JP2002514578A5 - - Google Patents
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- JP2002514578A5 JP2002514578A5 JP2000547948A JP2000547948A JP2002514578A5 JP 2002514578 A5 JP2002514578 A5 JP 2002514578A5 JP 2000547948 A JP2000547948 A JP 2000547948A JP 2000547948 A JP2000547948 A JP 2000547948A JP 2002514578 A5 JP2002514578 A5 JP 2002514578A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- acid
- phthalimidinoglutaric
- pharmaceutical composition
- phthalimidinoglutaric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 17
- 239000008194 pharmaceutical composition Substances 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 230000033115 angiogenesis Effects 0.000 description 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
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- 230000000699 topical effect Effects 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- NQHKBLCGDONZQI-AWEZNQCLSA-N (2S)-2-[(2-carboxybenzoyl)amino]-2-methylpentanedioic acid Chemical compound C[C@](NC(C=1C(C(=O)O)=CC=CC=1)=O)(CCC(=O)O)C(=O)O NQHKBLCGDONZQI-AWEZNQCLSA-N 0.000 description 2
- 229910004373 HOAc Inorganic materials 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 206010038933 Retinopathy of prematurity Diseases 0.000 description 2
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- QHSCIWIRXWFIGH-UHFFFAOYSA-N 2-amino-2-methylpentanedioic acid Chemical compound OC(=O)C(N)(C)CCC(O)=O QHSCIWIRXWFIGH-UHFFFAOYSA-N 0.000 description 1
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- 0 CC(CC*)(C(O)=O)N(Cc1c2cccc1)C2=O Chemical compound CC(CC*)(C(O)=O)N(Cc1c2cccc1)C2=O 0.000 description 1
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- 206010029260 Neuroblastoma Diseases 0.000 description 1
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- 208000027868 Paget disease Diseases 0.000 description 1
- 206010034277 Pemphigoid Diseases 0.000 description 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 1
- 208000003971 Posterior uveitis Diseases 0.000 description 1
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 description 1
- 208000010362 Protozoan Infections Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 201000002154 Pterygium Diseases 0.000 description 1
- 206010038848 Retinal detachment Diseases 0.000 description 1
- 206010038910 Retinitis Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 206010038934 Retinopathy proliferative Diseases 0.000 description 1
- 206010039705 Scleritis Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 208000027073 Stargardt disease Diseases 0.000 description 1
- 201000005485 Toxoplasmosis Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 206010058990 Venous occlusion Diseases 0.000 description 1
- 208000010011 Vitamin A Deficiency Diseases 0.000 description 1
- 206010047663 Vitritis Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 208000021328 arterial occlusion Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 206010004145 bartonellosis Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 208000021373 epidemic keratoconjunctivitis Diseases 0.000 description 1
- 230000001497 fibrovascular Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 208000013653 hyalitis Diseases 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 201000001371 inclusion conjunctivitis Diseases 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 230000002197 limbic effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 208000027202 mammary Paget disease Diseases 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 201000003142 neovascular glaucoma Diseases 0.000 description 1
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
- 230000006785 proliferative vitreoretinopathy Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004264 retinal detachment Effects 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
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- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
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- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 201000007790 vitelliform macular dystrophy Diseases 0.000 description 1
- 208000020938 vitelliform macular dystrophy 2 Diseases 0.000 description 1
Images
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8503798P | 1998-05-11 | 1998-05-11 | |
| US9738498P | 1998-08-21 | 1998-08-21 | |
| US10803798P | 1998-11-12 | 1998-11-12 | |
| US60/085,037 | 1998-11-12 | ||
| US60/097,384 | 1998-11-12 | ||
| US60/108,037 | 1998-11-12 | ||
| PCT/US1999/010287 WO1999058096A2 (en) | 1998-05-11 | 1999-05-11 | Analogs of 2-phthalimidinoglutaric acid and their use as inhibitors of angiogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002514578A JP2002514578A (ja) | 2002-05-21 |
| JP2002514578A5 true JP2002514578A5 (https=) | 2006-05-18 |
Family
ID=27374997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547948A Pending JP2002514578A (ja) | 1998-05-11 | 1999-05-11 | 2−フタルイミジノグルタル酸の類似体および血管新生の阻害剤としてのそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1091726A2 (https=) |
| JP (1) | JP2002514578A (https=) |
| KR (1) | KR100699968B1 (https=) |
| AU (1) | AU749356B2 (https=) |
| CA (1) | CA2331461C (https=) |
| WO (1) | WO1999058096A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7182953B2 (en) * | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
| AU2002306596B2 (en) | 2001-02-27 | 2008-01-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
| CN1731997A (zh) * | 2002-10-31 | 2006-02-08 | 细胞基因公司 | 使用包含选择性细胞因子抑制药物的组合物治疗和控制黄斑变性的方法 |
| US7776907B2 (en) | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
| US8952895B2 (en) | 2011-06-03 | 2015-02-10 | Apple Inc. | Motion-based device operations |
| CN1867331B (zh) | 2003-09-17 | 2010-05-26 | 美国政府健康及人类服务部 | 作为TNF-α调节剂的沙利度胺类似物 |
| US8927725B2 (en) | 2011-12-02 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
| CN102603610B (zh) * | 2012-02-21 | 2014-07-09 | 四川大学 | 1,3-二氢-1-氧-2h-异吲哚类化合物、其制备方法和用途 |
| CN104045594B (zh) * | 2012-02-21 | 2016-08-17 | 四川大学 | 一类1,3-二氢-1-氧-2h-异吲哚类化合物及其用途 |
| US9617212B2 (en) | 2013-12-17 | 2017-04-11 | Controlled Chemicals, Inc. | Isoindolin-1-ones as macrophage migration inhibitory factor (MIF) inhibitors |
| CN109467550B (zh) * | 2017-12-31 | 2022-02-18 | 苏州亚科科技股份有限公司 | 一种邻苯二甲酰胺基-l-谷氨酸酐的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| DE4422237A1 (de) * | 1994-06-24 | 1996-01-04 | Gruenenthal Gmbh | Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe |
-
1999
- 1999-05-11 WO PCT/US1999/010287 patent/WO1999058096A2/en not_active Ceased
- 1999-05-11 CA CA002331461A patent/CA2331461C/en not_active Expired - Fee Related
- 1999-05-11 JP JP2000547948A patent/JP2002514578A/ja active Pending
- 1999-05-11 EP EP99925585A patent/EP1091726A2/en not_active Withdrawn
- 1999-05-11 KR KR1020007012550A patent/KR100699968B1/ko not_active Expired - Fee Related
- 1999-05-11 AU AU41837/99A patent/AU749356B2/en not_active Ceased
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