JP2006508336A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006508336A5 JP2006508336A5 JP2004521625A JP2004521625A JP2006508336A5 JP 2006508336 A5 JP2006508336 A5 JP 2006508336A5 JP 2004521625 A JP2004521625 A JP 2004521625A JP 2004521625 A JP2004521625 A JP 2004521625A JP 2006508336 A5 JP2006508336 A5 JP 2006508336A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- her2
- tumor
- her1
- her3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 52
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 52
- 238000000034 method Methods 0.000 claims 46
- 206010028980 Neoplasm Diseases 0.000 claims 33
- 102000001301 EGF receptor Human genes 0.000 claims 28
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 19
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 19
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 17
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 17
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 15
- 239000003446 ligand Substances 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 10
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 10
- 108060006698 EGF receptor Proteins 0.000 claims 9
- 239000000833 heterodimer Substances 0.000 claims 9
- 238000001114 immunoprecipitation Methods 0.000 claims 9
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 7
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 7
- 230000026731 phosphorylation Effects 0.000 claims 7
- 238000006366 phosphorylation reaction Methods 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 2
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 2
- 238000003364 immunohistochemistry Methods 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39629002P | 2002-07-15 | 2002-07-15 | |
| US60/396,290 | 2002-07-15 | ||
| US48004303P | 2003-06-20 | 2003-06-20 | |
| US60/480,043 | 2003-06-20 | ||
| PCT/US2003/021590 WO2004008099A2 (en) | 2002-07-15 | 2003-07-11 | METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012145330A Division JP5678005B2 (ja) | 2002-07-15 | 2012-06-28 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006508336A JP2006508336A (ja) | 2006-03-09 |
| JP2006508336A5 true JP2006508336A5 (enExample) | 2009-03-12 |
| JP5069843B2 JP5069843B2 (ja) | 2012-11-07 |
Family
ID=30118578
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521625A Expired - Lifetime JP5069843B2 (ja) | 2002-07-15 | 2003-07-11 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
| JP2012145330A Expired - Lifetime JP5678005B2 (ja) | 2002-07-15 | 2012-06-28 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
| JP2014144190A Pending JP2014237667A (ja) | 2002-07-15 | 2014-07-14 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012145330A Expired - Lifetime JP5678005B2 (ja) | 2002-07-15 | 2012-06-28 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
| JP2014144190A Pending JP2014237667A (ja) | 2002-07-15 | 2014-07-14 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20040106161A1 (enExample) |
| EP (2) | EP2263691B1 (enExample) |
| JP (3) | JP5069843B2 (enExample) |
| CN (2) | CN102295703A (enExample) |
| AT (1) | ATE535254T1 (enExample) |
| AU (2) | AU2003273218C1 (enExample) |
| BR (1) | BR0312534A (enExample) |
| CA (1) | CA2490758C (enExample) |
| CY (2) | CY1112631T1 (enExample) |
| DK (2) | DK2263691T3 (enExample) |
| ES (2) | ES2376165T3 (enExample) |
| HU (1) | HUP0600340A3 (enExample) |
| IL (2) | IL165952A (enExample) |
| MX (1) | MXPA05000403A (enExample) |
| NO (1) | NO337855B1 (enExample) |
| NZ (1) | NZ537660A (enExample) |
| PL (1) | PL214010B1 (enExample) |
| PT (2) | PT2263691E (enExample) |
| RU (2) | RU2338751C2 (enExample) |
| WO (1) | WO2004008099A2 (enExample) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US7625859B1 (en) * | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
| US7393823B1 (en) | 1999-01-20 | 2008-07-01 | Oregon Health And Science University | HER-2 binding antagonists |
| CA2407556C (en) | 2000-05-19 | 2011-06-21 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy |
| US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| US20040229380A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
| US20090111127A1 (en) * | 2002-05-21 | 2009-04-30 | Monogram Biosciences Inc. | Surface Receptor Complexes as Biomarkers |
| US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| EP1613205B1 (en) * | 2003-04-01 | 2013-04-24 | Monogram BioSciences, Inc. | Erbb surface receptor complexes as biomarkers |
| US20100291594A1 (en) * | 2003-07-17 | 2010-11-18 | Laboratory Corporation Of America Holdings | ErbB Surface Receptor Complexes as Biomarkers |
| US7402398B2 (en) * | 2003-07-17 | 2008-07-22 | Monogram Biosciences, Inc. | Measuring receptor homodimerization |
| EP1673399B1 (en) * | 2003-08-11 | 2017-04-05 | Monogram BioSciences, Inc. | Detecting and profiling molecular complexes |
| US7402399B2 (en) | 2003-10-14 | 2008-07-22 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
| US7329495B2 (en) | 2004-06-09 | 2008-02-12 | Board Of Regents, The University Of Texas System | Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors |
| GT200500155A (es) * | 2004-06-16 | 2006-05-15 | Terapia del càncer resistente al platino | |
| DK1771482T3 (da) | 2004-07-22 | 2014-10-20 | Genentech Inc | HER2-antistofsammensætning |
| CA2583230A1 (en) * | 2004-10-05 | 2006-04-20 | Oregon Health And Science University | Compositions and methods for treating disease |
| US20080261243A1 (en) * | 2004-10-06 | 2008-10-23 | Wellstat Biologics Corporation | Detection of Elevated Levels of Her-2/Neu Protein on Circulating Cancer Cells and Treatment |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| WO2006045991A1 (en) * | 2004-10-25 | 2006-05-04 | Astrazeneca Ab | Method to predict whether a tumor will react to a chemotherapeutic treatment |
| WO2006063042A2 (en) * | 2004-12-07 | 2006-06-15 | Genentech, Inc. | Selecting patients for therapy with a her inhibitor |
| CN102580084B (zh) * | 2005-01-21 | 2016-11-23 | 健泰科生物技术公司 | Her抗体的固定剂量给药 |
| EP1850874B1 (en) * | 2005-02-23 | 2013-10-16 | Genentech, Inc. | Extending time to disease progression or survival in ovarian cancer patients using pertuzumab |
| US20060204505A1 (en) * | 2005-03-08 | 2006-09-14 | Sliwkowski Mark X | Methods for identifying tumors responsive to treatment with HER dimerization inhibitors (HDIs) |
| JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| MY157955A (en) * | 2005-07-06 | 2016-08-30 | Hoffmann La Roche | Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody |
| PE20070207A1 (es) | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| US7700299B2 (en) * | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
| JP5025724B2 (ja) | 2006-04-18 | 2012-09-12 | ウェルスタット バイオロジクス コーポレイション | 循環腫瘍性細胞からのタンパク質の検出 |
| JP2009534666A (ja) * | 2006-04-18 | 2009-09-24 | ウェルスタット バイオロジックス コーポレイション | 循環内皮細胞の検出 |
| EP2036584B1 (en) * | 2006-06-27 | 2015-01-21 | Asahi Kasei Kabushiki Kaisha | Substrate for biological fluid treatment |
| BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
| BRPI0808551B1 (pt) | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| SI2132573T1 (sl) | 2007-03-02 | 2014-07-31 | Genentech, Inc. | Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3 |
| US20090258005A1 (en) * | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
| US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
| PL2171090T3 (pl) * | 2007-06-08 | 2013-09-30 | Genentech Inc | Markery ekspresji genów odporności guza na leczenie hamujące HER2 |
| EP2179291B1 (en) * | 2007-07-13 | 2014-10-22 | Nestec S.A. | Drug selection for lung cancer therapy using antibody-based arrays |
| MX2010005099A (es) * | 2007-11-09 | 2010-05-27 | Novartis Ag | Usos de anticuerpos anti-cd40. |
| EP2650311A3 (en) * | 2007-11-27 | 2014-06-04 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
| EP2235536A4 (en) | 2007-12-20 | 2011-05-04 | Lab Corp America Holdings | HER-2-DIAGNOSTIC PROCEDURE |
| CA2710680C (en) | 2007-12-26 | 2018-10-16 | Vaccinex, Inc. | Anti-c35 antibody combination therapies and methods |
| US20140127200A1 (en) * | 2008-01-03 | 2014-05-08 | The Scripps Research Institute | Multispecific Antibody Targeting and Multivalency Through Modular Recognition Domains |
| MX340916B (es) * | 2008-01-18 | 2016-07-29 | President And Fellows Of Harvard College * | Metodos para detectar señales de identificacion de enfermedad o condiciones en fluidos corporales. |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物 |
| AU2009219437B2 (en) * | 2008-02-25 | 2014-10-16 | Nestec S.A. | Drug selection for breast cancer therapy using antibody-based arrays |
| JP5800454B2 (ja) * | 2008-05-23 | 2015-10-28 | 株式会社ノエビア | 皮膚外用剤、経口剤、抗酸化剤、抗老化剤、及び免疫賦活剤 |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| CA2729796C (en) | 2008-07-08 | 2017-07-04 | George Mason Intellectual Properties, Inc. | Phosphorylated c-erbb2 as a superior predictive theranostic marker for the diagnosis and treatment of cancer |
| MX367196B (es) * | 2008-08-05 | 2019-08-08 | Alm Holding Co | Proceso para el reciclamiento frio en el sitio utilizando asfalto en espuma y aditivo de lubricacion. |
| WO2010022736A2 (en) | 2008-08-29 | 2010-03-04 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| ES2637411T3 (es) | 2008-12-01 | 2017-10-13 | Laboratory Corporation Of America Holdings | Métodos y ensayos para medir p95 Y/O p95 en una muestra y anticuerpos específicos para p95 |
| EP2387711B1 (en) | 2009-01-15 | 2015-04-22 | Laboratory Corporation of America Holdings | Methods of determining patient response by measurement of her-3 |
| JP2012515353A (ja) * | 2009-01-15 | 2012-07-05 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
| MY152068A (en) | 2009-03-20 | 2014-08-15 | Genentech Inc | Bispecific anti-her antibodies |
| NZ596468A (en) * | 2009-05-14 | 2013-11-29 | Nestec Sa | Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy |
| CN102421448A (zh) | 2009-05-29 | 2012-04-18 | 霍夫曼-拉罗奇有限公司 | Her2信号传导调控剂在表达her2的胃癌患者中 |
| JP5795311B2 (ja) | 2009-07-15 | 2015-10-14 | ネステク ソシエテ アノニム | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
| RU2411915C1 (ru) * | 2009-10-05 | 2011-02-20 | Константин Петрович Гайденко | Способ диагностики больных, пораженных опухолями головного мозга |
| US9556249B2 (en) | 2010-02-18 | 2017-01-31 | Genentech, Inc. | Neuregulin antagonists and use thereof in treating cancer |
| WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| WO2012069466A1 (en) | 2010-11-24 | 2012-05-31 | Novartis Ag | Multispecific molecules |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| MX2014001766A (es) | 2011-08-17 | 2014-05-01 | Genentech Inc | Anticuerpos de neuregulina y sus usos. |
| EP2751562B1 (en) | 2011-09-02 | 2015-09-16 | Nestec S.A. | Profiling of signal pathway proteins to determine therapeutic efficacy |
| PH12014500483A1 (en) | 2011-09-30 | 2014-04-14 | Regeneron Pharma | Anti-erbb3 antibodies and uses thereof |
| US9273143B2 (en) | 2011-09-30 | 2016-03-01 | Regeneron Pharmaceuticals, Inc. | Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody |
| JP6169085B2 (ja) | 2011-10-06 | 2017-07-26 | アベオ ファーマシューティカルズ， インコーポレイテッド | 抗ｅｒｂｂ３抗体に対する腫瘍応答の推定 |
| IL301603A (en) | 2011-10-14 | 2023-05-01 | Genentech Inc | Pertuzumab, trastuzumab, docetaxel and carboplatin for use in the preoperative treatment of a patient |
| US9327023B2 (en) | 2011-10-25 | 2016-05-03 | The Regents Of The University Of Michigan | HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells |
| DK2797957T3 (da) | 2011-11-23 | 2019-09-23 | Medimmune Llc | Bindingsmolekyler specifikke for her3 og anvendelser deraf |
| BR112014012979A2 (pt) | 2011-11-30 | 2020-10-20 | Genentech, Inc. | mutações erbb3 em câncer |
| US9376715B2 (en) | 2011-12-09 | 2016-06-28 | Roche Molecular Systems, Inc | Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene |
| US20130259867A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Diagnosis and treatments relating to her3 inhibitors |
| WO2013164689A2 (en) | 2012-05-02 | 2013-11-07 | Lantto, Johan | Humanized pan-her antibody compositions |
| TWI641619B (zh) * | 2012-06-25 | 2018-11-21 | 美商再生元醫藥公司 | 抗－ｅｇｆｒ抗體及其用途 |
| WO2014060365A1 (en) | 2012-10-15 | 2014-04-24 | Universität Zürich Prorektorat Mnw | Bispecific her2 ligands for cancer therapy |
| EP2719706A1 (en) | 2012-10-15 | 2014-04-16 | Universität Zürich | Bispecific HER2 ligands for cancer therapy |
| KR102291355B1 (ko) | 2012-11-30 | 2021-08-19 | 에프. 호프만-라 로슈 아게 | Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법 |
| US10150800B2 (en) | 2013-03-15 | 2018-12-11 | Zyngenia, Inc. | EGFR-binding modular recognition domains |
| US20160041171A1 (en) * | 2013-04-05 | 2016-02-11 | Laboratory Corporation Of America Holdings | Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation |
| MX368259B (es) * | 2013-04-16 | 2019-09-25 | Genentech Inc | Variantes de pertuzumab y su evaluacion. |
| US11305012B2 (en) | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| EP3087394A2 (en) | 2013-12-27 | 2016-11-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| WO2015157634A1 (en) | 2014-04-11 | 2015-10-15 | Kolltan Pharmaceuticals, Inc. | Anti-erbb antibodies and methods of use thereof |
| KR20160141857A (ko) | 2014-04-25 | 2016-12-09 | 제넨테크, 인크. | 트라스투주맙-mcc-dm1 및 퍼투주맙을 이용하는 초기 유방암의 치료방법 |
| CN105985435B (zh) | 2015-01-30 | 2019-10-15 | 嘉和生物药业有限公司 | 全人源her2抗体的突变抗体及其编码基因和应用 |
| WO2016196373A2 (en) | 2015-05-30 | 2016-12-08 | Genentech, Inc. | Methods of treating her2-positive metastatic breast cancer |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
| EP3418744A4 (en) * | 2016-02-19 | 2018-12-26 | Konica Minolta, Inc. | Non-clinical test method characterized by quantitative evaluation of experimental animal specimen |
| US20190151346A1 (en) | 2016-05-10 | 2019-05-23 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Combinations therapies for the treatment of cancer |
| US10377833B2 (en) | 2016-07-22 | 2019-08-13 | Beijing Mabworks Biotech Co., Ltd. | Bispecific anti-HER2 antibody |
| CN107446045A (zh) | 2016-07-22 | 2017-12-08 | 北京天广实生物技术股份有限公司 | 一种抗her2的抗体、其药物组合物及用途 |
| WO2018085513A1 (en) | 2016-11-04 | 2018-05-11 | Genentech, Inc. | Treatment of her2-positive breast cancer |
| EP3562844A1 (en) | 2016-12-28 | 2019-11-06 | Genentech, Inc. | Treatment of advanced her2 expressing cancer |
| TW202508629A (zh) | 2017-01-17 | 2025-03-01 | 美商建南德克公司 | 皮下her2抗體調配物 |
| PT3589661T (pt) | 2017-03-02 | 2024-01-29 | Genentech Inc | Tratamento com adjuvante de cancro da mama positivo para her2 |
| WO2018200505A1 (en) | 2017-04-24 | 2018-11-01 | Genentech, Inc. | Erbb2/her2 mutations in the transmbrane or juxtamembrane domain |
| WO2019241599A1 (en) * | 2018-06-14 | 2019-12-19 | Memorial Sloan Kettering Cancer Center | Methods for predicting responsiveness of lung cancer patients to her2-targeting therapies |
| IL318587A (en) | 2018-07-23 | 2025-03-01 | Trevi Therapeutics Inc | Treatment of chronic cough, shortness of breath and wheezing |
| EP3848054B1 (en) | 2018-09-06 | 2025-01-29 | Daiichi Sankyo Company, Limited | Antibody-drug conjugates of cyclic dinucleotide derivatives |
| BR112021005670A2 (pt) | 2018-10-08 | 2021-06-22 | Universität Zürich | polipeptídeos tetraméricos de ligação a her2 |
| JP7624922B2 (ja) | 2018-12-19 | 2025-01-31 | インサイト・コーポレイション | 胃腸疾患の治療のためのｊａｋ１経路阻害剤 |
| CN113993902B (zh) * | 2019-03-22 | 2025-03-14 | 瑟缇斯治疗私人有限公司 | 抗her2结合分子 |
| MX2022002980A (es) | 2019-09-16 | 2022-04-06 | Amgen Inc | Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos. |
| IL294601A (en) | 2020-01-10 | 2022-09-01 | Trevi Therapeutics Inc | Methods of administration of nalbuphine |
| WO2021188578A1 (en) * | 2020-03-16 | 2021-09-23 | University Of Southern California | Screening methods to identify small molecule compounds that promote or inhibit the growth of circulating tumor cells, and uses thereof |
| JP2023532122A (ja) | 2020-06-29 | 2023-07-26 | ジェネンテック， インコーポレイテッド | ペルツズマブにトラスツズマブを加えた固定用量配合剤 |
| TW202241454A (zh) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | 抗體－免疫賦活化劑共軛物之新穎製造方法 |
| US20240279364A1 (en) | 2021-03-12 | 2024-08-22 | Daiichi Sankyo Company, Limited | Glycan, and method for producing medicine containing glycan |
| CN118804983A (zh) | 2022-03-02 | 2024-10-18 | 第一三共株式会社 | 含Fc分子的制造方法 |
| KR20250064682A (ko) | 2022-09-09 | 2025-05-09 | 다이이찌 산쿄 가부시키가이샤 | 신규 올리고당, 그 올리고당의 제조 중간체, 및 그것들의 제조 방법 |
Family Cites Families (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US229293A (en) * | 1880-06-29 | Swinging can | ||
| US190689A (en) * | 1877-05-15 | Improvement in car-brakes | ||
| US229380A (en) * | 1880-06-29 | John charles | ||
| US197835A (en) * | 1877-12-04 | Improvement in dovetailing and grooving machines | ||
| US126818A (en) * | 1872-05-14 | Improvement in carpet-stretchers | ||
| US229294A (en) * | 1880-06-29 | woolnoug-h | ||
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4474683A (en) | 1981-08-10 | 1984-10-02 | Armour-Dial, Inc. | Soap making process |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| EP0171407B1 (en) | 1984-01-30 | 1993-11-18 | Imperial Cancer Research Technology Limited | Improvements relating to growth factors |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| JP3040121B2 (ja) * | 1988-01-12 | 2000-05-08 | ジェネンテク，インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| ATE135397T1 (de) | 1988-09-23 | 1996-03-15 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| ES2096590T3 (es) | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
| EP0491007B1 (en) | 1989-09-08 | 1996-03-13 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| WO1991005264A1 (en) | 1989-09-29 | 1991-04-18 | Oncogenetics Partners | Detection and quantification of neu related proteins in the biological fluids of humans |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5264586A (en) | 1991-07-17 | 1993-11-23 | The Scripps Research Institute | Analogs of calicheamicin gamma1I, method of making and using the same |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
| WO1993016177A1 (en) | 1992-02-11 | 1993-08-19 | Cell Genesys, Inc. | Homogenotization of gene-targeting events |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| AU4025193A (en) | 1992-04-08 | 1993-11-18 | Cetus Oncology Corporation | Humanized C-erbB-2 specific antibodies |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| EP0646178A1 (en) | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | expression cassette with regularoty regions functional in the mammmlian host |
| AU687346B2 (en) | 1992-06-30 | 1998-02-26 | Oncologix, Inc. | A combination of anti-erbB-2 monoclonal antibodies and method of using |
| CA2140280A1 (en) | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| US5811098A (en) * | 1992-11-24 | 1998-09-22 | Bristol-Myers Squibb Company | Antibodies to HER4, human receptor tyrosine kinase |
| CA2103323A1 (en) | 1992-11-24 | 1994-05-25 | Gregory D. Plowman | Her4 human receptor tyrosine kinase |
| PT616812E (pt) | 1993-03-24 | 2000-04-28 | Berlex Biosciences | Combinacao de compostos anti-hormonais e moleculas de ligacao no tratamento do cancro |
| WO1994022478A1 (en) | 1993-03-30 | 1994-10-13 | The Trustees Of The University Of Pennsylvania | PREVENTION OF TUMORS WITH MONOCLONAL ANTIBODIES AGAINST $i(NEU) |
| US6025145A (en) | 1993-11-23 | 2000-02-15 | Genentech, Inc. | Kinase receptor activation assay |
| CA2175893C (en) | 1993-11-23 | 2010-06-22 | Paul J. Godowski | Protein tyrosine kinases named rse |
| US6287784B1 (en) | 1993-11-23 | 2001-09-11 | Genentech, Inc. | Kinase receptor activation assay |
| DE69428764T2 (de) | 1993-12-24 | 2002-06-20 | Merck Patent Gmbh | Immunokonjugate |
| PT699237E (pt) | 1994-03-17 | 2003-07-31 | Merck Patent Gmbh | Fvs de cadeia anti-egfr e anticorpos anti-egfr |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| WO1996003397A1 (en) | 1994-07-21 | 1996-02-08 | Akzo Nobel N.V. | Cyclic ketone peroxide formulations |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| AU4289496A (en) | 1994-12-02 | 1996-06-19 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| JPH11507535A (ja) | 1995-06-07 | 1999-07-06 | イムクローン システムズ インコーポレイテッド | 腫瘍の成長を抑制する抗体および抗体フラグメント類 |
| US5977322A (en) | 1995-06-14 | 1999-11-02 | The Regents Of The University Of California | High affinity human antibodies to tumor antigens |
| ES2434840T3 (es) | 1995-07-27 | 2013-12-17 | Genentech, Inc. | Formulación de proteína liofilizada isotónica estable |
| US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
| DE69736806T3 (de) | 1996-03-27 | 2015-10-08 | Genentech, Inc. | ErbB3 ANTIKÖRPER |
| US5968511A (en) * | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
| EA001595B1 (ru) | 1996-04-12 | 2001-06-25 | Варнер-Ламберт Компани | Необратимые ингибиторы тирозинкиназ |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| MY131805A (en) * | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
| AU9805398A (en) | 1997-10-15 | 1999-05-03 | Children's Medical Center Corporation | Novel human egf receptors and use thereof |
| BR9907852A (pt) * | 1998-02-12 | 2000-10-24 | Immunivest Corp | Processos para detectar e enumerar células raras e cancerosas em uma população celular mista, para diagnosticar câncer de estágio precoce em um paciente de teste, para determinar a probabilidade de recorrência de câncer em um paciente humano anteriormente tratado de câncer, para distinguir um carcinoma confinado ao órgão de um carcinoma com propriedades metastáticas, para acompanhar a situação de remissão em um paciente humano com câncer que passa pelo tratamento de terapia contra o câncer e para aumentar quantidades de células epiteliais circulantes em uma amostra de sangue, partìcula magnética revestida, composição, conjuntos de teste para avaliar uma amostra de paciente quanto a presença de células raras circulantes, quanto a presença de células de tumor circulantes, quanto a presença de células de câncer de mama circulantes, quanto a presença de células de câncer de próstata circulantes, quanto a presença de células de câncer de cólon circulantes, quanto a presença de células de câncer de bexiga circulantes e para monitorar um paciente quanto a recorrência de câncer, e, fração de sangue periférico enriquecido quanto a células neoplásticas circulantes |
| US6417168B1 (en) * | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
| US6627400B1 (en) * | 1999-04-30 | 2003-09-30 | Aclara Biosciences, Inc. | Multiplexed measurement of membrane protein populations |
| US6322980B1 (en) | 1999-04-30 | 2001-11-27 | Aclara Biosciences, Inc. | Single nucleotide detection using degradation of a fluorescent sequence |
| US6514700B1 (en) | 1999-04-30 | 2003-02-04 | Aclara Biosciences, Inc. | Nucleic acid detection using degradation of a tagged sequence |
| US7049410B2 (en) | 1999-05-14 | 2006-05-23 | Majumdar Adhip P N | Antibodies to a novel EGF-receptor related protein (ERRP) |
| AU5003200A (en) | 1999-05-14 | 2000-12-05 | United States Of America As Represented By The Department Of Veterans Affairs, The | Isolation and characterization of epidermal growth factor related protein |
| US7041292B1 (en) * | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
| BR0012196A (pt) * | 1999-06-25 | 2002-03-19 | Genentech Inc | Método de tratamento de um tumor em mamìferos através do uso de conjugados de maitansinóide e anticorpo receptor anti-erbb e artigo industrializado |
| US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| CN100340575C (zh) * | 1999-06-25 | 2007-10-03 | 杰南技术公司 | 人源化抗ErbB2抗体及其在制备药物中的应用 |
| EP1212366B1 (en) * | 1999-07-30 | 2007-09-12 | Medarex, Inc. | Therapeutic compounds comprised of anti-fc receptor binding agents |
| KR20110008112A (ko) * | 1999-08-27 | 2011-01-25 | 제넨테크, 인크. | 항-ＥｒｂＢ2 항체 투여 치료 방법 |
| CA2407556C (en) | 2000-05-19 | 2011-06-21 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy |
| US20020119148A1 (en) | 2000-09-01 | 2002-08-29 | Gerritsen Mary E. | ErbB4 antagonists |
| US20040138160A1 (en) * | 2001-04-27 | 2004-07-15 | Kenichiro Naito | Preventive/therapeutic method for cancer |
| JP2004002211A (ja) * | 2001-04-27 | 2004-01-08 | Takeda Chem Ind Ltd | 癌の予防・治療方法 |
| US20030190689A1 (en) * | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
| US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| US20040229380A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
| US20040229293A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | Surface receptor complexes as biomarkers |
| AU2003251597A1 (en) * | 2002-06-19 | 2004-01-06 | Abgenix, Inc. | Method for predicting response to epidermal growth factor receptor-directed therapy |
| JP4443407B2 (ja) * | 2002-07-25 | 2010-03-31 | アクララ バイオサイエンシーズ， インコーポレイテッド | レセプターオリゴマー形成の検出 |
| CN102580084B (zh) * | 2005-01-21 | 2016-11-23 | 健泰科生物技术公司 | Her抗体的固定剂量给药 |
-
2003
- 2003-07-11 WO PCT/US2003/021590 patent/WO2004008099A2/en not_active Ceased
- 2003-07-11 CN CN2011102788307A patent/CN102295703A/zh active Pending
- 2003-07-11 DK DK10176072.6T patent/DK2263691T3/da active
- 2003-07-11 BR BRPI0312534-3A patent/BR0312534A/pt not_active Application Discontinuation
- 2003-07-11 MX MXPA05000403A patent/MXPA05000403A/es active IP Right Grant
- 2003-07-11 DK DK03755724.6T patent/DK1585966T3/da active
- 2003-07-11 PL PL377743A patent/PL214010B1/pl unknown
- 2003-07-11 AU AU2003273218A patent/AU2003273218C1/en not_active Expired
- 2003-07-11 PT PT10176072T patent/PT2263691E/pt unknown
- 2003-07-11 EP EP10176072A patent/EP2263691B1/en not_active Expired - Lifetime
- 2003-07-11 NZ NZ537660A patent/NZ537660A/en not_active IP Right Cessation
- 2003-07-11 JP JP2004521625A patent/JP5069843B2/ja not_active Expired - Lifetime
- 2003-07-11 ES ES03755724T patent/ES2376165T3/es not_active Expired - Lifetime
- 2003-07-11 ES ES10176072T patent/ES2392525T3/es not_active Expired - Lifetime
- 2003-07-11 EP EP03755724A patent/EP1585966B8/en not_active Expired - Lifetime
- 2003-07-11 HU HU0600340A patent/HUP0600340A3/hu unknown
- 2003-07-11 PT PT03755724T patent/PT1585966E/pt unknown
- 2003-07-11 AT AT03755724T patent/ATE535254T1/de active
- 2003-07-11 CN CN200910207004A patent/CN101711866A/zh active Pending
- 2003-07-11 RU RU2005103824/13A patent/RU2338751C2/ru active
- 2003-07-11 CA CA2490758A patent/CA2490758C/en not_active Expired - Lifetime
- 2003-07-14 US US10/619,754 patent/US20040106161A1/en not_active Abandoned
-
2004
- 2004-12-23 IL IL165952A patent/IL165952A/en active IP Right Grant
-
2005
- 2005-02-14 NO NO20050775A patent/NO337855B1/no not_active IP Right Cessation
-
2008
- 2008-07-10 RU RU2008128244/13A patent/RU2008128244A/ru not_active Application Discontinuation
-
2010
- 2010-02-25 AU AU2010200692A patent/AU2010200692A1/en not_active Abandoned
- 2010-11-29 US US12/955,727 patent/US20110117096A1/en not_active Abandoned
-
2012
- 2012-02-17 CY CY20121100167T patent/CY1112631T1/el unknown
- 2012-04-24 IL IL219381A patent/IL219381A/en active IP Right Grant
- 2012-06-28 JP JP2012145330A patent/JP5678005B2/ja not_active Expired - Lifetime
- 2012-10-29 CY CY20121101025T patent/CY1113260T1/el unknown
-
2014
- 2014-07-14 JP JP2014144190A patent/JP2014237667A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006508336A5 (enExample) | ||
| RU2005103824A (ru) | Способы идентификации опухолей, восприимчивых к лечению антителами против erbb2 | |
| Meric-Bernstam et al. | Advances in HER2-targeted therapy: novel agents and opportunities beyond breast and gastric cancer | |
| JP6449308B2 (ja) | がんバイオマーカー及びその使用 | |
| Moasser | Targeting the function of the HER2 oncogene in human cancer therapeutics | |
| Bossi et al. | Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma | |
| Esteva et al. | Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies | |
| Matsubara et al. | Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer | |
| CN104813168B (zh) | 需要pd‑l1抑制剂综合疗法的患者的鉴定 | |
| LoRusso et al. | Phase I study of U3-1287, a fully human anti-HER3 monoclonal antibody, in patients with advanced solid tumors | |
| US20220412976A1 (en) | Clinical management of oropharyngeal squamous cell carcinoma | |
| Tagliabue et al. | HER2 as a target for breast cancer therapy | |
| CA2749846A1 (en) | Methods of determining patient response by measurement of her-3 | |
| Guo et al. | L1 cell adhesion molecule overexpression in hepatocellular carcinoma associates with advanced tumor progression and poor patient survival | |
| Takano et al. | Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors | |
| JP2012515226A5 (enExample) | ||
| KR20190140945A (ko) | NRG1 융합 유전자를 가지는 세포를 치료하기 위한 ErbB-2 및 ErbB-3 결합 이중특이적 항체 | |
| Kim et al. | Amphiregulin confers trastuzumab resistance via AKT and ERK activation in HER2-positive breast cancer | |
| JP2002527404A5 (enExample) | ||
| TW201642897A (zh) | Ｈｅｒ２結合劑治療 | |
| Takei et al. | A novel anti-EGFR monoclonal antibody (EMab-17) exerts antitumor activity against oral squamous cell carcinomas via antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity | |
| JP2014527035A (ja) | 婦人科悪性腫瘍を治療するためのパクリタキセルとの組み合わせの抗ＥｒｂＢ３抗体 | |
| Cheng et al. | Quantitative measurements of HER2 and phospho-HER2 expression: correlation with pathologic response to neoadjuvant chemotherapy and trastuzumab | |
| Hickish et al. | Afatinib alone and in combination with vinorelbine or paclitaxel, in patients with HER2-positive breast cancer who failed or progressed on prior trastuzumab and/or lapatinib (LUX-Breast 2): an open-label, multicenter, phase II trial | |
| Todeschini et al. | Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumab |