CA2496867A1 - Therapeutic treatment methods - Google Patents

Therapeutic treatment methods Download PDF

Info

Publication number
CA2496867A1
CA2496867A1 CA002496867A CA2496867A CA2496867A1 CA 2496867 A1 CA2496867 A1 CA 2496867A1 CA 002496867 A CA002496867 A CA 002496867A CA 2496867 A CA2496867 A CA 2496867A CA 2496867 A1 CA2496867 A1 CA 2496867A1
Authority
CA
Canada
Prior art keywords
alpha
beta
ene
fluoroandrost
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002496867A
Other languages
English (en)
French (fr)
Inventor
Christopher Reading
Clarence N. Ahlem
Dominick L. Auci
Charles Dowding
James Frincke
Mei Li
Theodore M. Page
Richard J. Trauger
Dwight R. Stickney
Steven K. White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbor Biosciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2496867A1 publication Critical patent/CA2496867A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002496867A 2002-08-28 2003-08-28 Therapeutic treatment methods Abandoned CA2496867A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US40714602P 2002-08-28 2002-08-28
US60/407,146 2002-08-28
US40833202P 2002-09-04 2002-09-04
US60/408,332 2002-09-04
US47925703P 2003-06-17 2003-06-17
US60/479,257 2003-06-17
PCT/US2003/027186 WO2004019953A1 (en) 2002-08-28 2003-08-28 Therapeutic treatment methods

Publications (1)

Publication Number Publication Date
CA2496867A1 true CA2496867A1 (en) 2004-03-11

Family

ID=31982343

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002496867A Abandoned CA2496867A1 (en) 2002-08-28 2003-08-28 Therapeutic treatment methods

Country Status (7)

Country Link
US (6) US20040138187A1 (enExample)
EP (3) EP2298315A1 (enExample)
JP (1) JP2006506445A (enExample)
KR (1) KR20050057086A (enExample)
AU (1) AU2003278744B2 (enExample)
CA (1) CA2496867A1 (enExample)
WO (1) WO2004019953A1 (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US20060079492A1 (en) * 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US20030060425A1 (en) * 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
US7163918B2 (en) 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
CA2484963A1 (en) * 2002-05-01 2003-11-13 Arthur Schwartz 7-hydroxy-16a-fluoro-5-androsten-17-ones and 7-hydroxy-16a-fluoro-5-androstan-17-ones and derivatives thereof
CA2496867A1 (en) 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
US20050101581A1 (en) 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
US7572780B2 (en) 2003-01-21 2009-08-11 Dimera, Incorporated Method and kit for reducing the symptoms of peripheral vascular disease
WO2005107792A2 (en) * 2004-04-02 2005-11-17 Whitehead Institute For Biomedical Research Compositions and methods for treatment of protein misfolding diseases
US20090162315A1 (en) * 2004-06-29 2009-06-25 Terman David S Enterotoxin gene cluster (egc) superantigens to treat malignant disease
WO2006019379A1 (en) * 2004-07-19 2006-02-23 American Diagnostica Inc. Methods for measuring adamts13 activity and protein on platelets and in plasma
US7270976B2 (en) * 2004-07-19 2007-09-18 American Diagnostica, Inc. Methods for measuring ADAMTS13 activity and protein on platelets and in plasma
US20080138837A1 (en) * 2004-07-19 2008-06-12 Robert Greenfield Methods and kits for detecting and measuring ADAMTS13/FXI complexes
US8865749B2 (en) * 2004-08-01 2014-10-21 Trevor Gordon Marshall Treatment and prevention of Th1 and ‘autoimmune’ diseases effected with antibiotics and/or angiotensin inhibition
JPWO2006033355A1 (ja) * 2004-09-21 2008-05-15 協和醗酵工業株式会社 皮膚の乾燥予防または改善用経口剤
US7910755B2 (en) * 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) * 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
KR100766750B1 (ko) * 2004-12-13 2007-10-17 주식회사 엘지생명과학 바이오칩의 제조방법
US20100048595A1 (en) * 2005-03-23 2010-02-25 Washington University In St. Louis Use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota
US20060281720A1 (en) * 2005-06-08 2006-12-14 Loria Roger M 5-Androstenediol As An Inhibitor of Gliomas
CN101282646B (zh) 2005-07-12 2013-03-27 Dmi生物科学公司 治疗疾病的方法和产品
CN101951914A (zh) * 2005-10-20 2011-01-19 加利福尼亚太平洋医学中心 雄甾酮衍生物及其使用方法
US20070135504A1 (en) * 2005-12-11 2007-06-14 Marshall Trevor G Method of Treating and/or Preventing Inflammatory Diseases, including many Autoimmune and Neurological diseases, using drugs to modulate the VDR, and/or PPAR, and/or GCR and/or CB1 nuclear and GPCR receptors; in conjunction with antibiotics which target prokaryotic protein translation
KR101250181B1 (ko) * 2006-02-10 2013-04-05 동화약품주식회사 감수에서 분리된 테르페노이드 또는 이를 포함하는감수추출물을 함유하는 골다공증 예방 및 치료용 약학조성물
KR100917657B1 (ko) * 2006-02-15 2009-09-18 주식회사 머젠스 산화환원 효소에 의해 nad(p)/nad(p)h비율을 조절하는 방법
US8252532B2 (en) * 2006-04-05 2012-08-28 University Of Connecticut Regulators of the non-genomic action of progesterone and methods of use
DK2012773T3 (da) * 2006-04-22 2012-09-24 Harbor Biosciences Inc Lægemidler og anvendelser deraf
US20080051380A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20080221074A1 (en) * 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
US8486926B2 (en) 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
US8354396B2 (en) * 2006-11-17 2013-01-15 Harbor Therapeutics, Inc. Drug identification and treatment method
US8217025B2 (en) 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
WO2008086452A2 (en) * 2007-01-10 2008-07-17 Columbia University Treatment and prevention of alzheimer's disease
WO2008100791A1 (en) * 2007-02-16 2008-08-21 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of sickle cell
WO2009009132A1 (en) * 2007-07-12 2009-01-15 Cougar Biotechnology, Inc. Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer
ITMI20071616A1 (it) 2007-08-03 2009-02-04 Cosmo Spa Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
EP2185112A4 (en) * 2007-08-21 2012-01-18 Harbor Biosciences Inc Stabilized therapeutic compositions and formulations
WO2009055864A1 (en) * 2007-10-31 2009-05-07 Crc For Asthma And Airways Ltd Methods and compositions for regulating airway tissue remodelling
US20090214641A1 (en) * 2008-02-26 2009-08-27 Joar Opheim Sweetened Capsules for Administration
US20100286106A1 (en) * 2008-03-10 2010-11-11 Yigal Gat Methods and apparatus for treating the prostate
WO2009129525A2 (en) * 2008-04-18 2009-10-22 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Antifungal and anti-cariogenic cellobio-oligosaccharides produced by dextransucrase
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
ES2554688T3 (es) 2009-06-22 2015-12-22 Ampio Pharmaceuticals, Inc. Procedimiento de tratamiento de enfermedades
BRPI1010086A2 (pt) * 2009-06-22 2018-02-06 Dmi Acquisition Corp método e produtos para tratamento de doenças
US8811535B2 (en) * 2009-07-17 2014-08-19 Mitre Corporation Time-frequency space constructions of families of signals
WO2011022619A1 (en) * 2009-08-20 2011-02-24 Glaxo Group Limited TREATING INFLAMMATORY DISEASES BY ADMINISTRATION OF REV-ERB α LIGANDS
WO2011032109A1 (en) * 2009-09-11 2011-03-17 Sma Foundation Biomarkers for spinal muscular atrophy
US20110129423A1 (en) * 2009-11-30 2011-06-02 Frincke James M Anticancer compounds and screening method
KR20110097498A (ko) * 2010-02-25 2011-08-31 서울대학교산학협력단 전자파 노출을 진단하기 위한 마커 및 이를 포함하는 키트
KR20110097497A (ko) * 2010-02-25 2011-08-31 서울대학교산학협력단 전자파 노출을 진단하기 위한 마커 및 이를 포함하는 키트
KR20110097499A (ko) * 2010-02-25 2011-08-31 서울대학교산학협력단 전자파 노출을 진단하기 위한 마커 및 이를 포함하는 키트
WO2012024489A2 (en) * 2010-08-18 2012-02-23 Emory University Compounds and compositions for ossification and methods related thereto
CN102079771B (zh) * 2010-12-10 2012-10-03 郑州大学 具有抗肿瘤活性的雌甾氨基酸酯化合物及其合成方法
KR101286743B1 (ko) * 2011-02-18 2013-07-15 충남대학교산학협력단 페노피브레이트를 함유하는 패혈증 예방용 약학 조성물
WO2012115987A2 (en) * 2011-02-21 2012-08-30 The Trustees Of Columbia University In The City Of New York Methods for Treating and Preventing Cardiac Dysfunction in Septic Shock
DK2694640T3 (da) * 2011-04-08 2017-11-20 Baylor College Medicine Reversion af effekterne af tumormikromiljø ved anvendelse af kimæriske cytokinreceptorer
WO2013043985A1 (en) 2011-09-23 2013-03-28 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
US9675582B2 (en) 2011-10-25 2017-06-13 U.S. Phytotherapy, Inc. Alternative ACT with natural botanical active GRAS ingredients for treatment and prevention of the Zika virus
EP2770985A4 (en) 2011-10-25 2015-01-21 U S Phytotherapy Inc ARTEMISININE AND BERBERINE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
US9358261B2 (en) 2011-10-25 2016-06-07 U.S. Phytotherapy, Inc. Additional artemisinin and berberine compositions and methods of making
WO2013106672A1 (en) * 2012-01-13 2013-07-18 Tufts Medical Center, Inc. Methods and compositions for the treatment of neurodegenerative disease
NZ773177A (en) 2012-01-23 2022-09-30 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
IL275725B (en) 2012-08-21 2022-08-01 Sage Therapeutics Inc Treatment methods for epilepsy and status epilepticus
EP3795694A3 (en) 2012-10-02 2021-06-23 The General Hospital Corporation d/b/a Massachusetts General Hospital Methods relating to dna-sensing pathway related conditions
DK2925327T3 (da) 2012-11-30 2024-03-25 Univ California Allopregnanolon til behandling, reduktion eller lindring af symptomer på fødselsdepression
WO2014100352A1 (en) 2012-12-19 2014-06-26 Ampio Pharmaceuticals, Inc. Method for treatment of diseases
CA2896939C (en) 2013-01-03 2022-07-12 Hidros Therapeutics International Ab Treatment of hyperhidrosis
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
EP3108879A1 (en) 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation
WO2017004205A1 (en) * 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
WO2017156103A1 (en) 2016-03-08 2017-09-14 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
KR101765600B1 (ko) * 2016-04-18 2017-08-07 주식회사 바이오리더스 폴리감마글루탐산의자궁경부상피이형증 치료용도
IL322013A (en) 2016-07-29 2025-09-01 Janssen Pharmaceutica Nv Niraparib or its salts for use in the treatment of prostate cancer
KR20200070273A (ko) * 2017-10-16 2020-06-17 아미그달라 뉴로사이언시즈, 인크. 중독을 예방하기 위한 병용 요법
GB201718667D0 (en) * 2017-11-10 2017-12-27 Mologic Ltd Monitoring inflammation status
US11993574B2 (en) * 2018-06-15 2024-05-28 Reata Pharmaceuticals, Inc Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma
US20200108120A1 (en) 2018-10-09 2020-04-09 King Faisal Specialist Hospital & Research Centre Method for treating pulmonary fibrosis using s100a3 protein
JP7558167B2 (ja) 2018-12-03 2024-09-30 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CN113318114B (zh) * 2020-02-28 2023-02-17 广州市赛普特医药科技股份有限公司 小分子化合物在治疗肺上皮细胞损伤和/或血管内皮细胞损伤介导的疾病中的用途
CN113321695B (zh) * 2021-07-01 2024-01-12 海南师范大学 一种甾体类化合物及其制备方法和应用
JP2025520426A (ja) 2022-06-14 2025-07-03 アミグダラ ニューロサイエンシーズ, インコーポレイテッド Aldh-2阻害化合物及び使用方法
KR102704483B1 (ko) * 2023-02-28 2024-09-10 대한민국(질병관리청 국립보건연구원장) 스테로이드 유도체 계열 화합물 및 이를 유효성분으로 함유하는 항바이러스제
WO2025172841A1 (en) * 2024-02-15 2025-08-21 Ricerfarma S.R.L. Mucoadhesive oral tablet for symptomatic treatment of xerostomia, mouth ulcers and inflammations of the oral cavity

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2566336A (en) * 1947-08-28 1951-09-04 Glidden Co Preparation of keto-amine salts in the steroid series and products
US2561378A (en) * 1947-09-11 1951-07-24 Glidden Co 20-dimethylamino-pregnenes and their quaternary halides
US2793217A (en) * 1953-06-27 1957-05-21 Lab Francais Chimiotherapie New derivatives of adrenosterone and a process of making same
US2940991A (en) * 1957-03-01 1960-06-14 Julian Lab Inc Method of epimerizing 11-bromo steroids
US2851454A (en) * 1957-08-02 1958-09-09 Searle & Co 1, 2-epoxy-3, 17-dioxygenated androstane derivatives and their reduction
US2833794A (en) * 1957-12-18 1958-05-06 Searle & Co 3-oxygenated 4-androstene-1, 17-diols and derivatives
US2838544A (en) * 1958-02-19 1958-06-10 Upjohn Co 6alpha-fluoro-16alpha-hydroxy progesterones
US3189597A (en) * 1959-03-04 1965-06-15 Ciba Geigy Corp 3-glycosides of 17-amino-3-hydroxy-5-androstenes
US3080360A (en) * 1960-07-11 1963-03-05 Searle & Co 17alpha-alkyl-17beta-hydroxy-18-norandrost-4-en-3-ones
US3001988A (en) * 1960-07-19 1961-09-26 Searle & Co 3-oxygenated 17beta-aminoalkanamidoandrost-4/5-enes, 5alpha-androstanes corresponding, and intermediates thereto
US3107254A (en) * 1960-10-05 1963-10-15 Upjohn Co 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives
US3137710A (en) 1961-03-30 1964-06-16 Ormonoterapia Richter Spa Method for the preparation of primary amines
US3153063A (en) * 1961-05-30 1964-10-13 Ormonoterapia Richter Spa 16-methyl-17-amino-androstane
GB1003681A (en) * 1962-03-09 1965-09-08 May & Baker Ltd Androstane and androstene derivatives
US3155690A (en) * 1962-08-17 1964-11-03 Abbott Lab Nu-substituted 17alpha-aminosteroids
US3187022A (en) * 1964-01-31 1965-06-01 Parke Davis & Co 17beta-amino-17alpha-pregnen-20-one compounds and the production thereof
US3264326A (en) * 1964-04-29 1966-08-02 American Home Prod 17beta-substituted-3alpha-amino-5alpha-androstanes
BE667232A (enExample) * 1964-07-22
IL31997A (en) * 1968-05-03 1974-03-14 Lepetit Spa Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3917829A (en) * 1971-11-08 1975-11-04 Research Corp Novel methods of inhibiting the activity of testosterone 5{60 -reductase
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
US3984566A (en) 1974-02-25 1976-10-05 Scott Eugene J Van Method of alleviating the symptoms of dandruff
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4234599A (en) 1978-10-04 1980-11-18 Scott Eugene J Van Treatment of skin keratoses with α-hydroxy acids and related compounds
US4246261A (en) 1979-08-09 1981-01-20 Scott Eugene J Van Additives enhancing topical corticosteroid action
US4424218A (en) * 1979-08-17 1984-01-03 Roussel Uclaf Novel 3 α-amino steroids
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US5169857A (en) 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
FR2494697A1 (fr) * 1980-11-21 1982-05-28 Roussel Uclaf Nouveaux derives steroides 3-amines, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
IT1134455B (it) * 1980-11-26 1986-08-13 Lepetit Spa Procedimento per la preparazione di derivati 16alfa-idrossi-17alfa-aminopregnanici
US4330539A (en) * 1981-01-29 1982-05-18 Akzo Nv Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof
US4739073A (en) 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US4908358A (en) * 1987-08-27 1990-03-13 Trustees Of The University Of Pennsylvania Inhibition of immune clearance using progesterone analogues
ATE90355T1 (de) * 1987-10-13 1993-06-15 Nicholas S Bodor Weiche steroide mit anti-entzuendungswirkung.
US4898694A (en) * 1987-11-25 1990-02-06 Schwartz Arthur G 17-Hydroxy-steroids
NO177005C (no) 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
US5262407A (en) 1988-12-16 1993-11-16 L'oreal Use of salicylic derivatives for the treatment of skin aging
US5077284A (en) * 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
US5461042A (en) * 1988-12-30 1995-10-24 Loria; Roger M. Regulation of the immune system
US5128450A (en) 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
DE69033541D1 (de) * 1989-09-25 2000-06-15 Univ Utah Res Found Verwendung von steroidhormonen in zubereitungen zur induzierung von t-zell-lymphokin-erzeugung
US5837269A (en) 1989-09-25 1998-11-17 University Of Utah Research Foundation Vaccine compositions and method for enhancing an immune response
US5919465A (en) 1989-09-25 1999-07-06 University Of Utah Research Foundation Methods for augmenting immunological responses through the administration of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S)
US5641768A (en) * 1989-11-17 1997-06-24 Loria; Roger M. 5-androstene 3β, 17β diol for treatment
US5424463A (en) 1990-08-29 1995-06-13 Humanetics Corporation Δ5-androstenes useful for promoting weight maintenance or weight loss and treatment process
US5585371A (en) * 1990-08-29 1996-12-17 Humanetics Corporation Treatment of immune system with Δ5-androstenes
US5641766A (en) * 1990-08-29 1997-06-24 Humanetics Corporation UP-regulation of immune system with Δ 5-Androstenes
US5080139A (en) 1990-10-31 1992-01-14 Reseal International Limited Partnership Valve assembly with disk-like valve body
US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
US5254343A (en) 1991-03-19 1993-10-19 Bristol-Myers Squibb Company Reduction of cutaneous atrophy
US5206008A (en) * 1991-04-15 1993-04-27 Virginia Commonwealth University Enhancement of immune response
US5834213A (en) 1991-05-02 1998-11-10 Baylor College Of Medicine Screening system and assay for identifying compounds that regulate steroid and orphan receptors mediation of DNA transcription
US6093706A (en) * 1992-03-04 2000-07-25 Bioresponse, L.L.C. Combined dehydroepiandrosterone and retinoid therapy for epithelial disorders
DK0633893T3 (da) * 1992-03-31 2000-04-17 Btg Int Ltd 17-Substituerede steroider, der er nyttige ved cancerbehandling
US5686438A (en) * 1993-03-09 1997-11-11 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5846963A (en) * 1995-06-07 1998-12-08 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5635496A (en) * 1993-03-09 1997-06-03 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
DE69434149T2 (de) * 1993-03-09 2006-07-20 University Of Utah Research Foundation, Salt Lake City Verwendung von dhea oder dessen derivate zur herstellung eines medikaments zur vorbeugung von progressiver gewebe-nekrose, reperfusionsschädigung, bakterieller translokation und vom atemnotsyndrom bei erwachsenen
US5977095A (en) * 1993-03-09 1999-11-02 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and respiratory distress syndrome
US5811418A (en) * 1993-03-09 1998-09-22 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5387583A (en) * 1993-04-20 1995-02-07 Loria; Roger M. Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof
US5478566A (en) * 1993-09-29 1995-12-26 Loria; Roger M. Stimulation of cytokine production
DE69425439D1 (de) 1993-09-29 2000-09-07 Nissin Food Products Ltd In stellung 21 substituierte steroide
JPH07258091A (ja) * 1994-03-17 1995-10-09 Kyowa Hakko Kogyo Co Ltd アトピー性皮膚炎治療剤
US5658744A (en) 1994-07-22 1997-08-19 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying patients having an altered immune status
US5792757A (en) 1994-08-04 1998-08-11 Pherin Pharmaceuticals 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function
US5693647A (en) 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
EP1043326A1 (en) 1994-12-22 2000-10-11 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US20020032160A1 (en) * 1995-02-24 2002-03-14 Nyce Jonathan W. Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
US5663054A (en) 1995-03-03 1997-09-02 Abbott Laboratories Determination of steroids by competitive immunoassay
EP0838223B1 (en) 1995-06-02 2003-07-23 Shionogi & Co., Ltd. Brain edema inhibitor
US5958710A (en) 1995-09-08 1999-09-28 Karo Bio Ab Orphan receptor
IL118836A (en) 1996-07-11 2001-01-11 Teva Pharma Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
US5958892A (en) 1996-07-30 1999-09-28 Board Of Regents, The University Of Texas System 2-methoxyestradiol-induced apoptosis in cancer cells
DE19633376A1 (de) 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue Seco-D-Steroide, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
US5952371A (en) 1996-10-16 1999-09-14 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5945412A (en) 1996-12-09 1999-08-31 Merck & Co., Inc. Methods and compositions for preventing and treating bone loss
US5885977A (en) * 1997-01-15 1999-03-23 Humanetics Corporation Use of Δ5 androstenes in the treatment of HIV wasting syndrome
JP3688446B2 (ja) 1997-01-23 2005-08-31 ヒゲタ醤油株式会社 新規テルペン系化合物0406tp−1
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US5935968A (en) 1997-03-17 1999-08-10 Merck & Co., Inc. Methods for treating polycystic ovary syndrome
US5925657A (en) 1997-06-18 1999-07-20 The General Hospital Corporation Use of PPARγ agonists for inhibition of inflammatory cytokine production
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
CA2260584C (en) * 1998-02-04 2007-07-31 Charlotte-Mecklenburg Hospital D/B/A Carolinas Medical Center Androsterone derivatives for inhibiting dna binding of ap-1 and airway smooth muscle proliferation
US6380207B2 (en) 1998-02-13 2002-04-30 Abbott Laboratories Glucocortiocoid-selective antiinflammatory agents
US6107034A (en) 1998-03-09 2000-08-22 The Board Of Trustees Of The Leland Stanford Junior University GATA-3 expression in human breast carcinoma
AU3083299A (en) 1998-03-13 1999-09-27 Pharmadigm, Inc. Screening for dhea mimetics using members of the inflammatory cell signalling cascade specifically modulated by dhea as targets
WO1999052532A1 (en) * 1998-04-14 1999-10-21 Pharmadigm, Inc. Method for reducing central nervous system impairment
AU752581B2 (en) 1998-05-26 2002-09-26 Peter Louis Carlen Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals
RU2221569C2 (ru) * 1998-06-11 2004-01-20 Андорешерш, Инк. ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ АНДРОСТ-5-ЕН-3-β, 17β -ДИОЛ, И ЕГО ИСПОЛЬЗОВАНИЕ
US20070129282A1 (en) 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
IL142942A0 (en) * 1998-11-24 2002-04-21 Holis Eden Pharmaceuticals Inc Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in the treatment of hepatitis c virus and other toga viruses
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
JP2002540119A (ja) * 1999-03-23 2002-11-26 ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド 免疫修飾ステロイドとくに16α−ブロモエピアンドロステロンのヘミハイドレート
DK1955700T3 (da) 1999-09-30 2011-05-23 Harbor Biosciences Inc Terapeutisk behandling af androgenreceptor-betingede lidelser
CA2388939C (en) * 1999-10-25 2009-06-09 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatments for blood cell deficiencies
US6348489B1 (en) 2000-04-11 2002-02-19 Daiichi Pharmaceutical Co., Ltd. Method of treating traumatic brain injury and other neuronal disorders
IL135707A0 (en) * 2000-04-17 2001-05-20 Yissum Res Dev Co 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them
GB2363984A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids
GB2363983A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 7-hydroxyepiandrosterone
EP1351971A2 (en) * 2000-10-06 2003-10-15 Aeson Therapeutics Inc. Compounds useful for treating hypertriglyceridemia
AU2002244247B2 (en) * 2001-03-01 2007-12-13 Harbor Biosciences, Inc. Use of certain steroids for treatment of blood cell deficiencies
US6465446B1 (en) * 2001-03-12 2002-10-15 John C. Dykstra Treatment of dermatitis by the topical application of Δ5-androstene-3β-ol-7,17 dione and metabolizable precursors thereof
US20050070487A1 (en) * 2001-04-24 2005-03-31 Nyce Jonathan W. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
AU2002303427A1 (en) * 2001-04-24 2002-11-05 East Carolina University Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease
EP1310258A1 (en) * 2001-11-08 2003-05-14 Etienne-Emile Baulieu Enantiomers of steroids for the enhancement of memory and cognitive function
JP2005530820A (ja) * 2002-06-17 2005-10-13 エピジェネシス ファーマシューティカルズ リミティド ライアビリティー カンパニー 二水和デヒドロエピアンドロステロン及びその組成物を用いた喘息又は慢性閉塞性肺疾患の治療方法
CA2496867A1 (en) * 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
CA2522784C (en) 2003-04-01 2012-06-19 Hollis-Eden Pharmaceuticals, Inc. Antiandrogens with marginal agonist activity and methods of use
US7910755B2 (en) 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
US20080065873A1 (en) * 2006-09-11 2008-03-13 Ronald Hall Dynamic livelock resolution with variable delay memory access queue
KR20080095683A (ko) * 2007-04-25 2008-10-29 삼성전자주식회사 상변화 메모리 소자 및 그 형성 방법

Also Published As

Publication number Publication date
JP2006506445A (ja) 2006-02-23
US20080085873A1 (en) 2008-04-10
EP2298316A1 (en) 2011-03-23
EP1539183A1 (en) 2005-06-15
US20080090791A1 (en) 2008-04-17
AU2003278744A1 (en) 2004-03-19
AU2003278744B2 (en) 2010-07-29
EP2298315A1 (en) 2011-03-23
EP1539183A4 (en) 2007-04-25
US20040138187A1 (en) 2004-07-15
US20070265236A1 (en) 2007-11-15
WO2004019953A1 (en) 2004-03-11
US20070203107A1 (en) 2007-08-30
US20070213309A1 (en) 2007-09-13
KR20050057086A (ko) 2005-06-16
US7935839B2 (en) 2011-05-03
US7910571B2 (en) 2011-03-22

Similar Documents

Publication Publication Date Title
CA2496867A1 (en) Therapeutic treatment methods
US7910755B2 (en) Stem cell expansion and uses
AU2011200199B2 (en) Steroid analogs and characterization and treatment methods
AU2008201188B2 (en) Use of certain steroids for treatment of blood cell deficiencies
US7482334B2 (en) Therapeutic treatment methods
US20120101052A9 (en) 15-thia steroid compounds and compositions
AU2002244247A1 (en) Use of certain steroids for treatment of blood cell deficiencies
US20150353596A1 (en) 17-Substituted Steroid Compounds

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131211