|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US20120225033A1
(en)
|
2010-11-24 |
2012-09-06 |
Durect Corporation |
Biodegradable Drug Delivery Composition
|
|
PL1615945T3
(pl)
|
2003-04-09 |
2012-03-30 |
Ratiopharm Gmbh |
Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
US9005625B2
(en)
|
2003-07-25 |
2015-04-14 |
Novo Nordisk A/S |
Antibody toxin conjugates
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
ATE461217T1
(de)
*
|
2003-12-18 |
2010-04-15 |
Novo Nordisk As |
Glp-1-verbindungen
|
|
US20080300173A1
(en)
*
|
2004-07-13 |
2008-12-04 |
Defrees Shawn |
Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
|
|
WO2006050247A2
(en)
|
2004-10-29 |
2006-05-11 |
Neose Technologies, Inc. |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
US9029331B2
(en)
|
2005-01-10 |
2015-05-12 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
TWI376234B
(en)
|
2005-02-01 |
2012-11-11 |
Msd Oss Bv |
Conjugates of a polypeptide and an oligosaccharide
|
|
US8603972B2
(en)
|
2005-03-18 |
2013-12-10 |
Novo Nordisk A/S |
Extended GLP-1 compounds
|
|
TWI362392B
(en)
|
2005-03-18 |
2012-04-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
|
WO2006121569A2
(en)
|
2005-04-08 |
2006-11-16 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
|
CA2607566A1
(en)
*
|
2005-05-06 |
2006-11-16 |
Bayer Pharmaceuticals Corporation |
Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use
|
|
CA2608311C
(en)
*
|
2005-05-13 |
2012-11-27 |
Eli Lilly And Company |
Glp-1 pegylated compounds
|
|
EP2975135A1
(en)
|
2005-05-25 |
2016-01-20 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
CN101296708B
(zh)
*
|
2005-10-26 |
2011-12-07 |
伊莱利利公司 |
选择性vpac2受体肽激动剂
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
CA2913805A1
(en)
|
2005-11-07 |
2007-05-18 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
EP2364735A3
(en)
|
2005-12-16 |
2012-04-11 |
Nektar Therapeutics |
Branched PEG conjugates of GLP-1
|
|
JP2009534423A
(ja)
*
|
2006-04-20 |
2009-09-24 |
アムジェン インコーポレイテッド |
Glp−1化合物
|
|
EP2049144B8
(en)
|
2006-07-21 |
2015-02-18 |
ratiopharm GmbH |
Glycosylation of peptides via o-linked glycosylation sequences
|
|
EP2054521A4
(en)
|
2006-10-03 |
2012-12-19 |
Novo Nordisk As |
PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES
|
|
CN101125207B
(zh)
*
|
2006-11-14 |
2012-09-05 |
上海华谊生物技术有限公司 |
带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途
|
|
WO2008076933A2
(en)
*
|
2006-12-14 |
2008-06-26 |
Bolder Biotechnology, Inc. |
Long acting proteins and peptides and methods of making and using the same
|
|
RU2477286C2
(ru)
|
2007-01-05 |
2013-03-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
АНАЛОГИ ГЛЮКАГОНА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ РАСТВОРИМОСТЬЮ В БУФЕРАХ С ФИЗИОЛОГИЧЕСКИМ ЗНАЧЕНИЕМ pH
|
|
JP2008169195A
(ja)
*
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
キャリア物質を用いたインスリン分泌ペプチド薬物結合体
|
|
CA2677932A1
(en)
|
2007-02-15 |
2008-08-21 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
|
HRP20130382T1
(hr)
|
2007-04-03 |
2013-05-31 |
Biogenerix Ag |
Postupci lijeäśenja pomoä†u glikopegiliranog g-csf
|
|
CA2690611C
(en)
|
2007-06-12 |
2015-12-08 |
Novo Nordisk A/S |
Improved process for the production of nucleotide sugars
|
|
KR20100049032A
(ko)
|
2007-06-19 |
2010-05-11 |
오츠카 가가쿠 가부시키가이샤 |
당사슬 부가 glp―1 펩티드
|
|
EP2190872B1
(en)
|
2007-09-05 |
2018-03-14 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
|
WO2009030771A1
(en)
|
2007-09-05 |
2009-03-12 |
Novo Nordisk A/S |
Peptides derivatized with a-b-c-d- and their therapeutical use
|
|
US20100292133A1
(en)
|
2007-09-05 |
2010-11-18 |
Novo Nordisk A/S |
Truncated glp-1 derivaties and their therapeutical use
|
|
MX2010004298A
(es)
*
|
2007-10-30 |
2010-05-03 |
Univ Indiana Res & Tech Corp |
Compuestos que exhiben actividad antagonista de glucagon y agonista de glp-1.
|
|
ES2509883T3
(es)
|
2007-10-30 |
2014-10-20 |
Indiana University Research And Technology Corporation |
Antagonistas de glucagón
|
|
EP2249853A4
(en)
|
2008-01-30 |
2012-12-26 |
Univ Indiana Res & Tech Corp |
ESTER BASED PEPTIDE PRODRUGS
|
|
PL2257311T3
(pl)
|
2008-02-27 |
2014-09-30 |
Novo Nordisk As |
Koniugaty cząsteczek czynnika VIII
|
|
AR072160A1
(es)
|
2008-06-17 |
2010-08-11 |
Univ Indiana Res & Tech Corp |
Co-agonistas del receptor de glucagon/glp-1
|
|
US8450270B2
(en)
|
2008-06-17 |
2013-05-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
|
|
CN102105159B
(zh)
|
2008-06-17 |
2015-07-08 |
印第安纳大学研究及科技有限公司 |
基于gip的混合激动剂用于治疗代谢紊乱和肥胖症
|
|
IT1392655B1
(it)
*
|
2008-11-20 |
2012-03-16 |
Bio Ker S R L |
Site-specific monoconjugated insulinotropic glp-1 peptides.
|
|
PE20120332A1
(es)
|
2008-12-19 |
2012-04-14 |
Univ Indiana Res & Tech Corp |
Profarmacos de peptido de la superfamilia de glucagon basado en amida
|
|
JP5789515B2
(ja)
|
2008-12-19 |
2015-10-07 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリン類似体
|
|
AU2009335715B2
(en)
|
2008-12-19 |
2016-09-15 |
Indiana University Research And Technology Corporation |
Amide-based insulin prodrugs
|
|
WO2010080605A1
(en)
*
|
2008-12-19 |
2010-07-15 |
Indiana University Research And Technology Corporation |
Dipeptide linked medicinal agents
|
|
MX2011009803A
(es)
*
|
2009-03-20 |
2011-09-30 |
Hanmi Holdings Co Ltd |
Metodo para preparar un polipeptido conjugado fisiologicamente activo en un sitio especifico.
|
|
CN101870728A
(zh)
|
2009-04-23 |
2010-10-27 |
派格生物医药(苏州)有限公司 |
新型Exendin变体及其缀合物
|
|
EP2443146B1
(en)
|
2009-06-16 |
2016-10-05 |
Indiana University Research And Technology Corporation |
Gip receptor-active glucagon compounds
|
|
KR20120101037A
(ko)
|
2009-10-30 |
2012-09-12 |
오츠카 가가쿠 가부시키가이샤 |
항원성 glp?1 아날로그의 당쇄 부가체
|
|
JP6006118B2
(ja)
|
2009-12-16 |
2016-10-12 |
ノヴォ ノルディスク アー/エス |
Glp−1アナログ及び誘導体
|
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
|
JO2976B1
(en)
|
2009-12-22 |
2016-03-15 |
ايلي ليلي اند كومباني |
Axentomodulin polypeptide
|
|
KR20120123443A
(ko)
|
2010-01-27 |
2012-11-08 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
대사 장애 및 비만 치료용 글루카곤 길항제-gip 항진제 콘쥬게이트
|
|
MX2012013001A
(es)
|
2010-05-13 |
2013-02-26 |
Univ Indiana Res & Tech Corp |
Peptidos de la superfamilia de glucagon que presentan actividad del receptor nuclear de hormonas.
|
|
JP6050746B2
(ja)
|
2010-05-13 |
2016-12-21 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
Gタンパク質共役受容体活性を示すグルカゴンスーパーファミリーのペプチド
|
|
JP5819946B2
(ja)
*
|
2010-05-17 |
2015-11-24 |
ベータ ファーマシューティカルズ カンパニー リミテッド |
新規のグルカゴン様ペプチド類似体、組成物、および使用方法
|
|
JP5969469B2
(ja)
|
2010-06-16 |
2016-08-17 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト
|
|
EP2585102B1
(en)
|
2010-06-24 |
2015-05-06 |
Indiana University Research and Technology Corporation |
Amide-based insulin prodrugs
|
|
EP2588126A4
(en)
|
2010-06-24 |
2015-07-08 |
Univ Indiana Res & Tech Corp |
AMID-BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS
|
|
CN102397558B
(zh)
*
|
2010-09-09 |
2013-08-14 |
中国人民解放军军事医学科学院毒物药物研究所 |
Exendin-4类似物的定位聚乙二醇化修饰物及其用途
|
|
WO2012054822A1
(en)
|
2010-10-22 |
2012-04-26 |
Nektar Therapeutics |
Pharmacologically active polymer-glp-1 conjugates
|
|
SI2651398T1
(en)
|
2010-12-16 |
2018-04-30 |
Novo Nordisk A/S |
SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS
|
|
US8507428B2
(en)
|
2010-12-22 |
2013-08-13 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting GIP receptor activity
|
|
CN102718858B
(zh)
*
|
2011-03-29 |
2014-07-02 |
天津药物研究院 |
胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
|
|
CN106928341B
(zh)
*
|
2011-03-30 |
2021-06-01 |
上海仁会生物制药股份有限公司 |
定点单取代聚乙二醇化Exendin类似物及其制备方法
|
|
PL2696687T3
(pl)
|
2011-04-12 |
2017-06-30 |
Novo Nordisk A/S |
Pochodne podwójnie acylowanej GLP-1
|
|
CN102180963B
(zh)
*
|
2011-04-22 |
2014-06-25 |
中国药科大学 |
胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN102766204B
(zh)
*
|
2011-05-05 |
2014-10-15 |
天津药物研究院 |
胰高血糖素样肽-1突变体多肽及其制备方法和其应用
|
|
CN102786590A
(zh)
*
|
2011-05-19 |
2012-11-21 |
江苏豪森药业股份有限公司 |
分枝型peg修饰的glp-1类似物及其可药用盐
|
|
RS56173B1
(sr)
|
2011-06-22 |
2017-11-30 |
Univ Indiana Res & Tech Corp |
Koagonisti receptora za glukagon/glp-1 receptora
|
|
KR20140043793A
(ko)
|
2011-06-22 |
2014-04-10 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
글루카곤/glp-1 수용체 공동-작용물질
|
|
CN102321170B
(zh)
*
|
2011-09-14 |
2013-11-13 |
深圳翰宇药业股份有限公司 |
利拉鲁肽变构体及其缀合物
|
|
JP6324315B2
(ja)
|
2011-11-17 |
2018-05-16 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
グルココルチコイド受容体の活性を示すグルカゴンスーパーファミリーのペプチド
|
|
EP2782590A4
(en)
|
2011-11-23 |
2016-08-03 |
Durect Corp |
BIODEGRADABLE AND MEDIUM-RADIATED STERILIZED MEDICAMENTAL COMPOSITIONS
|
|
BR112014015156A2
(pt)
|
2011-12-20 |
2020-10-27 |
Indiana University Research And Technology Corporation |
análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira
|
|
PT2827845T
(pt)
|
2012-03-22 |
2019-03-29 |
Novo Nordisk As |
Composições compreendendo um agente de entrega e sua preparação
|
|
HRP20181447T1
(hr)
|
2012-03-22 |
2018-11-02 |
Novo Nordisk A/S |
Pripravci glp-1 peptida i njihova priprava
|
|
EP2851429B1
(en)
|
2012-05-18 |
2019-07-24 |
Adda Biotech Inc. |
Protein and protein conjugate for diabetes treatment, and applications thereof
|
|
JP6517690B2
(ja)
|
2012-06-20 |
2019-05-22 |
ノヴォ ノルディスク アー/エス |
ペプチド及び送達剤を含む錠剤製剤
|
|
CN104583232B
(zh)
|
2012-06-21 |
2018-04-13 |
印第安纳大学研究及科技有限公司 |
展现gip受体活性的胰高血糖素类似物
|
|
EP3395358B1
(en)
|
2012-09-26 |
2019-11-06 |
Indiana University Research and Technology Corporation |
Insulin analog dimers
|
|
CN103087179A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087175A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
新型长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087176A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087177A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
一类长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
CN103087178A
(zh)
*
|
2012-11-30 |
2013-05-08 |
中国药科大学 |
长效化胰高血糖素样肽-1(glp-1)类似物及其应用
|
|
JP6538645B2
(ja)
|
2013-03-14 |
2019-07-03 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリン‐インクレチン複合物
|
|
KR102272671B1
(ko)
|
2013-05-02 |
2021-07-06 |
노보 노르디스크 에이/에스 |
Glp-1 화합물의 경구 투여
|
|
JP6475233B2
(ja)
|
2013-06-20 |
2019-02-27 |
ノヴォ ノルディスク アー/エス |
Glp−1誘導体及びその使用
|
|
EP3016975B1
(en)
|
2013-07-04 |
2019-01-16 |
Novo Nordisk A/S |
Derivatives of glp-1 like peptides, and uses thereof
|
|
US10626156B2
(en)
|
2013-12-06 |
2020-04-21 |
Jie Han |
Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
|
|
EP3079668A1
(en)
|
2013-12-09 |
2016-10-19 |
Durect Corporation |
Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
|
|
JP6701208B2
(ja)
|
2014-09-24 |
2020-05-27 |
インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション |
脂質化アミド系インスリンプロドラッグ
|
|
CN108271356A
(zh)
|
2014-09-24 |
2018-07-10 |
印第安纳大学研究及科技有限公司 |
肠降血糖素-胰岛素缀合物
|
|
US9616109B2
(en)
|
2014-10-22 |
2017-04-11 |
Extend Biosciences, Inc. |
Insulin vitamin D conjugates
|
|
WO2016065042A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Therapeutic vitamin d conjugates
|
|
JP6730278B2
(ja)
|
2014-11-27 |
2020-07-29 |
ノヴォ ノルディスク アー/エス |
Glp−1誘導体及びその使用
|
|
US20160151511A1
(en)
*
|
2014-12-02 |
2016-06-02 |
Antriabio, Inc. |
Proteins and protein conjugates with increased hydrophobicity
|
|
WO2016097108A1
(en)
|
2014-12-17 |
2016-06-23 |
Novo Nordisk A/S |
Glp-1 derivatives and uses thereof
|
|
PE20171154A1
(es)
|
2014-12-30 |
2017-08-16 |
Hanmi Pharm Ind Co Ltd |
Derivados de glucagon con estabilidad mejorada
|
|
WO2016196017A1
(en)
|
2015-06-04 |
2016-12-08 |
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|
|
EP4523705A3
(en)
|
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2025-06-11 |
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|
|
SG11201805586SA
(en)
|
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2018-07-30 |
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|
|
CN107266557B
(zh)
*
|
2016-04-06 |
2020-04-07 |
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|
|
EP3479841A4
(en)
|
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|
|
JP6898518B2
(ja)
|
2018-02-02 |
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|
|
US20220056077A1
(en)
|
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|
|
WO2020214013A1
(ko)
*
|
2019-04-19 |
2020-10-22 |
한미약품 주식회사 |
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|
|
WO2020214012A1
(ko)
*
|
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|
|
US20210187077A1
(en)
*
|
2019-12-23 |
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|
|
KR20250075704A
(ko)
|
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|