JP2006514946A5 - - Google Patents
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- JP2006514946A5 JP2006514946A5 JP2004559325A JP2004559325A JP2006514946A5 JP 2006514946 A5 JP2006514946 A5 JP 2006514946A5 JP 2004559325 A JP2004559325 A JP 2004559325A JP 2004559325 A JP2004559325 A JP 2004559325A JP 2006514946 A5 JP2006514946 A5 JP 2006514946A5
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- JP
- Japan
- Prior art keywords
- alkyl
- use according
- hydrogen
- group
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43165002P | 2002-12-06 | 2002-12-06 | |
| US60/431,650 | 2002-12-06 | ||
| PCT/US2003/038708 WO2004052365A2 (en) | 2002-12-06 | 2003-12-05 | Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014401A Division JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514946A JP2006514946A (ja) | 2006-05-18 |
| JP2006514946A5 true JP2006514946A5 (https=) | 2007-02-01 |
| JP4750421B2 JP4750421B2 (ja) | 2011-08-17 |
Family
ID=32507772
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559325A Expired - Fee Related JP4750421B2 (ja) | 2002-12-06 | 2003-12-05 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2011014401A Withdrawn JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2013257181A Expired - Fee Related JP5925178B2 (ja) | 2002-12-06 | 2013-12-12 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2016007291A Pending JP2016084355A (ja) | 2002-12-06 | 2016-01-18 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014401A Withdrawn JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2013257181A Expired - Fee Related JP5925178B2 (ja) | 2002-12-06 | 2013-12-12 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2016007291A Pending JP2016084355A (ja) | 2002-12-06 | 2016-01-18 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7273872B2 (https=) |
| EP (3) | EP2062595A1 (https=) |
| JP (4) | JP4750421B2 (https=) |
| CN (2) | CN102657651A (https=) |
| AT (1) | ATE378048T1 (https=) |
| AU (1) | AU2003298939B2 (https=) |
| CA (1) | CA2507502C (https=) |
| DE (1) | DE60317564T2 (https=) |
| DK (1) | DK1949901T3 (https=) |
| ES (2) | ES2462545T3 (https=) |
| IL (2) | IL168787A (https=) |
| PT (1) | PT1949901E (https=) |
| SI (1) | SI1949901T1 (https=) |
| WO (1) | WO2004052365A2 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8188043B2 (en) * | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US7045534B2 (en) * | 2002-02-12 | 2006-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of reducing angiogenesis |
| US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| JP4750421B2 (ja) * | 2002-12-06 | 2011-08-17 | ノース ショア−ロング アイランド ジュ−イッシュ リサ−チ インスティチュ−ト | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| EP1603585A2 (en) | 2003-03-14 | 2005-12-14 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| JP2007530586A (ja) | 2004-03-25 | 2007-11-01 | ザ ファインスタイン インスティテュート フォー メディカル リサーチ | 神経性止血法 |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| CN101124012B (zh) * | 2004-12-27 | 2012-09-05 | 范因斯坦医学研究院 | 通过电刺激迷走神经治疗炎症性疾病的装置 |
| US11207518B2 (en) * | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| US8316104B2 (en) * | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| AU2006331790A1 (en) * | 2005-12-19 | 2007-07-05 | Comentis, Inc. | Topical mecamylamine formulations for ocular administration and uses therof |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| US8391970B2 (en) | 2007-08-27 | 2013-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| WO2009066107A1 (en) * | 2007-11-21 | 2009-05-28 | Astrazeneca Ab | Use of a nicotinic receptor agonist |
| WO2009146030A1 (en) | 2008-03-31 | 2009-12-03 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of t-cell activity |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| US8722630B2 (en) * | 2008-06-13 | 2014-05-13 | The General Hospital Corporation | Use of apolipoproteins to decrease inflammation |
| US20120053117A1 (en) * | 2008-10-03 | 2012-03-01 | Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo- Fapesp | Pharmaceutical composition, drug screening method and method for treating malaria |
| US8412338B2 (en) | 2008-11-18 | 2013-04-02 | Setpoint Medical Corporation | Devices and methods for optimizing electrode placement for anti-inflamatory stimulation |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| CN102573986B (zh) | 2009-06-09 | 2016-01-20 | 赛博恩特医疗器械公司 | 用于无导线刺激器的具有袋部的神经封套 |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| US11051744B2 (en) | 2009-11-17 | 2021-07-06 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| CN102821814B (zh) | 2009-12-23 | 2015-07-15 | 赛博恩特医疗器械公司 | 用于治疗慢性炎症的神经刺激设备和系统 |
| KR101712874B1 (ko) * | 2010-09-30 | 2017-03-07 | 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 | 인간화 항 TNF α 항체 및 그의 항원 결합 단편 (Fab) 및 용도 |
| EP2640378A4 (en) * | 2010-11-18 | 2014-05-21 | Envivo Pharmaceuticals Inc | INFLAMMATION TREATMENT WITH CERTAIN NICOTINIC ACID ALPHA-7 RECEPTOR AGONISTS IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITORS |
| KR101987736B1 (ko) * | 2011-03-18 | 2019-06-11 | 젠자임 코포레이션 | 글루코실세라마이드 합성효소 억제제 |
| CA2834467A1 (en) * | 2011-04-29 | 2012-11-01 | Chiesi Farmaceutici S.P.A. | Alkaloid ester and carbamate derivatives and medicinal compositions thereof |
| US12172017B2 (en) | 2011-05-09 | 2024-12-24 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| US8865641B2 (en) | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| WO2016126807A1 (en) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| EP3405107B1 (en) | 2016-01-20 | 2023-04-12 | Setpoint Medical Corporation | Control of vagal stimulation |
| EP3405255B1 (en) | 2016-01-20 | 2025-12-31 | Setpoint Medical Corporation | IMPLANTABLE MICROSTIMULATORS AND INDUCTION CHARGING SYSTEMS |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| EP3442583B1 (en) | 2016-04-12 | 2024-04-10 | Arturo Solis Herrera | Composition comprising nicotine for treating bleeding of the nasal or paranasal mucosa |
| EP3478287A4 (en) | 2016-06-29 | 2020-04-08 | Tulavi Therapeutics, Inc. | TREATMENT OF SEPTICEMIA AND ASSOCIATED INFLAMMATORY CONDITIONS BY LOCAL NEUROMODULATION OF THE AUTONOMOUS NERVOUS SYSTEM |
| WO2018064529A1 (en) * | 2016-09-29 | 2018-04-05 | The Uab Research Foundation | Methods and compositions for increasing mucus clearance |
| WO2018064633A1 (en) * | 2016-09-30 | 2018-04-05 | University Of Southern California | Nicotinic acetylcholine receptor agonist attenuates ilc2-dependent airway hyperreactivity |
| WO2019036470A1 (en) | 2017-08-14 | 2019-02-21 | Setpoint Medical Corporation | TESTING TEST FOR STIMULATION OF NERVE WAVE |
| US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| CN109652524A (zh) * | 2018-11-09 | 2019-04-19 | 山西中医药大学 | 类风湿关节炎大鼠模型中chrna7基因生物信息分析的试验方法 |
| CN114040762A (zh) | 2019-02-04 | 2022-02-11 | 建新公司 | 使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病 |
| AU2020272128B9 (en) | 2019-04-12 | 2025-11-20 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| JP2023512447A (ja) | 2020-01-13 | 2023-03-27 | ザ ファインスタイン インスティチューツ フォー メディカル リサーチ | 脾臓への高密度集束超音波刺激による出血及び出血性疾患の治療 |
| JP2023512366A (ja) | 2020-02-03 | 2023-03-27 | ジェンザイム・コーポレーション | リソソーム蓄積性疾患と関連する神経学的症状を処置するための方法 |
| WO2021236977A1 (en) | 2020-05-21 | 2021-11-25 | The Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
| AU2021311131B2 (en) | 2020-07-24 | 2026-02-19 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
| CN112023050A (zh) * | 2020-09-10 | 2020-12-04 | 中国科学院深圳先进技术研究院 | 一种调节巨噬细胞极化状态的方法 |
| WO2022245878A1 (en) | 2021-05-17 | 2022-11-24 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
| CN114028570A (zh) * | 2021-12-27 | 2022-02-11 | 中国药科大学 | α7烟碱型胆碱受体激动剂在制备肽酰基精氨酸脱亚氨酶4抑制剂中的用途 |
| US20250229086A1 (en) | 2022-01-20 | 2025-07-17 | Setpoint Medical Corporation | Treatment of inflammatory disorders |
| CN119792529A (zh) * | 2025-01-16 | 2025-04-11 | 山东第一医科大学(山东省医学科学院) | 抑制Chrm3受体表达的试剂在制备治疗由脂多糖引起的相关疾病的药物中的应用 |
| CN121041449A (zh) * | 2025-07-31 | 2025-12-02 | 中国人民解放军军事科学院军事医学研究院 | 乙酰胆碱受体激动剂在治疗脑膜炎中的应用 |
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|---|---|---|---|---|
| KR100272614B1 (ko) * | 1992-08-31 | 2000-11-15 | 엠. 잭 오해니언 | 신경계의 퇴행성 질환의 치료에 유용한 아나바세인 유도체 |
| US5977144A (en) * | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
| ATE192157T1 (de) | 1994-08-24 | 2000-05-15 | Astra Ab | Therapeutisch verwendbare spiro-azabicyclische verbindungen |
| SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| FR2756826B1 (fr) * | 1996-12-05 | 1999-01-08 | Adir | Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6323000B2 (en) * | 1996-12-20 | 2001-11-27 | Clark A. Briggs | Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof |
| WO1998054182A1 (en) † | 1997-05-30 | 1998-12-03 | Neurosearch A/S | 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS |
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| DK1083889T3 (da) * | 1998-06-01 | 2004-04-13 | Ortho Mcneil Pharm Inc | Tetrahydronaphthalenforbindelser og deres anvendelse til behandling af neurodegenerative sygdomme |
| FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| US6432975B1 (en) * | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| SE9900100D0 (sv) * | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
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| JP3699392B2 (ja) * | 2001-12-04 | 2005-09-28 | 本田技研工業株式会社 | 艇体の接着剤硬化促進装置 |
| DE10211415A1 (de) | 2002-03-15 | 2003-09-25 | Bayer Ag | Bicyclische N-Biarylamide |
| JP4750421B2 (ja) * | 2002-12-06 | 2011-08-17 | ノース ショア−ロング アイランド ジュ−イッシュ リサ−チ インスティチュ−ト | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
-
2003
- 2003-12-05 JP JP2004559325A patent/JP4750421B2/ja not_active Expired - Fee Related
- 2003-12-05 WO PCT/US2003/038708 patent/WO2004052365A2/en not_active Ceased
- 2003-12-05 ES ES07020473.0T patent/ES2462545T3/es not_active Expired - Lifetime
- 2003-12-05 EP EP09001425A patent/EP2062595A1/en not_active Withdrawn
- 2003-12-05 SI SI200332349T patent/SI1949901T1/sl unknown
- 2003-12-05 AT AT03796701T patent/ATE378048T1/de not_active IP Right Cessation
- 2003-12-05 EP EP07020473.0A patent/EP1949901B1/en not_active Expired - Lifetime
- 2003-12-05 CN CN2012100243080A patent/CN102657651A/zh active Pending
- 2003-12-05 DE DE60317564T patent/DE60317564T2/de not_active Expired - Lifetime
- 2003-12-05 ES ES03796701T patent/ES2293086T3/es not_active Expired - Lifetime
- 2003-12-05 DK DK07020473.0T patent/DK1949901T3/da active
- 2003-12-05 AU AU2003298939A patent/AU2003298939B2/en not_active Ceased
- 2003-12-05 CA CA2507502A patent/CA2507502C/en not_active Expired - Fee Related
- 2003-12-05 CN CNA2003801082615A patent/CN1735414A/zh active Pending
- 2003-12-05 EP EP03796701.5A patent/EP1581223B2/en not_active Expired - Lifetime
- 2003-12-05 US US10/729,427 patent/US7273872B2/en not_active Expired - Fee Related
- 2003-12-05 PT PT70204730T patent/PT1949901E/pt unknown
-
2005
- 2005-05-25 IL IL168787A patent/IL168787A/en not_active IP Right Cessation
-
2010
- 2010-07-07 IL IL206855A patent/IL206855A/en not_active IP Right Cessation
-
2011
- 2011-01-26 JP JP2011014401A patent/JP2011105745A/ja not_active Withdrawn
-
2013
- 2013-12-12 JP JP2013257181A patent/JP5925178B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-18 JP JP2016007291A patent/JP2016084355A/ja active Pending
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