PT1949901E - Método para a determinação de um agonista colinérgico selectivo para um receptor nicotínico alfa 7 - Google Patents
Método para a determinação de um agonista colinérgico selectivo para um receptor nicotínico alfa 7 Download PDFInfo
- Publication number
- PT1949901E PT1949901E PT70204730T PT07020473T PT1949901E PT 1949901 E PT1949901 E PT 1949901E PT 70204730 T PT70204730 T PT 70204730T PT 07020473 T PT07020473 T PT 07020473T PT 1949901 E PT1949901 E PT 1949901E
- Authority
- PT
- Portugal
- Prior art keywords
- macrophage
- cholinergic agonist
- methods
- nicotinic receptor
- release
- Prior art date
Links
- 239000000064 cholinergic agonist Substances 0.000 title abstract 9
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title abstract 5
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title abstract 5
- 210000002540 macrophage Anatomy 0.000 abstract 8
- 102000004127 Cytokines Human genes 0.000 abstract 6
- 108090000695 Cytokines Proteins 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 230000000770 proinflammatory effect Effects 0.000 abstract 4
- 108091034117 Oligonucleotide Proteins 0.000 abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| US7045534B2 (en) * | 2002-02-12 | 2006-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of reducing angiogenesis |
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| US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
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| CN119792529A (zh) * | 2025-01-16 | 2025-04-11 | 山东第一医科大学(山东省医学科学院) | 抑制Chrm3受体表达的试剂在制备治疗由脂多糖引起的相关疾病的药物中的应用 |
| CN121041449A (zh) * | 2025-07-31 | 2025-12-02 | 中国人民解放军军事科学院军事医学研究院 | 乙酰胆碱受体激动剂在治疗脑膜炎中的应用 |
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- 2003-12-05 CN CN2012100243080A patent/CN102657651A/zh active Pending
- 2003-12-05 DK DK07020473.0T patent/DK1949901T3/da active
- 2003-12-05 CA CA2507502A patent/CA2507502C/en not_active Expired - Fee Related
- 2003-12-05 CN CNA2003801082615A patent/CN1735414A/zh active Pending
- 2003-12-05 SI SI200332349T patent/SI1949901T1/sl unknown
- 2003-12-05 ES ES03796701T patent/ES2293086T3/es not_active Expired - Lifetime
- 2003-12-05 EP EP07020473.0A patent/EP1949901B1/en not_active Expired - Lifetime
- 2003-12-05 EP EP09001425A patent/EP2062595A1/en not_active Withdrawn
- 2003-12-05 PT PT70204730T patent/PT1949901E/pt unknown
- 2003-12-05 US US10/729,427 patent/US7273872B2/en not_active Expired - Fee Related
- 2003-12-05 AT AT03796701T patent/ATE378048T1/de not_active IP Right Cessation
- 2003-12-05 JP JP2004559325A patent/JP4750421B2/ja not_active Expired - Fee Related
- 2003-12-05 AU AU2003298939A patent/AU2003298939B2/en not_active Ceased
-
2005
- 2005-05-25 IL IL168787A patent/IL168787A/en not_active IP Right Cessation
-
2010
- 2010-07-07 IL IL206855A patent/IL206855A/en not_active IP Right Cessation
-
2011
- 2011-01-26 JP JP2011014401A patent/JP2011105745A/ja not_active Withdrawn
-
2013
- 2013-12-12 JP JP2013257181A patent/JP5925178B2/ja not_active Expired - Fee Related
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2016
- 2016-01-18 JP JP2016007291A patent/JP2016084355A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1949901B1 (en) | 2014-02-12 |
| IL168787A (en) | 2010-11-30 |
| JP2014055178A (ja) | 2014-03-27 |
| CN1735414A (zh) | 2006-02-15 |
| ES2293086T3 (es) | 2008-03-16 |
| DE60317564D1 (de) | 2007-12-27 |
| EP1949901A2 (en) | 2008-07-30 |
| AU2003298939C1 (en) | 2004-06-30 |
| US7273872B2 (en) | 2007-09-25 |
| DE60317564T2 (de) | 2008-10-23 |
| WO2004052365A3 (en) | 2004-09-23 |
| CN102657651A (zh) | 2012-09-12 |
| WO2004052365A2 (en) | 2004-06-24 |
| EP1581223B1 (en) | 2007-11-14 |
| SI1949901T1 (sl) | 2014-06-30 |
| JP2006514946A (ja) | 2006-05-18 |
| DK1949901T3 (da) | 2014-05-19 |
| JP5925178B2 (ja) | 2016-05-25 |
| EP1949901A3 (en) | 2008-10-15 |
| EP1581223B2 (en) | 2016-05-25 |
| US20040204355A1 (en) | 2004-10-14 |
| EP2062595A1 (en) | 2009-05-27 |
| AU2003298939B2 (en) | 2007-03-15 |
| JP4750421B2 (ja) | 2011-08-17 |
| CA2507502A1 (en) | 2004-06-24 |
| EP1581223A2 (en) | 2005-10-05 |
| JP2011105745A (ja) | 2011-06-02 |
| ATE378048T1 (de) | 2007-11-15 |
| CA2507502C (en) | 2011-11-29 |
| AU2003298939A1 (en) | 2004-06-30 |
| IL206855A (en) | 2015-11-30 |
| JP2016084355A (ja) | 2016-05-19 |
| ES2462545T3 (es) | 2014-05-23 |
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