JP2005530763A5 - - Google Patents
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- Publication number
- JP2005530763A5 JP2005530763A5 JP2004502949A JP2004502949A JP2005530763A5 JP 2005530763 A5 JP2005530763 A5 JP 2005530763A5 JP 2004502949 A JP2004502949 A JP 2004502949A JP 2004502949 A JP2004502949 A JP 2004502949A JP 2005530763 A5 JP2005530763 A5 JP 2005530763A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- group
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 53
- 125000003118 aryl group Chemical group 0.000 claims description 32
- 125000001072 heteroaryl group Chemical group 0.000 claims description 32
- -1 C (O) NH 2 Chemical class 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 20
- 150000002367 halogens Chemical class 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 11
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 150000003973 alkyl amines Chemical class 0.000 claims description 11
- 150000004982 aromatic amines Chemical class 0.000 claims description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 229940124530 sulfonamide Drugs 0.000 claims description 11
- 150000003456 sulfonamides Chemical class 0.000 claims description 11
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 150000003949 imides Chemical class 0.000 claims description 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 5
- 150000002576 ketones Chemical class 0.000 claims description 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 14
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 102000004257 Potassium Channel Human genes 0.000 claims 2
- 108020001213 potassium channel Proteins 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 108091082572 SK family Proteins 0.000 claims 1
- 102000003734 Voltage-Gated Potassium Channels Human genes 0.000 claims 1
- 108090000013 Voltage-Gated Potassium Channels Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 *CCC*1C(C(CCC*CCCC2)C2C(NC2C(*)CCCCCCCC2)I)NC2C1CCCCCC2 Chemical compound *CCC*1C(C(CCC*CCCC2)C2C(NC2C(*)CCCCCCCC2)I)NC2C1CCCCCC2 0.000 description 8
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38036702P | 2002-05-13 | 2002-05-13 | |
| PCT/US2003/015225 WO2003094861A2 (en) | 2002-05-13 | 2003-05-13 | Bis-benzimidazoles and related compounds as potassium channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530763A JP2005530763A (ja) | 2005-10-13 |
| JP2005530763A5 true JP2005530763A5 (enExample) | 2006-06-29 |
Family
ID=29420615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004502949A Pending JP2005530763A (ja) | 2002-05-13 | 2003-05-13 | カリウム・チャネル調節物質としてのビス−ベンズイミダゾール及び関連化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7132439B2 (enExample) |
| EP (1) | EP1511744A4 (enExample) |
| JP (1) | JP2005530763A (enExample) |
| AU (1) | AU2003230401A1 (enExample) |
| WO (1) | WO2003094861A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7777051B2 (en) * | 2003-05-13 | 2010-08-17 | Icagen, Inc. | Asymmetric benzimidazoles and related compounds as potassium channel modulators |
| ATE458730T1 (de) | 2004-04-13 | 2010-03-15 | Icagen Inc | Polycyclische pyrazine als kaliumionenkanal- modulatoren |
| AU2005233632A1 (en) * | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
| AU2005232745A1 (en) | 2004-04-13 | 2005-10-27 | Astellas Pharma Inc. | Polycyclic pyrimidines as potassium ion channel modulators |
| DE602005007241D1 (de) | 2004-08-05 | 2008-07-10 | Neurosearch As | 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit |
| JP2008526815A (ja) | 2005-01-11 | 2008-07-24 | ノイロサーチ アクティーゼルスカブ | 低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用 |
| WO2006110683A1 (en) | 2005-04-11 | 2006-10-19 | Abbott Laboratories | 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors |
| TWI375673B (en) | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| TW200736229A (en) | 2005-11-15 | 2007-10-01 | Abbott Lab | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors |
| WO2007131016A2 (en) | 2006-05-02 | 2007-11-15 | Abbott Laboratories | Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors |
| US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
| WO2010083199A1 (en) | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Benzthiazole inhibitors of poly(adp-ribose)polymerase |
| WO2012020725A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体 |
| JP5822934B2 (ja) | 2010-09-15 | 2015-11-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アザベンゾチアゾール化合物、組成物及び使用方法 |
| US20120087981A1 (en) | 2010-10-11 | 2012-04-12 | Xiandong Wang | Skin Engaging Member Comprising Encapsulated Actives |
| US20130042482A1 (en) | 2011-08-16 | 2013-02-21 | Valerie Jean Bradford | Skin Engaging Member Comprising An Anti-Irritation Agent |
| WO2014047355A1 (en) | 2012-09-19 | 2014-03-27 | Denervx LLC | Cooled microwave denervation |
| WO2014052390A2 (en) | 2012-09-28 | 2014-04-03 | The Gillette Company | A skin engaging member comprising at least one thermally resilient sensate |
| AU2013323689B2 (en) | 2012-09-28 | 2016-09-22 | The Gillette Company Llc | A skin engaging shaving aid member comprising at least one thermally resilient sensate |
| KR20150039551A (ko) * | 2013-10-02 | 2015-04-10 | 제이에스알 가부시끼가이샤 | 경화성 조성물, 경화막 및 그의 형성 방법, 그리고 화합물 |
| US10390881B2 (en) | 2013-10-25 | 2019-08-27 | Denervx LLC | Cooled microwave denervation catheter with insertion feature |
| US20150209107A1 (en) | 2014-01-24 | 2015-07-30 | Denervx LLC | Cooled microwave denervation catheter configuration |
| US20150273711A1 (en) | 2014-03-26 | 2015-10-01 | The Gillette Company | Razor Comprising A Molded Shaving Aid Composition Comprising A Thermally Resilient Sensate |
| US20150272847A1 (en) | 2014-03-26 | 2015-10-01 | The Gillette Company | Skin Engaging Shaving Aid Comprising A Thermally Resilient Sensate And A TRPA1 Receptor Inhibitor |
| JP2017518963A (ja) | 2014-04-23 | 2017-07-13 | ザ プロクター アンド ギャンブル カンパニー | 生体表面付着組成物 |
| AU2015353904B2 (en) | 2014-11-26 | 2018-12-20 | The Gillette Company Llc | A skin engaging member comprising ethylene vinyl acetate |
| US20170334082A1 (en) | 2016-05-18 | 2017-11-23 | The Gillette Company Llc | Skin Engaging Member Comprising Ethylene Vinyl Acetate |
| WO2018022014A1 (en) | 2016-07-26 | 2018-02-01 | Hewlett-Packard Development Company, L.P. | Microfluidic device with manifold |
| WO2018085479A1 (en) | 2016-11-03 | 2018-05-11 | The Gillette Company Llc | Skin engaging member comprising ethylene vinyl acetate |
| CN109843385B (zh) | 2016-11-17 | 2022-06-03 | 吉列有限责任公司 | 包含乙烯-乙酸乙烯酯和芳香剂的皮肤接合构件 |
| WO2019038315A1 (en) * | 2017-08-23 | 2019-02-28 | Acesion Pharma Aps | BENZIMIDAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS |
| KR102134268B1 (ko) * | 2017-11-08 | 2020-07-15 | 삼성에스디아이 주식회사 | 모노머, 중합체, 유기막 조성물 및 패턴 형성 방법 |
| TW201930298A (zh) * | 2017-11-17 | 2019-08-01 | 美商史基普研究協會 | 雙苯并咪唑化合物及其使用方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3250780A (en) * | 1962-05-21 | 1966-05-10 | Union Oil Co | Bis-benzoxazolythyl sulfide |
| US3314894A (en) * | 1962-11-30 | 1967-04-18 | American Polymer And Chemical | Scintillators, compounds useful therein, and method of making the same |
| FR1488286A (fr) * | 1966-04-01 | 1967-07-13 | Chimetron Sarl | Bis (benzimidazolyl-2) pyridines |
| US3621076A (en) * | 1969-08-11 | 1971-11-16 | Walter F De Winter | Block polyheterocyclic polyimide elastomers having high thermal resistance |
| SU1348335A1 (ru) * | 1986-03-07 | 1987-10-30 | Московская сельскохозяйственная академия им.К.А.Тимирязева | Способ получени 3-азинилиндолов |
| US5760230A (en) * | 1996-10-11 | 1998-06-02 | Bayer Aktiengesellschaft | 4, 4'-bridged bis-2, 4-diaminoquinazolines |
| US5739127A (en) * | 1996-11-08 | 1998-04-14 | Bayer Aktiengesellschaft | 2,4'-bridged bis-2,4-diaminoquinazolines |
| US5922794A (en) | 1997-03-26 | 1999-07-13 | General Electric Company | Compositions stabilized with tertiary amine oxides |
| AU1608399A (en) * | 1997-11-26 | 1999-06-15 | Axys Pharmaceuticals, Inc. | Substituted amidinoaryl derivatives and their use as anticoagulants |
| ATE292120T1 (de) * | 1998-07-02 | 2005-04-15 | Neurosearch As | Kaliumkanal-blockierende mittel |
| US6194447B1 (en) * | 1998-07-02 | 2001-02-27 | Neurosearch A/S | Bis (benzimidazole) derivatives serving as potassium blocking agents |
| FR2818128B1 (fr) * | 2000-12-18 | 2004-04-02 | Oreal | Compositions cosmetiques antisolaires a base d'un melange synergetique de filtres et utilisations |
| FR2833164B1 (fr) * | 2001-12-07 | 2004-07-16 | Oreal | Compositions cosmetiques antisolaires a base d'un melange synergique de filtres et utilisations |
| AU2003271548A1 (en) | 2002-10-13 | 2004-05-04 | Neurosearch A/S | Use of skca channel blocking drugs for combating parkinson's disease |
| JP4966958B2 (ja) | 2005-03-14 | 2012-07-04 | ノイロサーチ アクティーゼルスカブ | カリウムチャネル調節剤及び医療における使用 |
-
2003
- 2003-05-13 JP JP2004502949A patent/JP2005530763A/ja active Pending
- 2003-05-13 US US10/437,732 patent/US7132439B2/en not_active Expired - Fee Related
- 2003-05-13 EP EP03724584A patent/EP1511744A4/en not_active Withdrawn
- 2003-05-13 AU AU2003230401A patent/AU2003230401A1/en not_active Abandoned
- 2003-05-13 WO PCT/US2003/015225 patent/WO2003094861A2/en not_active Ceased
-
2006
- 2006-09-29 US US11/540,772 patent/US7482373B2/en not_active Expired - Fee Related