JP2006524636A5 - - Google Patents
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- JP2006524636A5 JP2006524636A5 JP2006500346A JP2006500346A JP2006524636A5 JP 2006524636 A5 JP2006524636 A5 JP 2006524636A5 JP 2006500346 A JP2006500346 A JP 2006500346A JP 2006500346 A JP2006500346 A JP 2006500346A JP 2006524636 A5 JP2006524636 A5 JP 2006524636A5
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- JP
- Japan
- Prior art keywords
- nme
- nhme
- nhco
- halo
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- -1 hydroxy, methoxy Chemical group 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
Description
より好ましくは、R10は、ハロ、メチル、エチル、イソプロピル、ヒドロキシ、メトキシ、NH2、NHMe、NMe2、NHCO2 tBu、CO2H、CO2 tBu、オキソ、ベンジル、−CH2OH、−CH2NH2、CH2NHMe、−CH2NMe2または−CH2NMeCO2 tBuである。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0309780 | 2003-04-29 | ||
GBGB0327748.0A GB0327748D0 (en) | 2003-11-28 | 2003-11-28 | Novel pharmaceuticals |
PCT/IB2004/001433 WO2004096810A1 (en) | 2003-04-29 | 2004-04-22 | 5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007067736A Division JP2007217419A (ja) | 2003-04-29 | 2007-03-16 | 高血圧症の治療に有用な5,7−ジアミノピラゾロ4,3−ジピリミジン類 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2006524636A JP2006524636A (ja) | 2006-11-02 |
JP2006524636A5 true JP2006524636A5 (ja) | 2007-09-27 |
JP4015176B2 JP4015176B2 (ja) | 2007-11-28 |
Family
ID=33420887
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006500346A Expired - Fee Related JP4015176B2 (ja) | 2003-04-29 | 2004-04-22 | 高血圧症の治療に有用な5,7−ジアミノピラゾロ4,3−ジピリミジン類 |
JP2007067736A Pending JP2007217419A (ja) | 2003-04-29 | 2007-03-16 | 高血圧症の治療に有用な5,7−ジアミノピラゾロ4,3−ジピリミジン類 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007067736A Pending JP2007217419A (ja) | 2003-04-29 | 2007-03-16 | 高血圧症の治療に有用な5,7−ジアミノピラゾロ4,3−ジピリミジン類 |
Country Status (32)
Country | Link |
---|---|
US (2) | US7262192B2 (ja) |
EP (1) | EP1620437B1 (ja) |
JP (2) | JP4015176B2 (ja) |
KR (1) | KR100824193B1 (ja) |
AR (1) | AR044116A1 (ja) |
AT (1) | ATE433978T1 (ja) |
AU (1) | AU2004234158B2 (ja) |
BR (1) | BRPI0409903A (ja) |
CA (1) | CA2523831C (ja) |
CL (1) | CL2004000889A1 (ja) |
CO (1) | CO5640118A2 (ja) |
CR (1) | CR8051A (ja) |
DE (1) | DE602004021585D1 (ja) |
DK (1) | DK1620437T3 (ja) |
EA (1) | EA008596B1 (ja) |
EC (1) | ECSP056130A (ja) |
ES (1) | ES2326119T3 (ja) |
GE (1) | GEP20084329B (ja) |
HK (1) | HK1087108A1 (ja) |
IS (1) | IS8009A (ja) |
MA (1) | MA27771A1 (ja) |
MX (1) | MXPA05011643A (ja) |
NL (1) | NL1026074C2 (ja) |
NO (1) | NO333850B1 (ja) |
NZ (1) | NZ542097A (ja) |
OA (1) | OA13050A (ja) |
PA (1) | PA8601701A1 (ja) |
PE (1) | PE20050462A1 (ja) |
RS (1) | RS20050810A (ja) |
TW (1) | TWI273908B (ja) |
UY (1) | UY28290A1 (ja) |
WO (1) | WO2004096810A1 (ja) |
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MXPA03005393A (es) | 2000-12-19 | 2003-09-25 | Merck Patent Gmbh | Formulacion farmaceutica que contiene pirazolo (4,3-d) pirimidinas y antitromboticos, antagonistas de calcio, prostaglandinas o derivados de prostaglandina. |
DE10104095A1 (de) | 2001-01-31 | 2002-08-01 | Merck Patent Gmbh | Pharmazeutische Formulierung enthaltend Pyrazolo [4,3-d]pyrimidine und Nitrate |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
JP2002255932A (ja) | 2001-03-01 | 2002-09-11 | Katayama Seiyakushiyo:Kk | 3−アルキルアミノアゼチジンの製造方法 |
US20020127593A1 (en) | 2001-03-12 | 2002-09-12 | Regents Of The University Of California | Fluorescence assay for DNA modifying enzymes |
GB0106631D0 (en) | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
US6432957B1 (en) | 2001-06-29 | 2002-08-13 | Kowa Co., Ltd. | Piperazine derivative |
AU2003276824B8 (en) | 2002-03-15 | 2009-01-22 | The Regents Of The University Of Michigan | Novel 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents |
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-
2004
- 2004-04-22 OA OA1200500306A patent/OA13050A/en unknown
- 2004-04-22 DK DK04728868T patent/DK1620437T3/da active
- 2004-04-22 RS YUP-2005/0810A patent/RS20050810A/sr unknown
- 2004-04-22 NZ NZ542097A patent/NZ542097A/en unknown
- 2004-04-22 AT AT04728868T patent/ATE433978T1/de not_active IP Right Cessation
- 2004-04-22 WO PCT/IB2004/001433 patent/WO2004096810A1/en active Application Filing
- 2004-04-22 AU AU2004234158A patent/AU2004234158B2/en not_active Ceased
- 2004-04-22 ES ES04728868T patent/ES2326119T3/es not_active Expired - Lifetime
- 2004-04-22 KR KR1020057020497A patent/KR100824193B1/ko not_active IP Right Cessation
- 2004-04-22 GE GEAP20049033A patent/GEP20084329B/en unknown
- 2004-04-22 MX MXPA05011643A patent/MXPA05011643A/es active IP Right Grant
- 2004-04-22 JP JP2006500346A patent/JP4015176B2/ja not_active Expired - Fee Related
- 2004-04-22 EA EA200501333A patent/EA008596B1/ru not_active IP Right Cessation
- 2004-04-22 BR BRPI0409903-6A patent/BRPI0409903A/pt not_active IP Right Cessation
- 2004-04-22 EP EP04728868A patent/EP1620437B1/en not_active Expired - Lifetime
- 2004-04-22 CA CA002523831A patent/CA2523831C/en not_active Expired - Lifetime
- 2004-04-22 DE DE602004021585T patent/DE602004021585D1/de not_active Expired - Lifetime
- 2004-04-26 PE PE2004000411A patent/PE20050462A1/es not_active Application Discontinuation
- 2004-04-27 UY UY28290A patent/UY28290A1/es not_active Application Discontinuation
- 2004-04-27 CL CL200400889A patent/CL2004000889A1/es unknown
- 2004-04-28 TW TW093111926A patent/TWI273908B/zh not_active IP Right Cessation
- 2004-04-28 NL NL1026074A patent/NL1026074C2/nl not_active IP Right Cessation
- 2004-04-28 AR ARP040101440A patent/AR044116A1/es unknown
- 2004-04-29 PA PA20048601701A patent/PA8601701A1/es unknown
- 2004-04-29 US US10/834,484 patent/US7262192B2/en not_active Expired - Fee Related
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2005
- 2005-08-31 IS IS8009A patent/IS8009A/is unknown
- 2005-09-22 NO NO20054404A patent/NO333850B1/no not_active IP Right Cessation
- 2005-10-20 CR CR8051A patent/CR8051A/es not_active Application Discontinuation
- 2005-10-28 MA MA28571A patent/MA27771A1/fr unknown
- 2005-10-28 CO CO05110249A patent/CO5640118A2/es not_active Application Discontinuation
- 2005-10-28 EC EC2005006130A patent/ECSP056130A/es unknown
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2006
- 2006-06-28 HK HK06107285.3A patent/HK1087108A1/xx not_active IP Right Cessation
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2007
- 2007-03-16 JP JP2007067736A patent/JP2007217419A/ja active Pending
- 2007-07-31 US US11/831,021 patent/US20070270412A1/en not_active Abandoned
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