JP2017513917A5 - - Google Patents
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- Publication number
- JP2017513917A5 JP2017513917A5 JP2016565186A JP2016565186A JP2017513917A5 JP 2017513917 A5 JP2017513917 A5 JP 2017513917A5 JP 2016565186 A JP2016565186 A JP 2016565186A JP 2016565186 A JP2016565186 A JP 2016565186A JP 2017513917 A5 JP2017513917 A5 JP 2017513917A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- solvate
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461985207P | 2014-04-28 | 2014-04-28 | |
| US61/985,207 | 2014-04-28 | ||
| US201562101768P | 2015-01-09 | 2015-01-09 | |
| US201562176883P | 2015-01-09 | 2015-01-09 | |
| US62/101,768 | 2015-01-09 | ||
| US62/176,883 | 2015-01-09 | ||
| PCT/US2015/027781 WO2015168014A1 (en) | 2014-04-28 | 2015-04-27 | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513917A JP2017513917A (ja) | 2017-06-01 |
| JP2017513917A5 true JP2017513917A5 (enExample) | 2018-06-14 |
| JP6466970B2 JP6466970B2 (ja) | 2019-02-06 |
Family
ID=53040687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565239A Expired - Fee Related JP6568102B2 (ja) | 2014-04-28 | 2015-04-27 | ブプレノルフィン二量体及び消化管疾患の治療におけるその使用 |
| JP2016565186A Expired - Fee Related JP6466970B2 (ja) | 2014-04-28 | 2015-04-27 | フェノール性ヒドロキシル基を介して連結された医薬的に活性な二量体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565239A Expired - Fee Related JP6568102B2 (ja) | 2014-04-28 | 2015-04-27 | ブプレノルフィン二量体及び消化管疾患の治療におけるその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US9321780B2 (enExample) |
| EP (2) | EP3137080B1 (enExample) |
| JP (2) | JP6568102B2 (enExample) |
| KR (2) | KR102374506B1 (enExample) |
| CN (2) | CN106458850B (enExample) |
| AU (2) | AU2015253417B2 (enExample) |
| CA (2) | CA2945181C (enExample) |
| CY (1) | CY1119900T1 (enExample) |
| DK (1) | DK3137081T3 (enExample) |
| ES (1) | ES2658766T3 (enExample) |
| HR (1) | HRP20180260T1 (enExample) |
| HU (1) | HUE036084T2 (enExample) |
| IL (3) | IL248324B (enExample) |
| LT (1) | LT3137081T (enExample) |
| MA (1) | MA43129A (enExample) |
| ME (1) | ME02946B (enExample) |
| MX (3) | MX375600B (enExample) |
| PL (1) | PL3137081T3 (enExample) |
| PT (1) | PT3137081T (enExample) |
| RS (1) | RS56920B1 (enExample) |
| SG (3) | SG11201608918SA (enExample) |
| SI (1) | SI3137081T1 (enExample) |
| SM (1) | SMT201800073T1 (enExample) |
| WO (2) | WO2015168014A1 (enExample) |
| ZA (2) | ZA201606937B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015253417B2 (en) * | 2014-04-28 | 2020-02-20 | Dimerx, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
| CN108289869B (zh) * | 2014-04-28 | 2021-08-27 | 奥佛麦德公司 | 使用通过酚羟基连接的药学活性的对乙酰氨基酚二聚体治疗疼痛的方法 |
| CN108712900A (zh) * | 2015-12-19 | 2018-10-26 | 第时间美国泛型药物有限公司 | 软咀嚼片剂药物制剂 |
| US20190022013A1 (en) | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
| EP3740494A4 (en) | 2018-02-02 | 2021-11-03 | Ripple Therapeutics Corporation | GLASS FORMULATIONS WITH STEROID DIMERS AND USES THEREOF |
| US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
| US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
| US10975099B2 (en) | 2018-11-05 | 2021-04-13 | Alkermes Pharma Ireland Limited | Thiophene compounds for long-acting injectable compositions and related methods |
| WO2020154815A1 (en) | 2019-02-01 | 2020-08-06 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| WO2021011327A1 (en) * | 2019-07-12 | 2021-01-21 | Orphomed, Inc. | Compound for treating cystic fibrosis |
| US12509469B2 (en) | 2019-08-07 | 2025-12-30 | Ripple Therapeutics Corporation | Compositions and methods for the treatment of pain and dependence disorders |
| CA3176134A1 (en) | 2020-05-01 | 2021-11-04 | Ripple Therapeutics Corporation | Heterodimer compositions and methods for the treatment of ocular disorders |
| WO2021262763A1 (en) * | 2020-06-23 | 2021-12-30 | Arriba Biopharma, Inc. | Opioid receptor modulator and use thereof |
| WO2023248161A1 (en) | 2022-06-22 | 2023-12-28 | Teva Czech Industries S.R.O | Solid state forms of dibuprenorphine ethyl ether and process for preparation thereof |
| JP2026525291A (ja) * | 2023-07-10 | 2026-07-29 | ディマークス インコーポレイティド | ブプレノルフィン二量体を使用する慢性疼痛又は胃腸障害の治療 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896235A (en) * | 1970-09-01 | 1975-07-22 | Burroughs Wellcome Co | Anthelmintic ethers and composition thereof |
| US5716631A (en) | 1995-09-29 | 1998-02-10 | Rdn Therapeutics Inc. | Long acting narcotic analgesics and antagonists |
| US7056500B2 (en) | 2001-10-18 | 2006-06-06 | Nektar Therapeutics Al, Corporation | Polymer conjugates of opioid antagonists |
| EP1554290B1 (en) | 2002-10-25 | 2009-09-30 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| CN1263760C (zh) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物 |
| ATE382050T1 (de) | 2002-11-25 | 2008-01-15 | Chi Mei Foundation Medical Ct | Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel |
| JP2004175706A (ja) * | 2002-11-26 | 2004-06-24 | Chi Mei Foundation Medical Center | 新規なブプレノルフィンのエステル誘導体及びそれらの調製方法、及び長時間効力持続性鎮痛薬剤組成物 |
| WO2004103317A2 (en) | 2003-05-15 | 2004-12-02 | Euro-Celtique S.A. | Transdermal buprenorphine dosage regimen for treatment of diarrhea |
| WO2005009377A2 (en) * | 2003-07-23 | 2005-02-03 | University Of Kentucky Research Foundation | Novel oral bioavailable prodrugs |
| US8097239B2 (en) | 2005-06-06 | 2012-01-17 | Camurus Ab | Controlled-release formulations |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| PL2001456T3 (pl) | 2006-04-04 | 2010-05-31 | Emodys Gmbh | Zastosowanie kompozycji zawierających antagonistę receptora opioidowego kappa do leczenia zaburzeń dysocjacyjnych |
| ES2629766T3 (es) | 2006-04-21 | 2017-08-14 | Nektar Therapeutics | Reducción estereoselectiva de una morfinona |
| CN102014907A (zh) | 2008-05-07 | 2011-04-13 | 尼克塔治疗公司 | 外周作用阿片拮抗剂的口服给药 |
| US20100068786A1 (en) * | 2008-09-16 | 2010-03-18 | Chmielewski Jean A | Methods and compositions for reversing p-glycoprotein medicated drug resistance |
| US8461171B2 (en) * | 2010-02-09 | 2013-06-11 | QRxPharma Ltd. | Hybrid opioid compounds and compositions |
| GB2481018B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| AU2010359346B2 (en) | 2010-08-20 | 2015-01-29 | Dr. Reddy's Laboratories Sa | Phospholipid depot |
| CN103289075B (zh) * | 2012-02-22 | 2016-01-20 | 天津键凯科技有限公司 | 聚乙二醇与纳洛酮的结合物及其药物组合物和应用 |
| AU2015253417B2 (en) | 2014-04-28 | 2020-02-20 | Dimerx, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
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2015
- 2015-04-27 AU AU2015253417A patent/AU2015253417B2/en active Active
- 2015-04-27 RS RS20180148A patent/RS56920B1/sr unknown
- 2015-04-27 KR KR1020167032992A patent/KR102374506B1/ko not_active Expired - Fee Related
- 2015-04-27 MX MX2016013829A patent/MX375600B/es active IP Right Grant
- 2015-04-27 CA CA2945181A patent/CA2945181C/en active Active
- 2015-04-27 WO PCT/US2015/027781 patent/WO2015168014A1/en not_active Ceased
- 2015-04-27 EP EP15720242.5A patent/EP3137080B1/en active Active
- 2015-04-27 HR HRP20180260TT patent/HRP20180260T1/hr unknown
- 2015-04-27 US US14/697,174 patent/US9321780B2/en active Active
- 2015-04-27 SI SI201530180T patent/SI3137081T1/en unknown
- 2015-04-27 EP EP15720244.1A patent/EP3137081B1/en active Active
- 2015-04-27 SG SG11201608918SA patent/SG11201608918SA/en unknown
- 2015-04-27 LT LTEP15720244.1T patent/LT3137081T/lt unknown
- 2015-04-27 JP JP2016565239A patent/JP6568102B2/ja not_active Expired - Fee Related
- 2015-04-27 AU AU2015253434A patent/AU2015253434B2/en active Active
- 2015-04-27 CN CN201580023293.8A patent/CN106458850B/zh active Active
- 2015-04-27 WO PCT/US2015/027820 patent/WO2015168031A1/en not_active Ceased
- 2015-04-27 SG SG11201608910UA patent/SG11201608910UA/en unknown
- 2015-04-27 MX MX2016013823A patent/MX375597B/es active IP Right Grant
- 2015-04-27 ME MEP-2018-31A patent/ME02946B/me unknown
- 2015-04-27 PT PT157202441T patent/PT3137081T/pt unknown
- 2015-04-27 DK DK15720244.1T patent/DK3137081T3/da active
- 2015-04-27 ES ES15720244.1T patent/ES2658766T3/es active Active
- 2015-04-27 PL PL15720244T patent/PL3137081T3/pl unknown
- 2015-04-27 SM SM20180073T patent/SMT201800073T1/it unknown
- 2015-04-27 US US14/697,155 patent/US9309256B2/en active Active
- 2015-04-27 CA CA2945509A patent/CA2945509C/en active Active
- 2015-04-27 JP JP2016565186A patent/JP6466970B2/ja not_active Expired - Fee Related
- 2015-04-27 CN CN201580023367.8A patent/CN106470999B/zh active Active
- 2015-04-27 KR KR1020167032991A patent/KR102452348B1/ko active Active
- 2015-04-27 HU HUE15720244A patent/HUE036084T2/hu unknown
- 2015-10-26 US US14/922,362 patent/US9480665B2/en active Active
- 2015-10-26 US US14/922,373 patent/US9549924B2/en active Active
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2016
- 2016-03-18 US US15/074,933 patent/US20160368931A1/en not_active Abandoned
- 2016-03-18 US US15/074,960 patent/US9732096B2/en active Active
- 2016-10-04 US US15/285,312 patent/US9782369B2/en active Active
- 2016-10-10 ZA ZA2016/06937A patent/ZA201606937B/en unknown
- 2016-10-13 IL IL248324A patent/IL248324B/en active IP Right Grant
- 2016-10-13 IL IL248326A patent/IL248326B/en active IP Right Grant
- 2016-10-25 SG SG11201803266XA patent/SG11201803266XA/en unknown
- 2016-10-25 MA MA043129A patent/MA43129A/fr unknown
- 2016-10-25 MX MX2018004834A patent/MX376379B/es active IP Right Grant
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2018
- 2018-02-12 CY CY20181100169T patent/CY1119900T1/el unknown
- 2018-04-17 IL IL258762A patent/IL258762B/en active IP Right Grant
- 2018-04-20 ZA ZA2018/02643A patent/ZA201802643B/en unknown