JP2006508067A5 - - Google Patents
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- Publication number
- JP2006508067A5 JP2006508067A5 JP2004539882A JP2004539882A JP2006508067A5 JP 2006508067 A5 JP2006508067 A5 JP 2006508067A5 JP 2004539882 A JP2004539882 A JP 2004539882A JP 2004539882 A JP2004539882 A JP 2004539882A JP 2006508067 A5 JP2006508067 A5 JP 2006508067A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- alkyl
- membered
- cycloalkenyl
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001475 halogen functional group Chemical group 0.000 claims description 78
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 28
- 125000000623 heterocyclic group Chemical group 0.000 claims description 26
- 125000006370 trihalo methyl group Chemical group 0.000 claims description 24
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 20
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 18
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 10
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 150000001602 bicycloalkyls Chemical group 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 125000000304 alkynyl group Chemical group 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 0 C*(C)c1c(*)cccn1 Chemical compound C*(C)c1c(*)cccn1 0.000 description 5
- 125000006375 C2-C10 alkynyl group Chemical group 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41284702P | 2002-09-24 | 2002-09-24 | |
| PCT/US2003/030185 WO2004029031A2 (en) | 2002-09-24 | 2003-09-24 | Therapeutic piperazine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006508067A JP2006508067A (ja) | 2006-03-09 |
| JP2006508067A5 true JP2006508067A5 (enExample) | 2006-11-02 |
| JP4560610B2 JP4560610B2 (ja) | 2010-10-13 |
Family
ID=32043195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004539882A Expired - Fee Related JP4560610B2 (ja) | 2002-09-24 | 2003-09-24 | 治療的ピペラジン化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7157462B2 (enExample) |
| EP (2) | EP1810970B8 (enExample) |
| JP (1) | JP4560610B2 (enExample) |
| KR (1) | KR20050052514A (enExample) |
| CN (1) | CN100393713C (enExample) |
| AT (2) | ATE356817T1 (enExample) |
| AU (1) | AU2003272685A1 (enExample) |
| BR (1) | BR0314699A (enExample) |
| CA (1) | CA2500113C (enExample) |
| CY (1) | CY1106634T1 (enExample) |
| DE (2) | DE60312544T2 (enExample) |
| DK (1) | DK1562936T3 (enExample) |
| ES (1) | ES2285170T3 (enExample) |
| MX (1) | MXPA05003302A (enExample) |
| NZ (1) | NZ539205A (enExample) |
| PT (1) | PT1562936E (enExample) |
| SI (1) | SI1562936T1 (enExample) |
| WO (1) | WO2004029031A2 (enExample) |
| ZA (1) | ZA200502326B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60234812D1 (de) | 2001-01-29 | 2010-02-04 | Shionogi & Co | Arzneipräparat, das als wirkstoff 5-methyl-1-phenyl-2-(1h)-pyridon enthält |
| US7157462B2 (en) * | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| ES2327684T3 (es) | 2003-07-24 | 2009-11-02 | Euro-Celtique S.A. | Compuestos heteroaril-tetrahidropiridilo utiles para el tratamiento o la prevencion del dolor. |
| EP1648878B9 (en) * | 2003-07-24 | 2011-03-16 | Euro-Celtique S.A. | Piperidine compounds and pharmaceutical compositions containing them |
| MXPA06001331A (es) * | 2003-08-01 | 2006-05-04 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor. |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| DK1879573T3 (da) | 2005-05-10 | 2013-02-25 | Incyte Corp | Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| US20070203140A1 (en) * | 2006-02-09 | 2007-08-30 | Combs Andrew P | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase |
| EA200870449A1 (ru) * | 2006-04-19 | 2009-04-28 | Джилл П. Смит | Лечение воспалительных и язвенных заболеваний кишечника опиоидными антагонистами |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| CA2663057C (en) | 2006-09-19 | 2015-12-08 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| WO2008057300A2 (en) * | 2006-10-27 | 2008-05-15 | Redpoint Bio Corporation | Trpvi antagonists and uses thereof |
| EP2142529B1 (en) * | 2007-04-27 | 2013-12-25 | Purdue Pharma LP | Trpv1 antagonists and uses thereof |
| US20090105348A1 (en) * | 2007-10-18 | 2009-04-23 | Harry Fisch | Treatment of migraine headaches using antiestrogens |
| WO2009096701A2 (en) | 2008-01-28 | 2009-08-06 | Amorepacific Corporation | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same |
| JP5438103B2 (ja) | 2008-07-02 | 2014-03-12 | アモーレパシフィック コーポレイション | バニロイド受容体アンタゴニストとしての新規化合物、その異性体またはその薬学的に許容される塩、並びにそれを含む医薬組成物 |
| CA3012229C (en) | 2008-07-08 | 2020-11-10 | Incyte Holdings Corporation | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase |
| TWI510241B (zh) | 2010-02-18 | 2015-12-01 | Vtv Therapeutice Llc | 苯基－雜芳基衍生物及其使用方法 |
| US8921373B2 (en) | 2010-06-22 | 2014-12-30 | Shionogi & Co., Ltd. | Compounds having TRPV1 antagonistic activity and uses thereof |
| JP6130827B2 (ja) | 2011-05-17 | 2017-05-17 | 塩野義製薬株式会社 | ヘテロ環化合物 |
| RS55701B1 (sr) | 2011-06-22 | 2017-07-31 | Purdue Pharma Lp | Trpv1 antagonisti koji uključuju dihidroksi supstituent i njihove upotrebe |
| EP3744715A1 (en) | 2013-11-08 | 2020-12-02 | Incyte Holdings Corporation | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| WO2018023017A1 (en) | 2016-07-29 | 2018-02-01 | Janssen Pharmaceutica Nv | Methods of treating prostate cancer |
| US11443441B2 (en) | 2017-02-24 | 2022-09-13 | Brainlab Ag | Deep inspiration breath-hold setup using x-ray imaging |
| US12649744B2 (en) | 2020-12-22 | 2026-06-09 | Pathios Therapeutics Limited | N-(pyridin-2-yl)-6,7,8,9-tetrahydro-5h-5,8-epiminocyclohepta[c]pyridine-10-carboxamide derivatives and similar compounds as GPR65 modulators for the treatment of cancer |
| EP4330258A1 (en) | 2021-04-26 | 2024-03-06 | Pathios Therapeutics Limited | Compounds |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450272A (en) | 1982-05-06 | 1984-05-22 | American Cyanamid Company | Antiatherosclerotic 1-piperazine-thicarboxamides |
| US4439606A (en) | 1982-05-06 | 1984-03-27 | American Cyanamid Company | Antiatherosclerotic 1-piperazinecarbonyl compounds |
| US5316759A (en) | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
| DE3822792C2 (de) | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| US5198459A (en) | 1987-07-11 | 1993-03-30 | Sandoz Ltd. | Use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents |
| US5075341A (en) | 1989-12-01 | 1991-12-24 | The Mclean Hospital Corporation | Treatment for cocaine abuse |
| US6204284B1 (en) | 1991-12-20 | 2001-03-20 | American Cyanamid Company | Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies |
| US5232934A (en) | 1992-07-17 | 1993-08-03 | Warner-Lambert Co. | Method for the treatment of psychomotor stimulant addiction |
| DE4234295A1 (de) | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5321012A (en) | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| GB9306578D0 (en) | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| GB9308725D0 (en) | 1993-04-27 | 1993-06-09 | Wyeth John & Brother Ltd | Piperazine derivatives |
| US5461047A (en) | 1993-06-16 | 1995-10-24 | G. D. Searle & Co. | 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| FR2722788B1 (fr) | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| US5556837A (en) | 1994-08-01 | 1996-09-17 | Regeneron Pharmaceuticals Inc. | Methods for treating addictive disorders |
| US5762925A (en) | 1994-11-03 | 1998-06-09 | Sagen; Jacqueline | Preventing opiate tolerance by cellular implantation |
| SK282252B6 (sk) | 1995-01-11 | 2001-12-03 | Samjin Pharmaceutical Co., Ltd. | Piperazínové deriváty a farmaceutický prostriedok s ich obsahom |
| EP0850222B1 (en) | 1996-06-29 | 2003-05-28 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
| WO1999007672A1 (en) | 1997-08-05 | 1999-02-18 | Novo Nordisk A/S | Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use |
| DE69943144D1 (de) | 1998-03-31 | 2011-03-03 | Kyowa Hakko Kirin Co Ltd | Stickstoffenthaltende heterocyclische verbindungen |
| US6329395B1 (en) | 1998-06-08 | 2001-12-11 | Schering Corporation | Neuropeptide Y5 receptor antagonists |
| WO2000017163A1 (en) | 1998-09-22 | 2000-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Cyanophenyl derivatives |
| WO2000052001A1 (en) | 1999-03-03 | 2000-09-08 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
| US6109269A (en) | 1999-04-30 | 2000-08-29 | Medtronic, Inc. | Method of treating addiction by brain infusion |
| EP1313477A4 (en) | 2000-07-15 | 2004-03-03 | Smithkline Beecham Corp | COMPILATIONS AND METHODS |
| IL153884A0 (en) * | 2000-07-20 | 2003-07-31 | Neurogen Corp | Capsaicin receptor ligands |
| EP1311478B1 (en) | 2000-08-21 | 2006-06-07 | Pacific Corporation | Novel (thio)urea compounds and the pharmaceutical compositions containing the same |
| NZ523882A (en) | 2000-08-21 | 2004-11-26 | Pacific Corp | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
| MY138086A (en) | 2001-09-13 | 2009-04-30 | Smithkline Beecham Plc | Novel urea derivative as vanilloid receptor-1 antagonist |
| RS63204A (sr) | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina |
| ATE416168T1 (de) | 2002-02-15 | 2008-12-15 | Glaxo Group Ltd | Modulatoren des vanilloidrezeptors |
| US7074805B2 (en) | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US20030158188A1 (en) | 2002-02-20 | 2003-08-21 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| DE60318875T2 (de) | 2002-06-28 | 2009-01-15 | Euro-Celtique S.A. | Therapeutische piperazin-derivate für die behandlung von schmerzen |
| US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| ES2327684T3 (es) | 2003-07-24 | 2009-11-02 | Euro-Celtique S.A. | Compuestos heteroaril-tetrahidropiridilo utiles para el tratamiento o la prevencion del dolor. |
| EP1648878B9 (en) | 2003-07-24 | 2011-03-16 | Euro-Celtique S.A. | Piperidine compounds and pharmaceutical compositions containing them |
| ES2322907T3 (es) | 2003-12-30 | 2009-07-01 | Euro-Celtique S.A. | Piperazinas utiles para el tratamiento de dolor. |
-
2003
- 2003-09-23 US US10/669,823 patent/US7157462B2/en not_active Expired - Lifetime
- 2003-09-24 DE DE60312544T patent/DE60312544T2/de not_active Expired - Lifetime
- 2003-09-24 DE DE60332562T patent/DE60332562D1/de not_active Expired - Lifetime
- 2003-09-24 CA CA2500113A patent/CA2500113C/en not_active Expired - Fee Related
- 2003-09-24 AT AT03754883T patent/ATE356817T1/de active
- 2003-09-24 MX MXPA05003302A patent/MXPA05003302A/es active IP Right Grant
- 2003-09-24 ES ES03754883T patent/ES2285170T3/es not_active Expired - Lifetime
- 2003-09-24 JP JP2004539882A patent/JP4560610B2/ja not_active Expired - Fee Related
- 2003-09-24 EP EP07104074A patent/EP1810970B8/en not_active Expired - Lifetime
- 2003-09-24 PT PT03754883T patent/PT1562936E/pt unknown
- 2003-09-24 AU AU2003272685A patent/AU2003272685A1/en not_active Abandoned
- 2003-09-24 CN CNB03825297XA patent/CN100393713C/zh not_active Expired - Fee Related
- 2003-09-24 DK DK03754883T patent/DK1562936T3/da active
- 2003-09-24 WO PCT/US2003/030185 patent/WO2004029031A2/en not_active Ceased
- 2003-09-24 BR BR0314699-5A patent/BR0314699A/pt not_active IP Right Cessation
- 2003-09-24 SI SI200330815T patent/SI1562936T1/sl unknown
- 2003-09-24 AT AT07104074T patent/ATE467627T1/de not_active IP Right Cessation
- 2003-09-24 EP EP03754883A patent/EP1562936B1/en not_active Expired - Lifetime
- 2003-09-24 KR KR1020057005096A patent/KR20050052514A/ko not_active Ceased
- 2003-09-24 NZ NZ539205A patent/NZ539205A/en not_active IP Right Cessation
-
2005
- 2005-03-18 ZA ZA200502326A patent/ZA200502326B/en unknown
-
2006
- 2006-11-16 US US11/601,792 patent/US7737148B2/en not_active Expired - Lifetime
-
2007
- 2007-06-04 CY CY20071100730T patent/CY1106634T1/el unknown
-
2008
- 2008-09-29 US US12/240,688 patent/US7855210B2/en not_active Expired - Lifetime
-
2010
- 2010-11-10 US US12/943,739 patent/US20110082152A1/en not_active Abandoned
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