JP2006506445A5 - - Google Patents

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Publication number
JP2006506445A5
JP2006506445A5 JP2004569763A JP2004569763A JP2006506445A5 JP 2006506445 A5 JP2006506445 A5 JP 2006506445A5 JP 2004569763 A JP2004569763 A JP 2004569763A JP 2004569763 A JP2004569763 A JP 2004569763A JP 2006506445 A5 JP2006506445 A5 JP 2006506445A5
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JP
Japan
Prior art keywords
pharmaceutical composition
alkyl
composition according
optionally substituted
carbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2004569763A
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English (en)
Japanese (ja)
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JP2006506445A (ja
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Priority claimed from PCT/US2003/027186 external-priority patent/WO2004019953A1/en
Publication of JP2006506445A publication Critical patent/JP2006506445A/ja
Publication of JP2006506445A5 publication Critical patent/JP2006506445A5/ja
Pending legal-status Critical Current

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JP2004569763A 2002-08-28 2003-08-28 治療処置の方法 Pending JP2006506445A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40714602P 2002-08-28 2002-08-28
US40833202P 2002-09-04 2002-09-04
US47925703P 2003-06-17 2003-06-17
PCT/US2003/027186 WO2004019953A1 (en) 2002-08-28 2003-08-28 Therapeutic treatment methods

Publications (2)

Publication Number Publication Date
JP2006506445A JP2006506445A (ja) 2006-02-23
JP2006506445A5 true JP2006506445A5 (enExample) 2006-12-28

Family

ID=31982343

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004569763A Pending JP2006506445A (ja) 2002-08-28 2003-08-28 治療処置の方法

Country Status (7)

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US (6) US20040138187A1 (enExample)
EP (3) EP2298316A1 (enExample)
JP (1) JP2006506445A (enExample)
KR (1) KR20050057086A (enExample)
AU (1) AU2003278744B2 (enExample)
CA (1) CA2496867A1 (enExample)
WO (1) WO2004019953A1 (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20060079492A1 (en) * 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US20030060425A1 (en) * 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
US7163918B2 (en) 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
EP1499338A4 (en) * 2002-05-01 2008-06-18 Arthur Schwartz 7-HYDROXY-16ALPHA-FLUORO-5-ANDROSENES-17-ONE AND 7-HYDROXY-16ALPHA-FLUORO-5-ANDROSTAN-17-ONE AND THEIR DERIVATIVES
JP2006506445A (ja) * 2002-08-28 2006-02-23 ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド 治療処置の方法
US20050101581A1 (en) 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
US7572780B2 (en) 2003-01-21 2009-08-11 Dimera, Incorporated Method and kit for reducing the symptoms of peripheral vascular disease
US20080249129A1 (en) * 2004-04-02 2008-10-09 Whitehead Institute For Biomedical Research Compositions and Methods for Treatment of Protein Misfolding Diseases
US20090162315A1 (en) * 2004-06-29 2009-06-25 Terman David S Enterotoxin gene cluster (egc) superantigens to treat malignant disease
US20080138837A1 (en) * 2004-07-19 2008-06-12 Robert Greenfield Methods and kits for detecting and measuring ADAMTS13/FXI complexes
WO2006019379A1 (en) * 2004-07-19 2006-02-23 American Diagnostica Inc. Methods for measuring adamts13 activity and protein on platelets and in plasma
US7270976B2 (en) * 2004-07-19 2007-09-18 American Diagnostica, Inc. Methods for measuring ADAMTS13 activity and protein on platelets and in plasma
US8865749B2 (en) * 2004-08-01 2014-10-21 Trevor Gordon Marshall Treatment and prevention of Th1 and ‘autoimmune’ diseases effected with antibiotics and/or angiotensin inhibition
EP1795191A4 (en) * 2004-09-21 2007-12-19 Kyowa Hakko Kogyo Kk ORAL PHARMACEUTICAL FOR THE PREVENTION OR TREATMENT OF SKIN DRYNESS
US7910755B2 (en) * 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) * 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
KR100766750B1 (ko) * 2004-12-13 2007-10-17 주식회사 엘지생명과학 바이오칩의 제조방법
EP1861490A4 (en) * 2005-03-23 2010-11-17 Univ St Louis USE OF ARCHAEA FOR MODULATING NUTRITIONAL FUNCTIONALITY OF GASTROINTESTINAL BIOZOOSIS
US20060281720A1 (en) * 2005-06-08 2006-12-14 Loria Roger M 5-Androstenediol As An Inhibitor of Gliomas
DE202006021081U1 (de) * 2005-07-12 2012-05-08 Dmi Biosciences, Inc. Produkte zur Behandlung von Krankheiten
AU2006304906B8 (en) * 2005-10-20 2011-11-03 Catholic Healthcare West Androsterone derivatives and method of use thereof
US20070135504A1 (en) * 2005-12-11 2007-06-14 Marshall Trevor G Method of Treating and/or Preventing Inflammatory Diseases, including many Autoimmune and Neurological diseases, using drugs to modulate the VDR, and/or PPAR, and/or GCR and/or CB1 nuclear and GPCR receptors; in conjunction with antibiotics which target prokaryotic protein translation
KR101250181B1 (ko) * 2006-02-10 2013-04-05 동화약품주식회사 감수에서 분리된 테르페노이드 또는 이를 포함하는감수추출물을 함유하는 골다공증 예방 및 치료용 약학조성물
EP1994168A4 (en) * 2006-02-15 2009-05-27 Md Bioalpha Co Ltd METHOD FOR CONTROLLING THE NAD (P) / NAD (P) H RATIO WITH OXIDOREDUCTASE
US8252532B2 (en) * 2006-04-05 2012-08-28 University Of Connecticut Regulators of the non-genomic action of progesterone and methods of use
KR20080112413A (ko) * 2006-04-22 2008-12-24 홀리스-에덴 파마슈티칼즈, 인코포레이티드 약물 및 그 용도
US20080051380A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20080221074A1 (en) * 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
US8354396B2 (en) * 2006-11-17 2013-01-15 Harbor Therapeutics, Inc. Drug identification and treatment method
US8486926B2 (en) 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
US8217025B2 (en) 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
WO2008086452A2 (en) * 2007-01-10 2008-07-17 Columbia University Treatment and prevention of alzheimer's disease
WO2008100791A1 (en) * 2007-02-16 2008-08-21 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of sickle cell
US20090124587A1 (en) * 2007-07-12 2009-05-14 Auerbach Alan H METHODS FOR TREATING CANCER USING 17alpha-HYDROXYLASE/C17,20-LYASE INHIBITORS
ITMI20071616A1 (it) 2007-08-03 2009-02-04 Cosmo Spa Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
US20090258850A1 (en) * 2007-08-21 2009-10-15 Frincke James M Stabilized therapeutic compositions and formulations
WO2009055864A1 (en) * 2007-10-31 2009-05-07 Crc For Asthma And Airways Ltd Methods and compositions for regulating airway tissue remodelling
US20090214641A1 (en) * 2008-02-26 2009-08-27 Joar Opheim Sweetened Capsules for Administration
US20100286106A1 (en) * 2008-03-10 2010-11-11 Yigal Gat Methods and apparatus for treating the prostate
US20110076240A1 (en) * 2008-04-18 2011-03-31 Day Donal F Antifungal and Anti-Cariogenic Cellobio-Oligosaccharides Produced by Dextransucrase
HUE027463T2 (en) 2008-05-28 2016-09-28 Reveragen Biopharma Inc Non-hormonal steroid modulators of nf-kb for treatment of disease
SG177302A1 (en) * 2009-06-22 2012-02-28 Dmi Acquisition Corp Methods and products for treatment of diseases
DK2326332T3 (da) * 2009-06-22 2013-03-04 Dmi Acquistion Corp Fremgangsmåde til behandling af sygdomme
US8811535B2 (en) * 2009-07-17 2014-08-19 Mitre Corporation Time-frequency space constructions of families of signals
WO2011022619A1 (en) * 2009-08-20 2011-02-24 Glaxo Group Limited TREATING INFLAMMATORY DISEASES BY ADMINISTRATION OF REV-ERB α LIGANDS
WO2011032109A1 (en) * 2009-09-11 2011-03-17 Sma Foundation Biomarkers for spinal muscular atrophy
EP2506855A4 (en) * 2009-11-30 2014-07-30 Harbor Biosciences Inc ANTICARCINOMA COMPOUNDS AND SCREENING METHODS
KR20110097499A (ko) * 2010-02-25 2011-08-31 서울대학교산학협력단 전자파 노출을 진단하기 위한 마커 및 이를 포함하는 키트
KR20110097497A (ko) * 2010-02-25 2011-08-31 서울대학교산학협력단 전자파 노출을 진단하기 위한 마커 및 이를 포함하는 키트
KR20110097498A (ko) * 2010-02-25 2011-08-31 서울대학교산학협력단 전자파 노출을 진단하기 위한 마커 및 이를 포함하는 키트
US9511071B2 (en) 2010-08-18 2016-12-06 Emory University Compounds and compositions for ossification and methods related thereto
CN102079771B (zh) * 2010-12-10 2012-10-03 郑州大学 具有抗肿瘤活性的雌甾氨基酸酯化合物及其合成方法
KR101286743B1 (ko) * 2011-02-18 2013-07-15 충남대학교산학협력단 페노피브레이트를 함유하는 패혈증 예방용 약학 조성물
WO2012115987A2 (en) * 2011-02-21 2012-08-30 The Trustees Of Columbia University In The City Of New York Methods for Treating and Preventing Cardiac Dysfunction in Septic Shock
CA2832569A1 (en) 2011-04-08 2012-10-11 Baylor College Of Medicine Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
EP2770985A4 (en) 2011-10-25 2015-01-21 U S Phytotherapy Inc ARTEMISININE AND BERBERINE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
US9675582B2 (en) 2011-10-25 2017-06-13 U.S. Phytotherapy, Inc. Alternative ACT with natural botanical active GRAS ingredients for treatment and prevention of the Zika virus
US9358261B2 (en) 2011-10-25 2016-06-07 U.S. Phytotherapy, Inc. Additional artemisinin and berberine compositions and methods of making
WO2013106672A1 (en) * 2012-01-13 2013-07-18 Tufts Medical Center, Inc. Methods and compositions for the treatment of neurodegenerative disease
SMT202000008T1 (it) 2012-01-23 2020-03-13 Sage Therapeutics Inc Formulazione di steroide neuroattivo comprendente un complesso di allopregnanolone e solfobutil eter beta-ciclodestrina
PL2887944T3 (pl) 2012-08-21 2022-02-21 Sage Therapeutics, Inc. Allopregnanolon do leczenia lekoopornego stanu padaczkowego
EP2904119B1 (en) 2012-10-02 2020-06-17 The General Hospital Corporation d/b/a Massachusetts General Hospital Methods relating to dna-sensing pathway related conditions
ES2973320T3 (es) 2012-11-30 2024-06-19 Univ California Alopregnanolona para tratar, reducir o mitigar los síntomas de la depresión posparto
CN104968350A (zh) 2012-12-19 2015-10-07 安皮奥制药股份有限公司 疾病的治疗方法
WO2014107124A1 (en) 2013-01-03 2014-07-10 Niklas Dahl Treatment of hyperhidrosis
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
EP3108879A1 (en) 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
RU2766155C2 (ru) 2016-03-08 2022-02-08 Сейдж Терапьютикс, Инк. Нейроактивные стероиды, их композиции и применения
US10485823B2 (en) * 2016-04-18 2019-11-26 Bioleaders Corporation Method for treating cervical intraepithelial neoplasia using poly-gamma- glutamic acid
CN119606965A (zh) 2016-07-29 2025-03-14 詹森药业有限公司 治疗前列腺癌的方法
EP3697415A4 (en) * 2017-10-16 2021-07-14 Amygdala Neurosciences, Inc. COMBINATION THERAPY TO PREVENT ADDICTION
GB201718667D0 (en) * 2017-11-10 2017-12-27 Mologic Ltd Monitoring inflammation status
CN112654610B (zh) * 2018-06-15 2024-12-24 里亚塔医药公司 用于抑制IL-17和RORγ的吡唑和咪唑化合物
US20200108120A1 (en) 2018-10-09 2020-04-09 King Faisal Specialist Hospital & Research Centre Method for treating pulmonary fibrosis using s100a3 protein
JP7558167B2 (ja) 2018-12-03 2024-09-30 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CN113318114B (zh) * 2020-02-28 2023-02-17 广州市赛普特医药科技股份有限公司 小分子化合物在治疗肺上皮细胞损伤和/或血管内皮细胞损伤介导的疾病中的用途
CN113321695B (zh) * 2021-07-01 2024-01-12 海南师范大学 一种甾体类化合物及其制备方法和应用
AU2023295214A1 (en) 2022-06-14 2025-03-06 Amygdala Neurosciences, Inc. Aldh-2 inhibitor compounds and methods of use
KR102704483B1 (ko) * 2023-02-28 2024-09-10 대한민국(질병관리청 국립보건연구원장) 스테로이드 유도체 계열 화합물 및 이를 유효성분으로 함유하는 항바이러스제
IT202400003238A1 (it) * 2024-02-15 2025-08-15 Ricerfarma Srl Compressa orale mucoadesiva per il trattamento sintomatico della xerostomia, delle afte e delle infiammazioni del cavo orale

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2566336A (en) * 1947-08-28 1951-09-04 Glidden Co Preparation of keto-amine salts in the steroid series and products
US2561378A (en) * 1947-09-11 1951-07-24 Glidden Co 20-dimethylamino-pregnenes and their quaternary halides
US2793217A (en) * 1953-06-27 1957-05-21 Lab Francais Chimiotherapie New derivatives of adrenosterone and a process of making same
US2940991A (en) * 1957-03-01 1960-06-14 Julian Lab Inc Method of epimerizing 11-bromo steroids
US2851454A (en) * 1957-08-02 1958-09-09 Searle & Co 1, 2-epoxy-3, 17-dioxygenated androstane derivatives and their reduction
US2833794A (en) * 1957-12-18 1958-05-06 Searle & Co 3-oxygenated 4-androstene-1, 17-diols and derivatives
US2838544A (en) * 1958-02-19 1958-06-10 Upjohn Co 6alpha-fluoro-16alpha-hydroxy progesterones
US3189597A (en) * 1959-03-04 1965-06-15 Ciba Geigy Corp 3-glycosides of 17-amino-3-hydroxy-5-androstenes
US3080360A (en) * 1960-07-11 1963-03-05 Searle & Co 17alpha-alkyl-17beta-hydroxy-18-norandrost-4-en-3-ones
US3001988A (en) * 1960-07-19 1961-09-26 Searle & Co 3-oxygenated 17beta-aminoalkanamidoandrost-4/5-enes, 5alpha-androstanes corresponding, and intermediates thereto
US3107254A (en) * 1960-10-05 1963-10-15 Upjohn Co 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives
US3137710A (en) 1961-03-30 1964-06-16 Ormonoterapia Richter Spa Method for the preparation of primary amines
US3153063A (en) * 1961-05-30 1964-10-13 Ormonoterapia Richter Spa 16-methyl-17-amino-androstane
GB1003681A (en) * 1962-03-09 1965-09-08 May & Baker Ltd Androstane and androstene derivatives
US3155690A (en) * 1962-08-17 1964-11-03 Abbott Lab Nu-substituted 17alpha-aminosteroids
US3187022A (en) * 1964-01-31 1965-06-01 Parke Davis & Co 17beta-amino-17alpha-pregnen-20-one compounds and the production thereof
US3264326A (en) * 1964-04-29 1966-08-02 American Home Prod 17beta-substituted-3alpha-amino-5alpha-androstanes
BE667232A (enExample) * 1964-07-22
IL31997A (en) * 1968-05-03 1974-03-14 Lepetit Spa Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3917829A (en) * 1971-11-08 1975-11-04 Research Corp Novel methods of inhibiting the activity of testosterone 5{60 -reductase
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
US3984566A (en) 1974-02-25 1976-10-05 Scott Eugene J Van Method of alleviating the symptoms of dandruff
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4234599A (en) 1978-10-04 1980-11-18 Scott Eugene J Van Treatment of skin keratoses with α-hydroxy acids and related compounds
US4246261A (en) 1979-08-09 1981-01-20 Scott Eugene J Van Additives enhancing topical corticosteroid action
US4424218A (en) * 1979-08-17 1984-01-03 Roussel Uclaf Novel 3 α-amino steroids
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US5169857A (en) 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
FR2494697A1 (fr) * 1980-11-21 1982-05-28 Roussel Uclaf Nouveaux derives steroides 3-amines, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
IT1134455B (it) * 1980-11-26 1986-08-13 Lepetit Spa Procedimento per la preparazione di derivati 16alfa-idrossi-17alfa-aminopregnanici
US4330539A (en) * 1981-01-29 1982-05-18 Akzo Nv Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof
US4739073A (en) 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US4908358A (en) * 1987-08-27 1990-03-13 Trustees Of The University Of Pennsylvania Inhibition of immune clearance using progesterone analogues
DE3786174T2 (de) * 1987-10-13 1993-10-21 Nicholas S Bodor Weiche steroide mit anti-entzündungswirkung.
US4898694A (en) * 1987-11-25 1990-02-06 Schwartz Arthur G 17-Hydroxy-steroids
NO177005C (no) 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
US5262407A (en) 1988-12-16 1993-11-16 L'oreal Use of salicylic derivatives for the treatment of skin aging
US5077284A (en) * 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
US5461042A (en) * 1988-12-30 1995-10-24 Loria; Roger M. Regulation of the immune system
US5128450A (en) 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
DE69033541D1 (de) 1989-09-25 2000-06-15 Univ Utah Res Found Verwendung von steroidhormonen in zubereitungen zur induzierung von t-zell-lymphokin-erzeugung
US5753237A (en) 1989-09-25 1998-05-19 University Of Utah Research Foundation Method for augmenting immunological responses
US5837269A (en) 1989-09-25 1998-11-17 University Of Utah Research Foundation Vaccine compositions and method for enhancing an immune response
US5641768A (en) * 1989-11-17 1997-06-24 Loria; Roger M. 5-androstene 3β, 17β diol for treatment
US5641766A (en) * 1990-08-29 1997-06-24 Humanetics Corporation UP-regulation of immune system with Δ 5-Androstenes
US5585371A (en) * 1990-08-29 1996-12-17 Humanetics Corporation Treatment of immune system with Δ5-androstenes
US5506223A (en) 1990-08-29 1996-04-09 Humanetics Corporation Δ5-androstenes useful for promoting weight maintenance or weight loss and treatment process
US5080139A (en) 1990-10-31 1992-01-14 Reseal International Limited Partnership Valve assembly with disk-like valve body
US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
US5254343A (en) 1991-03-19 1993-10-19 Bristol-Myers Squibb Company Reduction of cutaneous atrophy
US5206008A (en) * 1991-04-15 1993-04-27 Virginia Commonwealth University Enhancement of immune response
US5834213A (en) 1991-05-02 1998-11-10 Baylor College Of Medicine Screening system and assay for identifying compounds that regulate steroid and orphan receptors mediation of DNA transcription
US6093706A (en) * 1992-03-04 2000-07-25 Bioresponse, L.L.C. Combined dehydroepiandrosterone and retinoid therapy for epithelial disorders
GB2265624B (en) * 1992-03-31 1995-04-19 British Tech Group 17-substituted steroids useful in cancer treatment
US5686438A (en) * 1993-03-09 1997-11-11 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5811418A (en) * 1993-03-09 1998-09-22 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5846963A (en) * 1995-06-07 1998-12-08 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
SK103195A3 (en) * 1993-03-09 1996-12-04 Univ Utah Res Found Use of dehydroepiandrosterone derivative for pharmaceutical compositions production and pharmaceutical composition containing dehydroepiandrosterone derivative
US5635496A (en) * 1993-03-09 1997-06-03 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5977095A (en) * 1993-03-09 1999-11-02 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and respiratory distress syndrome
US5387583A (en) * 1993-04-20 1995-02-07 Loria; Roger M. Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof
US5478566A (en) * 1993-09-29 1995-12-26 Loria; Roger M. Stimulation of cytokine production
EP0721956B1 (en) 1993-09-29 2000-08-02 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
JPH07258091A (ja) * 1994-03-17 1995-10-09 Kyowa Hakko Kogyo Co Ltd アトピー性皮膚炎治療剤
US5658744A (en) 1994-07-22 1997-08-19 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying patients having an altered immune status
US5792757A (en) 1994-08-04 1998-08-11 Pherin Pharmaceuticals 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function
US5696130A (en) 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Tricyclic steroid receptor modulator compounds and methods
WO1996019458A2 (en) 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US20020032160A1 (en) * 1995-02-24 2002-03-14 Nyce Jonathan W. Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
US5663054A (en) 1995-03-03 1997-09-02 Abbott Laboratories Determination of steroids by competitive immunoassay
TR199701497T1 (xx) 1995-06-02 1998-06-22 Shionogi & Co., Ltd. Beyin �demini �nleyen terkip.
DE792292T1 (de) 1995-09-08 1998-09-03 Karo Bio Ab, Huddinge Waisen-rezeptor
IL118836A (en) 1996-07-11 2001-01-11 Teva Pharma Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
US5958892A (en) 1996-07-30 1999-09-28 Board Of Regents, The University Of Texas System 2-methoxyestradiol-induced apoptosis in cancer cells
DE19633376A1 (de) 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue Seco-D-Steroide, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
US5952371A (en) 1996-10-16 1999-09-14 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5945412A (en) 1996-12-09 1999-08-31 Merck & Co., Inc. Methods and compositions for preventing and treating bone loss
US5885977A (en) * 1997-01-15 1999-03-23 Humanetics Corporation Use of Δ5 androstenes in the treatment of HIV wasting syndrome
JP3688446B2 (ja) 1997-01-23 2005-08-31 ヒゲタ醤油株式会社 新規テルペン系化合物0406tp−1
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US5935968A (en) 1997-03-17 1999-08-10 Merck & Co., Inc. Methods for treating polycystic ovary syndrome
US5925657A (en) 1997-06-18 1999-07-20 The General Hospital Corporation Use of PPARγ agonists for inhibition of inflammatory cytokine production
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
AU763307B2 (en) * 1998-02-04 2003-07-17 Charlotte-Mecklenburg Hospital Authority Androsterone derivatives for inhibiting DNA binding of AP-1 and airway smooth muscle proliferation
US6380207B2 (en) 1998-02-13 2002-04-30 Abbott Laboratories Glucocortiocoid-selective antiinflammatory agents
US6107034A (en) 1998-03-09 2000-08-22 The Board Of Trustees Of The Leland Stanford Junior University GATA-3 expression in human breast carcinoma
WO1999045930A1 (en) 1998-03-13 1999-09-16 Pharmadigm, Inc. Screening for dhea mimetics using members of the inflammatory cell signalling cascade specifically modulated by dhea as targets
WO1999052532A1 (en) * 1998-04-14 1999-10-21 Pharmadigm, Inc. Method for reducing central nervous system impairment
NZ508414A (en) 1998-05-26 2003-12-19 Carlen Peter Louis Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals
KR20060098399A (ko) * 1998-06-11 2006-09-18 앙도르쉐르슈 인코포레이티드 안드로스트-5-엔-3β,17β-디올을 포함하는 약학 조성물 및그 용도
IL142942A0 (en) * 1998-11-24 2002-04-21 Holis Eden Pharmaceuticals Inc Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in the treatment of hepatitis c virus and other toga viruses
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US20070129282A1 (en) 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
ATE259825T1 (de) * 1999-03-23 2004-03-15 Hollis Eden Pharmaceuticals Hemihydrat von 16.alpha.-bromoepiandrosterone
DE60045751D1 (de) 1999-09-30 2011-04-28 Harbor Biosciences Inc Therapeutische Behandlung androgenrezeptorbedingter Leiden
CA2388939C (en) * 1999-10-25 2009-06-09 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatments for blood cell deficiencies
US6348489B1 (en) 2000-04-11 2002-02-19 Daiichi Pharmaceutical Co., Ltd. Method of treating traumatic brain injury and other neuronal disorders
IL135707A0 (en) * 2000-04-17 2001-05-20 Yissum Res Dev Co 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them
GB2363984A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids
GB2363983A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 7-hydroxyepiandrosterone
JP2004510781A (ja) * 2000-10-06 2004-04-08 イーソン セラピューティクス インコーポレイテッド 高トリグリセリド血症の治療に有用な化合物
AU2002244247B2 (en) * 2001-03-01 2007-12-13 Harbor Biosciences, Inc. Use of certain steroids for treatment of blood cell deficiencies
US6465446B1 (en) * 2001-03-12 2002-10-15 John C. Dykstra Treatment of dermatitis by the topical application of Δ5-androstene-3β-ol-7,17 dione and metabolizable precursors thereof
WO2002085297A2 (en) * 2001-04-24 2002-10-31 East Carolina University Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease
WO2002085296A2 (en) * 2001-04-24 2002-10-31 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
EP1310258A1 (en) * 2001-11-08 2003-05-14 Etienne-Emile Baulieu Enantiomers of steroids for the enhancement of memory and cognitive function
AU2003269889B2 (en) * 2002-06-17 2007-04-19 Epigenesis Pharmaceuticals, Llc Dihydrate dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
JP2006506445A (ja) * 2002-08-28 2006-02-23 ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド 治療処置の方法
WO2004089304A2 (en) 2003-04-01 2004-10-21 Hollis-Eden Pharmaceuticals, Inc. Antiandrogens with marginal agonist activity and methods of use
US7910755B2 (en) 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
US20080065873A1 (en) * 2006-09-11 2008-03-13 Ronald Hall Dynamic livelock resolution with variable delay memory access queue
KR20080095683A (ko) * 2007-04-25 2008-10-29 삼성전자주식회사 상변화 메모리 소자 및 그 형성 방법

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