JP2006528597A5 - - Google Patents
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- Publication number
- JP2006528597A5 JP2006528597A5 JP2006520673A JP2006520673A JP2006528597A5 JP 2006528597 A5 JP2006528597 A5 JP 2006528597A5 JP 2006520673 A JP2006520673 A JP 2006520673A JP 2006520673 A JP2006520673 A JP 2006520673A JP 2006528597 A5 JP2006528597 A5 JP 2006528597A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carbocyclyl
- heterocyclyl
- alkenyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 125000004452 carbocyclyl group Chemical group 0.000 claims 21
- 125000000623 heterocyclic group Chemical group 0.000 claims 19
- 125000003342 alkenyl group Chemical group 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 7
- -1 hydroxy, mercapto Chemical class 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 150000001450 anions Chemical group 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000005208 trialkylammonium group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48948803P | 2003-07-24 | 2003-07-24 | |
| US60/489,488 | 2003-07-24 | ||
| PCT/DK2004/000490 WO2005009940A1 (en) | 2003-07-24 | 2004-07-09 | Novel aminobenzophenone compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006528597A JP2006528597A (ja) | 2006-12-21 |
| JP2006528597A5 true JP2006528597A5 (https=) | 2007-09-06 |
| JP4939216B2 JP4939216B2 (ja) | 2012-05-23 |
Family
ID=34102888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520673A Expired - Fee Related JP4939216B2 (ja) | 2003-07-24 | 2004-07-09 | 新規アミノベンゾフェノン化合物 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7977387B2 (https=) |
| JP (1) | JP4939216B2 (https=) |
| KR (1) | KR101128275B1 (https=) |
| CN (1) | CN1826310B (https=) |
| AR (1) | AR045082A1 (https=) |
| AT (1) | ATE469878T1 (https=) |
| AU (1) | AU2004259264B2 (https=) |
| BR (1) | BRPI0412893A (https=) |
| CA (1) | CA2530302C (https=) |
| DE (1) | DE602004027504D1 (https=) |
| DK (1) | DK1658263T3 (https=) |
| ES (1) | ES2346972T3 (https=) |
| HR (1) | HRP20100418T1 (https=) |
| IL (1) | IL172429A0 (https=) |
| IS (1) | IS2761B (https=) |
| MX (1) | MXPA06000708A (https=) |
| MY (1) | MY142988A (https=) |
| NO (1) | NO20060230L (https=) |
| NZ (1) | NZ544178A (https=) |
| PT (1) | PT1658263E (https=) |
| RU (1) | RU2396250C2 (https=) |
| TW (1) | TWI337075B (https=) |
| UA (1) | UA85559C2 (https=) |
| WO (1) | WO2005009940A1 (https=) |
| ZA (1) | ZA200510137B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200700811B (en) | 2004-08-06 | 2008-10-29 | Otsuka Pharma Co Ltd | Aromatic compound |
| ES2341473T3 (es) * | 2004-12-13 | 2010-06-21 | Leo Pharma A/S | Compuestos de aminobenzofenona sustituida con triazol. |
| JP5154406B2 (ja) | 2005-04-13 | 2013-02-27 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| BRPI0615948A2 (pt) * | 2005-09-07 | 2011-05-31 | Plexxikon Inc | composto ativo de ppar, sua composição, seu kit e seu uso |
| CN101321529B (zh) | 2005-12-05 | 2012-09-05 | 大塚制药株式会社 | 作为抗肿瘤剂的二芳基醚衍生物 |
| TW200732296A (en) * | 2005-12-15 | 2007-09-01 | Astrazeneca Ab | Novel compounds |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| KR100932093B1 (ko) * | 2006-09-27 | 2009-12-16 | 주식회사종근당 | 미세소관 형성 저해제로서 유용한 벤조페논 유도체 |
| UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2073802A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| PT2272845E (pt) * | 2008-03-26 | 2015-06-01 | Chong Kun Dang Pharm Corp | Derivados de benzofenona-tiazole úteis para inibir a formação de microtúbulos e método para produzir os mesmos |
| GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| MX2010014066A (es) | 2008-06-16 | 2011-06-01 | Univ Tennessee Res Foundation | Compuestos para el tratamiento del cancer. |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| JP5732471B2 (ja) | 2009-12-22 | 2015-06-10 | レオ ファーマ アクティーゼルスカブ | 溶媒混合物およびビタミンｄ誘導体から成る医薬品組成物または類似体 |
| RU2555339C2 (ru) | 2009-12-22 | 2015-07-10 | Лео Фарма А/С | Нанокристаллы кальципотриола моногидрита |
| US20120322776A1 (en) | 2009-12-22 | 2012-12-20 | Leo Pharma A/S | Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants |
| JP5879273B2 (ja) | 2010-03-01 | 2016-03-08 | ジーティーエックス・インコーポレイテッド | 癌を処置するための化合物 |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| KR101229365B1 (ko) * | 2012-07-02 | 2013-02-18 | 대한민국 | 〔ｚ〕ｎ〔３〔２，４디플루오로페닐아미노〕１〔４나이트로페닐〕３옥소프로프１엔２일〕２메톡시벤즈아마이드를 유효성분으로 함유하는 신경퇴행성 질환 예방 및 치료용 약학적 조성물 |
| DK2970139T3 (en) | 2013-03-15 | 2018-08-13 | Biomarin Pharm Inc | HDAC inhibitors |
| CN103926794B (zh) * | 2014-04-29 | 2017-11-14 | 常州强力电子新材料股份有限公司 | 一种含有二苯甲酮衍生物光引发剂的光固化组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9701453D0 (en) * | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
| KR20020013961A (ko) * | 1999-07-16 | 2002-02-21 | 룬딩 에른스트 | 신규한 아미노벤조페논 |
| EP1210320B1 (en) * | 1999-07-16 | 2004-09-29 | Leo Pharma A/S | Aminobenzophenones as inhibitors of il-1beta and tnf-alpha |
| DE60014681T2 (de) | 1999-07-16 | 2006-02-02 | Leo Pharma A/S | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
| US6555710B1 (en) | 1999-07-16 | 2003-04-29 | Leo Pharmaceutical Products Ltd A/S Lovens Kemiske Fabrik Produktionsaktieselskab | Aminobenzophenones as inhibitors of IL-1 β and TNF-α |
| AU768512B2 (en) * | 1999-07-16 | 2003-12-18 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha |
| ATE362912T1 (de) * | 1999-12-06 | 2007-06-15 | Leo Pharma As | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
| JP2004501191A (ja) * | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| US20020165286A1 (en) * | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
| GB0107368D0 (en) * | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
| EP1423356A2 (en) * | 2001-08-28 | 2004-06-02 | Leo Pharma A/S | Novel aminobenzoephenones |
-
2004
- 2004-07-09 DE DE602004027504T patent/DE602004027504D1/de not_active Expired - Lifetime
- 2004-07-09 CA CA2530302A patent/CA2530302C/en not_active Expired - Fee Related
- 2004-07-09 MX MXPA06000708A patent/MXPA06000708A/es active IP Right Grant
- 2004-07-09 KR KR1020067001537A patent/KR101128275B1/ko not_active Expired - Fee Related
- 2004-07-09 AU AU2004259264A patent/AU2004259264B2/en not_active Ceased
- 2004-07-09 WO PCT/DK2004/000490 patent/WO2005009940A1/en not_active Ceased
- 2004-07-09 RU RU2006105639/04A patent/RU2396250C2/ru not_active IP Right Cessation
- 2004-07-09 HR HR20100418T patent/HRP20100418T1/hr unknown
- 2004-07-09 CN CN2004800213784A patent/CN1826310B/zh not_active Expired - Fee Related
- 2004-07-09 DK DK04738987.9T patent/DK1658263T3/da active
- 2004-07-09 BR BRPI0412893-1A patent/BRPI0412893A/pt not_active IP Right Cessation
- 2004-07-09 ES ES04738987T patent/ES2346972T3/es not_active Expired - Lifetime
- 2004-07-09 ZA ZA200510137A patent/ZA200510137B/en unknown
- 2004-07-09 AT AT04738987T patent/ATE469878T1/de active
- 2004-07-09 JP JP2006520673A patent/JP4939216B2/ja not_active Expired - Fee Related
- 2004-07-09 PT PT04738987T patent/PT1658263E/pt unknown
- 2004-07-09 NZ NZ544178A patent/NZ544178A/en not_active IP Right Cessation
- 2004-07-09 US US10/563,474 patent/US7977387B2/en not_active Expired - Fee Related
- 2004-07-15 MY MYPI20042830A patent/MY142988A/en unknown
- 2004-07-22 AR ARP040102611A patent/AR045082A1/es unknown
- 2004-07-23 TW TW093122201A patent/TWI337075B/zh not_active IP Right Cessation
- 2004-09-07 UA UAA200601964A patent/UA85559C2/ru unknown
-
2005
- 2005-12-07 IL IL172429A patent/IL172429A0/en unknown
-
2006
- 2006-01-16 NO NO20060230A patent/NO20060230L/no not_active Application Discontinuation
- 2006-02-23 IS IS8323A patent/IS2761B/is unknown
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