MXPA02005604A - Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa. - Google Patents

Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa.

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Publication number
MXPA02005604A
MXPA02005604A MXPA02005604A MXPA02005604A MXPA02005604A MX PA02005604 A MXPA02005604 A MX PA02005604A MX PA02005604 A MXPA02005604 A MX PA02005604A MX PA02005604 A MXPA02005604 A MX PA02005604A MX PA02005604 A MXPA02005604 A MX PA02005604A
Authority
MX
Mexico
Prior art keywords
group
alkyl
hydrogen
alkoxycarbonyl
alkylthio
Prior art date
Application number
MXPA02005604A
Other languages
English (en)
Inventor
Rytter Ottosen Erik
Original Assignee
Leo Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma As filed Critical Leo Pharma As
Publication of MXPA02005604A publication Critical patent/MXPA02005604A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
    • C07C325/02—Thioketones; Oxides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de la formula general (I), (Ver formula I) en donde R1 representa un sustituyente seleccionado del grupo que consiste de halogeno, hidroxi, mercapto, trifluorometilo, amino, alquilo de C1-C3, grupo olefinico de C2-C3, alcoxi de C1-C3, alquiltio de C1-C3, alquilamino de C1-C6, alcoxicarbonilo de C1-C3, ciano, -CONH2, fenilo, y nitro; R2 representa uno o mas, sustituyentes iguales o diferentes seleccionados del grupo que consiste de hidrogeno, halogeno, hidroxi, mercapto, trifluorometilo, amino, alquilo de C1-C3, grupo olefinico de C2-C3, alcoxi de C1-C3, alquiltio de C1-C3, alquilamino de C1-C6, alcoxicarbonilo de C1-C3, ciano, -CONH2, fenilo, y nitro; R3 representa uno o mas, sustituyentes iguales o diferentes seleccionados del grupo que consiste de hidrogeno, halogeno, hidroxi, mercapto, trifluorometilo, ciano, carboxi, carbamoilo, alquilo de C1-C10, grupo olefinico de C2-C10, grupo hidrocarburo monociclico de C3-C8, alcoxi de C1-C10, alquiltio de C1-C10, alcoxicarbonilo de C1-C10, y ferilio; R4 representa hidrogeno, alquilo de C1-C6, grupo olefinico de C2-C6, o grupo hidrocarburo monociclico de C3-C6; R5 representa uno o mas, sustituyentes iguales o diferentes seleccionados del grupo que consiste de hidrogeno y R1; X representa oxigeno, azufre, o N-OH; y sales del mismo con acidos, hidratos y solvatos farmaceuticamente aceptables, pueden utilizarse en la profilaxis o tratamiento de enfermedades inflamatorias.
MXPA02005604A 1999-12-06 2000-11-29 Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa. MXPA02005604A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16933399P 1999-12-06 1999-12-06
PCT/DK2000/000653 WO2001042189A1 (en) 1999-12-06 2000-11-29 AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a)

Publications (1)

Publication Number Publication Date
MXPA02005604A true MXPA02005604A (es) 2004-09-10

Family

ID=22615235

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02005604A MXPA02005604A (es) 1999-12-06 2000-11-29 Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa.

Country Status (19)

Country Link
US (1) US6541670B2 (es)
EP (1) EP1237845B1 (es)
JP (1) JP4684515B2 (es)
KR (1) KR20020071876A (es)
CN (1) CN1193003C (es)
AT (1) ATE362912T1 (es)
AU (1) AU776395B2 (es)
BR (1) BR0016164A (es)
CA (1) CA2393312C (es)
CZ (1) CZ20021940A3 (es)
DE (1) DE60034961T2 (es)
ES (1) ES2287040T3 (es)
HK (1) HK1053463A1 (es)
HU (1) HUP0203813A3 (es)
MX (1) MXPA02005604A (es)
NZ (1) NZ519172A (es)
PL (1) PL356049A1 (es)
RU (1) RU2260422C2 (es)
WO (1) WO2001042189A1 (es)

Families Citing this family (28)

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US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
US6521608B1 (en) * 1998-03-27 2003-02-18 Oregon Health & Science University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
AU2001260081B2 (en) 2000-05-22 2005-07-28 Leo Pharma A/S Benzophenones as inhibitors of il-1beta and tnf-alpha
JP2004504295A (ja) * 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
PT1642885E (pt) 2000-08-29 2009-12-17 Biocon Ltd Utilização de uma composição farmacêutica contendo um derviado de ácido para-aminofenilacético para o tratamento de estados inflamatórios do tracto gastrointestinal
US20020165286A1 (en) * 2000-12-08 2002-11-07 Hanne Hedeman Dermal anti-inflammatory composition
GB0107368D0 (en) * 2001-03-23 2001-05-16 Novartis Ag Organic compounds
JP4540984B2 (ja) * 2001-08-28 2010-09-08 レオ ファーマ アクティーゼルスカブ 新規アミノベンゾフェノン
US8048924B2 (en) * 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
EP1534282B1 (en) 2002-07-09 2006-12-27 Boehringer Ingelheim Pharma GmbH & Co.KG Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
AU2003287917A1 (en) * 2002-12-20 2004-07-14 Leo Pharma A/S Novel aminobenzophenone compounds
DK1658263T3 (da) * 2003-07-24 2010-09-27 Leo Pharma As Aminobenzophenonforbindelser
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
EP1773767B1 (en) 2004-07-07 2016-03-09 Biocon Limited Synthesis of azo bonded immunoregulatory compounds
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
EP1828148B1 (en) * 2004-12-13 2010-01-20 Leo Pharma A/S Triazole substituted aminobenzophenone compounds
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
EP2206534A1 (de) 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
MX343328B (es) * 2009-10-26 2016-11-01 Nestec Sa Analisis para la deteccion de farmacos anti-tnf y anticuerpos.
JP6218229B2 (ja) 2011-12-28 2017-10-25 京都府公立大学法人 角膜内皮細胞の培養正常化
US9353078B2 (en) 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof
US10813920B2 (en) 2013-11-14 2020-10-27 The Doshisha Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage

Family Cites Families (7)

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JPS57177058A (en) 1981-04-24 1982-10-30 Hodogaya Chem Co Ltd Novel fluoran compound
CA2058952A1 (en) * 1989-06-13 1990-12-14 Nabil Hanna Monokine activity interference
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GB9701453D0 (en) * 1997-01-24 1997-03-12 Leo Pharm Prod Ltd Aminobenzophenones
JP3329337B2 (ja) * 1997-10-14 2002-09-30 三菱ウェルファーマ株式会社 ピペラジン化合物およびその医薬としての用途
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Also Published As

Publication number Publication date
HK1053463A1 (en) 2003-10-24
HUP0203813A3 (en) 2008-03-28
RU2002118113A (ru) 2004-02-20
DE60034961T2 (de) 2008-01-24
CA2393312A1 (en) 2001-06-14
NZ519172A (en) 2004-03-26
DE60034961D1 (de) 2007-07-05
US20030013770A1 (en) 2003-01-16
BR0016164A (pt) 2002-08-13
KR20020071876A (ko) 2002-09-13
RU2260422C2 (ru) 2005-09-20
EP1237845A1 (en) 2002-09-11
CZ20021940A3 (cs) 2003-01-15
PL356049A1 (en) 2004-06-14
JP4684515B2 (ja) 2011-05-18
ATE362912T1 (de) 2007-06-15
HUP0203813A2 (hu) 2003-03-28
CA2393312C (en) 2011-07-12
US6541670B2 (en) 2003-04-01
ES2287040T3 (es) 2007-12-16
AU776395B2 (en) 2004-09-09
WO2001042189A1 (en) 2001-06-14
EP1237845B1 (en) 2007-05-23
JP2003516377A (ja) 2003-05-13
CN1193003C (zh) 2005-03-16
AU1693501A (en) 2001-06-18
CN1413186A (zh) 2003-04-23

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