JP4560610B2 - 治療的ピペラジン化合物 - Google Patents

治療的ピペラジン化合物 Download PDF

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JP4560610B2
JP4560610B2 JP2004539882A JP2004539882A JP4560610B2 JP 4560610 B2 JP4560610 B2 JP 4560610B2 JP 2004539882 A JP2004539882 A JP 2004539882A JP 2004539882 A JP2004539882 A JP 2004539882A JP 4560610 B2 JP4560610 B2 JP 4560610B2
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halo
phenyl
substituted
alkyl
another embodiment
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JP2006508067A5 (enExample
JP2006508067A (ja
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サン，クン
ゾウ，シャオミン
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ユーロ−セルティーク エス．エイ．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2004539882A 2002-09-24 2003-09-24 治療的ピペラジン化合物 Expired - Fee Related JP4560610B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41284702P 2002-09-24 2002-09-24
PCT/US2003/030185 WO2004029031A2 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds

Publications (3)

Publication Number Publication Date
JP2006508067A JP2006508067A (ja) 2006-03-09
JP2006508067A5 JP2006508067A5 (enExample) 2006-11-02
JP4560610B2 true JP4560610B2 (ja) 2010-10-13

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US (4) US7157462B2 (enExample)
EP (2) EP1810970B8 (enExample)
JP (1) JP4560610B2 (enExample)
KR (1) KR20050052514A (enExample)
CN (1) CN100393713C (enExample)
AT (2) ATE356817T1 (enExample)
AU (1) AU2003272685A1 (enExample)
BR (1) BR0314699A (enExample)
CA (1) CA2500113C (enExample)
CY (1) CY1106634T1 (enExample)
DE (2) DE60312544T2 (enExample)
DK (1) DK1562936T3 (enExample)
ES (1) ES2285170T3 (enExample)
MX (1) MXPA05003302A (enExample)
NZ (1) NZ539205A (enExample)
PT (1) PT1562936E (enExample)
SI (1) SI1562936T1 (enExample)
WO (1) WO2004029031A2 (enExample)
ZA (1) ZA200502326B (enExample)

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TWI510241B (zh) 2010-02-18 2015-12-01 Vtv Therapeutice Llc 苯基－雜芳基衍生物及其使用方法
US8921373B2 (en) 2010-06-22 2014-12-30 Shionogi & Co., Ltd. Compounds having TRPV1 antagonistic activity and uses thereof
JP6130827B2 (ja) 2011-05-17 2017-05-17 塩野義製薬株式会社 ヘテロ環化合物
RS55701B1 (sr) 2011-06-22 2017-07-31 Purdue Pharma Lp Trpv1 antagonisti koji uključuju dihidroksi supstituent i njihove upotrebe
EP3744715A1 (en) 2013-11-08 2020-12-02 Incyte Holdings Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
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NZ539205A (en) 2007-05-31
BR0314699A (pt) 2005-08-09
ATE467627T1 (de) 2010-05-15
MXPA05003302A (es) 2005-10-18
US20110082152A1 (en) 2011-04-07
US7855210B2 (en) 2010-12-21
US7157462B2 (en) 2007-01-02
CA2500113A1 (en) 2004-04-08
JP2006508067A (ja) 2006-03-09
SI1562936T1 (sl) 2007-08-31
EP1562936A2 (en) 2005-08-17
HK1083216A1 (en) 2006-06-30
US20050059671A1 (en) 2005-03-17
PT1562936E (pt) 2007-06-12
KR20050052514A (ko) 2005-06-02
US7737148B2 (en) 2010-06-15
CN100393713C (zh) 2008-06-11
ES2285170T3 (es) 2007-11-16
CN1701071A (zh) 2005-11-23
EP1562936B1 (en) 2007-03-14
DE60312544T2 (de) 2007-12-13
DE60312544D1 (de) 2007-04-26
WO2004029031A2 (en) 2004-04-08
US20090042902A1 (en) 2009-02-12
DE60332562D1 (de) 2010-06-24
ZA200502326B (en) 2006-05-31
DK1562936T3 (da) 2007-07-16
CA2500113C (en) 2011-07-12
AU2003272685A1 (en) 2004-04-19
EP1810970A1 (en) 2007-07-25
WO2004029031A3 (en) 2004-08-05
ATE356817T1 (de) 2007-04-15
EP1810970B8 (en) 2012-03-21
EP1810970B1 (en) 2010-05-12

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