JP2006506439A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006506439A5 JP2006506439A5 JP2004553861A JP2004553861A JP2006506439A5 JP 2006506439 A5 JP2006506439 A5 JP 2006506439A5 JP 2004553861 A JP2004553861 A JP 2004553861A JP 2004553861 A JP2004553861 A JP 2004553861A JP 2006506439 A5 JP2006506439 A5 JP 2006506439A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- compound
- alkoxy
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 59
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 59
- 150000003839 salts Chemical class 0.000 claims 59
- 229910052736 halogen Inorganic materials 0.000 claims 38
- 150000002367 halogens Chemical class 0.000 claims 38
- 125000001188 haloalkyl group Chemical group 0.000 claims 35
- 125000001424 substituent group Chemical group 0.000 claims 35
- 125000004438 haloalkoxy group Chemical group 0.000 claims 34
- 229910052739 hydrogen Inorganic materials 0.000 claims 27
- 239000001257 hydrogen Substances 0.000 claims 27
- -1 hydroxy, amino Chemical group 0.000 claims 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 22
- 125000004093 cyano group Chemical group *C#N 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 16
- 150000003857 carboxamides Chemical class 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 229940124530 sulfonamide Drugs 0.000 claims 8
- 150000003456 sulfonamides Chemical class 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000004043 oxo group Chemical group O=* 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 4
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 4
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 4
- 125000004423 acyloxy group Chemical group 0.000 claims 4
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 claims 4
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 4
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 4
- 125000006164 6-membered heteroaryl group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- ZYFODNCNVGRNQV-UHFFFAOYSA-N 2-methyl-n-[(3-phenylmethoxyphenyl)carbamothioyl]pyridine-3-carboxamide Chemical compound CC1=NC=CC=C1C(=O)NC(=S)NC1=CC=CC(OCC=2C=CC=CC=2)=C1 ZYFODNCNVGRNQV-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001288 lysyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- RWHPHNDWWRLYDS-UHFFFAOYSA-N n-[(3-phenoxyphenyl)carbamothioyl]pyrazine-2-carboxamide Chemical compound C=1N=CC=NC=1C(=O)NC(=S)NC(C=1)=CC=CC=1OC1=CC=CC=C1 RWHPHNDWWRLYDS-UHFFFAOYSA-N 0.000 claims 1
- VHBCHIZHMPLFBO-UHFFFAOYSA-N n-[(3-phenylmethoxyphenyl)carbamothioyl]-2-pyridin-2-yloxyacetamide Chemical compound C=1C=CC(OCC=2C=CC=CC=2)=CC=1NC(=S)NC(=O)COC1=CC=CC=N1 VHBCHIZHMPLFBO-UHFFFAOYSA-N 0.000 claims 1
- QHVJRRFRSQHDCO-UHFFFAOYSA-N n-[(3-phenylmethoxyphenyl)carbamothioyl]-2-pyridin-3-yloxyacetamide Chemical compound C=1C=CC(OCC=2C=CC=CC=2)=CC=1NC(=S)NC(=O)COC1=CC=CN=C1 QHVJRRFRSQHDCO-UHFFFAOYSA-N 0.000 claims 1
- FEUDPOBDPXBYFK-UHFFFAOYSA-N n-[(4-pentoxyphenyl)carbamothioyl]-6-(trifluoromethyl)pyridine-3-carboxamide Chemical compound C1=CC(OCCCCC)=CC=C1NC(=S)NC(=O)C1=CC=C(C(F)(F)F)N=C1 FEUDPOBDPXBYFK-UHFFFAOYSA-N 0.000 claims 1
- JJVWMQKLDXKDIV-UHFFFAOYSA-N n-[(4-pentoxyphenyl)carbamothioyl]pyrazine-2-carboxamide Chemical compound C1=CC(OCCCCC)=CC=C1NC(=S)NC(=O)C1=CN=CC=N1 JJVWMQKLDXKDIV-UHFFFAOYSA-N 0.000 claims 1
- DNDGMOAXMLQILW-UHFFFAOYSA-N n-[(4-pentylphenyl)carbamothioyl]-3-propoxypyridine-2-carboxamide Chemical compound C1=CC(CCCCC)=CC=C1NC(=S)NC(=O)C1=NC=CC=C1OCCC DNDGMOAXMLQILW-UHFFFAOYSA-N 0.000 claims 1
- NMRQDGKIKFJXPB-UHFFFAOYSA-N n-[(4-pentylphenyl)carbamothioyl]-6-(trifluoromethyl)pyridine-3-carboxamide Chemical compound C1=CC(CCCCC)=CC=C1NC(=S)NC(=O)C1=CC=C(C(F)(F)F)N=C1 NMRQDGKIKFJXPB-UHFFFAOYSA-N 0.000 claims 1
- IUTODESYMOWBHQ-UHFFFAOYSA-N n-[(4-pentylphenyl)carbamothioyl]pyrazine-2-carboxamide Chemical compound C1=CC(CCCCC)=CC=C1NC(=S)NC(=O)C1=CN=CC=N1 IUTODESYMOWBHQ-UHFFFAOYSA-N 0.000 claims 1
- AYKHGGLHADXRBU-UHFFFAOYSA-N n-[[4-(1,3-benzothiazol-2-yl)phenyl]carbamothioyl]pyridine-3-carboxamide Chemical compound C=1C=C(C=2SC3=CC=CC=C3N=2)C=CC=1NC(=S)NC(=O)C1=CC=CN=C1 AYKHGGLHADXRBU-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 0 ***C(N(*)C(N(*)c1ccc(*)nc1)=S)=O Chemical compound ***C(N(*)C(N(*)c1ccc(*)nc1)=S)=O 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42763402P | 2002-11-19 | 2002-11-19 | |
| PCT/US2003/036809 WO2004046095A1 (en) | 2002-11-19 | 2003-11-18 | Substituted aryl thioureas and related compounds; inhibitors of viral replication |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006272359A Division JP2007084548A (ja) | 2002-11-19 | 2006-10-03 | 置換されたアリールチオウレアおよび関連化合物；ウイルス複製のインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006506439A JP2006506439A (ja) | 2006-02-23 |
| JP2006506439A5 true JP2006506439A5 (https=) | 2006-11-30 |
| JP4206382B2 JP4206382B2 (ja) | 2009-01-07 |
Family
ID=32326574
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553861A Expired - Fee Related JP4206382B2 (ja) | 2002-11-19 | 2003-11-18 | 置換されたアリールチオウレアおよび関連化合物；ウイルス複製のインヒビター |
| JP2006272359A Pending JP2007084548A (ja) | 2002-11-19 | 2006-10-03 | 置換されたアリールチオウレアおよび関連化合物；ウイルス複製のインヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006272359A Pending JP2007084548A (ja) | 2002-11-19 | 2006-10-03 | 置換されたアリールチオウレアおよび関連化合物；ウイルス複製のインヒビター |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7094807B2 (https=) |
| EP (1) | EP1562895A1 (https=) |
| JP (2) | JP4206382B2 (https=) |
| KR (1) | KR20050111306A (https=) |
| CN (1) | CN1738797A (https=) |
| AP (1) | AP2005003319A0 (https=) |
| AU (1) | AU2003295605A1 (https=) |
| BR (1) | BR0316397A (https=) |
| CA (1) | CA2506415A1 (https=) |
| EA (1) | EA200500846A1 (https=) |
| MX (1) | MXPA05005379A (https=) |
| NO (1) | NO20052546L (https=) |
| NZ (1) | NZ540033A (https=) |
| OA (1) | OA12961A (https=) |
| WO (1) | WO2004046095A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050111306A (ko) * | 2002-11-19 | 2005-11-24 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서의 치환된 아릴 티오우레아 및관련 화합물 |
| AU2005326813B2 (en) * | 2002-11-19 | 2011-08-04 | Achillion Pharmaceuticals, Inc. | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| TW200528459A (en) | 2004-01-06 | 2005-09-01 | Achillion Pharmaceuticals Inc | Azabenzofuran substituted thioureas; inhibitors of viral replication |
| US7501510B2 (en) * | 2004-03-26 | 2009-03-10 | The University Of Hong Kong | Thiourea compositions and uses thereof |
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| JP2008536932A (ja) * | 2005-04-18 | 2008-09-11 | サイード・アール・カーン | チューブリン重合阻害剤：ボンゾイルフェニル尿素（ｂｐｕ）硫黄類似体の設計及び合成 |
| US8864808B2 (en) * | 2005-09-21 | 2014-10-21 | The Cleveland Clinic Foundation | Endoluminal delivery assembly |
| TWI329102B (en) * | 2006-08-15 | 2010-08-21 | Nat Health Research Institutes | Thiourea compounds and method for inhibiting hepatitis c virus infection |
| MX2009006311A (es) * | 2006-12-18 | 2009-10-13 | Achillion Pharmaceuticals Inc | Terapia de combinacion para tratar infecciones de hepatitis c. |
| US7985763B2 (en) | 2007-04-10 | 2011-07-26 | National Health Research Institutes | Hepatitis C virus inhibitors |
| US7897764B2 (en) | 2007-06-08 | 2011-03-01 | National Health Research Institutes | Thiourea derivatives |
| TWI361808B (en) * | 2008-01-08 | 2012-04-11 | Nat Health Research Institutes | Imidazolidinone and imidazolidinethione derivatives |
| US8198284B2 (en) * | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
| CA2750577A1 (en) * | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| FR2943056A1 (fr) * | 2009-03-16 | 2010-09-17 | Sanofi Aventis | Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique |
| JP2012528195A (ja) | 2009-05-29 | 2012-11-12 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃ型肝炎などの疾患を処置するための３つの結合アリール部分で構成された抗菌性化合物 |
| US8377639B2 (en) | 2009-06-26 | 2013-02-19 | University Of Massachusetts | Compounds for modulating RNA binding proteins and uses therefor |
| EP2503881B1 (en) | 2009-11-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
| AU2010341537A1 (en) | 2009-12-22 | 2012-08-09 | Merck Sharp & Dohme Corp. | Fused Tricyclic Compounds and methods of use thereof for the treatment of viral diseases |
| EP2545060B1 (en) | 2010-03-09 | 2015-11-25 | Merck Sharp & Dohme Corp. | Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases |
| WO2011133929A2 (en) * | 2010-04-23 | 2011-10-27 | University Of Rochester | Reducing transmission of sexually transmitted infections |
| AU2011286276A1 (en) | 2010-07-26 | 2013-01-24 | Merck Sharp & Dohme Corp. | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
| JP2013540122A (ja) | 2010-09-29 | 2013-10-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合四環式化合物誘導体およびウィルス疾患治療のためのそれの使用方法 |
| EP2697242B1 (en) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
| WO2012162025A1 (en) * | 2011-05-20 | 2012-11-29 | President And Fellows Of Harvard College | Methods of selecting cancer patients for treatment with n,n'-diarylurea compounds and n,n'-diarylthiourea compounds |
| AR087119A1 (es) | 2011-07-12 | 2014-02-12 | Dow Agrosciences Llc | Composiciones plaguicidas y procesos relacionados |
| WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
| WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
| EP2755981A4 (en) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | SILICULAR HETEROCYCLIC DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
| CN104602524A (zh) * | 2012-07-09 | 2015-05-06 | 美国陶氏益农公司 | 杀虫组合物和与其相关的方法 |
| US10188538B2 (en) | 2015-12-30 | 2019-01-29 | Cook Medical Technologies Llc | Hybrid trigger wire for endografts |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| JP7042829B2 (ja) * | 2016-12-21 | 2022-03-28 | コルテバ アグリサイエンス エルエルシー | ある種の有害生物防除的有用性を有する分子ならびにそれに関連する中間体、組成物及び方法 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| US20190167670A1 (en) * | 2017-10-31 | 2019-06-06 | Nutech Ventures | Methods of treating or preventing zika virus infection |
| CN119735584B (zh) * | 2024-12-16 | 2025-10-14 | 东北农业大学 | 一种含有酰基硫脲和杂环结构的苯氧吡啶类化合物及其制备方法和应用 |
Family Cites Families (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL160809C (nl) * | 1970-05-15 | 1979-12-17 | Duphar Int Res | Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen. |
| US3699110A (en) * | 1970-11-05 | 1972-10-17 | Monsanto Co | Certain 1-aryl or aralkyl-3-(pyridyl) formimidoyl-ureas or thioureas |
| GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| US4044126A (en) * | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
| DE2303761A1 (de) * | 1973-01-26 | 1974-08-01 | Henkel & Cie Gmbh | Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen |
| GB1433934A (en) * | 1973-05-31 | 1976-04-28 | Wyeth John & Brother Ltd | Thioureas |
| JPS5143742A (ja) * | 1974-09-30 | 1976-04-14 | Haruo Ogura | Tansonukureoshidojudotai no seizoho |
| JPS51125323A (en) * | 1975-04-11 | 1976-11-01 | Haruo Ogura | Prosecc for preparing new c-nucleoside derivatives |
| BR7701058A (pt) * | 1976-02-23 | 1977-11-01 | Gulf Research Development Co | Processo e composto para combater insetos |
| US4160037A (en) * | 1977-09-30 | 1979-07-03 | The Upjohn Company | Compounds, compositions and methods of combatting pest employing thioureas |
| ZA793186B (en) * | 1978-07-06 | 1981-02-25 | Duphar Int Res | New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds |
| JPS55167282A (en) * | 1979-06-12 | 1980-12-26 | Fujisawa Pharmaceut Co Ltd | Piperazine derivative or its salt and its preparation |
| JPS5625148A (en) | 1979-08-08 | 1981-03-10 | Ishihara Sangyo Kaisha Ltd | N-benzoyl-n'-phenoxyphenylurea-based compound, and insecticide comprising it |
| US4338257A (en) | 1980-03-04 | 1982-07-06 | Gulf Oil Corporation | Benzoyl arylthioureas and use as plant growth regulators |
| DE3152942T1 (de) * | 1981-08-24 | 1983-12-15 | Rorer International (Overseas) Inc., 19899 Wilmington, Del. | Heterocyclisch substituierte amidinoharnstoffe und ihre therapeutische anwendung |
| DE3217620A1 (de) * | 1982-05-11 | 1983-11-17 | Bayer Ag, 5090 Leverkusen | 2,5-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
| US4880838A (en) | 1982-06-30 | 1989-11-14 | Rhone-Poulenc | Pesticidal 1-(4-Phenoxyphenyl)-5-Benzoyl urea compounds and process for preparation |
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4868215A (en) * | 1982-07-26 | 1989-09-19 | The Dow Chemical Company | Substituted N-aroyl N'-phenyl urea compounds |
| US5001266A (en) * | 1982-07-26 | 1991-03-19 | The Dow Chemical Company | Substituted aniline compounds |
| US4602109A (en) | 1982-12-30 | 1986-07-22 | Union Carbide Corporation | Novel pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for preparation |
| DK147084A (da) * | 1983-03-19 | 1984-09-20 | Bayer Ag | 1-phenyl-3-benzoyl-(thio)-urinstoffer, deres fremstilling og anvendelse som skadedyrsbekaempelsesmidler |
| US4665097A (en) * | 1983-03-31 | 1987-05-12 | Union Carbide Corporation | Novel bicyclooxyaryl thioureas and process for preparation |
| US4873264A (en) * | 1983-05-20 | 1989-10-10 | Rhone-Poulenc Nederlands B.V. | Novel pesticidal 1-(alkyl-phenoxy-aryl)-3-benzoyl ureas and process for preparation |
| US4659736A (en) * | 1984-01-21 | 1987-04-21 | Bayer Aktiengesellschaft | Benzoyl urea compounds as agents for repelling snails and slugs |
| JPS61106551A (ja) | 1984-10-30 | 1986-05-24 | Sumitomo Chem Co Ltd | ジフエニルエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤 |
| US4638088A (en) * | 1984-11-15 | 1987-01-20 | Union Carbide Corporation | Pesticidal biphenylyloxy and biphenylylalkoxy aryl acyl urea compounds |
| US5135953A (en) | 1984-12-28 | 1992-08-04 | Ciba-Geigy | Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals |
| US5166180A (en) * | 1988-01-11 | 1992-11-24 | Duphar International Research B.V. | Method of treating hematologic diseases and pharmaceutical composition to be used therefor |
| US5268389A (en) * | 1989-10-16 | 1993-12-07 | Uniroyal Chemical Company, Inc. | Thiocarboxylate ester compounds compositions containing the same |
| CA2032559C (en) * | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
| JPH04366852A (ja) | 1991-06-13 | 1992-12-18 | Canon Inc | 電子写真感光体、該電子写真感光体を備えた電子写真装置並びにファクシミリ |
| EP0539709A1 (en) * | 1991-09-18 | 1993-05-05 | FUJIREBIO Inc. | 3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors |
| US5591842A (en) * | 1991-11-29 | 1997-01-07 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives |
| US5437996A (en) * | 1992-11-24 | 1995-08-01 | Banyu Pharmaceutical Co., Ltd. | Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives |
| US5589365A (en) * | 1991-11-29 | 1996-12-31 | Banyu Pharmaceutical Co., Ltd. | Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms |
| AU665073B2 (en) * | 1992-06-03 | 1995-12-14 | Ciba-Geigy Ag | Novel thiosemicarbazone derivatives |
| JPH063787A (ja) | 1992-06-18 | 1994-01-14 | Konica Corp | ハロゲン化銀写真感光材料用固形発色現像処理剤及び該固形発色現像処理剤を用いた処理方法 |
| DE4236902A1 (de) * | 1992-10-31 | 1994-05-05 | Hoechst Ag | Neue Phenylsulfonylharnstoffe, Darstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| US5723409A (en) * | 1992-10-31 | 1998-03-03 | Hoechst Schering Agrevo Gmbh | Intermediates for the preparation of phenylsulfonylurea herbicides and plant growth regulators |
| JPH06287171A (ja) | 1993-02-05 | 1994-10-11 | Takeda Chem Ind Ltd | セミカルバジド誘導体、その製造法およびその殺虫組成物 |
| US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
| JP3203108B2 (ja) * | 1993-08-26 | 2001-08-27 | 協和メデックス株式会社 | グルコース−６−リン酸デヒドロゲナーゼの安定化方法 |
| JPH07206811A (ja) * | 1994-01-18 | 1995-08-08 | Wakunaga Pharmaceut Co Ltd | チオウレア誘導体、その製造法及びその利用 |
| DE4442236A1 (de) * | 1994-11-28 | 1996-05-30 | Hoechst Schering Agrevo Gmbh | N-substituierte Hydrazinophenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| DE19506742A1 (de) | 1995-02-27 | 1996-08-29 | Bayer Ag | Verwendung von Chinoxalinen in Kombination mit Protease-Inhibitoren als Arzneimittel zur Behandlung von AIDS und/oder HIV-Infektionen |
| GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
| IL117940A (en) * | 1995-04-19 | 2003-06-24 | Kumiai Chemical Industry Co | Benzylsulfide derivatives, process for their production and insecticide compositions containing them |
| AU6470396A (en) | 1995-07-21 | 1997-02-18 | Nissan Chemical Industries Ltd. | Semicarbazone derivatives and pesticides |
| CN1055083C (zh) | 1995-09-08 | 2000-08-02 | 化学工业部沈阳化工研究院 | 用于杀虫杀螨的吡唑类化合物及其制剂 |
| WO1997011050A1 (en) | 1995-09-19 | 1997-03-27 | Ube Industries, Ltd. | Benzylidenehydrazine compounds, process for producing the same, and agricultural and horticultural pesticides |
| AU7095296A (en) * | 1995-09-26 | 1997-04-17 | Takeda Chemical Industries Ltd. | Phosphorylamides, their preparation and use |
| US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| ATE248598T1 (de) * | 1995-11-15 | 2003-09-15 | Yamanouchi Pharma Co Ltd | Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate |
| GB9525262D0 (en) * | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
| WO1997030047A1 (en) | 1996-02-17 | 1997-08-21 | Agrevo Uk Limited | Fungicidal 1,2,4-oxadiazoles and analogues |
| CA2253502A1 (en) * | 1996-05-06 | 1997-11-13 | Stephen Warren Kaldor | Anti-viral compounds |
| GB9614718D0 (en) * | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| US6794392B1 (en) * | 1996-09-30 | 2004-09-21 | Schering Aktiengesellschaft | Cell differentiation inducer |
| AU6422798A (en) | 1997-03-25 | 1998-10-20 | Takeda Chemical Industries Ltd. | Stabilized urease inhibitor |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| CN1187036C (zh) | 1997-10-14 | 2005-02-02 | 普罗克特和甘保尔公司 | 含有中链支化表面活性剂的个人清洁组合物 |
| JP2001526255A (ja) * | 1997-12-23 | 2001-12-18 | ワーナー−ランバート・カンパニー | 炎症性疾患およびアテローム性動脈硬化症を治療または予防するチオ尿素およびベンズアミド化合物、組成物並びに方法 |
| US6138826A (en) * | 1998-02-02 | 2000-10-31 | Fuji Photo Film Co., Ltd. | Waterproof case for camera |
| US5874615A (en) * | 1998-03-17 | 1999-02-23 | American Cyanamid Co | Method for the preparation of insecticidal benzoylurea compounds |
| WO1999059586A1 (en) | 1998-05-19 | 1999-11-25 | Regents Of The University Of California | Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis |
| JPH11335375A (ja) | 1998-05-20 | 1999-12-07 | Mitsui Chem Inc | ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体 |
| CA2343522A1 (en) * | 1998-09-04 | 2000-03-16 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
| KR20010079907A (ko) * | 1998-09-25 | 2001-08-22 | 비로파마 인코포레이티드 | 바이러스 감염 및 관련 질병의 치료 및 예방 방법 |
| WO2001046124A1 (en) * | 1999-12-22 | 2001-06-28 | Nihon Nohyaku Co., Ltd. | Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof |
| US6207715B1 (en) * | 1998-12-09 | 2001-03-27 | American Home Products Corporation | Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group |
| US6255349B1 (en) * | 1998-12-09 | 2001-07-03 | American Home Products Corporation | Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group |
| US6335350B1 (en) * | 1998-12-09 | 2002-01-01 | American Home Products Corporation | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
| US6420396B1 (en) * | 1998-12-16 | 2002-07-16 | Beiersdorf Ag | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
| DE69927050T2 (de) | 1998-12-16 | 2006-06-29 | Bayer Healthcare Ag | Biphenylverbindungen und biphenyl-analoge als intergrin-antagonisten |
| US6677360B2 (en) * | 1998-12-16 | 2004-01-13 | Bayer Aktiengesellschaft | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
| WO2000073280A1 (en) * | 1999-05-28 | 2000-12-07 | Cheil Jedang Corporation | Cathecol hydrazone derivatives, process for preparing the same and pharmaceutical composition containing the same |
| US6541485B1 (en) * | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6331539B1 (en) * | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6207688B1 (en) * | 1999-06-23 | 2001-03-27 | Parker Hughes Institute | Phenethyl-thiourea compounds and use |
| US6143780A (en) * | 1999-09-17 | 2000-11-07 | Uniroyal Chemical Company, Inc. | N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV |
| ES2239035T3 (es) * | 1999-09-24 | 2005-09-16 | Nihon Nohyaku Co., Ltd. | Derivados de diamida aromatica o sales de estos derivados, productos quimicos para la agricultura/horticultura y procedimiento de utilizacion de estos productos. |
| GB9929988D0 (en) * | 1999-12-17 | 2000-02-09 | Celltech Therapeutics Ltd | Chemical compounds |
| AU2223201A (en) * | 1999-12-24 | 2001-07-09 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives and drugs containing the same |
| EP1251130B1 (en) | 1999-12-24 | 2005-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Fused purine derivatives |
| US6770666B2 (en) * | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
| TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| US6727267B2 (en) * | 2000-04-05 | 2004-04-27 | Tularik Inc. | NS5B HVC polymerase inhibitors |
| US6713502B2 (en) * | 2000-05-05 | 2004-03-30 | Smithkline Beecham Corporation | Anti-infectives |
| WO2001085172A1 (en) * | 2000-05-10 | 2001-11-15 | Smithkline Beecham Corporation | Novel anti-infectives |
| AU2001281817B2 (en) | 2000-06-21 | 2005-11-24 | F. Hoffmann-La Roche Ag | Benzothiazole derivatives |
| US6736336B2 (en) * | 2000-10-13 | 2004-05-18 | International Concepts, Inc. | Shower head |
| DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| AR035543A1 (es) * | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| ES2294190T3 (es) | 2001-11-01 | 2008-04-01 | Janssen Pharmaceutica N.V. | Derivados de amida como inhibidores de la glucogeno sintasa quinasa 3-beta. |
| IL165218A0 (en) * | 2002-05-16 | 2005-12-18 | Bayer Cropscience Gmbh | Pyridine carboxamide derivatives and their use as pesticides |
| ES2270080T3 (es) | 2002-05-16 | 2007-04-01 | Bayer Cropscience Gmbh | Derivados de piridincarboxamida pesticidas. |
| FR2839974B1 (fr) | 2002-05-24 | 2004-07-16 | Pf Medicament | Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament |
| US7517894B2 (en) | 2002-07-31 | 2009-04-14 | Bayer Schering Pharma Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
| US7148357B2 (en) * | 2002-07-31 | 2006-12-12 | Schering Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
| DE10239905A1 (de) | 2002-08-30 | 2004-03-04 | Bayer Cropscience Gmbh | Substituierte Pyridine oder Pyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
| KR20050111306A (ko) * | 2002-11-19 | 2005-11-24 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서의 치환된 아릴 티오우레아 및관련 화합물 |
-
2003
- 2003-11-18 KR KR1020057009112A patent/KR20050111306A/ko not_active Withdrawn
- 2003-11-18 EA EA200500846A patent/EA200500846A1/ru unknown
- 2003-11-18 NZ NZ540033A patent/NZ540033A/en not_active IP Right Cessation
- 2003-11-18 JP JP2004553861A patent/JP4206382B2/ja not_active Expired - Fee Related
- 2003-11-18 CN CNA2003801087106A patent/CN1738797A/zh active Pending
- 2003-11-18 US US10/716,175 patent/US7094807B2/en not_active Expired - Fee Related
- 2003-11-18 EP EP03786803A patent/EP1562895A1/en not_active Withdrawn
- 2003-11-18 CA CA002506415A patent/CA2506415A1/en not_active Abandoned
- 2003-11-18 AU AU2003295605A patent/AU2003295605A1/en not_active Abandoned
- 2003-11-18 MX MXPA05005379A patent/MXPA05005379A/es unknown
- 2003-11-18 OA OA1200500150A patent/OA12961A/en unknown
- 2003-11-18 BR BR0316397-0A patent/BR0316397A/pt not_active IP Right Cessation
- 2003-11-18 AP AP2005003319A patent/AP2005003319A0/xx unknown
- 2003-11-18 WO PCT/US2003/036809 patent/WO2004046095A1/en not_active Ceased
-
2004
- 2004-12-17 US US11/015,300 patent/US7476686B2/en not_active Expired - Fee Related
-
2005
- 2005-05-26 NO NO20052546A patent/NO20052546L/no not_active Application Discontinuation
-
2006
- 2006-10-03 JP JP2006272359A patent/JP2007084548A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006506439A5 (https=) | ||
| US9139529B2 (en) | Substituted quinoxalines as sodium channel modulators | |
| JP2024153683A (ja) | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 | |
| DE69922930T2 (de) | N-[(substitutierte fünfgliedrige di- oder triaza-doppeltungesättigter ring)carbonyl]guanidinderivate zur behandlung von ischemie | |
| ES2153340T3 (es) | Inhibicion de la quinasa raf utilizando ureas heterociclicas sustituidas. | |
| JP2022506887A5 (https=) | ||
| ES2340362T3 (es) | Derivados de sulfanilida farmaceuticamente activos. | |
| JPWO2002072145A1 (ja) | Ｅｐ１アンタゴニストを有効成分として含有するうつ病の治療剤 | |
| AU2016206247A1 (en) | Multisubstituted aromatic compounds as inhibitors of thrombin | |
| JP2009543843A (ja) | 直接トロンビン阻害剤に関する新規適応 | |
| CA2465382A1 (en) | Indole compound and medicinal use thereof | |
| WO2002039987A2 (en) | Use of malaria parasite anion channel blockers for treating malaria | |
| MXPA05009067A (es) | Derivados novedosos de cianopiridina utiles en el tratamiento de cancer y otros desordenes. | |
| MX2012009869A (es) | Derivado de 1, 3,4, 8-tetrahidro-2h-pirido[1, 2-a]pirazina y sus uso como inhibidor de la integrasa del vih. | |
| RU2009133259A (ru) | Производные пиразола в качестве ингибиторов 11-бета-hsd1 | |
| JP2009529059A5 (https=) | ||
| JP2007517887A5 (https=) | ||
| CA2936408A1 (en) | Triazine compounds and pharmaceutical use thereof | |
| AU2016252860B2 (en) | Compositions and methods for inhibiting kinases | |
| RU2008149246A (ru) | Соединение на основе терефталата, композиции и их применение в качестве ингибиторов интегразы вич | |
| JP5465233B2 (ja) | 置換ピラゾールアミドおよびその使用 | |
| US9096531B2 (en) | Fused imidazole derivative | |
| US6197797B1 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| US20070072876A1 (en) | Novel pyrimidine carboxamides | |
| WO2002045750A1 (en) | Combination drugs |