JP2006522779A - ４−置換キノリン誘導体、その調製方法、中間体及び医薬組成物 - Google Patents

４−置換キノリン誘導体、その調製方法、中間体及び医薬組成物 Download PDF

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Publication number
JP2006522779A
JP2006522779A JP2006505763A JP2006505763A JP2006522779A JP 2006522779 A JP2006522779 A JP 2006522779A JP 2006505763 A JP2006505763 A JP 2006505763A JP 2006505763 A JP2006505763 A JP 2006505763A JP 2006522779 A JP2006522779 A JP 2006522779A
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JP
Japan
Prior art keywords
group
alkyl
methoxyquinolin
propyl
fluoro
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006505763A
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English (en)
Japanese (ja)
Inventor
ビゴット・アントニー
シェヴ・ミシェル
エル・アーマド・ヨセフ
マレロン・ジャンルー
マルティン・ジャンポール
ミグナーニ・セルゲ
パンテル・ギー
ロナン・バプティステ
タバート・ミシェル
ヴィヴィアーニ・ファブリス
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Aventis Pharma SA
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Aventis Pharma SA
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Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of JP2006522779A publication Critical patent/JP2006522779A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006505763A 2003-03-28 2004-03-29 ４−置換キノリン誘導体、その調製方法、中間体及び医薬組成物 Pending JP2006522779A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0303812A FR2852954B1 (fr) 2003-03-28 2003-03-28 Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2004/000783 WO2004087647A2 (fr) 2003-03-28 2004-03-29 Derives de quinoleines-4-substituees avec une activite antimicrobienne

Publications (1)

Publication Number Publication Date
JP2006522779A true JP2006522779A (ja) 2006-10-05

Family

ID=32947235

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006505763A Pending JP2006522779A (ja) 2003-03-28 2004-03-29 ４−置換キノリン誘導体、その調製方法、中間体及び医薬組成物

Country Status (13)

Country Link
EP (1) EP1611127A2 (fr)
JP (1) JP2006522779A (fr)
KR (1) KR20050115321A (fr)
CN (1) CN1795191A (fr)
AR (1) AR043941A1 (fr)
AU (1) AU2004226207A1 (fr)
CA (1) CA2520764A1 (fr)
EA (1) EA010403B1 (fr)
FR (1) FR2852954B1 (fr)
HR (1) HRP20050855A2 (fr)
RS (1) RS20050806A (fr)
TW (1) TW200505899A (fr)
WO (1) WO2004087647A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
WO2004096982A2 (fr) 2002-11-05 2004-11-11 Smithkline Beecham Corporation Agents antibacteriens
DE60324179D1 (de) 2002-12-04 2008-11-27 Glaxo Group Ltd Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
WO2006002047A2 (fr) 2004-06-15 2006-01-05 Glaxo Group Limited Agents antibacteriens
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
JP2009532423A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌剤としてのピロロ−キノキサリノン誘導体
EP1992628A1 (fr) 2007-05-18 2008-11-19 Glaxo Group Limited Dérivés et analogues de N-éthylquinolones et N-éthylazaquinolones
EP2080761A1 (fr) 2008-01-18 2009-07-22 Glaxo Group Limited Composés
EP2254887B9 (fr) 2008-02-22 2013-05-29 Actelion Pharmaceuticals Ltd. Dérivés d'oxazolidinone
WO2010043714A1 (fr) 2008-10-17 2010-04-22 Glaxo Group Limited Composés azotés tricycliques utilisés comme agents antibactériens
JP5653935B2 (ja) 2009-01-15 2015-01-14 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
TW201618779A (zh) 2014-08-22 2016-06-01 葛蘭素史克智慧財產發展有限公司 方法
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087838A1 (fr) * 2000-05-19 2001-11-22 Merck Sharp & Dohme Limited Derives de cyclohexyle et leur utilisation comme agents therapeutiques
WO2002040474A2 (fr) * 2000-11-15 2002-05-23 Aventis Pharma S.A. Derives heterocyclylalcoyl piperidine et leur application comme antimicrobiens
US20020137734A1 (en) * 2001-01-11 2002-09-26 Xiao-Tao Chen 1,1-Disubstituted cyclic inhibitors of matrix metalloproteases and TNF-alpha
JP2003505455A (ja) * 1999-07-23 2003-02-12 スミスクライン ビーチャム パブリック リミテッド カンパニー 抗細菌剤としてのアミノピペリジン誘導体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003505455A (ja) * 1999-07-23 2003-02-12 スミスクライン ビーチャム パブリック リミテッド カンパニー 抗細菌剤としてのアミノピペリジン誘導体
WO2001087838A1 (fr) * 2000-05-19 2001-11-22 Merck Sharp & Dohme Limited Derives de cyclohexyle et leur utilisation comme agents therapeutiques
WO2002040474A2 (fr) * 2000-11-15 2002-05-23 Aventis Pharma S.A. Derives heterocyclylalcoyl piperidine et leur application comme antimicrobiens
US20020137734A1 (en) * 2001-01-11 2002-09-26 Xiao-Tao Chen 1,1-Disubstituted cyclic inhibitors of matrix metalloproteases and TNF-alpha

Also Published As

Publication number Publication date
KR20050115321A (ko) 2005-12-07
AR043941A1 (es) 2005-08-17
EP1611127A2 (fr) 2006-01-04
FR2852954B1 (fr) 2006-07-14
CA2520764A1 (fr) 2004-10-14
WO2004087647A2 (fr) 2004-10-14
FR2852954A1 (fr) 2004-10-01
EA010403B1 (ru) 2008-08-29
TW200505899A (en) 2005-02-16
RS20050806A (en) 2007-12-31
WO2004087647A3 (fr) 2005-01-27
HRP20050855A2 (en) 2005-12-31
AU2004226207A1 (en) 2004-10-14
EA200501526A1 (ru) 2006-04-28
CN1795191A (zh) 2006-06-28

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