JP2005513006A5 - - Google Patents
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- Publication number
- JP2005513006A5 JP2005513006A5 JP2003543529A JP2003543529A JP2005513006A5 JP 2005513006 A5 JP2005513006 A5 JP 2005513006A5 JP 2003543529 A JP2003543529 A JP 2003543529A JP 2003543529 A JP2003543529 A JP 2003543529A JP 2005513006 A5 JP2005513006 A5 JP 2005513006A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- biologically active
- residues
- residue
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
Claims (2)
- B1が生物学的活性成分の残基である請求項1に記載の化合物を含む、医薬組成物。
- B1およびB1'が生物学的活性成分の残基である請求項2に記載の化合物を含む、医薬組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34491201P | 2001-11-09 | 2001-11-09 | |
US60/344,912 | 2001-11-09 | ||
US36732002P | 2002-03-25 | 2002-03-25 | |
US60/367,320 | 2002-03-25 | ||
PCT/US2002/035871 WO2003041642A2 (en) | 2001-11-09 | 2002-11-08 | Polymeric thiol-linked prodrugs employing benzyl elimination systems |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010093856A Division JP2010195810A (ja) | 2001-11-09 | 2010-04-15 | ベンジル脱離系を利用する高分子チオール結合プロドラッグ |
Publications (4)
Publication Number | Publication Date |
---|---|
JP2005513006A JP2005513006A (ja) | 2005-05-12 |
JP2005513006A6 JP2005513006A6 (ja) | 2005-08-04 |
JP2005513006A5 true JP2005513006A5 (ja) | 2006-01-05 |
JP4663233B2 JP4663233B2 (ja) | 2011-04-06 |
Family
ID=26994160
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003543529A Expired - Fee Related JP4663233B2 (ja) | 2001-11-09 | 2002-11-08 | ベンジル脱離系を利用する高分子チオール結合プロドラッグ |
JP2010093856A Pending JP2010195810A (ja) | 2001-11-09 | 2010-04-15 | ベンジル脱離系を利用する高分子チオール結合プロドラッグ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010093856A Pending JP2010195810A (ja) | 2001-11-09 | 2010-04-15 | ベンジル脱離系を利用する高分子チオール結合プロドラッグ |
Country Status (6)
Country | Link |
---|---|
US (1) | US7262164B2 (ja) |
EP (1) | EP1450844A4 (ja) |
JP (2) | JP4663233B2 (ja) |
AU (1) | AU2002359364A1 (ja) |
CA (1) | CA2465090C (ja) |
WO (1) | WO2003041642A2 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002363334A1 (en) * | 2001-11-09 | 2003-05-19 | Enzon, Inc. | Polymeric thiol-linked prodrugs |
JP2007518825A (ja) * | 2004-01-23 | 2007-07-12 | イーラン ファーマスーティカルズ、インコーポレイテッド | 複素環式アルキルカルボキサミドプロパノン酸類のポリエチレングリコール抱合体類 |
WO2006015318A2 (en) * | 2004-07-30 | 2006-02-09 | Biogen Idec Inc. | Antibody conjugated to a drug moiety via a poptidic linker |
WO2007067417A1 (en) * | 2005-12-05 | 2007-06-14 | Nitto Denko Corporation | Polyglutamate-amino acid conjugates and methods |
US8197828B2 (en) | 2007-05-09 | 2012-06-12 | Nitto Denko Corporation | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
US20090092664A1 (en) * | 2007-10-08 | 2009-04-09 | University Of Kentucky Research Foundation | Polymer-metal chelator conjugates and uses thereof |
AU2010273816B2 (en) | 2009-06-29 | 2015-07-09 | Incyte Holdings Corporation | Pyrimidinones as PI3K inhibitors |
TW201130842A (en) * | 2009-12-18 | 2011-09-16 | Incyte Corp | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
WO2011075643A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
AR084366A1 (es) | 2010-12-20 | 2013-05-08 | Incyte Corp | N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k |
WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
PT3196202T (pt) | 2011-09-02 | 2019-05-31 | Incyte Holdings Corp | Heterociclilaminas como inibidores de pi3k |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
TWI636046B (zh) | 2013-05-17 | 2018-09-21 | 美國禮來大藥廠 | 苯氧基乙基二氫-1h-異喹啉化合物 |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
LT3831833T (lt) | 2015-02-27 | 2023-02-27 | Incyte Holdings Corporation | Pi3k inhibitoriaus gamybos būdai |
US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
WO2019010231A1 (en) * | 2017-07-05 | 2019-01-10 | Duke University | APPARATUS AS TARGETED PRODRUGS FOR PROSTATE CANCER AND METHODS OF MAKING AND USING THE SAME |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2944902A (en) * | 1956-07-30 | 1960-07-12 | Eastman Kodak Co | Sensitization of photographic emulsions with ionic polyalkylene oxide salts |
DE2343147C2 (de) * | 1973-08-27 | 1982-06-09 | Henkel KGaA, 4000 Düsseldorf | Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung |
US4479002A (en) * | 1975-12-01 | 1984-10-23 | Union Carbide Corporation | Carbamate-carbamoyl fluoride compounds |
US4623715A (en) * | 1984-10-22 | 1986-11-18 | Hoechst Aktiengeselleschaft | Novel peptides which are active on the central nervous system and have an action on the cholinergic system |
US4772586A (en) * | 1985-01-23 | 1988-09-20 | Medical College Of Ohio | Novel derivatives of arginine vasopressin antagonists |
US5112739A (en) * | 1988-08-02 | 1992-05-12 | Polaroid Corporation | Enzyme controlled release system |
JPH05132431A (ja) * | 1990-03-28 | 1993-05-28 | Nippon Oil & Fats Co Ltd | 高分子化薬剤およびその製造法 |
US5130126A (en) * | 1990-07-09 | 1992-07-14 | Nippon Oil & Fats Co., Ltd. | Polymer-drug conjugate and a method of producing it |
US5245032A (en) * | 1990-09-20 | 1993-09-14 | Union Carbide Chemicals & Plastics Technology Corporation | Catalytic processes for the preparation of n,n,n-trisubstituted nitrogen-containing compounds |
US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
WO1995010860A1 (en) * | 1993-10-13 | 1995-04-20 | Valence Technology, Inc. | Solid electrolytes containing oxyalkylene solvents and/or oxyalkylene polymers and electrolytic cells produced therefrom |
US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US6255361B1 (en) * | 1995-11-21 | 2001-07-03 | Acushnet Company | Golf ball compositions and method of making same |
WO1998025934A1 (fr) * | 1996-12-13 | 1998-06-18 | Kyowa Hakko Kogyo Co., Ltd. | Derives dc 107 (2) |
WO1999030727A1 (en) * | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
US6765019B1 (en) | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
AU2002363334A1 (en) * | 2001-11-09 | 2003-05-19 | Enzon, Inc. | Polymeric thiol-linked prodrugs |
-
2002
- 2002-11-08 US US10/290,694 patent/US7262164B2/en not_active Expired - Fee Related
- 2002-11-08 WO PCT/US2002/035871 patent/WO2003041642A2/en active Application Filing
- 2002-11-08 AU AU2002359364A patent/AU2002359364A1/en not_active Abandoned
- 2002-11-08 CA CA002465090A patent/CA2465090C/en not_active Expired - Fee Related
- 2002-11-08 JP JP2003543529A patent/JP4663233B2/ja not_active Expired - Fee Related
- 2002-11-08 EP EP02793896A patent/EP1450844A4/en not_active Withdrawn
-
2010
- 2010-04-15 JP JP2010093856A patent/JP2010195810A/ja active Pending
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