR (2) KR101120936B1 (https=)
CN (1) CN103087078A (https=)
AT (1) ATE419253T1 (https=)
AU (2) AU2004259765B2 (https=)
BR (1) BRPI0412894A (https=)
CA (1) CA2532982C (https=)
CY (1) CY1111599T1 (https=)
DE (1) DE602004018780D1 (https=)
DK (1) DK1648905T3 (https=)
ES (1) ES2319302T3 (https=)
IL (1) IL173348A (https=)
MX (1) MXPA06000919A (https=)
NZ (1) NZ544712A (https=)
PL (1) PL1648905T3 (https=)
PT (1) PT1648905E (https=)
WO (1) WO2005010009A1 (https=)

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BRPI0520482A2 (pt) * 2005-08-16 2009-05-12 Hoffmann La Roche amidas do ácido 4-amino-tieno [3,2-c] piridina-7-carboxìlico
WO2007031428A1 (en) * 2005-09-15 2007-03-22 F. Hoffmann-La Roche Ag 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives
US20080255184A1 (en) * 2005-11-04 2008-10-16 Smithkline Beecham Corporation Thienopyridine B-Raf Kinase Inhibitors
JP5237108B2 (ja) * 2005-12-08 2013-07-17 アボット・ラボラトリーズ タンパク質キナーゼ阻害薬としての９員ヘテロ二環式化合物
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ES2545907T3 (es) * 2005-12-29 2015-09-16 Abbvie Inc. Inhibidores de proteína quinasa
WO2007095223A2 (en) * 2006-02-14 2007-08-23 Vertex Pharmaceuticals Incorporated Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases
US7932390B2 (en) * 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
US7994321B2 (en) 2006-08-08 2011-08-09 Hoffmann-La Roche Inc. Substituted thieno[3,2-C]pyridine-7-carboxylic acid derivatives
WO2008018881A1 (en) * 2006-08-10 2008-02-14 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors
MX2010001636A (es) * 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
US20090275529A1 (en) * 2008-05-05 2009-11-05 Reiss Allison B Method for improving cardiovascular risk profile of cox inhibitors
CN102239171B (zh) * 2008-12-05 2014-06-11 艾伯维巴哈马有限公司 作为激酶抑制剂用于治疗癌症的噻吩并[3,2-c]吡啶衍生物
CN102574843B (zh) 2009-10-22 2015-06-17 法博太科制药有限公司 抗纤维化剂的稠环类似物
TWI482770B (zh) * 2010-06-09 2015-05-01 Abbvie Bahamas Ltd 結晶型激酶抑制劑
TWI492949B (zh) * 2010-06-09 2015-07-21 Abbvie Bahamas Ltd 結晶型激酶抑制劑
WO2011156473A1 (en) * 2010-06-09 2011-12-15 Abbott Laboratories Crystalline forms of kinase inhibitors
EP2588098A1 (en) 2010-07-02 2013-05-08 Alcon Research, Ltd. Compounds for the treatment of posterior segment disorders and diseases
RU2013120966A (ru) 2010-10-08 2014-11-20 Эббви Инк. ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
CN103396414B (zh) * 2013-07-16 2015-06-03 浙江医药高等专科学校 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途
CN104945411B (zh) * 2014-03-27 2018-07-31 南京勇山生物科技有限公司 噻吩并[3,2-c]吡啶类化合物、其制备方法及应用
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WO2016047678A1 (ja) * 2014-09-25 2016-03-31 武田薬品工業株式会社 複素環化合物
JP7185631B2 (ja) 2017-02-03 2022-12-07 サータ セラピューティクス プロプライエタリー リミテッド 抗線維化化合物
IL302807A (en) 2020-11-18 2023-07-01 Deciphera Pharmaceuticals Llc Gcn2 and perk kinase inhibitors and methods of use thereof
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AU2009251083B2 (en) 2012-02-16
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AU2004259765A1 (en) 2005-02-03
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ATE419253T1 (de) 2009-01-15
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