JP2006527230A - Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体 - Google Patents

Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体 Download PDF

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JP2006527230A
JP2006527230A JP2006515898A JP2006515898A JP2006527230A JP 2006527230 A JP2006527230 A JP 2006527230A JP 2006515898 A JP2006515898 A JP 2006515898A JP 2006515898 A JP2006515898 A JP 2006515898A JP 2006527230 A JP2006527230 A JP 2006527230A
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lower alkyl
halo
substituted
radical
compound
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JP2006527230A5 (https=
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デイビッド・ブライアント・バット
ティモシー・マイケル・ラムジー
マイケル・ロイド・サビオ
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ノバルティス アクチエンゲゼルシャフト
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Publication of JP2006527230A publication Critical patent/JP2006527230A/ja
Publication of JP2006527230A5 publication Critical patent/JP2006527230A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006515898A 2003-06-13 2004-06-11 Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体 Pending JP2006527230A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47870903P 2003-06-13 2003-06-13
PCT/EP2004/006317 WO2004110452A1 (en) 2003-06-13 2004-06-11 2-aminopyrimidine derivatives as raf kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2006527230A true JP2006527230A (ja) 2006-11-30
JP2006527230A5 JP2006527230A5 (https=) 2007-07-26

Family

ID=33551850

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006515898A Pending JP2006527230A (ja) 2003-06-13 2004-06-11 Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体

Country Status (14)

Country Link
US (1) US20060293340A1 (https=)
EP (1) EP1635835B1 (https=)
JP (1) JP2006527230A (https=)
CN (1) CN1805748B (https=)
AT (1) ATE454152T1 (https=)
AU (1) AU2004246800B2 (https=)
BR (1) BRPI0411365A (https=)
CA (1) CA2529090A1 (https=)
DE (1) DE602004024988D1 (https=)
ES (1) ES2338557T3 (https=)
MX (1) MXPA05013349A (https=)
PL (1) PL1635835T3 (https=)
PT (1) PT1635835E (https=)
WO (1) WO2004110452A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512448A (ja) * 2004-09-09 2008-04-24 ナトコ ファーマ リミテッド ｂｃｒ−ａｂｌキナーゼの阻害剤としての新規フェニルアミノピリミジン誘導体
JP2010526151A (ja) * 2007-05-04 2010-07-29 アイアールエム・リミテッド・ライアビリティ・カンパニー ｃ−ｋｉｔおよびＰＤＧＦＲキナーゼインヒビターとしての化合物および組成物
JP2010529131A (ja) * 2007-06-07 2010-08-26 イントラ−セルラー・セラピーズ・インコーポレイテッド 新規ヘテロ環化合物およびその使用
JP2011513379A (ja) * 2008-03-04 2011-04-28 ナトコ ファーマ リミテッド 中間体、およびその中間体を用いる（３−トリフルオロメチルスルホニル）−ｎ−［４−メチル−３−（４−ピリジン−３イル−ピリミジン−２イルアミノ）−フェニル］ベンズアミドの調製方法
JP2013510876A (ja) * 2009-11-13 2013-03-28 ジェノスコ キナーゼ阻害剤
JP2018513868A (ja) * 2015-04-23 2018-05-31 インヒビカーセ セラピューティクス，インコーポレーテッド キナーゼを阻害する組成物及び方法

Families Citing this family (40)

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US8735415B2 (en) 2004-09-09 2014-05-27 Natco Pharma Limited Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
CN1972917B (zh) * 2004-12-31 2010-08-25 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
CN1939910A (zh) 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
CN101160131A (zh) * 2005-02-25 2008-04-09 诺瓦提斯公司 Bcr-abl和raf抑制剂的药物组合产品
KR100674813B1 (ko) * 2005-08-05 2007-01-29 일양약품주식회사 Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
KR20080110998A (ko) * 2006-01-30 2008-12-22 엑셀리시스, 인코포레이티드 Ｊａｋ­２ 조절자로서 ４­아릴­２­아미노­피리미딘 또는 4­아릴­２­아미노알킬­피리미딘 및 이들을 포함하는 약제학적 조성물
US20100216791A1 (en) * 2006-08-17 2010-08-26 Astrazeneca Pyridinylquinazolinamine derivatives and their use as b-raf inhibitors
BRPI0718812A2 (pt) 2006-11-16 2013-12-03 Italiana Sint Spa Processo para a preparação de imatinib e intermediários deste
ES2607794T3 (es) * 2007-06-07 2017-04-04 Intra-Cellular Therapies, Inc. Compuestos heterocíclicos novedosos y usos de los mismos
AU2008337286B2 (en) 2007-12-19 2014-08-07 Cancer Research Technology Limited Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
PE20091561A1 (es) * 2008-02-29 2009-10-30 Array Biopharma Inc Compuestos inhibidores de raf y metodos para su uso
JP2011513331A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド ピラゾール［３，４−ｂ］ピリジンＲＡＦ阻害剤
JP2011513332A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド 癌の治療のためのｒａｆ阻害剤としてのｎ−（６−アミノピリジン−３−イル）−３−（スルホンアミド）ベンズアミド誘導体
ES2392482T3 (es) * 2008-02-29 2012-12-11 Array Biopharma, Inc. Derivados de imidazo[4,5-b] piridina usados como inhibidores de RAF
US8067422B2 (en) 2008-03-04 2011-11-29 Natco Pharma Limited Crystal form of phenylamino pyrimidine derivatives
US8513242B2 (en) 2008-12-12 2013-08-20 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
WO2010100127A1 (en) 2009-03-04 2010-09-10 Novartis Ag Disubstituted imidazole derivatives as modulators of raf kinase
SG178279A1 (en) 2009-08-05 2012-03-29 Intra Cellular Therapies Inc Novel regulatory proteins and inhibitors
NZ601085A (en) 2010-02-01 2015-04-24 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
EP2569288A2 (en) * 2010-05-11 2013-03-20 Krisani Biosciences (P) Ltd. 4,6-dibenzoylamino-2-methyl-pyrimidine derivatives and their use for the treatment of cancer
US8334292B1 (en) 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
US8551479B2 (en) * 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
CA2818544A1 (en) * 2010-11-19 2012-05-24 Glaxosmithkline Intellectual Property (No.2) Limited Method of treatment with braf inhibitor
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
CN108586439A (zh) * 2018-06-03 2018-09-28 刘思良 一种Raf激酶抑制剂及其在癌症治疗中的应用
CN108864060A (zh) * 2018-06-03 2018-11-23 刘思良 一种重氮类衍生物及其在癌症治疗中的应用
CN108484587A (zh) * 2018-06-03 2018-09-04 刘思良 一种Raf激酶抑制剂及其在癌症治疗中的应用
CN108610336A (zh) * 2018-06-03 2018-10-02 刘思良 一种重氮类衍生物及其在癌症治疗中的应用
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
TW202115024A (zh) 2019-08-14 2021-04-16 美商英塞特公司 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
AU2020364007A1 (en) 2019-10-11 2022-04-28 Incyte Corporation Bicyclic amines as CDK2 inhibitors
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
IL314582A (en) * 2022-02-03 2024-09-01 Nexys Therapeutics Inc Aryl hydrocarbon receptor agonists and uses thereof

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JPH0687834A (ja) * 1992-04-03 1994-03-29 Ciba Geigy Ag ピリミジン誘導体及びその製法
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
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WO2002022597A1 (en) * 2000-09-13 2002-03-21 Novartis Ag N-phenyl-2-pyrimidine-amine derivatives
WO2002093164A2 (en) * 2001-05-16 2002-11-21 Axxima Pharmaceuticals Ag Pyridylpyrimidine derivatives as effective compounds against prion diseases
WO2004002963A1 (ja) * 2002-06-28 2004-01-08 Nippon Shinyaku Co., Ltd. アミド誘導体及び医薬
WO2004060305A2 (en) * 2002-12-31 2004-07-22 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
WO2004074502A2 (en) * 2003-02-18 2004-09-02 Cipla Ltd A process of preparing imatinib

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JPH0687834A (ja) * 1992-04-03 1994-03-29 Ciba Geigy Ag ピリミジン誘導体及びその製法
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
WO2001027089A1 (en) * 1999-10-13 2001-04-19 Astrazeneca Ab Pyrimidine derivatives
WO2002022597A1 (en) * 2000-09-13 2002-03-21 Novartis Ag N-phenyl-2-pyrimidine-amine derivatives
WO2002093164A2 (en) * 2001-05-16 2002-11-21 Axxima Pharmaceuticals Ag Pyridylpyrimidine derivatives as effective compounds against prion diseases
WO2004002963A1 (ja) * 2002-06-28 2004-01-08 Nippon Shinyaku Co., Ltd. アミド誘導体及び医薬
WO2004060305A2 (en) * 2002-12-31 2004-07-22 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
WO2004074502A2 (en) * 2003-02-18 2004-09-02 Cipla Ltd A process of preparing imatinib

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512448A (ja) * 2004-09-09 2008-04-24 ナトコ ファーマ リミテッド ｂｃｒ−ａｂｌキナーゼの阻害剤としての新規フェニルアミノピリミジン誘導体
JP2010526151A (ja) * 2007-05-04 2010-07-29 アイアールエム・リミテッド・ライアビリティ・カンパニー ｃ−ｋｉｔおよびＰＤＧＦＲキナーゼインヒビターとしての化合物および組成物
JP2010529131A (ja) * 2007-06-07 2010-08-26 イントラ−セルラー・セラピーズ・インコーポレイテッド 新規ヘテロ環化合物およびその使用
JP2015007075A (ja) * 2007-06-07 2015-01-15 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規ヘテロ環化合物およびその使用
JP2011513379A (ja) * 2008-03-04 2011-04-28 ナトコ ファーマ リミテッド 中間体、およびその中間体を用いる（３−トリフルオロメチルスルホニル）−ｎ−［４−メチル−３−（４−ピリジン−３イル−ピリミジン−２イルアミノ）−フェニル］ベンズアミドの調製方法
JP2013510876A (ja) * 2009-11-13 2013-03-28 ジェノスコ キナーゼ阻害剤
JP2018513868A (ja) * 2015-04-23 2018-05-31 インヒビカーセ セラピューティクス，インコーポレーテッド キナーゼを阻害する組成物及び方法

Also Published As

Publication number Publication date
AU2004246800A1 (en) 2004-12-23
CN1805748A (zh) 2006-07-19
ATE454152T1 (de) 2010-01-15
BRPI0411365A (pt) 2006-07-25
PL1635835T3 (pl) 2010-06-30
DE602004024988D1 (de) 2010-02-25
EP1635835B1 (en) 2010-01-06
US20060293340A1 (en) 2006-12-28
CN1805748B (zh) 2010-05-26
WO2004110452A1 (en) 2004-12-23
PT1635835E (pt) 2010-03-17
EP1635835A1 (en) 2006-03-22
AU2004246800B2 (en) 2008-12-04
MXPA05013349A (es) 2006-03-09
ES2338557T3 (es) 2010-05-10
CA2529090A1 (en) 2004-12-23

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