TW200413324A - Enantioselective process for the preparation of both enantiomers of 10, 11-dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide and new crystal forms tmereof - Google Patents

Enantioselective process for the preparation of both enantiomers of 10, 11-dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide and new crystal forms tmereof Download PDF

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Publication number
TW200413324A
TW200413324A TW092127799A TW92127799A TW200413324A TW 200413324 A TW200413324 A TW 200413324A TW 092127799 A TW092127799 A TW 092127799A TW 92127799 A TW92127799 A TW 92127799A TW 200413324 A TW200413324 A TW 200413324A
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TW
Taiwan
Prior art keywords
dihydro
dibenzo
hydroxy
carboxamide
doc
Prior art date
Application number
TW092127799A
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English (en)
Chinese (zh)
Inventor
Christian Mathes
Gottfried Sedelmeier
Fritz Blatter
Sabine Pfeffer
Dominique Grimler
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Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TW200413324A publication Critical patent/TW200413324A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW092127799A 2002-10-07 2003-10-07 Enantioselective process for the preparation of both enantiomers of 10, 11-dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide and new crystal forms tmereof TW200413324A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0223224.7A GB0223224D0 (en) 2002-10-07 2002-10-07 Organic compounds

Publications (1)

Publication Number Publication Date
TW200413324A true TW200413324A (en) 2004-08-01

Family

ID=9945425

Family Applications (1)

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TW092127799A TW200413324A (en) 2002-10-07 2003-10-07 Enantioselective process for the preparation of both enantiomers of 10, 11-dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide and new crystal forms tmereof

Country Status (20)

Country Link
US (1) US20060142566A1 (https=)
EP (1) EP1551808A1 (https=)
JP (1) JP2006504710A (https=)
KR (1) KR20050071549A (https=)
CN (2) CN1703404A (https=)
AR (1) AR041544A1 (https=)
AU (1) AU2003276055B2 (https=)
BR (1) BR0315113A (https=)
CA (1) CA2501237A1 (https=)
EC (1) ECSP055738A (https=)
GB (1) GB0223224D0 (https=)
HK (1) HK1079790A1 (https=)
MX (1) MXPA05003737A (https=)
NO (1) NO20052244L (https=)
PE (1) PE20040686A1 (https=)
PL (1) PL376379A1 (https=)
RU (1) RU2005114350A (https=)
TW (1) TW200413324A (https=)
WO (1) WO2004031155A1 (https=)
ZA (1) ZA200502561B (https=)

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US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
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EP3016961B1 (en) * 2013-07-01 2017-11-15 Boehringer Ingelheim International GmbH Novel ruthenium catalysts and their use for asymmetric reduction of ketones
CN103483257A (zh) * 2013-09-06 2014-01-01 江苏同禾药业有限公司 一种亚氨基芪的合成方法
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CN107033079B (zh) * 2016-10-17 2020-07-28 扬子江药业集团北京海燕药业有限公司 醋酸艾司利卡西平的制备方法
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Also Published As

Publication number Publication date
MXPA05003737A (es) 2005-06-17
CN1703404A (zh) 2005-11-30
BR0315113A (pt) 2005-08-23
WO2004031155A1 (en) 2004-04-15
AU2003276055B2 (en) 2008-01-03
AU2003276055A1 (en) 2004-04-23
CN101062932A (zh) 2007-10-31
US20060142566A1 (en) 2006-06-29
KR20050071549A (ko) 2005-07-07
ECSP055738A (es) 2005-07-06
RU2005114350A (ru) 2006-01-20
PE20040686A1 (es) 2004-10-29
PL376379A1 (en) 2005-12-27
NO20052244L (no) 2005-07-07
HK1079790A1 (zh) 2006-04-13
GB0223224D0 (en) 2002-11-13
CA2501237A1 (en) 2004-04-15
AR041544A1 (es) 2005-05-18
JP2006504710A (ja) 2006-02-09
ZA200502561B (en) 2006-02-22
NO20052244D0 (no) 2005-05-06
EP1551808A1 (en) 2005-07-13

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