JP2006502162A5 - - Google Patents
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- JP2006502162A5 JP2006502162A5 JP2004534462A JP2004534462A JP2006502162A5 JP 2006502162 A5 JP2006502162 A5 JP 2006502162A5 JP 2004534462 A JP2004534462 A JP 2004534462A JP 2004534462 A JP2004534462 A JP 2004534462A JP 2006502162 A5 JP2006502162 A5 JP 2006502162A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 208000003577 HIV wasting syndrome Diseases 0.000 claims 1
- 206010020100 Hip fracture Diseases 0.000 claims 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 1
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 102000003982 Parathyroid hormone Human genes 0.000 claims 1
- 108090000445 Parathyroid hormone Proteins 0.000 claims 1
- 229940083324 Selective androgen receptor modulator Drugs 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000003178 anti-diabetic effect Effects 0.000 claims 1
- 230000003276 anti-hypertensive effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000000883 anti-obesity agent Substances 0.000 claims 1
- 230000003262 anti-osteoporosis Effects 0.000 claims 1
- 239000003529 anticholesteremic agent Substances 0.000 claims 1
- 229940127226 anticholesterol agent Drugs 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125710 antiobesity agent Drugs 0.000 claims 1
- 150000004663 bisphosphonates Chemical class 0.000 claims 1
- 229940097217 cardiac glycoside Drugs 0.000 claims 1
- 239000002368 cardiac glycoside Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000006132 lipodystrophy Diseases 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims 1
- 239000000199 parathyroid hormone Substances 0.000 claims 1
- 229960001319 parathyroid hormone Drugs 0.000 claims 1
- 102000003998 progesterone receptors Human genes 0.000 claims 1
- 108090000468 progesterone receptors Proteins 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 229930002534 steroid glycoside Natural products 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40809902P | 2002-09-04 | 2002-09-04 | |
| US49164503P | 2003-07-31 | 2003-07-31 | |
| PCT/US2003/027513 WO2004021984A2 (en) | 2002-09-04 | 2003-09-02 | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502162A JP2006502162A (ja) | 2006-01-19 |
| JP2006502162A5 true JP2006502162A5 (enExample) | 2006-05-18 |
| JP4658600B2 JP4658600B2 (ja) | 2011-03-23 |
Family
ID=31981567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534462A Expired - Lifetime JP4658600B2 (ja) | 2002-09-04 | 2003-09-02 | 成長ホルモン分泌促進剤として有用なヘテロ環状芳香族化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (8) | US7166596B2 (enExample) |
| EP (2) | EP1551511B1 (enExample) |
| JP (1) | JP4658600B2 (enExample) |
| KR (3) | KR20050040933A (enExample) |
| CN (2) | CN101863886A (enExample) |
| AR (1) | AR041143A1 (enExample) |
| AU (1) | AU2003270065B2 (enExample) |
| BR (1) | BR0314024A (enExample) |
| CA (1) | CA2496842C (enExample) |
| CY (2) | CY1120250T1 (enExample) |
| DK (2) | DK1551511T5 (enExample) |
| ES (2) | ES2706578T3 (enExample) |
| GE (1) | GEP20074019B (enExample) |
| HR (1) | HRP20050188B1 (enExample) |
| HU (2) | HUE041936T2 (enExample) |
| IL (5) | IL166802A (enExample) |
| IS (1) | IS7719A (enExample) |
| LT (2) | LT1551511T (enExample) |
| MX (1) | MXPA05002301A (enExample) |
| MY (1) | MY139563A (enExample) |
| NO (1) | NO332370B1 (enExample) |
| NZ (1) | NZ538166A (enExample) |
| PE (1) | PE20040997A1 (enExample) |
| PL (1) | PL219563B1 (enExample) |
| PT (2) | PT1551511T (enExample) |
| RS (2) | RS20050186A (enExample) |
| RU (1) | RU2382042C2 (enExample) |
| SI (2) | SI2570414T1 (enExample) |
| TW (2) | TWI362389B (enExample) |
| WO (1) | WO2004021984A2 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
| AR043443A1 (es) * | 2003-03-07 | 2005-07-27 | Merck & Co Inc | Procedimiento de preparacion de tetrahidrotriazolopirazinas y productos intermedios |
| JP2007521232A (ja) | 2003-08-08 | 2007-08-02 | アブジェニックス・インコーポレーテッド | 副甲状腺ホルモン（ｐｔｈ）に対する抗体およびその使用 |
| US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| US7745630B2 (en) | 2003-12-22 | 2010-06-29 | Justin Stephen Bryans | Triazolyl piperidine arginine vasopressin receptor modulators |
| WO2006020959A2 (en) * | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
| AU2005277389A1 (en) * | 2004-08-18 | 2006-03-02 | Elixir Pharmaceuticals, Inc. | Growth-hormone secretagogues |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| MX2007003398A (es) * | 2004-09-27 | 2007-05-21 | Elixir Pharmaceuticals Inc | Sulfonamidas y sus usos. |
| US8143425B2 (en) * | 2004-10-12 | 2012-03-27 | Bristol-Myers Squibb Company | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
| US7579360B2 (en) * | 2005-06-09 | 2009-08-25 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| US7829589B2 (en) | 2005-06-10 | 2010-11-09 | Elixir Pharmaceuticals, Inc. | Sulfonamide compounds and uses thereof |
| MX2007015617A (es) | 2005-06-10 | 2008-03-06 | Elixir Pharmaceuticals Inc | Compuestos de sulfonamida y usos de los mismos. |
| EP1757290A1 (en) | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors |
| AU2006331912B2 (en) | 2005-12-21 | 2012-08-30 | Janssen Pharmaceutica, N.V. | Triazolopyridazines as tyrosine kinase modulators |
| CN101421255A (zh) * | 2006-02-15 | 2009-04-29 | 艾博特公司 | 新的乙酰辅助a羧化酶（acc）抑制剂及其在糖尿病、肥胖症和代谢综合症中的应用 |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| WO2007113226A1 (en) * | 2006-03-31 | 2007-10-11 | Novartis Ag | Organic compounds |
| US20100035756A1 (en) * | 2006-07-12 | 2010-02-11 | Syngenta Limited | Triazolophyridine derivatives as herbicides |
| KR20090094336A (ko) | 2006-11-27 | 2009-09-04 | 하. 룬트벡 아크티에 셀스카브 | 헤테로아릴 아미드 유도체 |
| EP2119719A1 (en) * | 2006-12-26 | 2009-11-18 | Daiichi Sankyo Company, Limited | Thiazepine derivative |
| CN101657436A (zh) | 2007-02-09 | 2010-02-24 | 特兰齐姆制药公司 | 大环生长素释放肽受体调节剂及其使用方法 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| CA2682925A1 (en) | 2007-04-10 | 2008-10-16 | David C. Ihle | Heteroaryl amide analogues |
| US8546394B2 (en) | 2007-04-17 | 2013-10-01 | Bristol-Myers Squibb Company | Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors |
| TWI433677B (zh) * | 2007-06-04 | 2014-04-11 | Avila Therapeutics Inc | 雜環化合物及其用途 |
| AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
| EP2203439B1 (en) | 2007-09-14 | 2011-01-26 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones |
| CN101848893B (zh) | 2007-09-14 | 2012-06-06 | 奥梅-杨森制药有限公司 | 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮 |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| MX2011002042A (es) | 2008-09-02 | 2011-06-20 | Ortho Mcneil Janssen Pharm | Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico. |
| ES2466341T3 (es) | 2008-10-16 | 2014-06-10 | Janssen Pharmaceuticals, Inc. | Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
| JP5535931B2 (ja) * | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5707390B2 (ja) | 2009-05-12 | 2015-04-30 | ジャンセン ファーマシューティカルズ， インコーポレイテッド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用 |
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| US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| EP2431035A1 (en) | 2010-09-16 | 2012-03-21 | Æterna Zentaris GmbH | Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors |
| EP2446898A1 (en) * | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
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| MX367774B (es) | 2011-10-03 | 2019-09-04 | Ogeda S A | N-ACIL-5,6,7, (8-SUSTITUIDO)-TETRAHIDRO- [1,2,4] TRIAZOLO [4,3-a] PIRAZINAS QUIRALES, NOVEDOSAS, COMO ANTAGONISTAS SELECTIVOS DE RECEPTOR DE NK-3; COMPOSICIÓN FARMACÉUTICA, MÉTODOS PARA USO EN TRASTORNOS MEDIADOS POR RECEPTOR DE NK-3 Y SU SÍNTESIS QUIRAL. |
| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| US9724396B2 (en) | 2013-03-15 | 2017-08-08 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
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| WO2014154896A1 (en) | 2013-03-29 | 2014-10-02 | Euroscreen Sa | NOVEL N-ACYL-(3-SUBSTITUTED)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS |
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| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| CN111533745A (zh) * | 2020-05-20 | 2020-08-14 | 成都药明康德新药开发有限公司 | 叔丁基-3-(氨基甲基)二氢-5h-三唑并二氮杂卓-8(9h)-甲酸基酯制法 |
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Family Cites Families (57)
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| US5877173A (en) * | 1996-08-28 | 1999-03-02 | Washington University | Preventing neuronal degeneration in Alzheimer's disease |
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| WO2007113226A1 (en) * | 2006-03-31 | 2007-10-11 | Novartis Ag | Organic compounds |
-
2003
- 2003-08-28 MY MYPI20033269A patent/MY139563A/en unknown
- 2003-09-01 TW TW099113061A patent/TWI362389B/zh not_active IP Right Cessation
- 2003-09-01 TW TW092124121A patent/TWI330185B/zh not_active IP Right Cessation
- 2003-09-02 HU HUE03751958A patent/HUE041936T2/hu unknown
- 2003-09-02 LT LTEP03751958.4T patent/LT1551511T/lt unknown
- 2003-09-02 EP EP03751958.4A patent/EP1551511B1/en not_active Expired - Lifetime
- 2003-09-02 RS YUP-2005/0186A patent/RS20050186A/sr unknown
- 2003-09-02 CN CN201010154361A patent/CN101863886A/zh active Pending
- 2003-09-02 KR KR1020057003669A patent/KR20050040933A/ko not_active Ceased
- 2003-09-02 DK DK03751958T patent/DK1551511T5/da active
- 2003-09-02 HU HUE12191757A patent/HUE035498T2/en unknown
- 2003-09-02 PT PT03751958T patent/PT1551511T/pt unknown
- 2003-09-02 ES ES03751958T patent/ES2706578T3/es not_active Expired - Lifetime
- 2003-09-02 NZ NZ538166A patent/NZ538166A/en not_active IP Right Cessation
- 2003-09-02 SI SI200332548T patent/SI2570414T1/sl unknown
- 2003-09-02 JP JP2004534462A patent/JP4658600B2/ja not_active Expired - Lifetime
- 2003-09-02 PT PT121917579T patent/PT2570414T/pt unknown
- 2003-09-02 GE GEAP20038721A patent/GEP20074019B/en unknown
- 2003-09-02 WO PCT/US2003/027513 patent/WO2004021984A2/en not_active Ceased
- 2003-09-02 MX MXPA05002301A patent/MXPA05002301A/es active IP Right Grant
- 2003-09-02 ES ES12191757.9T patent/ES2644265T3/es not_active Expired - Lifetime
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- 2003-09-02 RU RU2005109545/04A patent/RU2382042C2/ru active
- 2003-09-02 BR BR0314024-5A patent/BR0314024A/pt not_active Application Discontinuation
- 2003-09-02 LT LTEP12191757.9T patent/LT2570414T/lt unknown
- 2003-09-02 HR HRP20050188AA patent/HRP20050188B1/hr not_active IP Right Cessation
- 2003-09-02 EP EP12191757.9A patent/EP2570414B1/en not_active Expired - Lifetime
- 2003-09-02 CN CNA038208644A patent/CN1678372A/zh active Pending
- 2003-09-02 SI SI200332585T patent/SI1551511T1/sl unknown
- 2003-09-02 DK DK12191757.9T patent/DK2570414T3/en active
- 2003-09-02 US US10/653,410 patent/US7166596B2/en not_active Expired - Lifetime
- 2003-09-02 KR KR1020107028594A patent/KR20110003592A/ko not_active Ceased
- 2003-09-02 AU AU2003270065A patent/AU2003270065B2/en not_active Expired
- 2003-09-02 KR KR1020117010024A patent/KR101238041B1/ko not_active Expired - Lifetime
- 2003-09-02 PL PL375882A patent/PL219563B1/pl unknown
- 2003-09-04 PE PE2003000897A patent/PE20040997A1/es active IP Right Grant
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- 2005-02-11 NO NO20050748A patent/NO332370B1/no not_active IP Right Cessation
- 2005-02-28 IS IS7719A patent/IS7719A/is unknown
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- 2008-06-05 IL IL191960A patent/IL191960A/en active IP Right Grant
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- 2009-07-22 US US12/507,413 patent/US7910601B2/en not_active Expired - Lifetime
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2010
- 2010-08-09 US US12/852,610 patent/US7977353B2/en not_active Expired - Lifetime
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