JP2006504710A - １０，１１−ジヒドロ−１０−ヒドロキシ−５Ｈ−ジベンズ［ｂ，ｆ］アゼピン−５−カルボキサミドの両エナンチオマーのエナンチオ選択的製造方法およびその新規結晶形 - Google Patents

１０，１１−ジヒドロ−１０−ヒドロキシ−５Ｈ−ジベンズ［ｂ，ｆ］アゼピン−５−カルボキサミドの両エナンチオマーのエナンチオ選択的製造方法およびその新規結晶形 Download PDF

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Publication number
JP2006504710A
JP2006504710A JP2004540788A JP2004540788A JP2006504710A JP 2006504710 A JP2006504710 A JP 2006504710A JP 2004540788 A JP2004540788 A JP 2004540788A JP 2004540788 A JP2004540788 A JP 2004540788A JP 2006504710 A JP2006504710 A JP 2006504710A
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Prior art keywords
azepine
hydroxy
dihydro
carboxamide
dibenz
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2004540788A
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English (en)
Japanese (ja)
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JP2006504710A5 (https=
Inventor
クリスティアン・マテス
ゴットフリート・ゼーデルマイヤー
フリッツ・ブラッター
ザビーネ・プフェファー
ドミニク・グリムレ
Original Assignee
ノバルティス アクチエンゲゼルシャフト
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Publication of JP2006504710A publication Critical patent/JP2006504710A/ja
Publication of JP2006504710A5 publication Critical patent/JP2006504710A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2004540788A 2002-10-07 2003-10-06 １０，１１−ジヒドロ−１０−ヒドロキシ−５Ｈ−ジベンズ［ｂ，ｆ］アゼピン−５−カルボキサミドの両エナンチオマーのエナンチオ選択的製造方法およびその新規結晶形 Pending JP2006504710A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0223224.7A GB0223224D0 (en) 2002-10-07 2002-10-07 Organic compounds
PCT/EP2003/011034 WO2004031155A1 (en) 2002-10-07 2003-10-06 ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF

Publications (2)

Publication Number Publication Date
JP2006504710A true JP2006504710A (ja) 2006-02-09
JP2006504710A5 JP2006504710A5 (https=) 2006-11-24

Family

ID=9945425

Family Applications (1)

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JP2004540788A Pending JP2006504710A (ja) 2002-10-07 2003-10-06 １０，１１−ジヒドロ−１０−ヒドロキシ−５Ｈ−ジベンズ［ｂ，ｆ］アゼピン−５−カルボキサミドの両エナンチオマーのエナンチオ選択的製造方法およびその新規結晶形

Country Status (20)

Country Link
US (1) US20060142566A1 (https=)
EP (1) EP1551808A1 (https=)
JP (1) JP2006504710A (https=)
KR (1) KR20050071549A (https=)
CN (2) CN1703404A (https=)
AR (1) AR041544A1 (https=)
AU (1) AU2003276055B2 (https=)
BR (1) BR0315113A (https=)
CA (1) CA2501237A1 (https=)
EC (1) ECSP055738A (https=)
GB (1) GB0223224D0 (https=)
HK (1) HK1079790A1 (https=)
MX (1) MXPA05003737A (https=)
NO (1) NO20052244L (https=)
PE (1) PE20040686A1 (https=)
PL (1) PL376379A1 (https=)
RU (1) RU2005114350A (https=)
TW (1) TW200413324A (https=)
WO (1) WO2004031155A1 (https=)
ZA (1) ZA200502561B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006517940A (ja) * 2003-02-17 2006-08-03 ノバルティス アクチエンゲゼルシャフト 神経障害性疼痛におけるｒ−１０−ヒドロキシ−１０，１１−ジヒドロ−カルバマゼピンの使用
JP2016527214A (ja) * 2013-07-01 2016-09-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ケトン類を不斉還元するための新規なルテニウム触媒及びその使用

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0425320D0 (en) 2004-11-17 2004-12-22 Johnson Matthey Plc Diamines
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB2437078A (en) 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
JP5172124B2 (ja) * 2006-09-29 2013-03-27 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
EP2383261B1 (en) 2010-04-23 2013-09-04 Euticals GmbH Process for the asymmetric hydrogenation of ketones
CN102250005B (zh) * 2010-05-19 2015-04-08 浙江九洲药物科技有限公司 艾利西平的制备方法
US9346760B2 (en) 2011-03-08 2016-05-24 Jubilant Life Sciences Limited Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy dihydrodibenz[B,F]azepines by enantioselective reduction of 10,11-dihydro-10-OXO-5H-dibenz[B,F]azepines and polymorphs thereof
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US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
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CN104364231A (zh) 2012-09-08 2015-02-18 塞利克斯比奥私人有限公司 用于治疗炎症和脂质异常的组合物和方法
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
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CN103483257A (zh) * 2013-09-06 2014-01-01 江苏同禾药业有限公司 一种亚氨基芪的合成方法
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09110836A (ja) * 1995-06-30 1997-04-28 Portela & Co Sa 置換されたジヒドロジベンゾ／ｂ，ｆ／アゼピン、これらの製造方法、幾つかの中枢神経系疾患の治療におけるこれらの使用、及びこれらを含有する薬学的組成物
WO2000076942A1 (fr) * 1999-06-15 2000-12-21 Rhodia Chimie Sulfonylamides et carboxamides et leur application en catalyse asymetrique
WO2002064557A2 (en) * 2001-02-12 2002-08-22 Teva Pharmaceutical Industries Ltd. New crystal forms of oxcarbazepine and processes for their preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09110836A (ja) * 1995-06-30 1997-04-28 Portela & Co Sa 置換されたジヒドロジベンゾ／ｂ，ｆ／アゼピン、これらの製造方法、幾つかの中枢神経系疾患の治療におけるこれらの使用、及びこれらを含有する薬学的組成物
WO2000076942A1 (fr) * 1999-06-15 2000-12-21 Rhodia Chimie Sulfonylamides et carboxamides et leur application en catalyse asymetrique
WO2002064557A2 (en) * 2001-02-12 2002-08-22 Teva Pharmaceutical Industries Ltd. New crystal forms of oxcarbazepine and processes for their preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006517940A (ja) * 2003-02-17 2006-08-03 ノバルティス アクチエンゲゼルシャフト 神経障害性疼痛におけるｒ−１０−ヒドロキシ−１０，１１−ジヒドロ−カルバマゼピンの使用
JP2016527214A (ja) * 2013-07-01 2016-09-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ケトン類を不斉還元するための新規なルテニウム触媒及びその使用

Also Published As

Publication number Publication date
MXPA05003737A (es) 2005-06-17
CN1703404A (zh) 2005-11-30
BR0315113A (pt) 2005-08-23
TW200413324A (en) 2004-08-01
WO2004031155A1 (en) 2004-04-15
AU2003276055B2 (en) 2008-01-03
AU2003276055A1 (en) 2004-04-23
CN101062932A (zh) 2007-10-31
US20060142566A1 (en) 2006-06-29
KR20050071549A (ko) 2005-07-07
ECSP055738A (es) 2005-07-06
RU2005114350A (ru) 2006-01-20
PE20040686A1 (es) 2004-10-29
PL376379A1 (en) 2005-12-27
NO20052244L (no) 2005-07-07
HK1079790A1 (zh) 2006-04-13
GB0223224D0 (en) 2002-11-13
CA2501237A1 (en) 2004-04-15
AR041544A1 (es) 2005-05-18
ZA200502561B (en) 2006-02-22
NO20052244D0 (no) 2005-05-06
EP1551808A1 (en) 2005-07-13

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