JP2006514946A5 - - Google Patents
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- JP2006514946A5 JP2006514946A5 JP2004559325A JP2004559325A JP2006514946A5 JP 2006514946 A5 JP2006514946 A5 JP 2006514946A5 JP 2004559325 A JP2004559325 A JP 2004559325A JP 2004559325 A JP2004559325 A JP 2004559325A JP 2006514946 A5 JP2006514946 A5 JP 2006514946A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43165002P | 2002-12-06 | 2002-12-06 | |
| US60/431,650 | 2002-12-06 | ||
| PCT/US2003/038708 WO2004052365A2 (en) | 2002-12-06 | 2003-12-05 | Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014401A Division JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514946A JP2006514946A (ja) | 2006-05-18 |
| JP2006514946A5 true JP2006514946A5 (https=) | 2007-02-01 |
| JP4750421B2 JP4750421B2 (ja) | 2011-08-17 |
Family
ID=32507772
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559325A Expired - Fee Related JP4750421B2 (ja) | 2002-12-06 | 2003-12-05 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2011014401A Withdrawn JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2013257181A Expired - Fee Related JP5925178B2 (ja) | 2002-12-06 | 2013-12-12 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2016007291A Pending JP2016084355A (ja) | 2002-12-06 | 2016-01-18 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014401A Withdrawn JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2013257181A Expired - Fee Related JP5925178B2 (ja) | 2002-12-06 | 2013-12-12 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2016007291A Pending JP2016084355A (ja) | 2002-12-06 | 2016-01-18 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7273872B2 (https=) |
| EP (3) | EP1581223B2 (https=) |
| JP (4) | JP4750421B2 (https=) |
| CN (2) | CN102657651A (https=) |
| AT (1) | ATE378048T1 (https=) |
| AU (1) | AU2003298939B2 (https=) |
| CA (1) | CA2507502C (https=) |
| DE (1) | DE60317564T2 (https=) |
| DK (1) | DK1949901T3 (https=) |
| ES (2) | ES2462545T3 (https=) |
| IL (2) | IL168787A (https=) |
| PT (1) | PT1949901E (https=) |
| SI (1) | SI1949901T1 (https=) |
| WO (1) | WO2004052365A2 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8188043B2 (en) * | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US7045534B2 (en) * | 2002-02-12 | 2006-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of reducing angiogenesis |
| WO2004052365A2 (en) * | 2002-12-06 | 2004-06-24 | North Shore-Long Island Jewish Research Institute | Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists |
| US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| WO2004083388A2 (en) | 2003-03-14 | 2004-09-30 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| US8729129B2 (en) | 2004-03-25 | 2014-05-20 | The Feinstein Institute For Medical Research | Neural tourniquet |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| US11207518B2 (en) * | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| CN102793972A (zh) * | 2004-12-27 | 2012-11-28 | 范因斯坦医学研究院 | 通过电刺激迷走神经治疗炎症性疾病 |
| US8316104B2 (en) * | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| CA2633655A1 (en) * | 2005-12-19 | 2007-07-05 | Comentis, Inc. | Topical mecamylamine formulations for ocular administration and uses therof |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| US8391970B2 (en) | 2007-08-27 | 2013-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| WO2009066107A1 (en) * | 2007-11-21 | 2009-05-28 | Astrazeneca Ab | Use of a nicotinic receptor agonist |
| US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| US8722630B2 (en) * | 2008-06-13 | 2014-05-13 | The General Hospital Corporation | Use of apolipoproteins to decrease inflammation |
| US20120053117A1 (en) * | 2008-10-03 | 2012-03-01 | Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo- Fapesp | Pharmaceutical composition, drug screening method and method for treating malaria |
| ES2452484T3 (es) | 2008-11-18 | 2014-04-01 | Setpoint Medical Corporation | Dispositivos para optimizar la colocación de electrodos para la estimulación antiinflamatoria |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| WO2010144578A2 (en) | 2009-06-09 | 2010-12-16 | Setpoint Medical Corporation | Nerve cuff with pocket for leadless stimulator |
| WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| CN105126248B (zh) | 2009-12-23 | 2018-06-12 | 赛博恩特医疗器械公司 | 用于治疗慢性炎症的神经刺激设备和系统 |
| JP5767708B2 (ja) * | 2010-09-30 | 2015-08-19 | ツェンドゥー カンホン バイオテクノロジーズ カンパニー リミテッド | ヒト化抗ヒト腫瘍壊死因子α（ＴＮＦ−α）抗体およびその抗原結合性フラグメント（Ｆａｂ）およびその使用方法 |
| EP2640378A4 (en) * | 2010-11-18 | 2014-05-21 | Envivo Pharmaceuticals Inc | INFLAMMATION TREATMENT WITH CERTAIN NICOTINIC ACID ALPHA-7 RECEPTOR AGONISTS IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITORS |
| AU2012231275A1 (en) * | 2011-03-18 | 2013-10-17 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
| CA2834467A1 (en) * | 2011-04-29 | 2012-11-01 | Chiesi Farmaceutici S.P.A. | Alkaloid ester and carbamate derivatives and medicinal compositions thereof |
| US12172017B2 (en) | 2011-05-09 | 2024-12-24 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| EP2707094B1 (en) | 2011-05-09 | 2016-02-03 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8865641B2 (en) | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| MA37975B2 (fr) * | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| US11406833B2 (en) | 2015-02-03 | 2022-08-09 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| CN108882885A (zh) | 2016-01-20 | 2018-11-23 | 赛博恩特医疗器械公司 | 迷走神经刺激的控制 |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| US10314501B2 (en) | 2016-01-20 | 2019-06-11 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| US10639300B2 (en) | 2016-04-12 | 2020-05-05 | Arturo Solis Herrera | Compositions and methods for treating nasal and paranasal mucosa diseases with nicotinic acetylcholine receptor agonists |
| US11154547B2 (en) | 2016-06-29 | 2021-10-26 | Tulavi Therapeutics, Inc. | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
| WO2018064529A1 (en) * | 2016-09-29 | 2018-04-05 | The Uab Research Foundation | Methods and compositions for increasing mucus clearance |
| US20190247376A1 (en) * | 2016-09-30 | 2019-08-15 | University Of Southern California | Nicotinic acetylcholine receptor agonist attenuates ilc2-dependent airway hyperreactivity |
| US11173307B2 (en) | 2017-08-14 | 2021-11-16 | Setpoint Medical Corporation | Vagus nerve stimulation pre-screening test |
| US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| CN109652524A (zh) * | 2018-11-09 | 2019-04-19 | 山西中医药大学 | 类风湿关节炎大鼠模型中chrna7基因生物信息分析的试验方法 |
| CN114040762A (zh) | 2019-02-04 | 2022-02-11 | 建新公司 | 使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病 |
| US12343535B2 (en) | 2019-04-12 | 2025-07-01 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| AU2021207815B2 (en) | 2020-01-13 | 2026-03-26 | The Feinstein Institutes For Medical Research | Treating bleeding and bleeding disorders via high intensity focused ultrasound stimulation of the spleen |
| TW202142236A (zh) | 2020-02-03 | 2021-11-16 | 美商健臻公司 | 用於治療與溶體儲積症相關的神經症狀之方法 |
| US11938324B2 (en) | 2020-05-21 | 2024-03-26 | The Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
| KR20230043024A (ko) | 2020-07-24 | 2023-03-30 | 젠자임 코포레이션 | 벤글루스타트를 포함하는 제약 조성물 |
| CN112023050A (zh) * | 2020-09-10 | 2020-12-04 | 中国科学院深圳先进技术研究院 | 一种调节巨噬细胞极化状态的方法 |
| WO2022245878A1 (en) | 2021-05-17 | 2022-11-24 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
| CN114028570A (zh) * | 2021-12-27 | 2022-02-11 | 中国药科大学 | α7烟碱型胆碱受体激动剂在制备肽酰基精氨酸脱亚氨酶4抑制剂中的用途 |
| US20250229086A1 (en) | 2022-01-20 | 2025-07-17 | Setpoint Medical Corporation | Treatment of inflammatory disorders |
| CN119792529A (zh) * | 2025-01-16 | 2025-04-11 | 山东第一医科大学(山东省医学科学院) | 抑制Chrm3受体表达的试剂在制备治疗由脂多糖引起的相关疾病的药物中的应用 |
| CN121041449A (zh) * | 2025-07-31 | 2025-12-02 | 中国人民解放军军事科学院军事医学研究院 | 乙酰胆碱受体激动剂在治疗脑膜炎中的应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977144A (en) | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
| EP0659078B1 (en) | 1992-08-31 | 2003-01-15 | University Of Florida Research Foundation, Inc. | Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system |
| JP3708962B2 (ja) | 1994-08-24 | 2005-10-19 | アストラゼネカ・アクチエボラーグ | 治療に有用なスピロ−アザ二環式化合物 |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| FR2756826B1 (fr) | 1996-12-05 | 1999-01-08 | Adir | Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6323000B2 (en) * | 1996-12-20 | 2001-11-27 | Clark A. Briggs | Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof |
| NZ500645A (en) † | 1997-05-30 | 2001-06-29 | Neurosearch As | 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors |
| AR013184A1 (es) * | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
| JP2003512290A (ja) | 1997-09-10 | 2003-04-02 | メルク エンド カムパニー インコーポレーテッド | 家畜抗菌剤としての８ａ−アザライド |
| EP1083889B1 (en) | 1998-06-01 | 2003-12-10 | Ortho-McNeil Pharmaceutical, Inc. | Tetrahydronaphtalene compounds and their use for the treatment of neurodegenerative diseases |
| FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| FR2786769B1 (fr) | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| US6432975B1 (en) | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| FR2790474B1 (fr) | 1999-03-05 | 2001-04-06 | Synthelabo | Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique |
| EP1177196B1 (en) | 1999-05-04 | 2004-03-10 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| JP2003509030A (ja) | 1999-09-17 | 2003-03-11 | アイシス・ファーマシューティカルス・インコーポレーテッド | トランスフォーミング成長因子−β発現のアンチセンスオリゴヌクレオチド調節 |
| EP1269201A1 (en) * | 2000-03-29 | 2003-01-02 | Synaptica Limited | Alpha 7 nicotinic receptor screening assays |
| GB0010955D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
| US6610713B2 (en) | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| ATE287888T1 (de) | 2000-07-04 | 2005-02-15 | Neurosearch As | Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung |
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| JP4312456B2 (ja) * | 2000-10-13 | 2009-08-12 | ニューロサーチ、アクティーゼルスカブ | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
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| WO2002057275A1 (en) | 2001-01-17 | 2002-07-25 | University Of Kentucky Research Foundation | Boron-containing nicotine analogs for use in the treatment of cns pathologies |
| US6479172B2 (en) | 2001-01-26 | 2002-11-12 | Xerox Corporation | Electroluminescent (EL) devices |
| WO2002074301A1 (en) * | 2001-03-15 | 2002-09-26 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions |
| EP1392844A4 (en) * | 2001-05-15 | 2006-09-06 | Long Island Jewish Res Inst | USE OF HMG FRAGMENTS AS ANTI-INFLAMMATORY AGENTS |
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| BR0212101A (pt) | 2001-08-24 | 2004-08-24 | Pharmacia & Up John Company | 7-aza [2.2.1] biciclo-heptanos substituìdos com heteroarila para o tratamento de doenças |
| JP2005527472A (ja) | 2001-09-12 | 2005-09-15 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 疾患治療のための置換された７−アザ［２．２．１］ビシクロヘプタン |
| HUP0402289A2 (hu) | 2001-10-02 | 2005-02-28 | Pharmacia & Upjohn Company | Gyógyhatású azabiciklusos csoporttal helyettesített kondenzált heteroaril-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
| AU2002339810A1 (en) | 2001-10-16 | 2003-04-28 | Astrazeneca Ab | Azabicyclic compounds for the treatment of fibromyalgia syndrome |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| US6951868B2 (en) | 2001-11-09 | 2005-10-04 | Pfizer Inc. | Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease |
| JP3699392B2 (ja) * | 2001-12-04 | 2005-09-28 | 本田技研工業株式会社 | 艇体の接着剤硬化促進装置 |
| DE10211415A1 (de) | 2002-03-15 | 2003-09-25 | Bayer Ag | Bicyclische N-Biarylamide |
| WO2004052365A2 (en) * | 2002-12-06 | 2004-06-24 | North Shore-Long Island Jewish Research Institute | Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists |
-
2003
- 2003-12-05 WO PCT/US2003/038708 patent/WO2004052365A2/en not_active Ceased
- 2003-12-05 EP EP03796701.5A patent/EP1581223B2/en not_active Expired - Lifetime
- 2003-12-05 DE DE60317564T patent/DE60317564T2/de not_active Expired - Lifetime
- 2003-12-05 ES ES07020473.0T patent/ES2462545T3/es not_active Expired - Lifetime
- 2003-12-05 CN CN2012100243080A patent/CN102657651A/zh active Pending
- 2003-12-05 DK DK07020473.0T patent/DK1949901T3/da active
- 2003-12-05 CA CA2507502A patent/CA2507502C/en not_active Expired - Fee Related
- 2003-12-05 CN CNA2003801082615A patent/CN1735414A/zh active Pending
- 2003-12-05 SI SI200332349T patent/SI1949901T1/sl unknown
- 2003-12-05 ES ES03796701T patent/ES2293086T3/es not_active Expired - Lifetime
- 2003-12-05 EP EP07020473.0A patent/EP1949901B1/en not_active Expired - Lifetime
- 2003-12-05 EP EP09001425A patent/EP2062595A1/en not_active Withdrawn
- 2003-12-05 PT PT70204730T patent/PT1949901E/pt unknown
- 2003-12-05 US US10/729,427 patent/US7273872B2/en not_active Expired - Fee Related
- 2003-12-05 AT AT03796701T patent/ATE378048T1/de not_active IP Right Cessation
- 2003-12-05 JP JP2004559325A patent/JP4750421B2/ja not_active Expired - Fee Related
- 2003-12-05 AU AU2003298939A patent/AU2003298939B2/en not_active Ceased
-
2005
- 2005-05-25 IL IL168787A patent/IL168787A/en not_active IP Right Cessation
-
2010
- 2010-07-07 IL IL206855A patent/IL206855A/en not_active IP Right Cessation
-
2011
- 2011-01-26 JP JP2011014401A patent/JP2011105745A/ja not_active Withdrawn
-
2013
- 2013-12-12 JP JP2013257181A patent/JP5925178B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-18 JP JP2016007291A patent/JP2016084355A/ja active Pending
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