JP2006508336A5 - - Google Patents
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- Publication number
- JP2006508336A5 JP2006508336A5 JP2004521625A JP2004521625A JP2006508336A5 JP 2006508336 A5 JP2006508336 A5 JP 2006508336A5 JP 2004521625 A JP2004521625 A JP 2004521625A JP 2004521625 A JP2004521625 A JP 2004521625A JP 2006508336 A5 JP2006508336 A5 JP 2006508336A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- her2
- tumor
- her1
- her3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 52
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 52
- 238000000034 method Methods 0.000 claims 46
- 206010028980 Neoplasm Diseases 0.000 claims 33
- 102000001301 EGF receptor Human genes 0.000 claims 28
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 19
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 19
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 17
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 17
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 15
- 239000003446 ligand Substances 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 10
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 10
- 108060006698 EGF receptor Proteins 0.000 claims 9
- 239000000833 heterodimer Substances 0.000 claims 9
- 238000001114 immunoprecipitation Methods 0.000 claims 9
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 7
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 7
- 230000026731 phosphorylation Effects 0.000 claims 7
- 238000006366 phosphorylation reaction Methods 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 2
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 2
- 238000003364 immunohistochemistry Methods 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39629002P | 2002-07-15 | 2002-07-15 | |
| US60/396,290 | 2002-07-15 | ||
| US48004303P | 2003-06-20 | 2003-06-20 | |
| US60/480,043 | 2003-06-20 | ||
| PCT/US2003/021590 WO2004008099A2 (en) | 2002-07-15 | 2003-07-11 | METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012145330A Division JP5678005B2 (ja) | 2002-07-15 | 2012-06-28 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006508336A JP2006508336A (ja) | 2006-03-09 |
| JP2006508336A5 true JP2006508336A5 (enExample) | 2009-03-12 |
| JP5069843B2 JP5069843B2 (ja) | 2012-11-07 |
Family
ID=30118578
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521625A Expired - Lifetime JP5069843B2 (ja) | 2002-07-15 | 2003-07-11 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
| JP2012145330A Expired - Lifetime JP5678005B2 (ja) | 2002-07-15 | 2012-06-28 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
| JP2014144190A Pending JP2014237667A (ja) | 2002-07-15 | 2014-07-14 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012145330A Expired - Lifetime JP5678005B2 (ja) | 2002-07-15 | 2012-06-28 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
| JP2014144190A Pending JP2014237667A (ja) | 2002-07-15 | 2014-07-14 | 抗ＥｒｂＢ２抗体を用いる処置に応答性である腫瘍を同定するための方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20040106161A1 (enExample) |
| EP (2) | EP2263691B1 (enExample) |
| JP (3) | JP5069843B2 (enExample) |
| CN (2) | CN101711866A (enExample) |
| AT (1) | ATE535254T1 (enExample) |
| AU (2) | AU2003273218C1 (enExample) |
| BR (1) | BR0312534A (enExample) |
| CA (1) | CA2490758C (enExample) |
| CY (2) | CY1112631T1 (enExample) |
| DK (2) | DK1585966T3 (enExample) |
| ES (2) | ES2392525T3 (enExample) |
| HU (1) | HUP0600340A3 (enExample) |
| IL (2) | IL165952A (enExample) |
| MX (1) | MXPA05000403A (enExample) |
| NO (1) | NO337855B1 (enExample) |
| NZ (1) | NZ537660A (enExample) |
| PL (1) | PL214010B1 (enExample) |
| PT (2) | PT1585966E (enExample) |
| RU (2) | RU2338751C2 (enExample) |
| WO (1) | WO2004008099A2 (enExample) |
Families Citing this family (118)
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2010
- 2010-02-25 AU AU2010200692A patent/AU2010200692A1/en not_active Abandoned
- 2010-11-29 US US12/955,727 patent/US20110117096A1/en not_active Abandoned
-
2012
- 2012-02-17 CY CY20121100167T patent/CY1112631T1/el unknown
- 2012-04-24 IL IL219381A patent/IL219381A/en active IP Right Grant
- 2012-06-28 JP JP2012145330A patent/JP5678005B2/ja not_active Expired - Lifetime
- 2012-10-29 CY CY20121101025T patent/CY1113260T1/el unknown
-
2014
- 2014-07-14 JP JP2014144190A patent/JP2014237667A/ja active Pending
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