BR112016024789A2 - métodos de tratamento de câncer de mama em fase inicial com trastuzumabe-mcc-dm1 e pertuzumabe - Google Patents

métodos de tratamento de câncer de mama em fase inicial com trastuzumabe-mcc-dm1 e pertuzumabe

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Publication number
BR112016024789A2
BR112016024789A2 BR112016024789A BR112016024789A BR112016024789A2 BR 112016024789 A2 BR112016024789 A2 BR 112016024789A2 BR 112016024789 A BR112016024789 A BR 112016024789A BR 112016024789 A BR112016024789 A BR 112016024789A BR 112016024789 A2 BR112016024789 A2 BR 112016024789A2
Authority
BR
Brazil
Prior art keywords
pertuzumab
mcc
trastuzumab
methods
breast cancer
Prior art date
Application number
BR112016024789A
Other languages
English (en)
Inventor
Elizabeth Guardino Alice
C Green Marjorie
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112016024789A2 publication Critical patent/BR112016024789A2/pt

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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

métodos de tratamento de pacientes com câncer de mama inflamatório ou localmente avançado, operável, positivo para her2 com o conjugado anticorpo-fármaco trastuzumabe-mcc-dm1 e pertuzumabe são fornecidos.
BR112016024789A 2014-04-25 2015-04-23 métodos de tratamento de câncer de mama em fase inicial com trastuzumabe-mcc-dm1 e pertuzumabe BR112016024789A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461984132P 2014-04-25 2014-04-25
PCT/US2015/027388 WO2015164665A1 (en) 2014-04-25 2015-04-23 Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab

Publications (1)

Publication Number Publication Date
BR112016024789A2 true BR112016024789A2 (pt) 2017-10-24

Family

ID=53053128

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016024789A BR112016024789A2 (pt) 2014-04-25 2015-04-23 métodos de tratamento de câncer de mama em fase inicial com trastuzumabe-mcc-dm1 e pertuzumabe

Country Status (13)

Country Link
US (1) US20170035907A1 (pt)
EP (2) EP3581586A1 (pt)
JP (2) JP2017513901A (pt)
KR (1) KR20160141857A (pt)
CN (1) CN106163558A (pt)
AU (2) AU2015249633B2 (pt)
BR (1) BR112016024789A2 (pt)
CA (1) CA2946860A1 (pt)
IL (1) IL248487A0 (pt)
MX (1) MX2016014007A (pt)
RU (2) RU2725093C2 (pt)
SG (2) SG10201809411PA (pt)
WO (1) WO2015164665A1 (pt)

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WO2018103739A1 (zh) * 2016-12-09 2018-06-14 凯惠科技发展(上海)有限公司 抗体药物偶联物、制备方法、中间体、药物组合物及应用
JP6914336B2 (ja) * 2016-12-28 2021-08-04 ジェネンテック， インコーポレイテッド 進行したｈｅｒ２発現がんの治療
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ES2928718T3 (es) 2017-04-03 2022-11-22 Hoffmann La Roche Inmunoconjugados de un anticuerpo anti-PD-1 con una IL-2 mutante o con IL-15
KR102408873B1 (ko) 2017-04-05 2022-06-15 에프. 호프만-라 로슈 아게 Pd1 및 lag3에 특이적으로 결합하는 이중특이적 항체
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