ATE362912T1 - Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha - Google Patents
Aminobenzophenone als inhibitoren von il-1beta und tnf-alphaInfo
- Publication number
- ATE362912T1 ATE362912T1 AT00979457T AT00979457T ATE362912T1 AT E362912 T1 ATE362912 T1 AT E362912T1 AT 00979457 T AT00979457 T AT 00979457T AT 00979457 T AT00979457 T AT 00979457T AT E362912 T1 ATE362912 T1 AT E362912T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- alkyl
- hydrogen
- alkoxycarbonyl
- alkylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
- C07C325/02—Thioketones; Oxides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16933399P | 1999-12-06 | 1999-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE362912T1 true ATE362912T1 (de) | 2007-06-15 |
Family
ID=22615235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00979457T ATE362912T1 (de) | 1999-12-06 | 2000-11-29 | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
Country Status (19)
Country | Link |
---|---|
US (1) | US6541670B2 (de) |
EP (1) | EP1237845B1 (de) |
JP (1) | JP4684515B2 (de) |
KR (1) | KR20020071876A (de) |
CN (1) | CN1193003C (de) |
AT (1) | ATE362912T1 (de) |
AU (1) | AU776395B2 (de) |
BR (1) | BR0016164A (de) |
CA (1) | CA2393312C (de) |
CZ (1) | CZ20021940A3 (de) |
DE (1) | DE60034961T2 (de) |
ES (1) | ES2287040T3 (de) |
HK (1) | HK1053463A1 (de) |
HU (1) | HUP0203813A3 (de) |
MX (1) | MXPA02005604A (de) |
NZ (1) | NZ519172A (de) |
PL (1) | PL356049A1 (de) |
RU (1) | RU2260422C2 (de) |
WO (1) | WO2001042189A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
CA2326117A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
BR0111034A (pt) | 2000-05-22 | 2003-06-17 | Leo Pharma S A | Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou profilaxia de condições ou doenças inflamatórias, para o tratamento e/ou profilaxia de osteoporose e para o tratamento de doenças relacionadas à aids |
IL153378A0 (en) * | 2000-07-18 | 2003-07-06 | Bone Care Internat Inc | STABILIZED 1alpha-HYDROXY VITAMIN D |
AU2001285311B2 (en) | 2000-08-29 | 2005-09-15 | Biocon, Ltd | Immunoregulatory compounds, derivatives thereof and their use |
US20020165286A1 (en) * | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
GB0107368D0 (en) * | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
MXPA04001912A (es) * | 2001-08-28 | 2004-07-23 | Leo Pharma As | Aminobenzofenonas novedosas. |
US8048924B2 (en) * | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
CA2492033A1 (en) | 2002-07-09 | 2004-01-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
PL377377A1 (pl) * | 2002-12-20 | 2006-02-06 | Leo Pharma A/S | Nowe związki aminobenzofenonu |
CA2530302C (en) * | 2003-07-24 | 2013-12-03 | Leo Pharma A/S | Novel aminobenzophenone compounds |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
EP1773767B1 (de) | 2004-07-07 | 2016-03-09 | Biocon Limited | Synthese von azogebundenen, das immunsystem regulierenden verbindungen |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
MX2007006739A (es) * | 2004-12-13 | 2007-08-02 | Leo Pharma As | Compuestos de aminobenzofenona sustituidos con triazol. |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
EP2206534A1 (de) | 2008-10-09 | 2010-07-14 | c-a-i-r biosciences GmbH | Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten |
CA2778454C (en) * | 2009-10-26 | 2021-03-02 | Prometheus Laboratories Inc. | Assays for the detection of anti-tnf drugs and autoantibodies |
WO2013100208A1 (ja) | 2011-12-28 | 2013-07-04 | 京都府公立大学法人 | 角膜内皮細胞の培養正常化 |
WO2015050984A1 (en) * | 2013-10-01 | 2015-04-09 | New York University | Amino, amido, and heterocyclic compounds as modulators of rage activity and uses thereof |
WO2015072580A1 (ja) | 2013-11-14 | 2015-05-21 | 学校法人同志社 | 細胞増殖促進または細胞障害抑制による角膜内皮治療薬 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57177058A (en) | 1981-04-24 | 1982-10-30 | Hodogaya Chem Co Ltd | Novel fluoran compound |
KR920702606A (ko) * | 1989-06-13 | 1992-10-06 | 스튜어트 알. 슈터 | 모노킨(Monokine)의 활성저해 |
JPH08104817A (ja) * | 1994-10-03 | 1996-04-23 | Nippon Soda Co Ltd | 新規なフルオラン化合物及びそれを用いた発色性記録材料 |
GB9701453D0 (en) * | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
JP3329337B2 (ja) * | 1997-10-14 | 2002-09-30 | 三菱ウェルファーマ株式会社 | ピペラジン化合物およびその医薬としての用途 |
JPH11217387A (ja) * | 1998-01-27 | 1999-08-10 | Yamada Chem Co Ltd | フルオラン化合物及びこれを用いた発色性記録材料 |
CN1231459C (zh) * | 1999-07-16 | 2005-12-14 | 里奥药物制品有限公司 | 新型氨基二苯酮 |
-
2000
- 2000-11-29 KR KR1020027007188A patent/KR20020071876A/ko not_active Application Discontinuation
- 2000-11-29 CN CNB008177767A patent/CN1193003C/zh not_active Expired - Fee Related
- 2000-11-29 NZ NZ519172A patent/NZ519172A/en not_active IP Right Cessation
- 2000-11-29 MX MXPA02005604A patent/MXPA02005604A/es active IP Right Grant
- 2000-11-29 HU HU0203813A patent/HUP0203813A3/hu unknown
- 2000-11-29 US US09/787,532 patent/US6541670B2/en not_active Expired - Lifetime
- 2000-11-29 ES ES00979457T patent/ES2287040T3/es not_active Expired - Lifetime
- 2000-11-29 RU RU2002118113/15A patent/RU2260422C2/ru not_active IP Right Cessation
- 2000-11-29 DE DE60034961T patent/DE60034961T2/de not_active Expired - Lifetime
- 2000-11-29 EP EP00979457A patent/EP1237845B1/de not_active Expired - Lifetime
- 2000-11-29 WO PCT/DK2000/000653 patent/WO2001042189A1/en active IP Right Grant
- 2000-11-29 AU AU16935/01A patent/AU776395B2/en not_active Ceased
- 2000-11-29 PL PL00356049A patent/PL356049A1/xx not_active Application Discontinuation
- 2000-11-29 BR BR0016164-0A patent/BR0016164A/pt not_active IP Right Cessation
- 2000-11-29 CZ CZ20021940A patent/CZ20021940A3/cs unknown
- 2000-11-29 AT AT00979457T patent/ATE362912T1/de not_active IP Right Cessation
- 2000-11-29 CA CA2393312A patent/CA2393312C/en not_active Expired - Fee Related
- 2000-11-29 JP JP2001543491A patent/JP4684515B2/ja not_active Expired - Fee Related
-
2003
- 2003-08-14 HK HK03105831A patent/HK1053463A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2393312C (en) | 2011-07-12 |
CN1413186A (zh) | 2003-04-23 |
RU2260422C2 (ru) | 2005-09-20 |
US20030013770A1 (en) | 2003-01-16 |
HUP0203813A3 (en) | 2008-03-28 |
EP1237845B1 (de) | 2007-05-23 |
AU1693501A (en) | 2001-06-18 |
NZ519172A (en) | 2004-03-26 |
DE60034961T2 (de) | 2008-01-24 |
KR20020071876A (ko) | 2002-09-13 |
DE60034961D1 (de) | 2007-07-05 |
CN1193003C (zh) | 2005-03-16 |
JP4684515B2 (ja) | 2011-05-18 |
PL356049A1 (en) | 2004-06-14 |
JP2003516377A (ja) | 2003-05-13 |
US6541670B2 (en) | 2003-04-01 |
MXPA02005604A (es) | 2004-09-10 |
AU776395B2 (en) | 2004-09-09 |
EP1237845A1 (de) | 2002-09-11 |
CZ20021940A3 (cs) | 2003-01-15 |
WO2001042189A1 (en) | 2001-06-14 |
RU2002118113A (ru) | 2004-02-20 |
HUP0203813A2 (hu) | 2003-03-28 |
ES2287040T3 (es) | 2007-12-16 |
HK1053463A1 (en) | 2003-10-24 |
CA2393312A1 (en) | 2001-06-14 |
BR0016164A (pt) | 2002-08-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE362912T1 (de) | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha | |
DE60014393D1 (de) | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha | |
ECSP066886A (es) | Compuestos y métodos para el tratamiento de dislipidemia | |
UA94571C2 (en) | 3-arylamino pyridine derivatives | |
MY147780A (en) | Carboxamide compounds and their use as calpain inhibitors | |
ATE277891T1 (de) | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha | |
DE60014394D1 (de) | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha | |
DK0984938T3 (da) | Cyanoguanidiner som celleproliferationsinhibitorer | |
DK1210325T3 (da) | Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa | |
SE0203304D0 (sv) | Novel Coumpounds | |
DK1202954T3 (da) | Nye aminobenzophenoner | |
ATE333457T1 (de) | Zyklische gmp-spezifische phosphodiesteraseinhibitoren | |
BG103867A (en) | Cyanoguanidines as cell proliferation inhibitors | |
DK0984936T3 (da) | Cyanoguanidiner som celleproliferationsinhibitorer | |
ATE324368T1 (de) | Heteroarylheteroalkylamin derivate und deren verwendung als inhibitoren der stickoxidsynthase | |
TW200630095A (en) | Pharmaceutical compounds | |
SE0202280D0 (sv) | Novel compounds | |
DE60014915D1 (de) | Hypoxanthin- und thiohypxanthin-verbindungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |