JP2006526025A5 - - Google Patents

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JP2006526025A5
JP2006526025A5 JP2006514998A JP2006514998A JP2006526025A5 JP 2006526025 A5 JP2006526025 A5 JP 2006526025A5 JP 2006514998 A JP2006514998 A JP 2006514998A JP 2006514998 A JP2006514998 A JP 2006514998A JP 2006526025 A5 JP2006526025 A5 JP 2006526025A5
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disease
compound
infection
och
pharmaceutical product
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JP2006514998A
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JP2006526025A (ja
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Priority claimed from PCT/US2004/016831 external-priority patent/WO2005030120A2/en
Publication of JP2006526025A publication Critical patent/JP2006526025A/ja
Publication of JP2006526025A5 publication Critical patent/JP2006526025A5/ja
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JP2006514998A 2003-05-28 2004-05-28 抗血管新生剤 Withdrawn JP2006526025A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47428803P 2003-05-28 2003-05-28
PCT/US2004/016831 WO2005030120A2 (en) 2003-05-28 2004-05-28 Antiangiogenic agents

Publications (2)

Publication Number Publication Date
JP2006526025A JP2006526025A (ja) 2006-11-16
JP2006526025A5 true JP2006526025A5 (https=) 2007-07-26

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JP2006514998A Withdrawn JP2006526025A (ja) 2003-05-28 2004-05-28 抗血管新生剤

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US (3) US7371741B2 (https=)
EP (1) EP1633367A2 (https=)
JP (1) JP2006526025A (https=)
AU (1) AU2004275693A1 (https=)
CA (1) CA2527074A1 (https=)
WO (1) WO2005030120A2 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214807A1 (en) * 1993-08-06 2004-10-28 D'amato Robert J. Estrogenic compounds as anti-mitotic agents
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US7135581B2 (en) * 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
JP2006526025A (ja) * 2003-05-28 2006-11-16 エントレメッド インコーポレイテッド 抗血管新生剤
CA2558036A1 (en) * 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
US20070004689A1 (en) * 2004-03-12 2007-01-04 Agoston Gregory E Antiangiogenic agents
US7498322B2 (en) * 2004-03-12 2009-03-03 Entremed, Inc. Antiangiogenic agents
WO2006058298A2 (en) * 2004-11-29 2006-06-01 Entremed, Inc. A method of administering anti-angiogenic agents and a method of treating disease using same
US20060264413A1 (en) 2005-04-18 2006-11-23 Sri International Method and composition for inhibiting cell proliferation and angiogenesis
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20070185069A1 (en) * 2005-11-14 2007-08-09 Plum Stacy M Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
WO2007109312A2 (en) * 2006-03-20 2007-09-27 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
US20080234243A1 (en) * 2007-01-31 2008-09-25 Lavallee Theresa M Method of treating amyloidosis mediated diseases
EP2170402B1 (en) * 2007-06-26 2015-03-25 Children's Medical Center Corporation Metap-2 inhibitor polymersomes for therapeutic administration
CZ2008275A3 (cs) * 2008-05-05 2009-05-06 Prírodovedecká Fakulta Uk Ligandy estrogenových receptoru alfa a beta, zpusob jejich prípravy a farmaceutické prostredky, které je obsahují
EP2334686B1 (en) 2008-08-28 2019-02-27 President and Fellows of Harvard College Cortistatin analogues and syntheses therof
WO2010123545A2 (en) * 2009-04-22 2010-10-28 President And Fellows Of Harvard College Angiogenesis inhibitors
AU2011242988B2 (en) * 2010-04-19 2013-02-07 Sri International Compositions and method for the treatment of multiple myeloma
FR2975008B1 (fr) * 2011-05-13 2014-03-07 Inst Biophytis Utilisation de composes et composition pour le traitement de la degenerescence maculaire liee a l'age (dmla)
SG11201605178WA (en) 2013-12-24 2016-07-28 Harvard College Cortistatin analogues and syntheses and uses thereof
WO2016182932A1 (en) 2015-05-08 2016-11-17 President And Fellows Of Harvard College Cortistatin analogues, syntheses, and uses thereof
WO2017004411A1 (en) 2015-07-01 2017-01-05 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
KR102914830B1 (ko) * 2019-10-15 2026-01-19 재단법인 한국파스퇴르연구소 2-메톡시에스트라디올 유도체 및 이들의 의약 용도
CN111041062B (zh) * 2019-12-19 2021-11-16 山东赛托生物科技股份有限公司 一种甾体化合物的制备方法

Family Cites Families (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US596245A (en) * 1897-12-28 Hinge for ink-well caps
US2584271A (en) * 1948-06-19 1952-02-05 Searle & Co Steroid derivatives and method for producing the same
GB857080A (en) 1956-05-29 1960-12-29 Syntex Sa Cyclopentanophenanthrene derivatives and process for the production thereof
US3166577A (en) * 1956-05-29 1965-01-19 Syntex Corp 1, 2-dimethyl estrogens and intermediates used in the production thereof
GB857081A (en) 1956-05-29 1960-12-29 Syntex Sa Cyclopentanophenanthrene derivatives and process for the production thereof
US2846453A (en) * 1957-05-28 1958-08-05 Searle & Co Alpha-ring-acylated estrone derivatives, and corresponding alcohols, their esters, and ethers
DE1907330U (de) 1964-04-13 1964-12-23 Standard Elektrik Lorenz Ag Maschine zum einfuehren von einlagen in briefumschlaege.
US3562260A (en) * 1965-08-23 1971-02-09 Ormonoterapia Richter Spa 2-carbonyl-estratrienes and method of their preparation
US3470218A (en) * 1966-12-27 1969-09-30 Allied Chem New 2-substituted estrogenic steroids
US3410879A (en) * 1967-04-12 1968-11-12 American Home Prod Process for preparing gonahexaenes
US3492321A (en) * 1968-01-22 1970-01-27 Syntex Corp Cyclopropenyl estra, -1,3,5(10)-trienes
US3496272A (en) * 1968-01-23 1970-02-17 American Home Prod Ester of 3-(2-propynyloxy)-estradiol
DE2004516A1 (en) 1969-03-05 1970-09-10 VEB Jenapharm, Jena Thermpentic steroidal sulphonate esters
GB1502635A (en) * 1974-02-27 1978-03-01 Schering Ag Process for splitting steroid ethers
JPS5265259A (en) 1975-11-27 1977-05-30 Takeda Chem Ind Ltd Synthesis of 16beta-alkylestradiol or its 17-esters
NL7613248A (nl) * 1976-11-26 1978-05-30 Akzo Nv Werkwijze voor het bereiden van nieuwe steroid- esters.
US4172132A (en) * 1977-07-26 1979-10-23 Schering Corporation 1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
DE2757157C3 (de) 1977-12-19 1980-10-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 16 a -alkylierten Steroiden
FR2515188A1 (fr) * 1981-10-27 1983-04-29 Roussel Uclaf Nouveaux derives du 3-amino-pregn-5-ene, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
JPS58131978U (ja) 1982-03-01 1983-09-06 日産自動車株式会社 空気噴射式織機の緯糸の案内通路を有する筬
US5001116A (en) * 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) * 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
JPS60126096A (ja) 1983-12-12 1985-07-05 Olympus Optical Co Ltd フロ−インジエクシヨン分析方法
US4552758A (en) * 1983-12-20 1985-11-12 St. Jude Children's Research Hospital Human use of avian-human reassortants as vaccines for influenza A virus
US4522758A (en) * 1983-12-22 1985-06-11 Eli Lilly And Company Method of preparing 2-fluoro-17β-estradiol
EP0166937B1 (en) 1984-06-06 1991-08-28 Abbott Laboratories Adrenergic compounds
US4634705A (en) * 1984-06-06 1987-01-06 Abbott Laboratories Adrenergic amidines
SU1240038A1 (ru) 1984-11-23 1996-10-27 Уральский политехнический институт им.С.М.Кирова 3-оксиэстра-1,3,5-триен-17-гидразон, обладающий гормональной и противоопухолевой активностью
WO1987002367A2 (en) 1985-10-18 1987-04-23 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
JPS62135472A (ja) 1985-12-10 1987-06-18 Yakult Honsha Co Ltd 新規な１，２−ビス−３，５−ジオキソピペラジニルエタン誘導体
US4743597A (en) * 1986-01-27 1988-05-10 Javitt Norman B Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases
DE3625315A1 (de) 1986-07-25 1988-01-28 Schering Ag 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
JP2517561B2 (ja) 1986-10-03 1996-07-24 新技術事業団 カテコ−ルエストロゲンのイムノアツセイキツド
US5352664A (en) 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
JPS63119500U (https=) 1987-01-30 1988-08-02
EP0356454B1 (en) 1987-04-16 1992-06-17 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US4808402A (en) * 1987-05-29 1989-02-28 Northwestern University Method and compositions for modulating neovascularization
US5135919A (en) * 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
EP0477195A1 (en) 1989-06-16 1992-04-01 The Upjohn Company Suramin type compounds and angiostatic steroids to inhibit angiogenesis
IT1247827B (it) 1991-02-05 1995-01-02 Erba Carlo Spa Benzoil carbinolo e suoi esteri, utili come inibitori dell'angiogenesi
WO1993003729A1 (en) 1991-08-12 1993-03-04 Research Corporation Technologies, Inc. N-substituted phenoxazines for treating multidrug resistant cancer cells
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
EP0619738B1 (en) 1991-12-02 2003-07-09 Millennium Pharmaceuticals, Inc. Inhibitory immunoglobulin polypeptides to human pdgf beta receptor
GB9207437D0 (en) 1992-04-03 1992-05-20 Orion Yhtymae Oy Topical administration of toremifene and its metabolites
DE4235657A1 (de) * 1992-10-22 1994-06-23 Schering Ag Verfahren zum Alkylieren von Östronderivaten
US5629340A (en) * 1993-01-11 1997-05-13 Tsumura & Co. Angiogenesis inhibitor and novel compound
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
ES2204919T3 (es) * 1993-05-27 2004-05-01 Entremed, Inc. Composiciones y procedimientos de tratamiento del cancer y de enfermedades hiperproliferativas.
US5643900A (en) * 1993-07-02 1997-07-01 Fotsis; Theodore Method for treatment of pathological conditions associated with angiogenesis and preparation therefor
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US20040214807A1 (en) * 1993-08-06 2004-10-28 D'amato Robert J. Estrogenic compounds as anti-mitotic agents
US6908910B2 (en) * 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
EP0657175B1 (en) 1993-12-09 2005-03-02 Centro de Inmunologia Molecular Vaccine comprising human autologous epidermal growth factor and use thereof
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
US5837682A (en) * 1996-03-08 1998-11-17 The Children's Medical Center Corporation Angiostatin fragments and method of use
US5639725A (en) * 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
HUT76095A (en) * 1994-04-26 1997-06-30 Childrens Medical Center Angiostatin and method of use for inhibition of angiogenesis
US5521168A (en) * 1994-10-13 1996-05-28 Alcon Laboratories, Inc. Estrogen metabolites for lowering intraocular pressure
US5861372A (en) 1996-02-22 1999-01-19 The Children's Medical Center Corporation Aggregate angiostatin and method of use
US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US5854205A (en) * 1995-10-23 1998-12-29 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods
US5854221A (en) * 1996-12-12 1998-12-29 The Children's Medical Center Corporation Endothelial cell proliferation inhibitor and method of use
EP0888310B1 (en) * 1996-03-15 2005-09-07 AstraZeneca AB Cinnoline derivatives and use as medicine
US5962445A (en) 1996-05-09 1999-10-05 Amrad Operations Pty Ltd. Treatment of asthma and airway diseases
JPH09316000A (ja) 1996-05-31 1997-12-09 Toagosei Co Ltd 血管新生抑制用ワクチン
US5958892A (en) * 1996-07-30 1999-09-28 Board Of Regents, The University Of Texas System 2-methoxyestradiol-induced apoptosis in cancer cells
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
US6051726A (en) 1997-03-13 2000-04-18 Pharm-Eco Laboratories, Inc. Synthesis of 2-alkoxyestradiols
US6136992A (en) * 1997-03-13 2000-10-24 The United States Of America As Represented By The Department Of Health And Human Services 2-alkoxy estradiols and derivatives thereof
CA2208916A1 (en) 1997-07-03 1999-01-03 Hyal Pharmaceutical Corporation Promotion of wound healing utilizing steroids having reduced deterioroussystemic side effects typical of glucocorticoids, mineralocorticoids andsex steroids
US6011023A (en) * 1997-08-27 2000-01-04 Alcon Laboratories, Inc. Angiostatic steroids
US20020002294A1 (en) 1997-09-24 2002-01-03 D' Amato Robert J. Estrogenic compounds as antiangiogenic agents
US6576660B1 (en) 1997-10-31 2003-06-10 Arch Development Corporation Methods and compositions for regulation of 5-α-reductase activity
US6054446A (en) 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
JPH11209322A (ja) 1998-01-27 1999-08-03 Kao Corp イソバニリルアルコール誘導体
CA2310252A1 (en) 1998-03-06 1999-09-10 Imclone Systems Incorporated Active immunization against angiogenesis-associated antigens
KR20010043558A (ko) * 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US6413513B1 (en) * 1998-05-22 2002-07-02 Entremed, Inc. Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using cancer markers
AR021757A1 (es) 1998-08-07 2002-08-07 Endorech Inc Metodo para inhibir la conversion de 4-androstan-3,17-diona en testosterona o de 3alfa-androstan-3,17-diona en dihidrotestosterona, inhibir la actividadde la 3alfa-hidroxiesteroide deshidrogenasa de tipo 3 humana, para determinar la eficacia de un inhibidor putativo de la conversion de 4-androsten-3
ATE284682T1 (de) * 1998-08-11 2005-01-15 Entremed Inc Verwendung von 2-methoxyestradiol als fungizide
WO2000010552A2 (en) 1998-08-24 2000-03-02 Global Vascular Concepts, Inc. Use of anti-angiogenic agents for inhibiting vessel wall injury
US6284789B1 (en) * 1998-09-04 2001-09-04 The Research Foundation Of State University Of New York Formation and composition of new optically active compounds
WO2000025780A1 (en) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
US20060025393A1 (en) * 1999-04-30 2006-02-02 Shutsung Liao Steroid derivatives
AU783910B2 (en) 1999-04-30 2005-12-22 Sterix Limited Use of estrone derivatives as antitumour agents
GB9910934D0 (en) 1999-05-11 1999-07-14 Res Inst Medicine Chem Chemical compounds
US6730665B1 (en) * 1999-05-12 2004-05-04 Mayo Foundation For Medical Education And Research Treatment of bone cancer
US7087592B1 (en) 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
US6358940B1 (en) * 1999-09-07 2002-03-19 Rutgers, The State University Modified 2-Alkoxyestradiol derivatives with prolonged pharmacological activity
AUPQ342599A0 (en) 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof
US20020068724A1 (en) * 2000-03-17 2002-06-06 Oncology Sciences Corporation Method and composition of novel compounds for the therapy and targeting of the primary modalities of cancer cell proliferation and homeostasis
US20030027803A1 (en) * 2000-03-17 2003-02-06 Oncology Sciences Corporation Method and composition for inhibiting the incidence and proliferation of nervous system and brain cancer cells
US20020035098A1 (en) * 2000-03-17 2002-03-21 Oncology Sciences Corporation Agents and methods for the prevention of initial onset and recurrence of existing cancers
AU5523701A (en) * 2000-04-06 2001-10-23 Wayne P Franco Methods of using growth factors for treating heart disease
US6953785B2 (en) * 2000-04-24 2005-10-11 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives
CN100338088C (zh) 2000-05-11 2007-09-19 医学与化学研究所 2－取代的孕－1,3,5(10)－三烯和胆－1,3,5(10)－三烯衍生物及其生物活性
AU2001279955A1 (en) * 2000-08-18 2002-03-04 Sterix Limited 2-substituted estradiol derivative for inhibiting superoxid dismutase
US6995278B2 (en) 2000-08-18 2006-02-07 Entre Med, Inc. Antiangiogenic agents
US20050192258A1 (en) 2000-08-18 2005-09-01 Agoston Gregory E. Antiangiogenic agents
US7135581B2 (en) 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
WO2002062347A1 (en) * 2001-02-05 2002-08-15 Oncology Sciences Corporation Method and composition of novel compounds for the therapy and targeting of the primary modalities of cancer cell proliferation and homeostasis
US20040116397A1 (en) * 2001-03-19 2004-06-17 Slaga Tom J Agents and methods for the prevention of initial onset of cancers, the treatment of cancers, and the recurrence of existing cancers
DK1390040T3 (da) * 2001-05-18 2007-04-23 Pantarhei Bioscience Bv Farmaceutisk præparat til anvendelse i hormonerstatningsterapi
EP1260225A1 (en) * 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
WO2002100877A1 (en) * 2001-06-11 2002-12-19 Southwest Foundation For Biomedical Research Novel 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity
US6448419B1 (en) * 2001-08-07 2002-09-10 Tetrionics, Inc. Synthesis of 2-hydroxyestradiol derivatives
US6998395B2 (en) * 2001-08-17 2006-02-14 University Of Pittsburg, Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders
DE60216630T2 (de) * 2001-11-15 2007-09-20 Pantarhei Bioscience B.V. Verwendung von östrogen in kombination mit progestogen für die hormonsubstitutiionstherapie
US20030175961A1 (en) * 2002-02-26 2003-09-18 Herron G. Scott Immortal micorvascular endothelial cells and uses thereof
US20040082558A1 (en) * 2002-08-02 2004-04-29 Tofovic Stevan P. Administration of estradiol metabolites for inhibition of drug-induced nephrotoxicity
CA2516452A1 (en) * 2003-02-20 2004-09-02 University Of Pittsburgh Estradiol metabolites for the treatment of pulmonary hypertension
US20050148565A1 (en) * 2003-04-29 2005-07-07 Cooperwood John S. Use of aminoalkyloxy derivatives of 1,3,5(10)-Estratrien and -Estratetraene steroids in the treatment of breast cancer
US7687486B2 (en) * 2003-04-29 2010-03-30 Florida Agricultural & Mechanical University Selective estrogen receptor modulators
JP2006528207A (ja) 2003-05-13 2006-12-14 クリプトファーマ ピーティーワイ リミテッド エストラトリエン誘導体
JP2006526025A (ja) * 2003-05-28 2006-11-16 エントレメッド インコーポレイテッド 抗血管新生剤
US7498322B2 (en) 2004-03-12 2009-03-03 Entremed, Inc. Antiangiogenic agents
US20070004689A1 (en) 2004-03-12 2007-01-04 Agoston Gregory E Antiangiogenic agents
WO2006058298A2 (en) 2004-11-29 2006-06-01 Entremed, Inc. A method of administering anti-angiogenic agents and a method of treating disease using same

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