JP2017513917A5 - - Google Patents
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- Publication number
- JP2017513917A5 JP2017513917A5 JP2016565186A JP2016565186A JP2017513917A5 JP 2017513917 A5 JP2017513917 A5 JP 2017513917A5 JP 2016565186 A JP2016565186 A JP 2016565186A JP 2016565186 A JP2016565186 A JP 2016565186A JP 2017513917 A5 JP2017513917 A5 JP 2017513917A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- solvate
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461985207P | 2014-04-28 | 2014-04-28 | |
| US61/985,207 | 2014-04-28 | ||
| US201562101768P | 2015-01-09 | 2015-01-09 | |
| US201562176883P | 2015-01-09 | 2015-01-09 | |
| US62/176,883 | 2015-01-09 | ||
| US62/101,768 | 2015-01-09 | ||
| PCT/US2015/027781 WO2015168014A1 (en) | 2014-04-28 | 2015-04-27 | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513917A JP2017513917A (ja) | 2017-06-01 |
| JP2017513917A5 true JP2017513917A5 (enExample) | 2018-06-14 |
| JP6466970B2 JP6466970B2 (ja) | 2019-02-06 |
Family
ID=53040687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565186A Expired - Fee Related JP6466970B2 (ja) | 2014-04-28 | 2015-04-27 | フェノール性ヒドロキシル基を介して連結された医薬的に活性な二量体 |
| JP2016565239A Expired - Fee Related JP6568102B2 (ja) | 2014-04-28 | 2015-04-27 | ブプレノルフィン二量体及び消化管疾患の治療におけるその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565239A Expired - Fee Related JP6568102B2 (ja) | 2014-04-28 | 2015-04-27 | ブプレノルフィン二量体及び消化管疾患の治療におけるその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US9309256B2 (enExample) |
| EP (2) | EP3137080B1 (enExample) |
| JP (2) | JP6466970B2 (enExample) |
| KR (2) | KR102374506B1 (enExample) |
| CN (2) | CN106470999B (enExample) |
| AU (2) | AU2015253417B2 (enExample) |
| CA (2) | CA2945181C (enExample) |
| CY (1) | CY1119900T1 (enExample) |
| DK (1) | DK3137081T3 (enExample) |
| ES (1) | ES2658766T3 (enExample) |
| HR (1) | HRP20180260T1 (enExample) |
| HU (1) | HUE036084T2 (enExample) |
| IL (3) | IL248324B (enExample) |
| LT (1) | LT3137081T (enExample) |
| MA (1) | MA43129A (enExample) |
| ME (1) | ME02946B (enExample) |
| MX (3) | MX375600B (enExample) |
| PL (1) | PL3137081T3 (enExample) |
| PT (1) | PT3137081T (enExample) |
| RS (1) | RS56920B1 (enExample) |
| SG (3) | SG11201608910UA (enExample) |
| SI (1) | SI3137081T1 (enExample) |
| SM (1) | SMT201800073T1 (enExample) |
| WO (2) | WO2015168014A1 (enExample) |
| ZA (2) | ZA201606937B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE036084T2 (hu) | 2014-04-28 | 2018-06-28 | Orphomed Inc | Buprenorfin dimer és alkalmazása gasztrointesztinális rendellenességek kezelésénél |
| CN108289869B (zh) * | 2014-04-28 | 2021-08-27 | 奥佛麦德公司 | 使用通过酚羟基连接的药学活性的对乙酰氨基酚二聚体治疗疼痛的方法 |
| US20190022013A1 (en) | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
| EP3389628A4 (en) * | 2015-12-19 | 2019-08-07 | Dixit, Manesh A. | PHARMACEUTICAL FORMULATIONS OF MOUSE CHEESE TABLETS |
| WO2019148294A1 (en) | 2018-02-02 | 2019-08-08 | Interface Biologics, Inc. | Dimeric dexamethasone prodrug compositions and uses thereof |
| US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
| WO2020012245A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Thienothiophene-naltrexone prodrugs for long-acting injectable compositions |
| US10975099B2 (en) | 2018-11-05 | 2021-04-13 | Alkermes Pharma Ireland Limited | Thiophene compounds for long-acting injectable compositions and related methods |
| US12473326B2 (en) | 2019-02-01 | 2025-11-18 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| WO2021011327A1 (en) * | 2019-07-12 | 2021-01-21 | Orphomed, Inc. | Compound for treating cystic fibrosis |
| US20220347305A1 (en) | 2019-08-07 | 2022-11-03 | Ripple Therapeutics Corporation | Controlled release drug dimers |
| WO2021220061A2 (en) | 2020-05-01 | 2021-11-04 | Ripple Therapeutics Corporation | Heterodimer compositions and methods for the treatment of ocular disorders |
| WO2021262763A1 (en) * | 2020-06-23 | 2021-12-30 | Arriba Biopharma, Inc. | Opioid receptor modulator and use thereof |
| WO2023248161A1 (en) | 2022-06-22 | 2023-12-28 | Teva Czech Industries S.R.O | Solid state forms of dibuprenorphine ethyl ether and process for preparation thereof |
| KR20260055394A (ko) * | 2023-07-10 | 2026-04-23 | 다이머엑스, 인코포레이티드 | 부프레노르핀 이량체를 사용한 만성 통증 또는 위장관 장애의 치료 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896235A (en) | 1970-09-01 | 1975-07-22 | Burroughs Wellcome Co | Anthelmintic ethers and composition thereof |
| US5716631A (en) | 1995-09-29 | 1998-02-10 | Rdn Therapeutics Inc. | Long acting narcotic analgesics and antagonists |
| EP2236161A1 (en) * | 2001-10-18 | 2010-10-06 | Nektar Therapeutics | Polymer conjugates of opioid antagonists |
| AU2003285934A1 (en) | 2002-10-25 | 2004-05-25 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| CN1263760C (zh) | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物 |
| DE60224288T2 (de) | 2002-11-25 | 2009-04-16 | Chi Mei Foundation Medical Center | Buprenorphinesterderivate, Verfahren zu ihrer Herstellung, und langwirksame analgetische Arzneimittel |
| JP2004175706A (ja) * | 2002-11-26 | 2004-06-24 | Chi Mei Foundation Medical Center | 新規なブプレノルフィンのエステル誘導体及びそれらの調製方法、及び長時間効力持続性鎮痛薬剤組成物 |
| WO2004103317A2 (en) * | 2003-05-15 | 2004-12-02 | Euro-Celtique S.A. | Transdermal buprenorphine dosage regimen for treatment of diarrhea |
| WO2005009377A2 (en) * | 2003-07-23 | 2005-02-03 | University Of Kentucky Research Foundation | Novel oral bioavailable prodrugs |
| US8097239B2 (en) | 2005-06-06 | 2012-01-17 | Camurus Ab | Controlled-release formulations |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| DE502007002185D1 (de) | 2006-04-04 | 2010-01-14 | Emodys Gmbh | Verwendung von zusammensetzungen enthaltend kappa-opioidrezeptor-antagonisten zur behandlung von dissoziativen störungen |
| MX2008013594A (es) | 2006-04-21 | 2009-01-16 | Nektar Therapeutics Al Corp | Reduccion estereoselectiva de una morfinona. |
| KR20110004425A (ko) | 2008-05-07 | 2011-01-13 | 넥타르 테라퓨틱스 | 말초적 작용 오피오이드 길항제의 경구 투여 |
| US20100068786A1 (en) | 2008-09-16 | 2010-03-18 | Chmielewski Jean A | Methods and compositions for reversing p-glycoprotein medicated drug resistance |
| US8461171B2 (en) * | 2010-02-09 | 2013-06-11 | QRxPharma Ltd. | Hybrid opioid compounds and compositions |
| GB2513267B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| CA2809022C (en) | 2010-08-20 | 2017-01-03 | Dr. Reddy`S Laboratories, Inc. | Phospholipid depot |
| CN103289075B (zh) | 2012-02-22 | 2016-01-20 | 天津键凯科技有限公司 | 聚乙二醇与纳洛酮的结合物及其药物组合物和应用 |
| HUE036084T2 (hu) | 2014-04-28 | 2018-06-28 | Orphomed Inc | Buprenorfin dimer és alkalmazása gasztrointesztinális rendellenességek kezelésénél |
-
2015
- 2015-04-27 HU HUE15720244A patent/HUE036084T2/hu unknown
- 2015-04-27 WO PCT/US2015/027781 patent/WO2015168014A1/en not_active Ceased
- 2015-04-27 ME MEP-2018-31A patent/ME02946B/me unknown
- 2015-04-27 EP EP15720242.5A patent/EP3137080B1/en active Active
- 2015-04-27 PT PT157202441T patent/PT3137081T/pt unknown
- 2015-04-27 HR HRP20180260TT patent/HRP20180260T1/hr unknown
- 2015-04-27 CN CN201580023367.8A patent/CN106470999B/zh active Active
- 2015-04-27 SM SM20180073T patent/SMT201800073T1/it unknown
- 2015-04-27 CA CA2945181A patent/CA2945181C/en active Active
- 2015-04-27 WO PCT/US2015/027820 patent/WO2015168031A1/en not_active Ceased
- 2015-04-27 LT LTEP15720244.1T patent/LT3137081T/lt unknown
- 2015-04-27 JP JP2016565186A patent/JP6466970B2/ja not_active Expired - Fee Related
- 2015-04-27 US US14/697,155 patent/US9309256B2/en active Active
- 2015-04-27 MX MX2016013829A patent/MX375600B/es active IP Right Grant
- 2015-04-27 SG SG11201608910UA patent/SG11201608910UA/en unknown
- 2015-04-27 ES ES15720244.1T patent/ES2658766T3/es active Active
- 2015-04-27 KR KR1020167032992A patent/KR102374506B1/ko not_active Expired - Fee Related
- 2015-04-27 EP EP15720244.1A patent/EP3137081B1/en active Active
- 2015-04-27 MX MX2016013823A patent/MX375597B/es active IP Right Grant
- 2015-04-27 CA CA2945509A patent/CA2945509C/en active Active
- 2015-04-27 AU AU2015253417A patent/AU2015253417B2/en active Active
- 2015-04-27 CN CN201580023293.8A patent/CN106458850B/zh active Active
- 2015-04-27 SG SG11201608918SA patent/SG11201608918SA/en unknown
- 2015-04-27 PL PL15720244T patent/PL3137081T3/pl unknown
- 2015-04-27 US US14/697,174 patent/US9321780B2/en active Active
- 2015-04-27 JP JP2016565239A patent/JP6568102B2/ja not_active Expired - Fee Related
- 2015-04-27 KR KR1020167032991A patent/KR102452348B1/ko active Active
- 2015-04-27 AU AU2015253434A patent/AU2015253434B2/en active Active
- 2015-04-27 RS RS20180148A patent/RS56920B1/sr unknown
- 2015-04-27 DK DK15720244.1T patent/DK3137081T3/da active
- 2015-04-27 SI SI201530180T patent/SI3137081T1/en unknown
- 2015-10-26 US US14/922,373 patent/US9549924B2/en active Active
- 2015-10-26 US US14/922,362 patent/US9480665B2/en active Active
-
2016
- 2016-03-18 US US15/074,960 patent/US9732096B2/en active Active
- 2016-03-18 US US15/074,933 patent/US20160368931A1/en not_active Abandoned
- 2016-10-04 US US15/285,312 patent/US9782369B2/en active Active
- 2016-10-10 ZA ZA2016/06937A patent/ZA201606937B/en unknown
- 2016-10-13 IL IL248324A patent/IL248324B/en active IP Right Grant
- 2016-10-13 IL IL248326A patent/IL248326B/en active IP Right Grant
- 2016-10-25 SG SG11201803266XA patent/SG11201803266XA/en unknown
- 2016-10-25 MA MA043129A patent/MA43129A/fr unknown
- 2016-10-25 MX MX2018004834A patent/MX376379B/es active IP Right Grant
-
2018
- 2018-02-12 CY CY20181100169T patent/CY1119900T1/el unknown
- 2018-04-17 IL IL258762A patent/IL258762B/en active IP Right Grant
- 2018-04-20 ZA ZA2018/02643A patent/ZA201802643B/en unknown