JP2006524636A5 - - Google Patents
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- Publication number
- JP2006524636A5 JP2006524636A5 JP2006500346A JP2006500346A JP2006524636A5 JP 2006524636 A5 JP2006524636 A5 JP 2006524636A5 JP 2006500346 A JP2006500346 A JP 2006500346A JP 2006500346 A JP2006500346 A JP 2006500346A JP 2006524636 A5 JP2006524636 A5 JP 2006524636A5
- Authority
- JP
- Japan
- Prior art keywords
- nme
- nhme
- nhco
- halo
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- -1 hydroxy, methoxy Chemical group 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0309780 | 2003-04-29 | ||
| GBGB0327748.0A GB0327748D0 (en) | 2003-11-28 | 2003-11-28 | Novel pharmaceuticals |
| PCT/IB2004/001433 WO2004096810A1 (en) | 2003-04-29 | 2004-04-22 | 5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007067736A Division JP2007217419A (ja) | 2003-04-29 | 2007-03-16 | 高血圧症の治療に有用な５，７−ジアミノピラゾロ４，３−ジピリミジン類 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006524636A JP2006524636A (ja) | 2006-11-02 |
| JP2006524636A5 true JP2006524636A5 (https=) | 2007-09-27 |
| JP4015176B2 JP4015176B2 (ja) | 2007-11-28 |
Family
ID=33420887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500346A Expired - Fee Related JP4015176B2 (ja) | 2003-04-29 | 2004-04-22 | 高血圧症の治療に有用な５，７−ジアミノピラゾロ４，３−ジピリミジン類 |
| JP2007067736A Pending JP2007217419A (ja) | 2003-04-29 | 2007-03-16 | 高血圧症の治療に有用な５，７−ジアミノピラゾロ４，３−ジピリミジン類 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007067736A Pending JP2007217419A (ja) | 2003-04-29 | 2007-03-16 | 高血圧症の治療に有用な５，７−ジアミノピラゾロ４，３−ジピリミジン類 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7262192B2 (https=) |
| EP (1) | EP1620437B1 (https=) |
| JP (2) | JP4015176B2 (https=) |
| KR (1) | KR100824193B1 (https=) |
| AR (1) | AR044116A1 (https=) |
| AT (1) | ATE433978T1 (https=) |
| AU (1) | AU2004234158B2 (https=) |
| BR (1) | BRPI0409903A (https=) |
| CA (1) | CA2523831C (https=) |
| CL (1) | CL2004000889A1 (https=) |
| CO (1) | CO5640118A2 (https=) |
| CR (1) | CR8051A (https=) |
| DE (1) | DE602004021585D1 (https=) |
| DK (1) | DK1620437T3 (https=) |
| EA (1) | EA008596B1 (https=) |
| EC (1) | ECSP056130A (https=) |
| ES (1) | ES2326119T3 (https=) |
| GE (1) | GEP20084329B (https=) |
| IS (1) | IS8009A (https=) |
| MA (1) | MA27771A1 (https=) |
| MX (1) | MXPA05011643A (https=) |
| NL (1) | NL1026074C2 (https=) |
| NO (1) | NO333850B1 (https=) |
| NZ (1) | NZ542097A (https=) |
| OA (1) | OA13050A (https=) |
| PA (1) | PA8601701A1 (https=) |
| PE (1) | PE20050462A1 (https=) |
| RS (1) | RS20050810A (https=) |
| TW (1) | TWI273908B (https=) |
| UY (1) | UY28290A1 (https=) |
| WO (1) | WO2004096810A1 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA008596B1 (ru) | 2003-04-29 | 2007-06-29 | Пфайзер Инк. | 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ |
| GB0322552D0 (en) * | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
| GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
| GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| DE602005011784D1 (de) | 2004-04-07 | 2009-01-29 | Pfizer | Pyrazoloä4,3-düpyrimidine |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| EP1807085B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| CA2580762A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| JP2008517994A (ja) * | 2004-10-28 | 2008-05-29 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 新規医薬品 |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| JP2008525422A (ja) * | 2004-12-23 | 2008-07-17 | ファイザー・プロダクツ・インク | 抗癌剤として有用な複素芳香族誘導体 |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| JP2008540335A (ja) * | 2005-04-27 | 2008-11-20 | アストラゼネカ・アクチエボラーグ | ピラゾリル・ピリミジン誘導体の疼痛治療における使用 |
| AP2007004219A0 (en) * | 2005-05-12 | 2007-10-31 | Pfizer | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-YL-amino)-1H-pyrazolo[4,3-D] pyrimidine-3-carbonyl]methanesulfonamide |
| BRPI0609225A2 (pt) * | 2005-05-12 | 2010-03-09 | Pfizer | formas cristalinas anidras de n-[1-(2-etoxietil)-5-(n-etil-n-metilamino)-7-(4-metilpiridi n-2-il-amino)-1h-pirazolo[4,3-d]pirimidina-3-carbonil] metanossulfonamida, composição farmacêutica compreendendo as mesmas e uso das mesmas |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
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| WO2009124119A2 (en) * | 2008-04-01 | 2009-10-08 | The Trustes of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
| WO2009145842A2 (en) | 2008-04-04 | 2009-12-03 | Forsight Labs, Llc | Therapeutic device for pain management and vision |
| JP2010043063A (ja) * | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
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| WO2011050327A1 (en) | 2009-10-23 | 2011-04-28 | Forsight Labs Llc | Corneal denervation for treatment of ocular pain |
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| US12044905B2 (en) | 2011-04-28 | 2024-07-23 | Journey1 Inc | Contact lenses for refractive correction |
| EA025496B1 (ru) * | 2011-05-17 | 2016-12-30 | Принсипиа Биофарма Инк. | Ингибиторы тирозинкиназы |
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| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| JO3753B1 (ar) | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه |
| CA2916885A1 (en) | 2013-06-26 | 2014-12-31 | Nexisvision, Inc. | Contact lenses for refractive correction |
| EP3055301B1 (en) * | 2013-10-07 | 2019-11-20 | Kadmon Corporation, LLC | (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases |
| PE20180187A1 (es) | 2015-03-03 | 2018-01-23 | Saniona As | Formulacion de combinacion de tesofensina y betabloqueante |
| JP6929286B2 (ja) * | 2015-12-18 | 2021-09-01 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 治療用化合物、組成物及びその使用方法 |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| UA125650C2 (uk) | 2016-09-09 | 2022-05-11 | Інсайт Корпорейшн | Регулятори нрk1 на основі похідних піразолопіридину та їх застосування для лікування раку |
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| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
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| US10864205B2 (en) | 2017-12-01 | 2020-12-15 | Innovus Pharmaceuticals, Inc. | Nutritional supplement for improving sexual health in men and women |
| US10500199B2 (en) | 2017-12-01 | 2019-12-10 | Innovus Pharmaceuticals, Inc. | Nutritional supplement for increasing cognitive functions |
| US20190167699A1 (en) | 2017-12-01 | 2019-06-06 | Innovus Pharmaceuticals, Inc. | Prostate function support formula |
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| US10800761B2 (en) | 2018-02-20 | 2020-10-13 | Incyte Corporation | Carboxamide compounds and uses thereof |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
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| US20010047013A1 (en) | 2000-03-10 | 2001-11-29 | Fengrui Lang | Process for the preparation of arylamines |
| DE10031584A1 (de) | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
| ES2231521T3 (es) | 2000-07-28 | 2005-05-16 | Pfizer Inc. | Agente terapeutico cristalino. |
| EP1176147A1 (en) | 2000-07-28 | 2002-01-30 | Pfizer Limited | Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof |
| EP1176142A1 (en) | 2000-07-28 | 2002-01-30 | Pfizer Inc. | Process for the preparation of pyrazoles |
| WO2002013798A2 (en) | 2000-08-11 | 2002-02-21 | Pfizer Limited | Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors |
| EP1341782A2 (en) | 2000-11-20 | 2003-09-10 | Scios Inc. | Inhibitors of p38 kinase |
| DE10058662A1 (de) | 2000-11-25 | 2002-05-29 | Merck Patent Gmbh | Verwendung von Pyrazolo[4,3-d]pyrimidinen |
| EP1343506A1 (de) | 2000-12-19 | 2003-09-17 | MERCK PATENT GmbH | Pharmazeutische formulierung enthaltend pyrazolo 4,3-d]pyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate |
| DE10104095A1 (de) | 2001-01-31 | 2002-08-01 | Merck Patent Gmbh | Pharmazeutische Formulierung enthaltend Pyrazolo [4,3-d]pyrimidine und Nitrate |
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| US20020127593A1 (en) | 2001-03-12 | 2002-09-12 | Regents Of The University Of California | Fluorescence assay for DNA modifying enzymes |
| GB0106631D0 (en) | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
| PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
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| EP1490015B1 (en) | 2002-03-15 | 2009-09-23 | Wayne State University | Novel 2-amino-9-((2-hydroxymethyl) cyclopropylidenemethyl) purines as antiviral agents |
| ATE478872T1 (de) * | 2002-03-28 | 2010-09-15 | Ustav Ex Botan Av Cr V V I I O | Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung |
| US7505971B2 (en) | 2002-06-28 | 2009-03-17 | Hewlett-Packard Development Company, L.P. | Shared drive that provides shared access to editable files in a database |
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-
2004
- 2004-04-22 EA EA200501333A patent/EA008596B1/ru not_active IP Right Cessation
- 2004-04-22 DK DK04728868T patent/DK1620437T3/da active
- 2004-04-22 OA OA1200500306A patent/OA13050A/en unknown
- 2004-04-22 AU AU2004234158A patent/AU2004234158B2/en not_active Ceased
- 2004-04-22 EP EP04728868A patent/EP1620437B1/en not_active Expired - Lifetime
- 2004-04-22 WO PCT/IB2004/001433 patent/WO2004096810A1/en not_active Ceased
- 2004-04-22 ES ES04728868T patent/ES2326119T3/es not_active Expired - Lifetime
- 2004-04-22 AT AT04728868T patent/ATE433978T1/de not_active IP Right Cessation
- 2004-04-22 KR KR1020057020497A patent/KR100824193B1/ko not_active Expired - Fee Related
- 2004-04-22 MX MXPA05011643A patent/MXPA05011643A/es active IP Right Grant
- 2004-04-22 DE DE602004021585T patent/DE602004021585D1/de not_active Expired - Lifetime
- 2004-04-22 BR BRPI0409903-6A patent/BRPI0409903A/pt not_active IP Right Cessation
- 2004-04-22 RS YUP-2005/0810A patent/RS20050810A/sr unknown
- 2004-04-22 JP JP2006500346A patent/JP4015176B2/ja not_active Expired - Fee Related
- 2004-04-22 GE GEAP20049033A patent/GEP20084329B/en unknown
- 2004-04-22 CA CA002523831A patent/CA2523831C/en not_active Expired - Lifetime
- 2004-04-22 NZ NZ542097A patent/NZ542097A/en unknown
- 2004-04-26 PE PE2004000411A patent/PE20050462A1/es not_active Application Discontinuation
- 2004-04-27 UY UY28290A patent/UY28290A1/es not_active Application Discontinuation
- 2004-04-27 CL CL200400889A patent/CL2004000889A1/es unknown
- 2004-04-28 TW TW093111926A patent/TWI273908B/zh not_active IP Right Cessation
- 2004-04-28 AR ARP040101440A patent/AR044116A1/es unknown
- 2004-04-28 NL NL1026074A patent/NL1026074C2/nl not_active IP Right Cessation
- 2004-04-29 PA PA20048601701A patent/PA8601701A1/es unknown
- 2004-04-29 US US10/834,484 patent/US7262192B2/en not_active Expired - Fee Related
-
2005
- 2005-08-31 IS IS8009A patent/IS8009A/is unknown
- 2005-09-22 NO NO20054404A patent/NO333850B1/no not_active IP Right Cessation
- 2005-10-20 CR CR8051A patent/CR8051A/es not_active Application Discontinuation
- 2005-10-28 CO CO05110249A patent/CO5640118A2/es not_active Application Discontinuation
- 2005-10-28 MA MA28571A patent/MA27771A1/fr unknown
- 2005-10-28 EC EC2005006130A patent/ECSP056130A/es unknown
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2007
- 2007-03-16 JP JP2007067736A patent/JP2007217419A/ja active Pending
- 2007-07-31 US US11/831,021 patent/US20070270412A1/en not_active Abandoned
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