JP2002524460A5 - - Google Patents
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- Publication number
- JP2002524460A5 JP2002524460A5 JP2000568846A JP2000568846A JP2002524460A5 JP 2002524460 A5 JP2002524460 A5 JP 2002524460A5 JP 2000568846 A JP2000568846 A JP 2000568846A JP 2000568846 A JP2000568846 A JP 2000568846A JP 2002524460 A5 JP2002524460 A5 JP 2002524460A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- hydroxy
- fluorinated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 19
- 239000001257 hydrogen Substances 0.000 description 19
- 150000002431 hydrogen Chemical class 0.000 description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000001072 heteroaryl group Chemical group 0.000 description 5
- 125000004093 cyano group Chemical group *C#N 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 125000002757 morpholinyl group Chemical group 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 125000003386 piperidinyl group Chemical group 0.000 description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 3
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 2
- BGNGWHSBYQYVRX-UHFFFAOYSA-N 4-(dimethylamino)benzaldehyde Chemical compound CN(C)C1=CC=C(C=O)C=C1 BGNGWHSBYQYVRX-UHFFFAOYSA-N 0.000 description 2
- 201000001880 Sexual dysfunction Diseases 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 208000002815 pulmonary hypertension Diseases 0.000 description 2
- 231100000872 sexual dysfunction Toxicity 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9926898P | 1998-09-04 | 1998-09-04 | |
| US60/099,268 | 1998-09-04 | ||
| PCT/US1999/020240 WO2000014088A1 (en) | 1998-09-04 | 1999-09-02 | 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002524460A JP2002524460A (ja) | 2002-08-06 |
| JP2002524460A5 true JP2002524460A5 (enExample) | 2006-11-02 |
| JP4717210B2 JP4717210B2 (ja) | 2011-07-06 |
Family
ID=22274049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000568846A Expired - Fee Related JP4717210B2 (ja) | 1998-09-04 | 1999-09-02 | 男性の勃起機能障害の処置のための５−ヘテロシクリルピラゾロ［４，３−ｄ］ピリミジン−７−オン |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6077841A (enExample) |
| EP (1) | EP1109814B1 (enExample) |
| JP (1) | JP4717210B2 (enExample) |
| AT (1) | ATE264861T1 (enExample) |
| AU (1) | AU5704199A (enExample) |
| CA (1) | CA2342830C (enExample) |
| DE (1) | DE69916627T2 (enExample) |
| DK (1) | DK1109814T3 (enExample) |
| ES (1) | ES2220109T3 (enExample) |
| PT (1) | PT1109814E (enExample) |
| WO (1) | WO2000014088A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403597B1 (en) | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
| US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| UA67802C2 (uk) * | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
| GB9828340D0 (en) * | 1998-12-22 | 1999-02-17 | Novartis Ag | Organic compounds |
| AU5925500A (en) * | 1999-07-09 | 2001-01-30 | Picower Institute For Medical Research, The | Pyrazolopyrimidinone derivatives conjugated to thiophene moieties or benzo [fused] 5-membered heterocycles for erectile dysfunction |
| KR100377782B1 (ko) * | 2000-06-23 | 2003-03-29 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
| IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| KR100435514B1 (ko) * | 2002-03-22 | 2004-06-10 | 한미약품 주식회사 | 실데나필 젖산염의 속효제형 |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| WO2005028480A2 (en) * | 2003-09-03 | 2005-03-31 | Neurogen Corporation | 5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds |
| CA2624788C (en) | 2005-10-12 | 2011-04-19 | Unimed Pharmaceuticals, Llc | Improved testosterone gel and method of use |
| CN101891747B (zh) * | 2010-07-02 | 2012-04-25 | 张南 | 抑制5型磷酸二酯酶的化合物及制备方法 |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| CN111606909B (zh) * | 2020-06-09 | 2022-12-20 | 浙江大学 | 吡唑并嘧啶类化合物及其药物组合物及制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666908A (en) * | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
| US5250534A (en) * | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
| US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
| GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| GB9315017D0 (en) * | 1993-07-20 | 1993-09-01 | Glaxo Lab Sa | Chemical compounds |
| GB9423910D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| GB9423911D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| GB9612514D0 (en) * | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
-
1999
- 1999-09-02 JP JP2000568846A patent/JP4717210B2/ja not_active Expired - Fee Related
- 1999-09-02 AT AT99944076T patent/ATE264861T1/de active
- 1999-09-02 WO PCT/US1999/020240 patent/WO2000014088A1/en not_active Ceased
- 1999-09-02 AU AU57041/99A patent/AU5704199A/en not_active Abandoned
- 1999-09-02 CA CA002342830A patent/CA2342830C/en not_active Expired - Lifetime
- 1999-09-02 DK DK99944076T patent/DK1109814T3/da active
- 1999-09-02 DE DE69916627T patent/DE69916627T2/de not_active Expired - Lifetime
- 1999-09-02 ES ES99944076T patent/ES2220109T3/es not_active Expired - Lifetime
- 1999-09-02 EP EP99944076A patent/EP1109814B1/en not_active Expired - Lifetime
- 1999-09-02 PT PT99944076T patent/PT1109814E/pt unknown
- 1999-09-02 US US09/388,851 patent/US6077841A/en not_active Expired - Lifetime
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