JP2017513917A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017513917A5 JP2017513917A5 JP2016565186A JP2016565186A JP2017513917A5 JP 2017513917 A5 JP2017513917 A5 JP 2017513917A5 JP 2016565186 A JP2016565186 A JP 2016565186A JP 2016565186 A JP2016565186 A JP 2016565186A JP 2017513917 A5 JP2017513917 A5 JP 2017513917A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- solvate
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461985207P | 2014-04-28 | 2014-04-28 | |
| US61/985,207 | 2014-04-28 | ||
| US201562176883P | 2015-01-09 | 2015-01-09 | |
| US201562101768P | 2015-01-09 | 2015-01-09 | |
| US62/176,883 | 2015-01-09 | ||
| US62/101,768 | 2015-01-09 | ||
| PCT/US2015/027781 WO2015168014A1 (en) | 2014-04-28 | 2015-04-27 | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513917A JP2017513917A (ja) | 2017-06-01 |
| JP2017513917A5 true JP2017513917A5 (enExample) | 2018-06-14 |
| JP6466970B2 JP6466970B2 (ja) | 2019-02-06 |
Family
ID=53040687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565186A Expired - Fee Related JP6466970B2 (ja) | 2014-04-28 | 2015-04-27 | フェノール性ヒドロキシル基を介して連結された医薬的に活性な二量体 |
| JP2016565239A Expired - Fee Related JP6568102B2 (ja) | 2014-04-28 | 2015-04-27 | ブプレノルフィン二量体及び消化管疾患の治療におけるその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565239A Expired - Fee Related JP6568102B2 (ja) | 2014-04-28 | 2015-04-27 | ブプレノルフィン二量体及び消化管疾患の治療におけるその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US9321780B2 (enExample) |
| EP (2) | EP3137080B1 (enExample) |
| JP (2) | JP6466970B2 (enExample) |
| KR (2) | KR102452348B1 (enExample) |
| CN (2) | CN106470999B (enExample) |
| AU (2) | AU2015253434B2 (enExample) |
| CA (2) | CA2945509C (enExample) |
| CY (1) | CY1119900T1 (enExample) |
| DK (1) | DK3137081T3 (enExample) |
| ES (1) | ES2658766T3 (enExample) |
| HR (1) | HRP20180260T1 (enExample) |
| HU (1) | HUE036084T2 (enExample) |
| IL (3) | IL248324B (enExample) |
| LT (1) | LT3137081T (enExample) |
| MA (1) | MA43129A (enExample) |
| ME (1) | ME02946B (enExample) |
| MX (3) | MX375600B (enExample) |
| PL (1) | PL3137081T3 (enExample) |
| PT (1) | PT3137081T (enExample) |
| RS (1) | RS56920B1 (enExample) |
| SG (3) | SG11201608910UA (enExample) |
| SI (1) | SI3137081T1 (enExample) |
| SM (1) | SMT201800073T1 (enExample) |
| WO (2) | WO2015168031A1 (enExample) |
| ZA (2) | ZA201606937B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108289869B (zh) * | 2014-04-28 | 2021-08-27 | 奥佛麦德公司 | 使用通过酚羟基连接的药学活性的对乙酰氨基酚二聚体治疗疼痛的方法 |
| EP3137080B1 (en) | 2014-04-28 | 2019-09-04 | Orphomed, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
| US20190022013A1 (en) | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
| WO2017106812A1 (en) * | 2015-12-19 | 2017-06-22 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
| CA3087898A1 (en) | 2018-02-02 | 2019-08-08 | Ripple Therapeutics Corporation | Glass formulations comprising steroid dimers and uses thereof |
| WO2020012248A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
| WO2020012245A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Thienothiophene-naltrexone prodrugs for long-acting injectable compositions |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
| WO2020154815A1 (en) | 2019-02-01 | 2020-08-06 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| TW202115014A (zh) * | 2019-07-12 | 2021-04-16 | 美商奧佛麥德公司 | 用於治療囊腫纖維化之化合物 |
| US12509469B2 (en) | 2019-08-07 | 2025-12-30 | Ripple Therapeutics Corporation | Compositions and methods for the treatment of pain and dependence disorders |
| JP2023524494A (ja) | 2020-05-01 | 2023-06-12 | リップル セラピューティクス コーポレーション | 眼障害を処置するためのヘテロ二量体組成物と方法 |
| WO2021262763A1 (en) * | 2020-06-23 | 2021-12-30 | Arriba Biopharma, Inc. | Opioid receptor modulator and use thereof |
| EP4543891A1 (en) | 2022-06-22 | 2025-04-30 | Teva Czech Industries s.r.o | Solid state forms of dibuprenorphine ethyl ether and process for preparation thereof |
| WO2025014912A1 (en) * | 2023-07-10 | 2025-01-16 | Dimerx, Inc. | Treatment of chronic pain or gastrointestinal disorders using buprenorphine dimer |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896235A (en) * | 1970-09-01 | 1975-07-22 | Burroughs Wellcome Co | Anthelmintic ethers and composition thereof |
| US5716631A (en) | 1995-09-29 | 1998-02-10 | Rdn Therapeutics Inc. | Long acting narcotic analgesics and antagonists |
| SI2939696T1 (sl) * | 2001-10-18 | 2016-06-30 | Nektar Therapeutics | Polimerni konjugati opioidnih antagonistov |
| ATE444296T1 (de) | 2002-10-25 | 2009-10-15 | Euro Celtique Sa | Analoga und prodrugs von buprenorphin |
| CN1263760C (zh) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物 |
| ATE382050T1 (de) | 2002-11-25 | 2008-01-15 | Chi Mei Foundation Medical Ct | Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel |
| JP2004175706A (ja) * | 2002-11-26 | 2004-06-24 | Chi Mei Foundation Medical Center | 新規なブプレノルフィンのエステル誘導体及びそれらの調製方法、及び長時間効力持続性鎮痛薬剤組成物 |
| WO2004103317A2 (en) | 2003-05-15 | 2004-12-02 | Euro-Celtique S.A. | Transdermal buprenorphine dosage regimen for treatment of diarrhea |
| US7759358B2 (en) * | 2003-07-23 | 2010-07-20 | Crooks Peter A | Oral bioavailable prodrugs |
| DK1888031T3 (da) | 2005-06-06 | 2013-02-18 | Camurus Ab | GLP-1-analogformuleringer |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| PL2001456T3 (pl) | 2006-04-04 | 2010-05-31 | Emodys Gmbh | Zastosowanie kompozycji zawierających antagonistę receptora opioidowego kappa do leczenia zaburzeń dysocjacyjnych |
| ES2629766T3 (es) | 2006-04-21 | 2017-08-14 | Nektar Therapeutics | Reducción estereoselectiva de una morfinona |
| EA201001643A1 (ru) | 2008-05-07 | 2011-06-30 | Нектар Терапеутикс | Пероральное введение периферически действующих опиоидных антагонистов |
| US20100068786A1 (en) * | 2008-09-16 | 2010-03-18 | Chmielewski Jean A | Methods and compositions for reversing p-glycoprotein medicated drug resistance |
| US8461171B2 (en) * | 2010-02-09 | 2013-06-11 | QRxPharma Ltd. | Hybrid opioid compounds and compositions |
| GB2481018B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| CA2809022C (en) | 2010-08-20 | 2017-01-03 | Dr. Reddy`S Laboratories, Inc. | Phospholipid depot |
| CN103289075B (zh) | 2012-02-22 | 2016-01-20 | 天津键凯科技有限公司 | 聚乙二醇与纳洛酮的结合物及其药物组合物和应用 |
| EP3137080B1 (en) | 2014-04-28 | 2019-09-04 | Orphomed, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
-
2015
- 2015-04-27 EP EP15720242.5A patent/EP3137080B1/en active Active
- 2015-04-27 LT LTEP15720244.1T patent/LT3137081T/lt unknown
- 2015-04-27 RS RS20180148A patent/RS56920B1/sr unknown
- 2015-04-27 WO PCT/US2015/027820 patent/WO2015168031A1/en not_active Ceased
- 2015-04-27 PT PT157202441T patent/PT3137081T/pt unknown
- 2015-04-27 AU AU2015253434A patent/AU2015253434B2/en active Active
- 2015-04-27 SI SI201530180T patent/SI3137081T1/en unknown
- 2015-04-27 PL PL15720244T patent/PL3137081T3/pl unknown
- 2015-04-27 KR KR1020167032991A patent/KR102452348B1/ko active Active
- 2015-04-27 CN CN201580023367.8A patent/CN106470999B/zh active Active
- 2015-04-27 ME MEP-2018-31A patent/ME02946B/me unknown
- 2015-04-27 MX MX2016013829A patent/MX375600B/es active IP Right Grant
- 2015-04-27 CA CA2945509A patent/CA2945509C/en active Active
- 2015-04-27 HR HRP20180260TT patent/HRP20180260T1/hr unknown
- 2015-04-27 SM SM20180073T patent/SMT201800073T1/it unknown
- 2015-04-27 DK DK15720244.1T patent/DK3137081T3/da active
- 2015-04-27 SG SG11201608910UA patent/SG11201608910UA/en unknown
- 2015-04-27 MX MX2016013823A patent/MX375597B/es active IP Right Grant
- 2015-04-27 CA CA2945181A patent/CA2945181C/en active Active
- 2015-04-27 HU HUE15720244A patent/HUE036084T2/hu unknown
- 2015-04-27 EP EP15720244.1A patent/EP3137081B1/en active Active
- 2015-04-27 KR KR1020167032992A patent/KR102374506B1/ko not_active Expired - Fee Related
- 2015-04-27 US US14/697,174 patent/US9321780B2/en active Active
- 2015-04-27 JP JP2016565186A patent/JP6466970B2/ja not_active Expired - Fee Related
- 2015-04-27 CN CN201580023293.8A patent/CN106458850B/zh active Active
- 2015-04-27 AU AU2015253417A patent/AU2015253417B2/en active Active
- 2015-04-27 SG SG11201608918SA patent/SG11201608918SA/en unknown
- 2015-04-27 ES ES15720244.1T patent/ES2658766T3/es active Active
- 2015-04-27 WO PCT/US2015/027781 patent/WO2015168014A1/en not_active Ceased
- 2015-04-27 US US14/697,155 patent/US9309256B2/en active Active
- 2015-04-27 JP JP2016565239A patent/JP6568102B2/ja not_active Expired - Fee Related
- 2015-10-26 US US14/922,373 patent/US9549924B2/en active Active
- 2015-10-26 US US14/922,362 patent/US9480665B2/en active Active
-
2016
- 2016-03-18 US US15/074,933 patent/US20160368931A1/en not_active Abandoned
- 2016-03-18 US US15/074,960 patent/US9732096B2/en active Active
- 2016-10-04 US US15/285,312 patent/US9782369B2/en active Active
- 2016-10-10 ZA ZA2016/06937A patent/ZA201606937B/en unknown
- 2016-10-13 IL IL248324A patent/IL248324B/en active IP Right Grant
- 2016-10-13 IL IL248326A patent/IL248326B/en active IP Right Grant
- 2016-10-25 MA MA043129A patent/MA43129A/fr unknown
- 2016-10-25 MX MX2018004834A patent/MX376379B/es active IP Right Grant
- 2016-10-25 SG SG11201803266XA patent/SG11201803266XA/en unknown
-
2018
- 2018-02-12 CY CY20181100169T patent/CY1119900T1/el unknown
- 2018-04-17 IL IL258762A patent/IL258762B/en active IP Right Grant
- 2018-04-20 ZA ZA2018/02643A patent/ZA201802643B/en unknown