JP2014503525A5 - - Google Patents
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- JP2014503525A5 JP2014503525A5 JP2013543801A JP2013543801A JP2014503525A5 JP 2014503525 A5 JP2014503525 A5 JP 2014503525A5 JP 2013543801 A JP2013543801 A JP 2013543801A JP 2013543801 A JP2013543801 A JP 2013543801A JP 2014503525 A5 JP2014503525 A5 JP 2014503525A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- group
- alkyl
- motomeko
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195468.3 | 2010-12-16 | ||
| EP10195468 | 2010-12-16 | ||
| PCT/EP2011/073011 WO2012080447A1 (en) | 2010-12-16 | 2011-12-16 | Indoles as respiratory syncytial virus antiviral agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016048038A Division JP2016145236A (ja) | 2010-12-16 | 2016-03-11 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503525A JP2014503525A (ja) | 2014-02-13 |
| JP2014503525A5 true JP2014503525A5 (https=) | 2014-07-10 |
| JP5945278B2 JP5945278B2 (ja) | 2016-07-05 |
Family
ID=43875270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543801A Expired - Fee Related JP5945278B2 (ja) | 2010-12-16 | 2011-12-16 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
| JP2016048038A Pending JP2016145236A (ja) | 2010-12-16 | 2016-03-11 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016048038A Pending JP2016145236A (ja) | 2010-12-16 | 2016-03-11 | 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US8921560B2 (https=) |
| EP (1) | EP2651922B1 (https=) |
| JP (2) | JP5945278B2 (https=) |
| KR (1) | KR101914606B1 (https=) |
| CN (1) | CN103347875B (https=) |
| AR (1) | AR084335A1 (https=) |
| AU (1) | AU2011343256C1 (https=) |
| BR (1) | BR112013011949B1 (https=) |
| CA (1) | CA2822000C (https=) |
| CL (1) | CL2013001715A1 (https=) |
| CY (1) | CY1117763T1 (https=) |
| DK (1) | DK2651922T3 (https=) |
| EA (1) | EA022339B1 (https=) |
| ES (1) | ES2572258T3 (https=) |
| HR (1) | HRP20160533T1 (https=) |
| HU (1) | HUE028009T2 (https=) |
| IL (1) | IL225641A (https=) |
| ME (1) | ME02406B (https=) |
| MX (1) | MX339944B (https=) |
| MY (1) | MY163981A (https=) |
| NZ (1) | NZ609487A (https=) |
| PH (1) | PH12013500797A1 (https=) |
| PL (1) | PL2651922T3 (https=) |
| RS (1) | RS54746B1 (https=) |
| SG (1) | SG189866A1 (https=) |
| SI (1) | SI2651922T1 (https=) |
| SM (1) | SMT201600142B (https=) |
| TW (1) | TWI515187B (https=) |
| UA (1) | UA109792C2 (https=) |
| WO (1) | WO2012080447A1 (https=) |
| ZA (1) | ZA201304423B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| US20150111868A1 (en) | 2012-06-15 | 2015-04-23 | Jansen R&D Ireland | Novel 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| JP2015519387A (ja) * | 2012-06-15 | 2015-07-09 | ヤンセン・アールアンドデイ・アイルランド | Ｒｓウイルス抗ウイルス薬としての、複素環によって置換された新規４−置換１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体 |
| ES2600318T3 (es) * | 2012-07-10 | 2017-02-08 | F. Hoffmann-La Roche Ag | Nuevos indazoles para el tratamiento y profilaxis de infección por virus sincitial respiratorio |
| MY172021A (en) | 2012-10-16 | 2019-11-12 | Janssen Sciences Ireland Uc | Rsv antiviral compounds |
| AU2014308991B2 (en) | 2013-08-21 | 2019-02-14 | Janssen Biopharma, Inc. | Antiviral compounds |
| TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| PE20170673A1 (es) * | 2014-08-05 | 2017-05-22 | Alios Biopharma Inc | Terapia de combinacion para tratar una paramixovirus |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| US9745253B2 (en) | 2015-03-13 | 2017-08-29 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as HDAC8 inhibitors |
| DK3324977T3 (da) | 2015-07-22 | 2022-10-17 | Enanta Pharm Inc | Benzodiazepinderivater som rsv-inhibitorer |
| CN108473495B (zh) | 2015-11-20 | 2022-04-12 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
| EP3402799B1 (en) | 2016-01-15 | 2022-05-04 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| EP3411028B1 (en) | 2016-02-03 | 2021-05-05 | Janssen Sciences Ireland Unlimited Company | Combination product for treating or ameliorating respiratory syncytial virus infection |
| CN109152368A (zh) | 2016-03-15 | 2019-01-04 | 拜耳作物科学股份公司 | 用于防治动物害虫的取代的磺酰胺 |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| CN110809472B (zh) | 2017-02-16 | 2023-05-23 | 英安塔制药有限公司 | 用于制备苯二氮䓬衍生物的方法 |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| BR112020006334A2 (pt) | 2017-09-29 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | combinação de agentes farmacêuticos como inibidores de rsv |
| CA3080138A1 (en) | 2017-11-13 | 2019-05-16 | Enanta Pharmaceuticals, Inc. | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
| TW201936193A (zh) | 2017-12-05 | 2019-09-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 使用組合產品治療ｒｓｖ |
| BR112021018335A2 (pt) | 2019-03-18 | 2021-11-23 | Enanta Pharm Inc | Derivados de benzodiazepina como inibidores de rsv |
| AU2020357452B2 (en) | 2019-10-04 | 2026-01-29 | Enanta Pharmaceuticals, Inc | Antiviral heterocyclic compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| AU2020372633A1 (en) * | 2019-10-30 | 2022-04-21 | Janssen Sciences Ireland Unlimited Company | Synthesis of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2 yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one |
| EP4051663B1 (en) * | 2019-10-30 | 2024-02-21 | Janssen Sciences Ireland Unlimited Company | Synthesis of 3-nitro-n-(2,2,2-trifluoroethyl)-4-pyridinamine |
| US20220380318A1 (en) | 2019-11-07 | 2022-12-01 | Bayer Aktiengesellschaft | Substituted sulfonyl amides for controlling animal pests |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| EP4165034A1 (en) * | 2020-06-11 | 2023-04-19 | Janssen Sciences Ireland Unlimited Company | Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| CA3200111C (en) | 2020-10-28 | 2025-02-18 | Shionogi & Co., Ltd. | AMIDE DERIVATIVE WITH ANTIVIRAL ACTIVITY |
| US12612412B2 (en) | 2021-02-26 | 2026-04-28 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| WO2022182861A1 (en) | 2021-02-26 | 2022-09-01 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| WO2022184606A1 (en) | 2021-03-01 | 2022-09-09 | Janssen Sciences Ireland Unlimited Company | Synthesis of rilematovir |
| CN114014856B (zh) * | 2021-11-26 | 2023-12-22 | 嘉兴安谛康生物科技有限公司 | 作为呼吸道合胞病毒抗病毒剂的咪唑并吡啶类衍生物 |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
| CN121648112B (zh) * | 2026-02-04 | 2026-04-14 | 中国人民解放军陆军军医大学第二附属医院 | 一种苯并咪唑酮化合物在制备治疗椎间盘退变药物中的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002514162A (ja) | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
| AU1099000A (en) | 1998-10-05 | 2000-04-26 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| HUP0104987A3 (en) | 1998-12-18 | 2002-09-30 | Axys Pharmaceuticals Inc South | Benzimidazole or indole derivatives protease inhibitors, and pharmaceutical compositions containing them |
| IL147327A0 (en) | 1999-06-28 | 2002-08-14 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
| SI1196408T1 (en) | 1999-06-28 | 2005-02-28 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| US6534535B1 (en) * | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| WO2001057019A1 (en) * | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa |
| EP1255750A1 (en) * | 2000-02-01 | 2002-11-13 | Millenium Pharmaceuticals, Inc. | INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| WO2003049688A2 (en) | 2001-12-10 | 2003-06-19 | Bristol-Myers Squibb Company | Bis hydrochloride monohydrate salt of rsv fusion inhibitor |
| AU2002358219A1 (en) | 2001-12-21 | 2003-07-15 | Sense Proteomic Limited | Protein analysis using mass spectrometry |
| WO2004043913A2 (en) | 2002-11-08 | 2004-05-27 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| PE20050068A1 (es) | 2003-02-06 | 2005-03-11 | Novartis Ag | 2-cianopirrolopirimidinas como inhibidores de la catepsina s |
| US7343930B2 (en) | 2004-12-03 | 2008-03-18 | Masco Corporation Of Indiana | Sprayer with non-faucet control |
| MY140748A (en) * | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| US9150556B2 (en) | 2007-05-22 | 2015-10-06 | Boehringer Ingelheim International Gmbh | Benzimidazolone chymase inhibitors |
| FR2926556B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI530495B (zh) * | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| CA2821367A1 (en) | 2010-12-17 | 2012-06-21 | Sanofi-Aventis Deutschland Gmbh | Medicament administration |
| JP2015519387A (ja) | 2012-06-15 | 2015-07-09 | ヤンセン・アールアンドデイ・アイルランド | Ｒｓウイルス抗ウイルス薬としての、複素環によって置換された新規４−置換１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体 |
| US20150111868A1 (en) | 2012-06-15 | 2015-04-23 | Jansen R&D Ireland | Novel 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| WO2013186334A1 (en) | 2012-06-15 | 2013-12-19 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| EA201590023A1 (ru) | 2012-06-15 | 2015-05-29 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса |
| MY172021A (en) | 2012-10-16 | 2019-11-12 | Janssen Sciences Ireland Uc | Rsv antiviral compounds |
-
2011
- 2011-12-15 TW TW100146391A patent/TWI515187B/zh not_active IP Right Cessation
- 2011-12-16 CA CA2822000A patent/CA2822000C/en active Active
- 2011-12-16 WO PCT/EP2011/073011 patent/WO2012080447A1/en not_active Ceased
- 2011-12-16 CN CN201180060358.8A patent/CN103347875B/zh not_active Expired - Fee Related
- 2011-12-16 HU HUE11794793A patent/HUE028009T2/en unknown
- 2011-12-16 BR BR112013011949-7A patent/BR112013011949B1/pt not_active IP Right Cessation
- 2011-12-16 RS RS20160332A patent/RS54746B1/sr unknown
- 2011-12-16 MY MYPI2013001279A patent/MY163981A/en unknown
- 2011-12-16 SI SI201130824A patent/SI2651922T1/sl unknown
- 2011-12-16 JP JP2013543801A patent/JP5945278B2/ja not_active Expired - Fee Related
- 2011-12-16 PH PH1/2013/500797A patent/PH12013500797A1/en unknown
- 2011-12-16 KR KR1020137016980A patent/KR101914606B1/ko not_active Expired - Fee Related
- 2011-12-16 PL PL11794793.7T patent/PL2651922T3/pl unknown
- 2011-12-16 SG SG2013026729A patent/SG189866A1/en unknown
- 2011-12-16 AR ARP110104740A patent/AR084335A1/es active IP Right Grant
- 2011-12-16 AU AU2011343256A patent/AU2011343256C1/en not_active Ceased
- 2011-12-16 HR HRP20160533TT patent/HRP20160533T1/hr unknown
- 2011-12-16 UA UAA201304193A patent/UA109792C2/ru unknown
- 2011-12-16 ES ES11794793T patent/ES2572258T3/es active Active
- 2011-12-16 MX MX2013006887A patent/MX339944B/es active IP Right Grant
- 2011-12-16 EA EA201390883A patent/EA022339B1/ru unknown
- 2011-12-16 US US13/993,200 patent/US8921560B2/en active Active
- 2011-12-16 EP EP11794793.7A patent/EP2651922B1/en active Active
- 2011-12-16 ME MEP-2016-97A patent/ME02406B/me unknown
- 2011-12-16 DK DK11794793.7T patent/DK2651922T3/en active
- 2011-12-16 NZ NZ609487A patent/NZ609487A/en not_active IP Right Cessation
-
2013
- 2013-04-09 IL IL225641A patent/IL225641A/en active IP Right Grant
- 2013-06-13 CL CL2013001715A patent/CL2013001715A1/es unknown
- 2013-06-14 ZA ZA2013/04423A patent/ZA201304423B/en unknown
-
2014
- 2014-11-18 US US14/546,289 patent/US9321768B2/en active Active
-
2016
- 2016-03-11 JP JP2016048038A patent/JP2016145236A/ja active Pending
- 2016-04-22 US US15/136,769 patent/US9944638B2/en active Active
- 2016-05-20 SM SM201600142T patent/SMT201600142B/it unknown
- 2016-05-24 CY CY20161100449T patent/CY1117763T1/el unknown
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