JP2005530763A - カリウム・チャネル調節物質としてのビス−ベンズイミダゾール及び関連化合物 - Google Patents

カリウム・チャネル調節物質としてのビス−ベンズイミダゾール及び関連化合物 Download PDF

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JP2005530763A
JP2005530763A JP2004502949A JP2004502949A JP2005530763A JP 2005530763 A JP2005530763 A JP 2005530763A JP 2004502949 A JP2004502949 A JP 2004502949A JP 2004502949 A JP2004502949 A JP 2004502949A JP 2005530763 A JP2005530763 A JP 2005530763A
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ワン，シャオドン
ブラッドリー フルプ，アラン
リー，アルバート ミヒエル ファン
レイ スピアー，ケリー
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アイシーエージェン，インコーポレイティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
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  • Reproductive Health (AREA)
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JP2004502949A 2002-05-13 2003-05-13 カリウム・チャネル調節物質としてのビス−ベンズイミダゾール及び関連化合物 Pending JP2005530763A (ja)

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Application Number Priority Date Filing Date Title
US38036702P 2002-05-13 2002-05-13
PCT/US2003/015225 WO2003094861A2 (en) 2002-05-13 2003-05-13 Bis-benzimidazoles and related compounds as potassium channel modulators

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JP2005530763A true JP2005530763A (ja) 2005-10-13
JP2005530763A5 JP2005530763A5 (enExample) 2006-06-29

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US (2) US7132439B2 (enExample)
EP (1) EP1511744A4 (enExample)
JP (1) JP2005530763A (enExample)
AU (1) AU2003230401A1 (enExample)
WO (1) WO2003094861A2 (enExample)

Cited By (1)

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WO2012020725A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体

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US7777051B2 (en) * 2003-05-13 2010-08-17 Icagen, Inc. Asymmetric benzimidazoles and related compounds as potassium channel modulators
ATE485824T1 (de) 2004-04-13 2010-11-15 Icagen Inc Polycyclische pyrimidine als kaliumionenkanal- modulatoren
US7642354B2 (en) 2004-04-13 2010-01-05 Icagen, Inc. Polycyclic pyrazines as potassium ion channel modulators
CA2561718A1 (en) * 2004-04-13 2005-10-27 Icagen, Inc. Polycyclic pyridines as potassium ion channel modulators
ATE396977T1 (de) 2004-08-05 2008-06-15 Neurosearch As 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
WO2006074991A1 (en) 2005-01-11 2006-07-20 Neurosearch A/S Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
TWI375673B (en) 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
WO2006110683A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors
EP1966157B1 (en) 2005-11-15 2010-03-24 Abbott Laboratories Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
ATE553104T1 (de) 2006-05-02 2012-04-15 Abbott Lab Substituierte 1h-benzimidazol-4-carboxamide als potente parp-hemmer
US8067613B2 (en) 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
WO2010083199A1 (en) 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
BR112013006016A2 (pt) 2010-09-15 2016-06-07 Hoffmann La Roche compostos de azabenzotiazol, composições e métodos de uso
US20120087981A1 (en) 2010-10-11 2012-04-12 Xiandong Wang Skin Engaging Member Comprising Encapsulated Actives
US20130042482A1 (en) 2011-08-16 2013-02-21 Valerie Jean Bradford Skin Engaging Member Comprising An Anti-Irritation Agent
US9333035B2 (en) 2012-09-19 2016-05-10 Denervx LLC Cooled microwave denervation
SG11201501482SA (en) 2012-09-28 2015-03-30 Gillette Co A skin engaging shaving aid member comprising at least one thermally resilient sensate
WO2014052390A2 (en) 2012-09-28 2014-04-03 The Gillette Company A skin engaging member comprising at least one thermally resilient sensate
KR20150039551A (ko) * 2013-10-02 2015-04-10 제이에스알 가부시끼가이샤 경화성 조성물, 경화막 및 그의 형성 방법, 그리고 화합물
US10390881B2 (en) 2013-10-25 2019-08-27 Denervx LLC Cooled microwave denervation catheter with insertion feature
US20150209107A1 (en) 2014-01-24 2015-07-30 Denervx LLC Cooled microwave denervation catheter configuration
US20150273711A1 (en) 2014-03-26 2015-10-01 The Gillette Company Razor Comprising A Molded Shaving Aid Composition Comprising A Thermally Resilient Sensate
US20150272847A1 (en) 2014-03-26 2015-10-01 The Gillette Company Skin Engaging Shaving Aid Comprising A Thermally Resilient Sensate And A TRPA1 Receptor Inhibitor
AU2015249706A1 (en) 2014-04-23 2016-11-03 The Procter & Gamble Company Cyclohexanecarboxamide with cooling properties
AU2015353904B2 (en) 2014-11-26 2018-12-20 The Gillette Company Llc A skin engaging member comprising ethylene vinyl acetate
US20170334082A1 (en) 2016-05-18 2017-11-23 The Gillette Company Llc Skin Engaging Member Comprising Ethylene Vinyl Acetate
WO2018022014A1 (en) 2016-07-26 2018-02-01 Hewlett-Packard Development Company, L.P. Microfluidic device with manifold
WO2018085479A1 (en) 2016-11-03 2018-05-11 The Gillette Company Llc Skin engaging member comprising ethylene vinyl acetate
EP3541476A1 (en) 2016-11-17 2019-09-25 The Gillette Company LLC Skin engaging member comprising ethylene vinyl acetate and a fragrance
CA3072668A1 (en) * 2017-08-23 2019-02-28 Acesion Pharma Aps Benzimidazole derivatives useful as potassium channel inhibitors
KR102134268B1 (ko) * 2017-11-08 2020-07-15 삼성에스디아이 주식회사 모노머, 중합체, 유기막 조성물 및 패턴 형성 방법
US10961202B2 (en) 2017-11-17 2021-03-30 The Scripps Research Institute Bis-benzimidazole compounds and methods of using the same

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