JP2005513006A5 - - Google Patents

Download PDF

Info

Publication number
JP2005513006A5
JP2005513006A5 JP2003543529A JP2003543529A JP2005513006A5 JP 2005513006 A5 JP2005513006 A5 JP 2005513006A5 JP 2003543529 A JP2003543529 A JP 2003543529A JP 2003543529 A JP2003543529 A JP 2003543529A JP 2005513006 A5 JP2005513006 A5 JP 2005513006A5
Authority
JP
Japan
Prior art keywords
compound according
biologically active
residues
residue
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003543529A
Other languages
English (en)
Japanese (ja)
Other versions
JP4663233B2 (ja
JP2005513006A (ja
JP2005513006A6 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/035871 external-priority patent/WO2003041642A2/en
Publication of JP2005513006A publication Critical patent/JP2005513006A/ja
Publication of JP2005513006A6 publication Critical patent/JP2005513006A6/ja
Publication of JP2005513006A5 publication Critical patent/JP2005513006A5/ja
Application granted granted Critical
Publication of JP4663233B2 publication Critical patent/JP4663233B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2003543529A 2001-11-09 2002-11-08 ベンジル脱離系を利用する高分子チオール結合プロドラッグ Expired - Fee Related JP4663233B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34491201P 2001-11-09 2001-11-09
US60/344,912 2001-11-09
US36732002P 2002-03-25 2002-03-25
US60/367,320 2002-03-25
PCT/US2002/035871 WO2003041642A2 (en) 2001-11-09 2002-11-08 Polymeric thiol-linked prodrugs employing benzyl elimination systems

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010093856A Division JP2010195810A (ja) 2001-11-09 2010-04-15 ベンジル脱離系を利用する高分子チオール結合プロドラッグ

Publications (4)

Publication Number Publication Date
JP2005513006A JP2005513006A (ja) 2005-05-12
JP2005513006A6 JP2005513006A6 (ja) 2005-08-04
JP2005513006A5 true JP2005513006A5 (enExample) 2006-01-05
JP4663233B2 JP4663233B2 (ja) 2011-04-06

Family

ID=26994160

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003543529A Expired - Fee Related JP4663233B2 (ja) 2001-11-09 2002-11-08 ベンジル脱離系を利用する高分子チオール結合プロドラッグ
JP2010093856A Pending JP2010195810A (ja) 2001-11-09 2010-04-15 ベンジル脱離系を利用する高分子チオール結合プロドラッグ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010093856A Pending JP2010195810A (ja) 2001-11-09 2010-04-15 ベンジル脱離系を利用する高分子チオール結合プロドラッグ

Country Status (6)

Country Link
US (1) US7262164B2 (enExample)
EP (1) EP1450844A4 (enExample)
JP (2) JP4663233B2 (enExample)
AU (1) AU2002359364A1 (enExample)
CA (1) CA2465090C (enExample)
WO (1) WO2003041642A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005512991A (ja) * 2001-11-09 2005-05-12 エンゾン，インコーポレーテッド 高分子チオール結合プロドラッグ
EP1706399A1 (en) * 2004-01-23 2006-10-04 Elan Pharmaceuticals, Inc. Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids
WO2006015318A2 (en) * 2004-07-30 2006-02-09 Biogen Idec Inc. Antibody conjugated to a drug moiety via a poptidic linker
DE602006007177D1 (de) 2005-12-05 2009-07-16 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
EP2155255B1 (en) 2007-05-09 2013-08-14 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
US20090092664A1 (en) * 2007-10-08 2009-04-09 University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
EP2448938B9 (en) 2009-06-29 2015-06-10 Incyte Corporation Pyrimidinones as pi3k inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
KR102030609B1 (ko) 2011-09-02 2019-10-11 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
DK3831833T3 (da) 2015-02-27 2022-11-14 Incyte Holdings Corp Fremgangsmåder til fremstillingen af en pi3k-inhibitor
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2019010231A1 (en) * 2017-07-05 2019-01-10 Duke University APPARATUS AS TARGETED PRODRUGS FOR PROSTATE CANCER AND METHODS OF MAKING AND USING THE SAME
CN119258070A (zh) 2018-06-01 2025-01-07 因赛特公司 治疗pi3k相关病症的给药方案

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944902A (en) * 1956-07-30 1960-07-12 Eastman Kodak Co Sensitization of photographic emulsions with ionic polyalkylene oxide salts
DE2343147C2 (de) * 1973-08-27 1982-06-09 Henkel KGaA, 4000 Düsseldorf Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung
US4479002A (en) * 1975-12-01 1984-10-23 Union Carbide Corporation Carbamate-carbamoyl fluoride compounds
US4623715A (en) * 1984-10-22 1986-11-18 Hoechst Aktiengeselleschaft Novel peptides which are active on the central nervous system and have an action on the cholinergic system
US4772586A (en) * 1985-01-23 1988-09-20 Medical College Of Ohio Novel derivatives of arginine vasopressin antagonists
US5112739A (en) * 1988-08-02 1992-05-12 Polaroid Corporation Enzyme controlled release system
JPH05132431A (ja) * 1990-03-28 1993-05-28 Nippon Oil & Fats Co Ltd 高分子化薬剤およびその製造法
US5130126A (en) * 1990-07-09 1992-07-14 Nippon Oil & Fats Co., Ltd. Polymer-drug conjugate and a method of producing it
US5245032A (en) * 1990-09-20 1993-09-14 Union Carbide Chemicals & Plastics Technology Corporation Catalytic processes for the preparation of n,n,n-trisubstituted nitrogen-containing compounds
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
AU7932494A (en) * 1993-10-13 1995-05-04 Valence Technology, Inc. Solid electrolytes containing oxyalkylene solvents and/or oxyalkylene polymers and electrolytic cells produced therefrom
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US6255361B1 (en) * 1995-11-21 2001-07-03 Acushnet Company Golf ball compositions and method of making same
CA2245922A1 (en) * 1996-12-13 1998-06-18 Shun-Ichi Ikeda Dc 107 derivatives (2)
CA2312975C (en) * 1997-12-17 2012-08-21 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
JP2005512991A (ja) * 2001-11-09 2005-05-12 エンゾン，インコーポレーテッド 高分子チオール結合プロドラッグ

Similar Documents

Publication Publication Date Title
JP2005513006A5 (enExample)
NO2025027I1 (no) Pharmaceutical mixture or association that includes as active ingredients: (1) ceftazidime or a salt thereof, and (2) avibactam or a pharmaceutically acceptable salt thereof - forlenget.
JP2005524658A5 (enExample)
JP2004523498A5 (enExample)
JP2004529078A5 (enExample)
JP2004532810A5 (enExample)
GEP20063890B (en) Hiv protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
RU2325389C2 (ru) Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью
IL164699A (en) Derivatives of diketohydrazine compounds and pharmaceutical compositions and medicaments containing the compounds as the active ingredient
JP2003503454A5 (enExample)
JP2004515500A5 (enExample)
IL163130A (en) Tripeptides having a hydroxyproline thereof a substituted quinoline, pharmaceutical compositions comprising them and their use in the manufacture of medicaments for the inhibition of ns3 (hepatitis c)
WO2006044362A3 (en) N-sulfonylpiperidine cannabinoid receptor 1 antagonists
NO20043367L (no) Oralt farmasoytisk preparat
CN1878757A (zh) 吡啶酮衍生物及其应用
EA200400664A1 (ru) Фармацевтические композиции, включающие метформин и глибенкламид, применяемые для лечения сахарного диабета типа ii
HUP0203176A2 (hu) Szimetikont tartalmazó orális, szilárd adagolási forma
WO2004030611A3 (en) Non-nucleoside reverse transcriptase inhibitors
NO20040881L (no) Orale antidiabetes midler.
SE0302116D0 (sv) Novel compounds
JP2005509503A5 (enExample)
ATE454385T1 (de) Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung
BRPI0413676A (pt) composto, e, composição farmacêutica
WO2003066597A3 (en) Guanidino compounds
WO2005004915A3 (en) Compositions comprising meloxicam