HK1079790A1 - 10，11-二氢-10-羟基-5h-二苯并b，f氮杂卓-5-羧酰胺的对映体及其新晶形两者制备的对映选择性方法 - Google Patents

10，11-二氢-10-羟基-5h-二苯并b，f氮杂卓-5-羧酰胺的对映体及其新晶形两者制备的对映选择性方法 Download PDF

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Publication number
HK1079790A1
HK1079790A1 HK05112208.8A HK05112208A HK1079790A1 HK 1079790 A1 HK1079790 A1 HK 1079790A1 HK 05112208 A HK05112208 A HK 05112208A HK 1079790 A1 HK1079790 A1 HK 1079790A1
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HK
Hong Kong
Prior art keywords
sup
sub
crystal forms
new crystal
azepine
Prior art date
Application number
HK05112208.8A
Other languages
English (en)
Chinese (zh)
Inventor
Christian Mathes
Fritz Blatter
Dominique Grimler
Gottfried Sedelmeier
Sabine Pfeffer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1079790A1 publication Critical patent/HK1079790A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK05112208.8A 2002-10-07 2003-10-06 10，11-二氢-10-羟基-5h-二苯并b，f氮杂卓-5-羧酰胺的对映体及其新晶形两者制备的对映选择性方法 HK1079790A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0223224.7A GB0223224D0 (en) 2002-10-07 2002-10-07 Organic compounds
GB0223224.7 2002-10-07
PCT/EP2003/011034 WO2004031155A1 (en) 2002-10-07 2003-10-06 ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF

Publications (1)

Publication Number Publication Date
HK1079790A1 true HK1079790A1 (zh) 2006-04-13

Family

ID=9945425

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05112208.8A HK1079790A1 (zh) 2002-10-07 2003-10-06 10，11-二氢-10-羟基-5h-二苯并b，f氮杂卓-5-羧酰胺的对映体及其新晶形两者制备的对映选择性方法

Country Status (20)

Country Link
US (1) US20060142566A1 (https=)
EP (1) EP1551808A1 (https=)
JP (1) JP2006504710A (https=)
KR (1) KR20050071549A (https=)
CN (2) CN1703404A (https=)
AR (1) AR041544A1 (https=)
AU (1) AU2003276055B2 (https=)
BR (1) BR0315113A (https=)
CA (1) CA2501237A1 (https=)
EC (1) ECSP055738A (https=)
GB (1) GB0223224D0 (https=)
HK (1) HK1079790A1 (https=)
MX (1) MXPA05003737A (https=)
NO (1) NO20052244L (https=)
PE (1) PE20040686A1 (https=)
PL (1) PL376379A1 (https=)
RU (1) RU2005114350A (https=)
TW (1) TW200413324A (https=)
WO (1) WO2004031155A1 (https=)
ZA (1) ZA200502561B (https=)

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WO2013168004A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of fibromyalgia pain
WO2013168005A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US9403857B2 (en) 2012-05-10 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
WO2013167997A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
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US9394288B2 (en) 2012-05-10 2016-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of asthma and allergy
WO2013168033A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for treatment of neurologic diseases
US9227974B2 (en) 2012-05-23 2016-01-05 Cellex Bio Private Limited Compositions and methods for the treatment of respiratory disorders
AU2013264820A1 (en) 2012-05-23 2014-11-27 Cellixbio Private Limited Compositions and methods for treatment of mucositis
EP2852569B1 (en) 2012-05-23 2020-10-14 Cellixbio Private Limited Compositions and methods for the treatment of multiple sclerosis
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WO2013175344A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
US9498461B2 (en) 2012-05-23 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
WO2014037833A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment inflammation and lipid disorders
CN104364231A (zh) 2012-09-08 2015-02-18 塞利克斯比奥私人有限公司 用于治疗炎症和脂质异常的组合物和方法
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US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
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US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
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Publication number Publication date
MXPA05003737A (es) 2005-06-17
CN1703404A (zh) 2005-11-30
BR0315113A (pt) 2005-08-23
TW200413324A (en) 2004-08-01
WO2004031155A1 (en) 2004-04-15
AU2003276055B2 (en) 2008-01-03
AU2003276055A1 (en) 2004-04-23
CN101062932A (zh) 2007-10-31
US20060142566A1 (en) 2006-06-29
KR20050071549A (ko) 2005-07-07
ECSP055738A (es) 2005-07-06
RU2005114350A (ru) 2006-01-20
PE20040686A1 (es) 2004-10-29
PL376379A1 (en) 2005-12-27
NO20052244L (no) 2005-07-07
GB0223224D0 (en) 2002-11-13
CA2501237A1 (en) 2004-04-15
AR041544A1 (es) 2005-05-18
JP2006504710A (ja) 2006-02-09
ZA200502561B (en) 2006-02-22
NO20052244D0 (no) 2005-05-06
EP1551808A1 (en) 2005-07-13

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